Aliases for SNAPC4 Gene
External Ids for SNAPC4 Gene
Previous GeneCards Identifiers for SNAPC4 Gene
This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016]
GeneCards Summary for SNAPC4 Gene
SNAPC4 (Small Nuclear RNA Activating Complex Polypeptide 4) is a Protein Coding gene. Diseases associated with SNAPC4 include Spondylitis. Among its related pathways are RNA Polymerase III Transcription Initiation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MYB.
UniProtKB/Swiss-Prot for SNAPC4 Gene
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.