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Aliases for SNAPC2 Gene

Aliases for SNAPC2 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 2 2 3 5
  • Proximal Sequence Element-Binding Transcription Factor Subunit Delta 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 2, 45kDa 2 3
  • Small Nuclear RNA Activating Complex, Polypeptide 2, 45kD 2 3
  • SnRNA-Activating Protein Complex 45 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Delta 3 4
  • PTF Subunit Delta 3 4
  • SNAPc Subunit 2 3 4
  • SNAP45 3 4
  • Small Nuclear RNA-Activating Complex Polypeptide 2 4
  • SnRNA-Activating Protein Complex Subunit 2 3
  • SNAPC 45 KDa Subunit 3
  • SNAPc 45 KDa Subunit 4
  • PTFDELTA 3

External Ids for SNAPC2 Gene

Previous GeneCards Identifiers for SNAPC2 Gene

  • GC19P007943
  • GC19P008090
  • GC19P007880
  • GC19P007891
  • GC19P007985
  • GC19P007655

Summaries for SNAPC2 Gene

Entrez Gene Summary for SNAPC2 Gene

  • This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for SNAPC2 Gene

SNAPC2 (Small Nuclear RNA Activating Complex Polypeptide 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for SNAPC2 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC2 Gene

Additional gene information for SNAPC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC2 Gene

Genomics for SNAPC2 Gene

GeneHancer (GH) Regulatory Elements for SNAPC2 Gene

Promoters and enhancers for SNAPC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I007915 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -1.2 -1237 6.6 HDGF HNRNPUL1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ENSG00000260500 TGFBR3L SNAPC2 HNRNPM XAB2 ZNF558 ELAVL1 ZNF557 MAP2K7 CD209
GH19I007521 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -397.5 -397452 2 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MCOLN1 GC19M007510 HNRNPM ELAVL1 XAB2 ZNF557 MAP2K7 ZNF414 TIMM44 SNAPC2
GH19I007673 Enhancer 1.1 FANTOM5 Ensembl ENCODE 9.9 -245.8 -245818 1.2 PKNOX1 FEZF1 ZNF280A GATA3 ZNF366 NFYB ZNF350 ZBTB20 SP3 NFYA MCEMP1 XAB2 HNRNPM ZNF414 ZNF557 ELAVL1 SNAPC2 MCOLN1 STXBP2 PEX11G
GH19I008552 Enhancer 0.8 ENCODE 9.8 +632.6 632633 0.2 HDAC1 ARID4B KLF17 SIN3A ZNF2 ZBTB40 YY1 ETS1 E2F8 ZNF350 ZNF266 XAB2 ZNF414 HNRNPM ZNF317 ZNF559 ZNF177 ZNF699 ELAVL1 SNAPC2
GH19I008032 Enhancer 1.2 Ensembl ENCODE 5.3 +114.7 114736 5.7 HDGF PKNOX1 ATF1 ARNT NCOA2 TCF12 POLR2B ZNF766 GATA2 E2F8 HNRNPM ZNF558 XAB2 ZNF557 ELAVL1 MAP2K7 TIMM44 ZNF414 ENSG00000269139 CCL25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNAPC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNAPC2 gene promoter:

Genomic Locations for SNAPC2 Gene

Genomic Locations for SNAPC2 Gene
chr19:7,920,309-7,923,251
(GRCh38/hg38)
Size:
2,943 bases
Orientation:
Plus strand
chr19:7,985,194-7,988,136
(GRCh37/hg19)

Genomic View for SNAPC2 Gene

Genes around SNAPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC2 Gene

Proteins for SNAPC2 Gene

  • Protein details for SNAPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13487-SNPC2_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 2
    Protein Accession:
    Q13487
    Secondary Accessions:
    • B2RBZ6
    • D6W663
    • Q13486

    Protein attributes for SNAPC2 Gene

    Size:
    334 amino acids
    Molecular mass:
    35556 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4.

neXtProt entry for SNAPC2 Gene

Post-translational modifications for SNAPC2 Gene

No Post-translational modifications

Other Protein References for SNAPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAPC2 Gene

Domains & Families for SNAPC2 Gene

Gene Families for SNAPC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNAPC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNAPC2: view

No data available for UniProtKB/Swiss-Prot for SNAPC2 Gene

Function for SNAPC2 Gene

Molecular function for SNAPC2 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Phenotypes From GWAS Catalog for SNAPC2 Gene

Gene Ontology (GO) - Molecular Function for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity TAS 7715707
genes like me logo Genes that share ontologies with SNAPC2: view
genes like me logo Genes that share phenotypes with SNAPC2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNAPC2 Gene

Localization for SNAPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAPC2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7715707
GO:0005654 nucleoplasm TAS,IDA --
GO:0005829 cytosol IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SNAPC2: view

Pathways & Interactions for SNAPC2 Gene

genes like me logo Genes that share pathways with SNAPC2: view

Gene Ontology (GO) - Biological Process for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 8524284
GO:0006383 transcription by RNA polymerase III TAS 8524284
GO:0009301 snRNA transcription TAS 8524284
genes like me logo Genes that share ontologies with SNAPC2: view

No data available for SIGNOR curated interactions for SNAPC2 Gene

Drugs & Compounds for SNAPC2 Gene

No Compound Related Data Available

Transcripts for SNAPC2 Gene

Unigene Clusters for SNAPC2 Gene

Small nuclear RNA activating complex, polypeptide 2, 45kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: -

Relevant External Links for SNAPC2 Gene

GeneLoc Exon Structure for
SNAPC2
ECgene alternative splicing isoforms for
SNAPC2

Expression for SNAPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAPC2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNAPC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SNAPC2 Gene:

SNAPC2

SOURCE GeneReport for Unigene cluster for SNAPC2 Gene:

Hs.631860

Evidence on tissue expression from TISSUES for SNAPC2 Gene

  • Lung(4.2)
  • Skin(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SNAPC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAPC2 Gene

Orthologs for SNAPC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC2 33 34
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia SNAPC2 33 34
  • 78.47 (n)
cow
(Bos Taurus)
Mammalia SNAPC2 33 34
  • 77.47 (n)
rat
(Rattus norvegicus)
Mammalia Snapc2 33
  • 74.58 (n)
mouse
(Mus musculus)
Mammalia Snapc2 33 16 34
  • 72.79 (n)
oppossum
(Monodelphis domestica)
Mammalia SNAPC2 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAPC2 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731544 33
  • 50.65 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC566292 33
  • 46.04 (n)
SNAPC2 34
  • 25 (a)
OneToOne
Species where no ortholog for SNAPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC2 Gene

ENSEMBL:
Gene Tree for SNAPC2 (if available)
TreeFam:
Gene Tree for SNAPC2 (if available)

Paralogs for SNAPC2 Gene

No data available for Paralogs for SNAPC2 Gene

Variants for SNAPC2 Gene

Sequence variations from dbSNP and Humsavar for SNAPC2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000267087 -- 7,918,731(+) G/A upstream_transcript_variant
rs1000281750 -- 7,923,365(+) G/C downstream_transcript_variant
rs1000382049 -- 7,923,473(+) C/T downstream_transcript_variant
rs1001690595 -- 7,919,835(+) T/C upstream_transcript_variant
rs1002273648 -- 7,921,338(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC2 Gene

Variant ID Type Subtype PubMed ID
nsv819168 CNV loss 19587683
nsv833733 CNV gain 17160897
nsv953961 CNV deletion 24416366

Variation tolerance for SNAPC2 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.02; 92.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNAPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC2 Gene

Disorders for SNAPC2 Gene

Additional Disease Information for SNAPC2

No disorders were found for SNAPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC2 Gene

Publications for SNAPC2 Gene

  1. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. (PMID: 9418884) Wong MW … Hernandez N (Molecular and cellular biology 1998) 3 4 22 58
  2. The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein. (PMID: 8633057) Sadowski CL … Hernandez N (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PMID: 12621023) Hinkley CS … Henry RW (The Journal of biological chemistry 2003) 3 4 58
  5. Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein. (PMID: 8524284) Yoon JB … Roeder RG (Molecular and cellular biology 1996) 3 4 58

Products for SNAPC2 Gene

Sources for SNAPC2 Gene

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