Aliases for SNCA Gene
External Ids for SNCA Gene
Previous HGNC Symbols for SNCA Gene
Previous GeneCards Identifiers for SNCA Gene
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
GeneCards Summary for SNCA Gene
SNCA (Synuclein Alpha) is a Protein Coding gene. Diseases associated with SNCA include Dementia, Lewy Body and Parkinson Disease 1. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Chks in Checkpoint Regulation. GO annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is SNCB.
UniProtKB/Swiss-Prot for SNCA Gene
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.