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Aliases for SNAPC5 Gene

Aliases for SNAPC5 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 5 2 3 5
  • SnRNA-Activating Protein Complex 19 KDa Subunit 3 4
  • SNAPc 19 KDa Subunit 3 4
  • SNAPc Subunit 5 3 4
  • SNAP19 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kDa 2
  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kD 2
  • Small Nuclear RNA-Activating Complex Polypeptide 5 4
  • SnRNA-Activating Protein Complex Subunit 5 3

External Ids for SNAPC5 Gene

Previous GeneCards Identifiers for SNAPC5 Gene

  • GC15M062578
  • GC15M059884
  • GC15M064360
  • GC15M064502
  • GC15M064573
  • GC15M066782
  • GC15M043618

Summaries for SNAPC5 Gene

Entrez Gene Summary for SNAPC5 Gene

  • This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]

GeneCards Summary for SNAPC5 Gene

SNAPC5 (Small Nuclear RNA Activating Complex Polypeptide 5) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for SNAPC5 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC5 Gene

Additional gene information for SNAPC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC5 Gene

Genomics for SNAPC5 Gene

GeneHancer (GH) Regulatory Elements for SNAPC5 Gene

Promoters and enhancers for SNAPC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I066495 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 573.9 +0.6 605 3.9 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNAPC5 MIR4512 TIPIN ENSG00000260773 RPL4 SLC24A1 INTS14 ZWILCH HACD3 SNORD16
GH15I066502 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.6 -6.4 -6433 4.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A SNORD16 ZWILCH RPL4 GC15M066535 GC15M066537 PIR57266 SNORD18A INTS14 ENSG00000260773 RPL35AP32
GH15I066385 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 25.2 +108.7 108734 6.5 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 MAP2K1 TIPIN SNAPC5 ZWILCH INTS14 SLC24A1 RPL35AP32 ENSG00000260773 SNORD16 DIS3L
GH15I066292 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.5 +203.9 203886 3.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 CBX5 KLF13 DIS3L LOC105370868 SNAPC5 TIPIN MAP2K1 ENSG00000260773
GH15I066355 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.1 +141.2 141162 1.9 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 TIPIN RPL35AP32 INTS14 SNORD16 SNAPC5 ENSG00000260773 ZWILCH DENND4A DIS3L ENSG00000223271
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNAPC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNAPC5 gene promoter:

Genomic Locations for SNAPC5 Gene

Genomic Locations for SNAPC5 Gene
chr15:66,490,135-66,497,813
(GRCh38/hg38)
Size:
7,679 bases
Orientation:
Minus strand
chr15:66,782,473-66,790,151
(GRCh37/hg19)

Genomic View for SNAPC5 Gene

Genes around SNAPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC5 Gene

Proteins for SNAPC5 Gene

  • Protein details for SNAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75971-SNPC5_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 5
    Protein Accession:
    O75971
    Secondary Accessions:
    • A8K7N6
    • Q96CF3

    Protein attributes for SNAPC5 Gene

    Size:
    98 amino acids
    Molecular mass:
    11328 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4.

    Alternative splice isoforms for SNAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAPC5 Gene

Post-translational modifications for SNAPC5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNAPC5 Gene

Domains & Families for SNAPC5 Gene

Gene Families for SNAPC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNAPC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNAPC5: view

No data available for UniProtKB/Swiss-Prot for SNAPC5 Gene

Function for SNAPC5 Gene

Molecular function for SNAPC5 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Phenotypes From GWAS Catalog for SNAPC5 Gene

Gene Ontology (GO) - Molecular Function for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SNAPC5: view
genes like me logo Genes that share phenotypes with SNAPC5: view

Animal Model Products

miRNA for SNAPC5 Gene

miRTarBase miRNAs that target SNAPC5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAPC5 Gene

Localization for SNAPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAPC5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SNAPC5: view

Pathways & Interactions for SNAPC5 Gene

genes like me logo Genes that share pathways with SNAPC5: view

Gene Ontology (GO) - Biological Process for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA,TAS 9732265
GO:0006384 transcription initiation from RNA polymerase III promoter IEA --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with SNAPC5: view

No data available for SIGNOR curated interactions for SNAPC5 Gene

Drugs & Compounds for SNAPC5 Gene

No Compound Related Data Available

Transcripts for SNAPC5 Gene

Unigene Clusters for SNAPC5 Gene

Small nuclear RNA activating complex, polypeptide 5, 19kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for SNAPC5 Gene

GeneLoc Exon Structure for
SNAPC5
ECgene alternative splicing isoforms for
SNAPC5

Expression for SNAPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAPC5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNAPC5 Gene



NURSA nuclear receptor signaling pathways regulating expression of SNAPC5 Gene:

SNAPC5

SOURCE GeneReport for Unigene cluster for SNAPC5 Gene:

Hs.30174

Evidence on tissue expression from TISSUES for SNAPC5 Gene

  • Spleen(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with SNAPC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAPC5 Gene

Orthologs for SNAPC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC5 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia SNAPC5 33 34
  • 91.67 (n)
cow
(Bos Taurus)
Mammalia SNAPC5 33 34
  • 86.9 (n)
rat
(Rattus norvegicus)
Mammalia Snapc5 33
  • 81.35 (n)
mouse
(Mus musculus)
Mammalia Snapc5 33 16 34
  • 80.08 (n)
oppossum
(Monodelphis domestica)
Mammalia SNAPC5 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAPC5 33 34
  • 67.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1394 33
zebrafish
(Danio rerio)
Actinopterygii snapc5 34
  • 44 (a)
OneToOne
Species where no ortholog for SNAPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC5 Gene

ENSEMBL:
Gene Tree for SNAPC5 (if available)
TreeFam:
Gene Tree for SNAPC5 (if available)

Paralogs for SNAPC5 Gene

Pseudogenes.org Pseudogenes for SNAPC5 Gene

genes like me logo Genes that share paralogs with SNAPC5: view

No data available for Paralogs for SNAPC5 Gene

Variants for SNAPC5 Gene

Sequence variations from dbSNP and Humsavar for SNAPC5 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1057519735 pathogenic, Malignant melanoma 66,490,577(-) A/C 3_prime_UTR_variant
rs138560168 uncertain-significance, Cardio-facio-cutaneous syndrome, Noonan syndrome 66,491,505(-) A/G intron_variant
rs14303 likely-benign, Noonan syndrome, Cardio-facio-cutaneous syndrome 66,490,923(-) C/A/G intron_variant
rs150841154 conflicting-interpretations-of-pathogenicity, uncertain-significance, benign, not specified, Noonan syndrome, Cardio-facio-cutaneous syndrome, Rasopathy 66,490,570(-) C/T 3_prime_UTR_variant
rs200293968 likely-benign, Rasopathy 66,490,531(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC5 Gene

Variant ID Type Subtype PubMed ID
nsv977729 CNV duplication 23825009

Variation tolerance for SNAPC5 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNAPC5 Gene

Human Gene Mutation Database (HGMD)
SNAPC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC5 Gene

Disorders for SNAPC5 Gene

Additional Disease Information for SNAPC5

No disorders were found for SNAPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC5 Gene

Publications for SNAPC5 Gene

  1. SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. (PMID: 9732265) Henry RW … Hernandez N (Genes & development 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. (PMID: 11056176) Ma B … Hernandez N (The Journal of biological chemistry 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SNAPC5 Gene

Sources for SNAPC5 Gene

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