Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNAPC4 Gene

Aliases for SNAPC4 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 4 2 3 5
  • Proximal Sequence Element-Binding Transcription Factor Subunit Alpha 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 4, 190kDa 2 3
  • Small Nuclear RNA Activating Complex, Polypeptide 4, 190kD 2 3
  • SnRNA-Activating Protein Complex 190 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Alpha 3 4
  • SNAPc 190 KDa Subunit 3 4
  • PTF Subunit Alpha 3 4
  • SNAPc Subunit 4 3 4
  • SNAP190 3 4
  • PTFalpha 3

External Ids for SNAPC4 Gene

Previous GeneCards Identifiers for SNAPC4 Gene

  • GC09M130337
  • GC09M130959
  • GC09M132711
  • GC09M134627
  • GC09M136545
  • GC09M138389
  • GC09M139270
  • GC09M108729

Summaries for SNAPC4 Gene

GeneCards Summary for SNAPC4 Gene

SNAPC4 (Small Nuclear RNA Activating Complex Polypeptide 4) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot for SNAPC4 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC4 Gene

Genomics for SNAPC4 Gene

Regulatory Elements for SNAPC4 Gene

Enhancers for SNAPC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNAPC4 on UCSC Golden Path with GeneCards custom track

Promoters for SNAPC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNAPC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNAPC4 Gene

Chromosome:
9
Start:
136,375,571 bp from pter
End:
136,400,208 bp from pter
Size:
24,638 bases
Orientation:
Minus strand

Genomic View for SNAPC4 Gene

Genes around SNAPC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC4 Gene

Proteins for SNAPC4 Gene

  • Protein details for SNAPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SXM2-SNPC4_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 4
    Protein Accession:
    Q5SXM2
    Secondary Accessions:
    • Q9Y6P7

    Protein attributes for SNAPC4 Gene

    Size:
    1469 amino acids
    Molecular mass:
    159433 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC4 interacts with SNAPC1, SNAPC2, SNAPC5, BRF2 and TBP.

neXtProt entry for SNAPC4 Gene

Proteomics data for SNAPC4 Gene at MOPED

Post-translational modifications for SNAPC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAPC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAPC4 Gene

Domains & Families for SNAPC4 Gene

Gene Families for SNAPC4 Gene

Protein Domains for SNAPC4 Gene

Suggested Antigen Peptide Sequences for SNAPC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SXM2

UniProtKB/Swiss-Prot:

SNPC4_HUMAN :
  • Contains 3 HTH myb-type DNA-binding domains.
Domain:
  • Contains 3 HTH myb-type DNA-binding domains.
  • Contains 2 Myb-like domains.
genes like me logo Genes that share domains with SNAPC4: view

Function for SNAPC4 Gene

Molecular function for SNAPC4 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
genes like me logo Genes that share phenotypes with SNAPC4: view

Animal Models for SNAPC4 Gene

MGI Knock Outs for SNAPC4:

Animal Model Products

miRNA for SNAPC4 Gene

miRTarBase miRNAs that target SNAPC4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAPC4 Gene

Localization for SNAPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC4 Gene COMPARTMENTS Subcellular localization image for SNAPC4 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for SNAPC4 Gene

Pathways & Interactions for SNAPC4 Gene

genes like me logo Genes that share pathways with SNAPC4: view

Gene Ontology (GO) - Biological Process for SNAPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 9418884
GO:0006383 transcription from RNA polymerase III promoter TAS 9418884
GO:0009301 snRNA transcription TAS 9418884
GO:0042795 snRNA transcription from RNA polymerase II promoter IDA,TAS --
genes like me logo Genes that share ontologies with SNAPC4: view

No data available for SIGNOR curated interactions for SNAPC4 Gene

Drugs & Compounds for SNAPC4 Gene

No Compound Related Data Available

Transcripts for SNAPC4 Gene

mRNA/cDNA for SNAPC4 Gene

Unigene Clusters for SNAPC4 Gene

Small nuclear RNA activating complex, polypeptide 4, 190kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SNAPC4 Gene

GeneLoc Exon Structure for
SNAPC4
ECgene alternative splicing isoforms for
SNAPC4

Expression for SNAPC4 Gene

mRNA expression in normal human tissues for SNAPC4 Gene

Protein differential expression in normal tissues from HIPED for SNAPC4 Gene

This gene is overexpressed in Pancreatic juice (31.2) and Lung (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAPC4 Gene



SOURCE GeneReport for Unigene cluster for SNAPC4 Gene Hs.113265

genes like me logo Genes that share expression patterns with SNAPC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SNAPC4 Gene

Orthologs for SNAPC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNAPC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNAPC4 35
  • 70.92 (n)
  • 63.87 (a)
SNAPC4 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC4 35
  • 76.31 (n)
  • 69.61 (a)
SNAPC4 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snapc4 35
  • 72.85 (n)
  • 65.4 (a)
Snapc4 16
Snapc4 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNAPC4 35
  • 96.79 (n)
  • 96.13 (a)
SNAPC4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc4 35
  • 73.26 (n)
  • 66.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SNAPC4 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAPC4 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAPC4 35
  • 54.13 (n)
  • 47.96 (a)
SNAPC4 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAPC4 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii snapc4 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pbp95 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gei-11 37
  • 29 (a)
snpc-4 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 36
  • 15 (a)
OneToMany
BAS1 38
Species with no ortholog for SNAPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SNAPC4 Gene

ENSEMBL:
Gene Tree for SNAPC4 (if available)
TreeFam:
Gene Tree for SNAPC4 (if available)

Paralogs for SNAPC4 Gene

Paralogs for SNAPC4 Gene

Pseudogenes.org Pseudogenes for SNAPC4 Gene

genes like me logo Genes that share paralogs with SNAPC4: view

Variants for SNAPC4 Gene

Sequence variations from dbSNP and Humsavar for SNAPC4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3812571 - 136,380,842(+) TCGAT(A/C/G)TGGAA nc-transcript-variant, reference, missense
rs3812561 - 136,376,424(+) GTCAG(A/C/G)GTCAT reference, missense
rs7031489 - 136,398,299(+) CTTAC(C/T)TGCTT nc-transcript-variant, reference, missense
rs7852145 -- 136,388,691(+) GCCAC(G/T)GGGGT intron-variant
rs112972359 -- 136,389,723(+) CCTGC(C/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC4 Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
dgv8386n71 CNV Loss 21882294
dgv8387n71 CNV Loss 21882294
dgv8389n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
nsv894357 CNV Loss 21882294
nsv894359 CNV Loss 21882294
nsv6764 CNV Loss 18451855
nsv509333 CNV Insertion 20534489
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8394n71 CNV Loss 21882294
nsv831760 CNV Loss 17160897
nsv894364 CNV Loss 21882294
nsv894365 CNV Loss 21882294
nsv894366 CNV Loss 21882294
nsv894367 CNV Loss 21882294

Variation tolerance for SNAPC4 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.15; 95.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAPC4 Gene

Human Gene Mutation Database (HGMD)
SNAPC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC4 Gene

Disorders for SNAPC4 Gene

Relevant External Links for SNAPC4

Genetic Association Database (GAD)
SNAPC4
Human Genome Epidemiology (HuGE) Navigator
SNAPC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAPC4

No disorders were found for SNAPC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC4 Gene

Publications for SNAPC4 Gene

  1. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. (PMID: 9418884) Wong M.W. … Hernandez N. (Mol. Cell. Biol. 1998) 2 3 4 23 67
  2. The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III. (PMID: 17670747) Gu L. … Henry R.W. (J. Biol. Chem. 2007) 3 23
  3. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PMID: 12621023) Hinkley C.S. … Henry R.W. (J. Biol. Chem. 2003) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SNAPC4 Gene

Sources for SNAPC4 Gene

Content