Aliases for SNCA Gene
External Ids for SNCA Gene
Previous Symbols for SNCA Gene
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for SNCA Gene
SNCA (Synuclein, Alpha (Non A4 Component Of Amyloid Precursor)) is a Protein Coding gene. Diseases associated with SNCA include parkinson disease 1 and parkinson disease 4. Among its related pathways are Disease and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is SNCB.
UniProtKB/Swiss-Prot for SNCA Gene
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation