Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNAPC4 Gene

Aliases for SNAPC4 Gene

  • Small Nuclear RNA Activating Complex, Polypeptide 4, 190kDa 2 3
  • SNAP190 3 4 6
  • Proximal Sequence Element-Binding Transcription Factor Subunit Alpha 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 4, 190kD 2 3
  • SnRNA-Activating Protein Complex 190 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Alpha 3 4
  • SNAPc 190 KDa Subunit 3 4
  • PTF Subunit Alpha 3 4
  • SNAPc Subunit 4 3 4
  • SnRNA-Activating Protein Complex Subunit 4 3
  • PTFalpha 3

External Ids for SNAPC4 Gene

Summaries for SNAPC4 Gene

GeneCards Summary for SNAPC4 Gene

SNAPC4 (Small Nuclear RNA Activating Complex, Polypeptide 4, 190kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot for SNAPC4 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC4 Gene

Genomics for SNAPC4 Gene

Genomic Location for SNAPC4 Gene

Start:
136,375,569 bp from pter
End:
136,400,208 bp from pter
Size:
24,640 bases
Orientation:
Minus strand

Genomic View for SNAPC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC4 Gene

Regulatory Elements for SNAPC4 Gene

Proteins for SNAPC4 Gene

  • Protein details for SNAPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SXM2-SNPC4_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 4
    Protein Accession:
    Q5SXM2
    Secondary Accessions:
    • Q9Y6P7

    Protein attributes for SNAPC4 Gene

    Size:
    1469 amino acids
    Molecular mass:
    159433 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC4 interacts with SNAPC1, SNAPC2, SNAPC5, BRF2 and TBP.

neXtProt entry for SNAPC4 Gene

Proteomics data for SNAPC4 Gene at MOPED

Post-translational modifications for SNAPC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAPC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAPC4 Gene

Domains for SNAPC4 Gene

Protein Domains for SNAPC4 Gene

UniProtKB/Swiss-Prot:

SNPC4_HUMAN
Domain:
  • Contains 3 HTH myb-type DNA-binding domains.:
    • Q5SXM2
  • Contains 2 Myb-like domains.:
    • Q5SXM2
genes like me logo Genes that share domains with SNAPC4: view

No data available for Gene Families for SNAPC4 Gene

Function for SNAPC4 Gene

Molecular function for SNAPC4 Gene

UniProtKB/Swiss-Prot Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Ontology (GO) - Molecular Function for SNAPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 11056176
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9418884
genes like me logo Genes that share ontologies with SNAPC4: view

Phenotypes for SNAPC4 Gene

MGI mutant phenotypes for SNAPC4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SNAPC4: view

miRNA for SNAPC4 Gene

miRTarBase miRNAs that target SNAPC4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNAPC4 Gene

Localization for SNAPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC4 Gene COMPARTMENTS Subcellular localization image for SNAPC4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SNAPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 11056176
GO:0005654 nucleoplasm TAS --
GO:0019185 snRNA-activating protein complex IDA 11056176
genes like me logo Genes that share ontologies with SNAPC4: view

Pathways for SNAPC4 Gene

genes like me logo Genes that share pathways with SNAPC4: view

Gene Ontology (GO) - Biological Process for SNAPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9418884
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0009301 snRNA transcription TAS 9418884
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNAPC4: view

Transcripts for SNAPC4 Gene

mRNA/cDNA for SNAPC4 Gene

Unigene Clusters for SNAPC4 Gene

Small nuclear RNA activating complex, polypeptide 4, 190kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SNAPC4 Gene

GeneLoc Exon Structure for
SNAPC4
ECgene alternative splicing isoforms for
SNAPC4

Expression for SNAPC4 Gene

mRNA expression in normal human tissues for SNAPC4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAPC4 Gene

SOURCE GeneReport for Unigene cluster for SNAPC4 Gene Hs.113265

genes like me logo Genes that share expressions with SNAPC4: view

Orthologs for SNAPC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNAPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC4 36
  • 96.79 (n)
  • 96.13 (a)
SNAPC4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAPC4 36
  • 70.92 (n)
  • 63.87 (a)
SNAPC4 37
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC4 36
  • 76.31 (n)
  • 69.61 (a)
SNAPC4 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snapc4 36
  • 72.85 (n)
  • 65.4 (a)
Snapc4 16
Snapc4 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAPC4 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAPC4 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc4 36
  • 73.26 (n)
  • 66.02 (a)
chicken
(Gallus gallus)
Aves SNAPC4 36
  • 54.13 (n)
  • 47.96 (a)
SNAPC4 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAPC4 37
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii snapc4 37
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pbp95 37
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snpc-4 37
  • 22 (a)
OneToOne
gei-11 38
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 37
  • 15 (a)
OneToMany
BAS1 39
Species with no ortholog for SNAPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SNAPC4 Gene

ENSEMBL:
Gene Tree for SNAPC4 (if available)
TreeFam:
Gene Tree for SNAPC4 (if available)

Paralogs for SNAPC4 Gene

Paralogs for SNAPC4 Gene

Pseudogenes.org Pseudogenes for SNAPC4 Gene

genes like me logo Genes that share paralogs with SNAPC4: view

Variants for SNAPC4 Gene

Sequence variations from dbSNP and Humsavar for SNAPC4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3088081 -- 136,375,697(+) TGGTC(A/G)GTCAG utr-variant-3-prime
rs3124994 -- 136,400,830(+) CTGCA(A/G)AGACA upstream-variant-2KB
rs3812561 - 136,376,424(+) GTCAG(A/G)GTCAT reference, missense
rs3812562 -- 136,376,523(+) ACCCC(C/G/T)GAGCC intron-variant
rs3812563 -- 136,376,654(+) TGTGC(A/G)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC4 Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
dgv8386n71 CNV Loss 21882294
dgv8387n71 CNV Loss 21882294
dgv8389n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
nsv894357 CNV Loss 21882294
nsv894359 CNV Loss 21882294
nsv6764 CNV Loss 18451855
nsv509333 CNV Insertion 20534489
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8394n71 CNV Loss 21882294
nsv831760 CNV Loss 17160897
nsv894364 CNV Loss 21882294
nsv894365 CNV Loss 21882294
nsv894366 CNV Loss 21882294
nsv894367 CNV Loss 21882294

Relevant External Links for SNAPC4 Gene

HapMap Linkage Disequilibrium report
SNAPC4
Human Gene Mutation Database (HGMD)
SNAPC4

Disorders for SNAPC4 Gene

Relevant External Links for SNAPC4

Genetic Association Database (GAD)
SNAPC4
Human Genome Epidemiology (HuGE) Navigator
SNAPC4
genes like me logo Genes that share disorders with SNAPC4: view

No data available for UniProtKB/Swiss-Prot for SNAPC4 Gene

Publications for SNAPC4 Gene

  1. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. (PMID: 9418884) Wong M.W. … Hernandez N. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PMID: 12621023) Hinkley C.S. … Henry R.W. (J. Biol. Chem. 2003) 3 4 23
  3. The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III. (PMID: 17670747) Gu L. … Henry R.W. (J. Biol. Chem. 2007) 3 23
  4. A map of protein-protein contacts within the small nuclear RNA- activating protein complex SNAPc. (PMID: 11056176) Ma B. … Hernandez N. (J. Biol. Chem. 2001) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for SNAPC4 Gene

Sources for SNAPC4 Gene

Back to Top

Content