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Aliases for SNAPC2 Gene

Aliases for SNAPC2 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 2 2 3 5
  • Proximal Sequence Element-Binding Transcription Factor Subunit Delta 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 2, 45kDa 2 3
  • Small Nuclear RNA Activating Complex, Polypeptide 2, 45kD 2 3
  • Small Nuclear RNA-Activating Complex Polypeptide 2 3 4
  • SnRNA-Activating Protein Complex 45 KDa Subunit 3 4
  • PSE-Binding Factor Subunit Delta 3 4
  • PTF Subunit Delta 3 4
  • SNAPc Subunit 2 3 4
  • SNAP45 3 4
  • SNAPC 45 KDa Subunit 3
  • SNAPc 45 KDa Subunit 4
  • PTFDELTA 3

External Ids for SNAPC2 Gene

Previous GeneCards Identifiers for SNAPC2 Gene

  • GC19P007943
  • GC19P008090
  • GC19P007880
  • GC19P007891
  • GC19P007985
  • GC19P007655

Summaries for SNAPC2 Gene

Entrez Gene Summary for SNAPC2 Gene

  • This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for SNAPC2 Gene

SNAPC2 (Small Nuclear RNA Activating Complex Polypeptide 2) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SNAPC2 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAPC2 Gene

Genomics for SNAPC2 Gene

Regulatory Elements for SNAPC2 Gene

Promoters for SNAPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNAPC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNAPC2 Gene

Chromosome:
19
Start:
7,920,309 bp from pter
End:
7,923,251 bp from pter
Size:
2,943 bases
Orientation:
Plus strand

Genomic View for SNAPC2 Gene

Genes around SNAPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC2 Gene

Proteins for SNAPC2 Gene

  • Protein details for SNAPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13487-SNPC2_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 2
    Protein Accession:
    Q13487
    Secondary Accessions:
    • B2RBZ6
    • D6W663
    • Q13486

    Protein attributes for SNAPC2 Gene

    Size:
    334 amino acids
    Molecular mass:
    35556 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4.

neXtProt entry for SNAPC2 Gene

Proteomics data for SNAPC2 Gene at MOPED

Post-translational modifications for SNAPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SNAPC2 Gene

Domains & Families for SNAPC2 Gene

Gene Families for SNAPC2 Gene

Protein Domains for SNAPC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNAPC2: view

No data available for UniProtKB/Swiss-Prot for SNAPC2 Gene

Function for SNAPC2 Gene

Molecular function for SNAPC2 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
genes like me logo Genes that share phenotypes with SNAPC2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNAPC2 Gene

Localization for SNAPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAPC2 Gene COMPARTMENTS Subcellular localization image for SNAPC2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SNAPC2: view

Pathways & Interactions for SNAPC2 Gene

genes like me logo Genes that share pathways with SNAPC2: view

Gene Ontology (GO) - Biological Process for SNAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 8524284
GO:0006383 transcription from RNA polymerase III promoter TAS 8524284
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SNAPC2: view

No data available for SIGNOR curated interactions for SNAPC2 Gene

Drugs & Compounds for SNAPC2 Gene

No Compound Related Data Available

Transcripts for SNAPC2 Gene

Unigene Clusters for SNAPC2 Gene

Small nuclear RNA activating complex, polypeptide 2, 45kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: -

Relevant External Links for SNAPC2 Gene

GeneLoc Exon Structure for
SNAPC2
ECgene alternative splicing isoforms for
SNAPC2

Expression for SNAPC2 Gene

mRNA expression in normal human tissues for SNAPC2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNAPC2 Gene



SOURCE GeneReport for Unigene cluster for SNAPC2 Gene Hs.631860

genes like me logo Genes that share expression patterns with SNAPC2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SNAPC2 Gene

Orthologs for SNAPC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC2 35
  • 99.1 (n)
  • 99.1 (a)
SNAPC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAPC2 36
  • 69 (a)
OneToOne
SNAPC2 35
  • 77.47 (n)
  • 71.82 (a)
dog
(Canis familiaris)
Mammalia SNAPC2 35
  • 78.47 (n)
  • 75.16 (a)
SNAPC2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snapc2 16
Snapc2 35
  • 72.79 (n)
  • 63.55 (a)
Snapc2 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAPC2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc2 35
  • 74.58 (n)
  • 67.41 (a)
lizard
(Anolis carolinensis)
Reptilia SNAPC2 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731544 35
  • 50.65 (n)
  • 40.91 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC566292 35
  • 46.04 (n)
  • 37.7 (a)
SNAPC2 36
  • 25 (a)
OneToOne
Species with no ortholog for SNAPC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC2 Gene

ENSEMBL:
Gene Tree for SNAPC2 (if available)
TreeFam:
Gene Tree for SNAPC2 (if available)

Paralogs for SNAPC2 Gene

No data available for Paralogs for SNAPC2 Gene

Variants for SNAPC2 Gene

Sequence variations from dbSNP and Humsavar for SNAPC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs475002 - 7,921,753(-) TGCCA(C/G)GGCTT nc-transcript-variant, reference, missense
rs9654 -- 7,922,916(-) CCCAA(A/C)GTATG nc-transcript-variant, utr-variant-3-prime
rs2303698 -- 7,921,712(-) GATCC(A/G)TCCAG nc-transcript-variant, reference, missense
rs7250749 -- 7,921,800(+) GGTCA(A/G)GGTGT intron-variant
rs7251437 -- 7,922,511(+) CACAG(C/G)CCTGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SNAPC2 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv910993 CNV Loss 21882294
nsv819168 CNV Loss 19587683

Variation tolerance for SNAPC2 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.02; 92.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAPC2 Gene

HapMap Linkage Disequilibrium report
SNAPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC2 Gene

Disorders for SNAPC2 Gene

Relevant External Links for SNAPC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAPC2

No disorders were found for SNAPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAPC2 Gene

Publications for SNAPC2 Gene

  1. The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein. (PMID: 8633057) Sadowski C.L. … Hernandez N. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 67
  2. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. (PMID: 9418884) Wong M.W. … Hernandez N. (Mol. Cell. Biol. 1998) 3 23
  3. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. (PMID: 7715707) Henry R.W. … Hernandez N. (Nature 1995) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Replication stress induces 53BP1-containing OPT domains in G1 cells. (PMID: 21444690) Harrigan J.A. … Jackson S.P. (J. Cell Biol. 2011) 3

Products for SNAPC2 Gene

Sources for SNAPC2 Gene

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