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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNAPIN Gene

protein-coding   GIFtS: 60
GCID: GC01P153631

SNAP-associated protein


(Previous symbol: SNAPAP)
 Explore 11 diseases affiliated with
SNAPIN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNAPIN    

Aliases
for SNAPIN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SNAP-Associated Protein1 2 3     Biogenesis Of Lysosomal Organelles Complex-1, Subunit 72
SNAPAP1 2 3 5     SNAP-25-Binding Protein2
BLOC1S71 2 3     SNARE Associated Protein Snapin2
Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 72 3     SNARE-Associated Protein Snapin2
Synaptosomal-Associated Protein 25-Binding Protein2 3     SNAP25BP3
BLOC-1 Subunit 72 3     

External Ids:    HGNC: 171451   Entrez Gene: 235572   Ensembl: ENSG000001435537   OMIM: 6070075   UniProtKB: O952953   

Export aliases for SNAPIN gene to outside databases

Previous GC identifers: GC01P151898 GC01P124994


Summaries
for SNAPIN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNAPIN:
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble
N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis
of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of
the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1
complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules.
Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of
Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jun
2012)

UniProtKB/Swiss-Prot: SNAPN_HUMAN, O95295
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related
organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1
complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into
neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved
in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming,
fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of
synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences
exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms
of SNARE-mediated membrane fusion in non-neuronal cells

Gene Wiki entry for SNAPIN (SNAPAP)


Genomic Views
for SNAPIN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNAPIN gene promoter:
         Max1   E2F-1   E2F   Sp1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNAPIN promoter sequence
   Search SABiosciences Chromatin IP Primers for SNAPIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAPIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q22

SNAPIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAPIN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153631:  view genomic region     (about GC identifiers)

Start:
 153,631,130 bp from pter      End:
 153,634,326 bp from pter
Size:
 3,197 bases      Orientation:
 plus strand

Proteins
for SNAPIN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNAPN_HUMAN, O95295 (See protein sequence)
Recommended Name: SNARE-associated protein Snapin  
Size: 136 amino acids; 14874 Da
Subunit: Interacts with CSNK1D, SNAP23 and STX4A but not with STX1A, VAMP2 and SYT1. Interacts with SNAP25; the
interaction with SNAP25 is increased by its phosphorylation (By similarity). Component of the biogenesis of
lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6,
DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5,
BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane
protein cargos. Associates with the SNARE complex. Interacts with CEP110, NANOS1, PUM2 and RGS7. Interacts with human
cytomegalovirus/HHV-5 protein UL70
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein; Cytoplasmic side (By
similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic
vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell
junction, synapse, synaptosome. Cytoplasm, perinuclear region. Golgi apparatus membrane (By similarity). Note=May be
cytoplasmic and peripheral membrane bound or anchored to the vesicular membrane through an N-terminal signal anchor
(By similarity). Co-localizes with NANOS1 and PUM2 in the perinuclear region of germ cells
Developmental stage: Expressed in germ cells of 22-week prenatal testis
Secondary accessions: D3DV56 Q5SXU8

Explore the universe of human proteins at neXtProt for SNAPIN: NX_O95295

Post-translational modifications:

  • Phosphorylated by CSNK1D/CK1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95295

    • SNAPIN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036569.1  
    ENSEMBL proteins: 
     ENSP00000357674  
    Reactome Protein details: O95295
    Human Recombinant Protein Products: 
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    Novus Biologicals SNAPIN Proteins
    Novus Biologicals SNAPIN Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SNAPIN
    Uscn Proteins for SNAPIN

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005730nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol ----
    GO:0008021synaptic vesicle TAS10195194


    SNAPIN for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for SNAPIN

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    Uscn ELISAs and CLIAs for SNAPIN

    Protein Domains /
    Families
    for SNAPIN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNAPIN for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR017246 Snapin

    Graphical View of Domain Structure for InterPro Entry O95295

    ProtoNet protein and cluster: O95295

    UniProtKB/Swiss-Prot: SNAPN_HUMAN, O95295
    Similarity: Belongs to the SNAPIN family


    Function
    for SNAPIN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNAPN_HUMAN, O95295
    Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related
    organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1
    complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into
    neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved
    in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming,
    fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of
    synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences
    exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms
    of SNARE-mediated membrane fusion in non-neuronal cells

    miRNA
    Products:            		miRTarBase miRNAs that target SNAPIN:
    hsa-mir-1 (MIRT005274)

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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAPIN (see all 17):
    hsa-miR-301b hsa-miR-30c hsa-miR-148b hsa-miR-575 hsa-miR-301a hsa-miR-30d hsa-miR-3666 hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmid: SNAPIN 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAPIN 

    Cell Line
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    Search LifeMap BioReagents cell lines for SNAPIN

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IDA10195194
    GO:0005515protein binding IPI--


    SNAPIN for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SNAPIN:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Snapintm1Zhs for SNAPIN
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Snapin):
     endocrine/exocrine gland  mortality/aging  nervous system 

    SNAPIN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SNAPIN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		trans-Golgi Network Vesicle Budding1.00
    		Golgi Associated Vesicle Biogenesis0.89
    		Clathrin derived vesicle budding1.00
    2Membrane Trafficking
    		Membrane Trafficking1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SNAPIN
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    SNAPIN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNAPIN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for SNAPIN (O952951, 2, 3 ENSP000003576744) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNBP1Q96EV81, 3, ENSP000003416804EBI-296723,EBI-465804 I2D: score=4 STRING: ENSP00000341680
    BLOC1S2Q6QNY11, 3EBI-296723,EBI-465872 I2D: score=5 
    DDR1Q083452, 3MINT-64069 I2D: score=5 
    EEF1GP266412, 3MINT-63277 I2D: score=5 
    IMMTQ168912, 3MINT-63279 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport TAS10195194
    GO:0007268synaptic transmission ----
    GO:0007269neurotransmitter secretion TAS10195194
    GO:0008089anterograde axon cargo transport ISS--
    GO:0016079synaptic vesicle exocytosis IDA10195194


    SNAPIN for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNAPIN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNAPIN

    1 HMDB Compound for SNAPIN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about SNAPIN / SNAPN 

    Transcripts
    for SNAPIN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNAPIN gene: 
    NM_012437.5  

    Unigene Cluster for SNAPIN:

    SNAP-associated protein
    Hs.32018  [show with all ESTs]
    Unigene Representative Sequence: BQ947794
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368685(uc001fcq.3) ENST00000474959 ENST00000462880 ENST00000478558


    miRNA
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    hsa-miR-301b hsa-miR-30c hsa-miR-148b hsa-miR-575 hsa-miR-301a hsa-miR-30d hsa-miR-3666 hsa-miR-152
    SwitchGear 3'UTR luciferase reporter plasmid: SNAPIN 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: SNAPIN
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNAPIN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAPIN

    Additional cDNA sequence: 

    AF086837.1 AK024555.1 BC000761.2 BC004494.2 BT006753.1 NR_052019.1 NR_052020.1 

    10 DOTS entries:

    DT.100684398  DT.97862522  DT.100860717  DT.100678194  DT.121394321  DT.40132647  DT.40132648  DT.91794691 
    DT.121394397  DT.95092703 

    24/158 AceView cDNA sequences (see all 158):

    BX282383 BU182390 AW246183 CF126163 BC000761 BF685842 AW105250 BQ878532 
    CR590362 R70532 BG774350 CR610984 BQ218849 BU542720 BE222373 BU190992 
    BQ678579 BM845926 AA293565 BM042198 BM469955 BM512166 CD675626 BI255950 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SNAPIN    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e
    SP1:                                                                        
    SP2:                          -     -                                       
    SP3:                                                                        
    SP4:                    -     -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for SNAPIN

    Expression
    for SNAPIN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNAPIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTCTACCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNAPIN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature follicles (In-vitro growth and ...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SNAPIN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNAPIN

    SOURCE GeneReport for Unigene cluster: Hs.32018

    UniProtKB/Swiss-Prot: SNAPN_HUMAN, O95295
    Tissue specificity: Expressed in male germ cells of adult testis (at protein level)

        SABiosciences Custom PCR Arrays for SNAPIN
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAPIN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAPIN

    Orthologs
    for SNAPIN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SNAPIN gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snapin1 , 5 SNAP-associated protein1, 5 89.95(n)1
    97.79(a)1    		   3 (39.24 cM)5
    206151  NM_133854.31  NP_598615.11 
     904880265 
    chicken
    (Gallus gallus)    		 Aves LOC1008581631 SNARE-associated protein Snapin-like 75.63(n)
    87.39(a)    		   100858163  XM_003642627.1  XP_003642675.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNAPIN6
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL344732.1(2030-5397)
    zebrafish
    (Danio rerio)    		 Actinopterygii snapin1 SNAP-associated protein 69.97(n)
    81.82(a)    		   567959  NM_001045148.1  NP_001038613.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta snapin6
    		 snapin
    		 31(a)
    		 1 ↔ 1
    		 2L(2758427-2759710)


    ENSEMBL Gene Tree for SNAPIN (if available)
    TreeFam Gene Tree for SNAPIN (if available) 

    Paralogs
    for SNAPIN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SNAPIN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/72 NCBI SNPs in SNAPIN are shown (see all 72)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1402407091,2
    		--153629140(+) ATGGGA/GGCAGG 3 -- us2k10--------
    rs94273911,2
    		--153629166(+) ttactC/Taggag 3 -- us2k10--------
    rs1480068211,2
    		--153629226(+) CTATGA/TTAACA 3 -- us2k10--------
    rs1899428081,2
    		--153629338(+) GGCGCA/GGTGGC 3 -- us2k10--------
    rs1837880901,2
    		--153629381(+) GAGGCA/GGGTGG 3 -- us2k10--------
    rs121399531,2
    		C,F,--153629755(+) GTAGCG/AGGGAC 3 -- us2k16Minor allele frequency- A:0.44WA NA CSA EA 364
    rs1416977151,2
    		--153629858(+) GGCGCG/TATCAG 3 -- us2k10--------
    rs667218141,2
    		C,F,--153630120(+) AGTCTC/TACTAG 3 -- us2k18Minor allele frequency- T:0.46NA WA CSA EA 368
    rs794831991,2
    		F,--153630324(+) AGAAAT/CAGACC 3 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1891969921,2
    		--153630399(+) GCCCAA/GGAGTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNAPIN (153631130 - 153634326 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNAPIN: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SNAPIN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNAPIN for disorders           About GeneDecksing

    OMIM gene information: 607007    OMIM disorders: --

    11 diseases for SNAPIN:    About MalaCards
    hermansky-pudlak syndrome    platelet storage pool deficiency    tricuspid valve stenosis    hepatitis b
    hepatocellular carcinoma    schizophrenia    hepatitis    carcinoma
    prostatitis    neuronitis    retinitis

    3 diseases from the University of Copenhagen DISEASES database for SNAPIN:
    Tricuspid valve stenosis     Hermansky-Pudlak syndrome     Platelet storage pool deficiency
    Human Genome Epidemiology (HuGE) Navigator: SNAPIN (1 document)

    Export disorders for SNAPIN gene to outside databases

    Publications
    for SNAPIN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNAPIN gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with SNAPIN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Snapin interacts with the N-terminus of regulator of G protein signaling 7. (PubMed id 12659861)1, 2, 3, 9 Hunt R.A.... Young K.H. (2003)
    2. Snapin: a SNARE-associated protein implicated in synaptic transmission. (PubMed id 10195194)1, 2, 3, 9 Ilardi J.M.... Sheng Z.-H. (1999)
    3. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. (PubMed id 19168546)1, 2, 9 Ginter-Matuszewska B....Jaruzelska J. (2009)
    4. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome- related organelles complex-1 (BLOC-1). (PubMed id 15102850)1, 2, 9 Starcevic M. and Dell'Angelica E.C. (2004)
    5. Assembly and architecture of biogenesis of lysosome-re lated organelles complex-1 (BLOC-1). (PubMed id 22203680)1, 2 Lee H.H....Hurley J.H. (2012)
    6. Human cytomegalovirus primase UL70 specifically inter acts with cellular factor Snapin. (PubMed id 21917956)1, 2 Shen A....Liu F. (2011)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. (PubMed id 12877659)1, 9 Buxton P....Rowe T. (2003)
    10. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. (PubMed id 17702749)1, 9 Mistry A.C....Sands J.M. (2007)

    External Searches for SNAPIN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SNAPIN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23557 HGNC: 17145 AceView: SNAPAP Ensembl:ENSG00000143553 euGenes: HUgn23557
    ECgene: SNAPIN H-InvDB: SNAPIN

    Other Databases showing SNAPIN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNAPIN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNAPIN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNAPIN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNAPIN gene:
    Search GeneIP for patents involving SNAPIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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