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Aliases for SNAPC5 Gene

Aliases for SNAPC5 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 5 2 3 5
  • SnRNA-Activating Protein Complex 19 KDa Subunit 3 4
  • SNAPc 19 KDa Subunit 3 4
  • SNAPc Subunit 5 3 4
  • SNAP19 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kDa 2
  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kD 2
  • Small Nuclear RNA-Activating Complex Polypeptide 5 4
  • SnRNA-Activating Protein Complex Subunit 5 3

External Ids for SNAPC5 Gene

Previous GeneCards Identifiers for SNAPC5 Gene

  • GC15M062578
  • GC15M059884
  • GC15M064360
  • GC15M064502
  • GC15M064573
  • GC15M066782
  • GC15M043618

Summaries for SNAPC5 Gene

Entrez Gene Summary for SNAPC5 Gene

  • This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]

GeneCards Summary for SNAPC5 Gene

SNAPC5 (Small Nuclear RNA Activating Complex Polypeptide 5) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SNAPC5 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC5 Gene

Genomics for SNAPC5 Gene

Regulatory Elements for SNAPC5 Gene

Enhancers for SNAPC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G066410 1.4 Ensembl ENCODE dbSUPER 35.5 +86.4 86423 1.6 WRNIP1 SIN3A ZNF48 ZNF2 ZNF335 GLIS2 ZNF391 EGR2 ZNF263 YY2 TIPIN SNAPC5 ENSG00000260773 MAP2K1 LOC646358 SLC24A1 SNORD18C SNORD16 SNORD18A SNORD18B
GH15G066502 1.4 ENCODE dbSUPER 31.6 -6.4 -6405 4.3 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D TIPIN SNAPC5 ENSG00000260773 SNORD16 HACD3 DIS3L LOC105370868 ZWILCH SNORD18A GC15M066529
GH15G066385 1.7 Ensembl ENCODE dbSUPER 25.2 +108.7 108735 6.5 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D TIPIN SNAPC5 SLC24A1 ZWILCH DIS3L LOC105370868 ENSG00000261351 MAP2K1 GC15M066415
GH15G066416 1.1 Ensembl ENCODE dbSUPER 35.4 +80.1 80079 1.9 PKNOX1 MTA2 BHLHE40 ZMYM3 NR2F2 ARID3A HDAC2 POLR2A ADNP KDM1A TIPIN SNAPC5 DIS3L MAP2K1 SNORD16 ZWILCH SNORD18A RPL4 ENSG00000261351 ATP5J2P6
GH15G066469 1.3 Ensembl ENCODE 26.1 +25.0 24991 5.9 PKNOX1 SIN3A FEZF1 YY1 ZNF121 GATA2 FOS DEK ZNF263 SP5 TIPIN SNAPC5 DIS3L GC15M066489 RPL35AP32
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNAPC5 on UCSC Golden Path with GeneCards custom track

Promoters for SNAPC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078183 308 1001 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for SNAPC5 Gene

Chromosome:
15
Start:
66,490,135 bp from pter
End:
66,497,813 bp from pter
Size:
7,679 bases
Orientation:
Minus strand

Genomic View for SNAPC5 Gene

Genes around SNAPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC5 Gene

Proteins for SNAPC5 Gene

  • Protein details for SNAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75971-SNPC5_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 5
    Protein Accession:
    O75971
    Secondary Accessions:
    • A8K7N6
    • Q96CF3

    Protein attributes for SNAPC5 Gene

    Size:
    98 amino acids
    Molecular mass:
    11328 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4.

    Alternative splice isoforms for SNAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAPC5 Gene

Post-translational modifications for SNAPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNAPC5 Gene

Domains & Families for SNAPC5 Gene

Gene Families for SNAPC5 Gene

Protein Domains for SNAPC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNAPC5: view

No data available for UniProtKB/Swiss-Prot for SNAPC5 Gene

Function for SNAPC5 Gene

Molecular function for SNAPC5 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Ontology (GO) - Molecular Function for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SNAPC5: view
genes like me logo Genes that share phenotypes with SNAPC5: view

Animal Model Products

CRISPR Products

miRNA for SNAPC5 Gene

miRTarBase miRNAs that target SNAPC5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAPC5 Gene

Localization for SNAPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAPC5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SNAPC5: view

Pathways & Interactions for SNAPC5 Gene

genes like me logo Genes that share pathways with SNAPC5: view

Gene Ontology (GO) - Biological Process for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA,TAS 9732265
GO:0006384 transcription initiation from RNA polymerase III promoter IEA --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SNAPC5: view

No data available for SIGNOR curated interactions for SNAPC5 Gene

Drugs & Compounds for SNAPC5 Gene

No Compound Related Data Available

Transcripts for SNAPC5 Gene

Unigene Clusters for SNAPC5 Gene

Small nuclear RNA activating complex, polypeptide 5, 19kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for SNAPC5 Gene

GeneLoc Exon Structure for
SNAPC5
ECgene alternative splicing isoforms for
SNAPC5

Expression for SNAPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAPC5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNAPC5 Gene



NURSA nuclear receptor signaling pathways regulating expression of SNAPC5 Gene:

SNAPC5

SOURCE GeneReport for Unigene cluster for SNAPC5 Gene:

Hs.30174

Evidence on tissue expression from TISSUES for SNAPC5 Gene

  • Spleen(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with SNAPC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAPC5 Gene

Orthologs for SNAPC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC5 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia SNAPC5 34 35
  • 91.67 (n)
cow
(Bos Taurus)
Mammalia SNAPC5 34 35
  • 86.9 (n)
rat
(Rattus norvegicus)
Mammalia Snapc5 34
  • 81.35 (n)
mouse
(Mus musculus)
Mammalia Snapc5 34 16 35
  • 80.08 (n)
oppossum
(Monodelphis domestica)
Mammalia SNAPC5 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAPC5 34 35
  • 67.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1394 34
zebrafish
(Danio rerio)
Actinopterygii snapc5 35
  • 44 (a)
OneToOne
Species where no ortholog for SNAPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC5 Gene

ENSEMBL:
Gene Tree for SNAPC5 (if available)
TreeFam:
Gene Tree for SNAPC5 (if available)

Paralogs for SNAPC5 Gene

Pseudogenes.org Pseudogenes for SNAPC5 Gene

genes like me logo Genes that share paralogs with SNAPC5: view

No data available for Paralogs for SNAPC5 Gene

Variants for SNAPC5 Gene

Sequence variations from dbSNP and Humsavar for SNAPC5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs14303 Likely benign 66,490,923(-) CAATT(C/G/T)TAAGA intron-variant, utr-variant-3-prime
rs200542677 Likely benign 66,489,698(+) CTTAC(C/T)TTGTC intron-variant
rs397516787 Likely benign 66,489,286(+) GTTGG(C/T)TCCTT intron-variant
rs41306345 Likely benign 66,489,710(+) TTCTT(C/T)CTTTA intron-variant
rs56366941 Likely benign 66,491,040(+) GCCTT(A/G/T)TGAGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNAPC5 Gene

Variant ID Type Subtype PubMed ID
nsv977729 CNV duplication 23825009

Variation tolerance for SNAPC5 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAPC5 Gene

Human Gene Mutation Database (HGMD)
SNAPC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC5 Gene

Disorders for SNAPC5 Gene

Relevant External Links for SNAPC5

Genetic Association Database (GAD)
SNAPC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAPC5

No disorders were found for SNAPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC5 Gene

Publications for SNAPC5 Gene

  1. SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. (PMID: 9732265) Henry R.W. … Hernandez N. (Genes Dev. 1998) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A map of protein-protein contacts within the small nuclear RNA- activating protein complex SNAPc. (PMID: 11056176) Ma B. … Hernandez N. (J. Biol. Chem. 2001) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SNAPC5 Gene

Sources for SNAPC5 Gene

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