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Aliases for SNAPC2 Gene

Aliases for SNAPC2 Gene

  • Small Nuclear RNA Activating Complex, Polypeptide 2, 45kDa 2 3
  • SNAP45 3 4 6
  • Proximal Sequence Element-Binding Transcription Factor Subunit Delta 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 2, 45kD 2 3
  • Small Nuclear RNA-Activating Complex Polypeptide 2 3 4
  • SnRNA-Activating Protein Complex 45 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Delta 3 4
  • PTF Subunit Delta 3 4
  • SNAPc Subunit 2 3 4
  • SnRNA-Activating Protein Complex Subunit 2 3
  • SNAPC 45 KDa Subunit 3
  • SNAPc 45 KDa Subunit 4
  • PTFDELTA 3

External Ids for SNAPC2 Gene

Summaries for SNAPC2 Gene

Entrez Gene Summary for SNAPC2 Gene

  • This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for SNAPC2 Gene

SNAPC2 (Small Nuclear RNA Activating Complex, Polypeptide 2, 45kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for SNAPC2 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box

Gene Wiki entry for SNAPC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC2 Gene

Genomics for SNAPC2 Gene

Genomic Location for SNAPC2 Gene

Start:
7,920,309 bp from pter
End:
7,923,251 bp from pter
Size:
2,943 bases
Orientation:
Plus strand

Genomic View for SNAPC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC2 Gene

Regulatory Elements for SNAPC2 Gene

Proteins for SNAPC2 Gene

  • Protein details for SNAPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13487-SNPC2_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 2
    Protein Accession:
    Q13487
    Secondary Accessions:
    • B2RBZ6
    • D6W663
    • Q13486

    Protein attributes for SNAPC2 Gene

    Size:
    334 amino acids
    Molecular mass:
    35556 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4.

neXtProt entry for SNAPC2 Gene

Proteomics data for SNAPC2 Gene at MOPED

Post-translational modifications for SNAPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAPC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAPC2 Gene

Domains for SNAPC2 Gene

Protein Domains for SNAPC2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SNAPC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SNAPC2 Gene

Function for SNAPC2 Gene

Molecular function for SNAPC2 Gene

UniProtKB/Swiss-Prot Function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box

Gene Ontology (GO) - Molecular Function for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 7715707
genes like me logo Genes that share ontologies with SNAPC2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNAPC2 Gene

Localization for SNAPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC2 Gene COMPARTMENTS Subcellular localization image for SNAPC2 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SNAPC2: view

Pathways for SNAPC2 Gene

genes like me logo Genes that share pathways with SNAPC2: view

Gene Ontology (GO) - Biological Process for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8524284
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0009301 snRNA transcription TAS 8524284
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNAPC2: view

Transcripts for SNAPC2 Gene

Unigene Clusters for SNAPC2 Gene

Small nuclear RNA activating complex, polypeptide 2, 45kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: -

Relevant External Links for SNAPC2 Gene

GeneLoc Exon Structure for
SNAPC2
ECgene alternative splicing isoforms for
SNAPC2

Expression for SNAPC2 Gene

mRNA expression in normal human tissues for SNAPC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNAPC2 Gene

SOURCE GeneReport for Unigene cluster for SNAPC2 Gene Hs.631860

genes like me logo Genes that share expressions with SNAPC2: view

Orthologs for SNAPC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC2 36
  • 99.1 (n)
  • 99.1 (a)
SNAPC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAPC2 36
  • 77.47 (n)
  • 71.82 (a)
SNAPC2 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC2 36
  • 78.47 (n)
  • 75.16 (a)
SNAPC2 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snapc2 36
  • 72.79 (n)
  • 63.55 (a)
Snapc2 16
Snapc2 37
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAPC2 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc2 36
  • 74.58 (n)
  • 67.41 (a)
lizard
(Anolis carolinensis)
Reptilia SNAPC2 37
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731544 36
  • 50.65 (n)
  • 40.91 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC566292 36
  • 46.04 (n)
  • 37.7 (a)
SNAPC2 37
  • 25 (a)
OneToOne
Species with no ortholog for SNAPC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC2 Gene

ENSEMBL:
Gene Tree for SNAPC2 (if available)
TreeFam:
Gene Tree for SNAPC2 (if available)

Paralogs for SNAPC2 Gene

No data available for Paralogs for SNAPC2 Gene

Variants for SNAPC2 Gene

Sequence variations from dbSNP and Humsavar for SNAPC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7788 -- 7,923,232(+) AGTTA(C/T)CATTC utr-variant-3-prime, nc-transcript-variant
rs9654 -- 7,922,916(-) CCCAA(A/C)GTATG utr-variant-3-prime, nc-transcript-variant
rs475002 - 7,921,753(-) TGCCA(C/G)GGCTT reference, missense, nc-transcript-variant
rs1107711 -- 7,922,986(+) CACAA(A/G)CCTCC utr-variant-3-prime, nc-transcript-variant
rs1560122 -- 7,922,952(-) CAACC(A/C/T)CTGTA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAPC2 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv910993 CNV Loss 21882294
nsv819168 CNV Loss 19587683

Relevant External Links for SNAPC2 Gene

HapMap Linkage Disequilibrium report
SNAPC2

Disorders for SNAPC2 Gene

No disorders were found for SNAPC2 Gene.

No data available for UniProtKB/Swiss-Prot for SNAPC2 Gene

Publications for SNAPC2 Gene

  1. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. (PMID: 9418884) Wong M.W. … Hernandez N. (Mol. Cell. Biol. 1998) 3 4 23
  2. The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein. (PMID: 8633057) Sadowski C.L. … Hernandez N. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  3. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. (PMID: 7715707) Henry R.W. … Hernandez N. (Nature 1995) 3 23
  4. Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein. (PMID: 8524284) Yoon J.B. … Roeder R.G. (Mol. Cell. Biol. 1996) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SNAPC2 Gene

Sources for SNAPC2 Gene

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