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Aliases for SNAPC5 Gene

Aliases for SNAPC5 Gene

  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kDa 2 3
  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kD 2 3
  • Small Nuclear RNA-Activating Complex Polypeptide 5 3 4
  • SnRNA-Activating Protein Complex 19 KDa Subunit 3 4
  • SNAPc 19 KDa Subunit 3 4
  • SNAPc Subunit 5 3 4
  • SNAP19 3 4
  • CTD-3185P2.1 3

External Ids for SNAPC5 Gene

Previous GeneCards Identifiers for SNAPC5 Gene

  • GC15M062578
  • GC15M059884
  • GC15M064360
  • GC15M064502
  • GC15M064573
  • GC15M066782
  • GC15M043618

Summaries for SNAPC5 Gene

GeneCards Summary for SNAPC5 Gene

SNAPC5 (Small Nuclear RNA Activating Complex, Polypeptide 5, 19kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SNAPC5 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box

Gene Wiki entry for SNAPC5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC5 Gene

Genomics for SNAPC5 Gene

Regulatory Elements for SNAPC5 Gene

Genomic Location for SNAPC5 Gene

Chromosome:
15
Start:
66,490,135 bp from pter
End:
66,497,813 bp from pter
Size:
7,679 bases
Orientation:
Minus strand

Genomic View for SNAPC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC5 Gene

Proteins for SNAPC5 Gene

  • Protein details for SNAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75971-SNPC5_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 5
    Protein Accession:
    O75971
    Secondary Accessions:
    • A8K7N6
    • Q96CF3

    Protein attributes for SNAPC5 Gene

    Size:
    98 amino acids
    Molecular mass:
    11328 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4.

    Alternative splice isoforms for SNAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAPC5 Gene

Proteomics data for SNAPC5 Gene at MOPED

Post-translational modifications for SNAPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SNAPC5 Gene

Domains & Families for SNAPC5 Gene

Gene Families for SNAPC5 Gene

Protein Domains for SNAPC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNAPC5: view

No data available for UniProtKB/Swiss-Prot for SNAPC5 Gene

Function for SNAPC5 Gene

Molecular function for SNAPC5 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box

Gene Ontology (GO) - Molecular Function for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SNAPC5: view

Phenotypes for SNAPC5 Gene

genes like me logo Genes that share phenotypes with SNAPC5: view

Animal Model Products

miRNA for SNAPC5 Gene

miRTarBase miRNAs that target SNAPC5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNAPC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAPC5 Gene

Localization for SNAPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC5 Gene COMPARTMENTS Subcellular localization image for SNAPC5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SNAPC5: view

Pathways & Interactions for SNAPC5 Gene

genes like me logo Genes that share pathways with SNAPC5: view

Gene Ontology (GO) - Biological Process for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0006384 transcription initiation from RNA polymerase III promoter IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNAPC5: view

No data available for SIGNOR curated interactions for SNAPC5 Gene

Drugs & Compounds for SNAPC5 Gene

No Compound Related Data Available

Transcripts for SNAPC5 Gene

Unigene Clusters for SNAPC5 Gene

Small nuclear RNA activating complex, polypeptide 5, 19kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNAPC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for SNAPC5 Gene

GeneLoc Exon Structure for
SNAPC5
ECgene alternative splicing isoforms for
SNAPC5

Expression for SNAPC5 Gene

mRNA expression in normal human tissues for SNAPC5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNAPC5 Gene



SOURCE GeneReport for Unigene cluster for SNAPC5 Gene Hs.30174

genes like me logo Genes that share expression patterns with SNAPC5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SNAPC5 Gene

Orthologs for SNAPC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNAPC5 35
  • 86.9 (n)
  • 89.29 (a)
SNAPC5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC5 35
  • 91.67 (n)
  • 92.86 (a)
SNAPC5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snapc5 35
  • 80.08 (n)
  • 80.49 (a)
Snapc5 16
Snapc5 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNAPC5 35
  • 100 (n)
  • 100 (a)
SNAPC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc5 35
  • 81.35 (n)
  • 77.38 (a)
oppossum
(Monodelphis domestica)
Mammalia SNAPC5 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAPC5 35
  • 67.9 (n)
  • 66.67 (a)
SNAPC5 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1394 35
zebrafish
(Danio rerio)
Actinopterygii snapc5 36
  • 44 (a)
OneToOne
Species with no ortholog for SNAPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC5 Gene

ENSEMBL:
Gene Tree for SNAPC5 (if available)
TreeFam:
Gene Tree for SNAPC5 (if available)

Paralogs for SNAPC5 Gene

Pseudogenes.org Pseudogenes for SNAPC5 Gene

genes like me logo Genes that share paralogs with SNAPC5: view

No data available for Paralogs for SNAPC5 Gene

Variants for SNAPC5 Gene

Sequence variations from dbSNP and Humsavar for SNAPC5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs781735432 -- 66,493,367(+) TCCAG(C/T)CTTCC intron-variant
rs781112297 -- 66,495,305(+) TCTCC(G/T)AGGCC intron-variant
rs781096655 -- 66,494,071(+) GAGGC(-/ATT)GTTGA intron-variant
rs780672398 -- 66,492,185(+) CTTCT(C/T)TTAGG intron-variant
rs780663154 -- 66,495,809(+) AAACA(C/G)AGGTG intron-variant

Variation tolerance for SNAPC5 Gene

Residual Variation Intolerance Score: 66.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAPC5 Gene

HapMap Linkage Disequilibrium report
SNAPC5
Human Gene Mutation Database (HGMD)
SNAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SNAPC5 Gene

Disorders for SNAPC5 Gene

Relevant External Links for SNAPC5

Genetic Association Database (GAD)
SNAPC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAPC5
genes like me logo Genes that share disorders with SNAPC5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC5 Gene

Publications for SNAPC5 Gene

  1. SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. (PMID: 9732265) Henry R.W. … Hernandez N. (Genes Dev. 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for SNAPC5 Gene

Sources for SNAPC5 Gene

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