SNAPC5 Gene
protein-coding GIFtS: 49
GCID: GC15M066782
|
|
small nuclear RNA activating complex, polypeptide 5, 19kDa(Previous names: small nuclear RNA activating complex, polypeptide 5, 19kD...)
| |
Aliases
for SNAPC5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Nuclear RNA Activating Complex, Polypeptide 5, 19kDa1 2 | | SNAPc Subunit 52 3 | | SNAP191 2 3 | | SnRNA-Activating Protein Complex 19 KDa Subunit2 3 | | Small Nuclear RNA-Activating Complex Polypeptide 52 3 | | Small Nuclear RNA Activating Complex, Polypeptide 5, 19kD1 | | SNAPc 19 KDa Subunit2 3 | | SnRNA-Activating Protein Complex Subunit 52 |
Export aliases for SNAPC5 gene to outside databasesPrevious GC identifers: GC15M062578 GC15M059884 GC15M064360 GC15M064502 GC15M064573 GC15M043618 |
Summaries
for SNAPC5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SNPC5_HUMAN, O75971Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNAgenes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types ofgenes. Recruits TBP and BRF2 to the U6 snRNA TATA box
Gene Wiki entry for SNAPC5
|
Genomic Views
for SNAPC5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNAPC5 gene promoter:
TBP FOXF2 TFIID Meis-1a Meis-1 Meis-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNAPC5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAPC5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22SNAPC5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M066782: view genomic region
(about GC identifiers)
Start:
|
66,782,644 bp from pter |
End:
|
66,790,151 bp from pter |
Size:
|
7,508 bases |
Orientation:
|
minus strand |
|
Proteins
for SNAPC5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNPC5_HUMAN, O75971 (See
protein sequence)Recommended Name: snRNA-activating protein complex subunit 5 Size: 98 amino acids; 11328 Da
Subunit: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interactswith SNAPC4
Subcellular location: Nucleus
Secondary accessions: A8K7N6 Q96CF3Alternative splicing: 2 isoforms: O75971-1 O75971-2 Explore the universe of human proteins at neXtProt for SNAPC5: NX_O75971
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75971
SNAPC5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006040.1
ENSEMBL proteins: ENSP00000378954 ENSP00000454421 ENSP00000457892 ENSP00000455680 ENSP00000319597 ENSP00000455626 ENSP00000308439 ENSP00000456716 Reactome Protein details: O75971
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SNAPC5 for ontologies About GeneDecksing
SNAPC5 Antibody Products:
Assay Products for SNAPC5: |
Protein
Domains /
Families
for SNAPC5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O75971 |
Function
for SNAPC5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNPC5_HUMAN, O75971Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNAgenes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types ofgenes. Recruits TBP and BRF2 to the U6 snRNA TATA box
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNAPC5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SNAPC5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAPC5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAPC5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
TAS | 9732265 |
SNAPC5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SNAPC5:
|
Pathways & Interactions
for SNAPC5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase III Transcription Initiation | | | 2 | Transcription | | | 3 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for SNAPC5 (see all 7)
SNAPC5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNAPC5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for SNAPC5 (O759712, 3 ENSP000003195974) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 9732265 | | GO:0006383 | transcription from RNA polymerase III promoter |
TAS | -- | | GO:0006384 | transcription initiation from RNA polymerase III promoter |
TAS | 9732265 | | GO:0010467 | gene expression |
TAS | -- |
SNAPC5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNAPC5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNAPC5
Search CenterWatch for drugs/clinical trials and news about SNAPC5 / SNPC5
|
Transcripts
for SNAPC5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNAPC5 gene: NM_006049.2 Unigene Cluster for SNAPC5: Small nuclear RNA activating complex, polypeptide 5, 19kDa Hs.30174 [show with all ESTs]Unigene Representative Sequence: AK0247638 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395589(uc002apu.1) ENST00000562411 ENST00000563480 ENST00000568875
ENST00000316634 ENST00000565465 ENST00000307979 ENST00000566658
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNAPC5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNAPC5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNAPC5 (NM_006049) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNAPC5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAPC5 |
Additional cDNA sequence: AF093593.1 AK024763.1 AK292051.1 AK312018.1 BC014315.1 BC066984.1 15 DOTS entries: DT.95288003 DT.100786451 DT.100786450 DT.97843965 DT.100790989 DT.97816512 DT.40295498 DT.100685506 DT.91727610 DT.115613 DT.121070776 DT.95135737 DT.100767185 DT.121478711 DT.455033 24/196 AceView cDNA sequences (see all 196): CB157458 BQ639459 BM452232 BX102496 AV653411 AA605059 CA391748 CR614188 BQ019982 AA371354 BM918152 C05226 BU192745 N42892 AL120781 BQ883131 AW137186 BU685315 BM992243 BM710223 BC066984 AA348995 BU679510 AA926802
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for SNAPC5
|
Expression
for SNAPC5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNAPC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATAAACTG
About this image
See SNAPC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNAPC5
SOURCE GeneReport for Unigene cluster: Hs.30174
SABiosciences Custom PCR Arrays for SNAPC5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNAPC5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNAPC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNAPC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAPC5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAPC5 |
Orthologs
for SNAPC5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SNAPC5 gene from 4/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Snapc51 , 5 |
small nuclear RNA activating complex, polypeptide 51, 5 |
78.69(n)1
78.35(a)1 |
|
9 (34.54 cM)5
3309591 NM_183316.21 NP_899139.21
641792975 |
chicken
(Gallus gallus) |
Aves |
SNAPC51 |
small nuclear RNA activating complex, polypeptide 5, more |
70.25(n)
69.89(a) |
|
415550 NM_001007829.1 NP_001007830.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.13942 |
Xenopus laevis, clone IMAGE5541951, mRNA |
75.81(n) |
|
BC046733.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
snapc51 |
small nuclear RNA activating complex, polypeptide 5 |
58.33(n)
56.52(a) |
|
492409 NM_001080163.2 NP_001073632.1 |
ENSEMBL Gene Tree for SNAPC5 (if available)
TreeFam Gene Tree for SNAPC5 (if available) |
Paralogs
for SNAPC5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNAPC5 gene
SNAPC5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SNAPC5
PGOHUM00000243051
|
Genomic Variants
for SNAPC5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNAPC5 (66782644 - 66790151 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNAPC5: --
Human Gene Mutation Database (HGMD): SNAPC5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNAPC5 |
|
Disorders
/ Diseases
for SNAPC5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SNAPC5 for disorders About MalaCards
SNAPC5 for disorders About GeneDecksing
OMIM gene information: 605979
OMIM disorders: --
Export disorders for SNAPC5 gene to outside databases
|
Publications
for SNAPC5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNAPC5 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with SNAPC5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. (PubMed id 9732265)1, 2, 3 Henry R.W.... Hernandez N. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A map of protein-protein contacts within the small nuclear RNA- activating protein complex SNAPc. (PubMed id 11056176)1, 2 Ma B. and Hernandez N. (2001)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for SNAPC5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNAPC5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNAPC5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNAPC5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNAPC5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNAPC5 gene:
Search GeneIP for patents involving SNAPC5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNAPC5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 | | | SNAPC5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAPC5 |
|  |  |  | | | | Search ThermoFisher Antibodies for SNAPC5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAPC5 |
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