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Aliases for SNAP91 Gene

Aliases for SNAP91 Gene

  • Synaptosome Associated Protein 91 2 3 5
  • Clathrin Coat-Associated Protein AP180 3 4
  • 91 KDa Synaptosomal-Associated Protein 3 4
  • Phosphoprotein F1-20 3 4
  • Synaptosomal-Associated Protein, 91 KDa (Mouse) Homolog 2
  • Synaptosomal-Associated Protein, 91kDa Homolog 3
  • Clathrin Coat Assembly Protein AP180 3
  • Synaptosome Associated Protein 91kDa 3
  • Assembly Protein, 180kDa 3
  • KIAA0656 4
  • AP180 3
  • CALM 3

External Ids for SNAP91 Gene

Previous GeneCards Identifiers for SNAP91 Gene

  • GC06M084208
  • GC06M084258
  • GC06M084261
  • GC06M084319
  • GC06M081492
  • GC06M084262

Summaries for SNAP91 Gene

GeneCards Summary for SNAP91 Gene

SNAP91 (Synaptosome Associated Protein 91) is a Protein Coding gene. Diseases associated with SNAP91 include Leukemia, Acute Myeloid. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi. GO annotations related to this gene include protein kinase binding and clathrin binding. An important paralog of this gene is PICALM.

UniProtKB/Swiss-Prot for SNAP91 Gene

  • Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).

Gene Wiki entry for SNAP91 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP91 Gene

Genomics for SNAP91 Gene

Regulatory Elements for SNAP91 Gene

Enhancers for SNAP91 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SNAP91 on UCSC Golden Path with GeneCards custom track

Promoters for SNAP91 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNAP91 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNAP91 Gene

Chromosome:
6
Start:
83,552,880 bp from pter
End:
83,709,691 bp from pter
Size:
156,812 bases
Orientation:
Minus strand

Genomic View for SNAP91 Gene

Genes around SNAP91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAP91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAP91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP91 Gene

Proteins for SNAP91 Gene

  • Protein details for SNAP91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60641-AP180_HUMAN
    Recommended name:
    Clathrin coat assembly protein AP180
    Protein Accession:
    O60641
    Secondary Accessions:
    • A8K0L7
    • E5RI02
    • Q5JX13
    • Q68DL9
    • Q6P9D3
    • Q9NTY7

    Protein attributes for SNAP91 Gene

    Size:
    907 amino acids
    Molecular mass:
    92502 Da
    Quaternary structure:
    • Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91 (By similarity).
    SequenceCaution:
    • Sequence=BAA31631.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB89292.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH18201.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SNAP91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAP91 Gene

Post-translational modifications for SNAP91 Gene

  • Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no evidence for direct Thr-310 phosphorylation (By similarity).
  • Glycosylation at Thr 310
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNAP91 Gene

Domains & Families for SNAP91 Gene

Protein Domains for SNAP91 Gene

Graphical View of Domain Structure for InterPro Entry

O60641

UniProtKB/Swiss-Prot:

AP180_HUMAN :
  • Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues).
  • Belongs to the PICALM/SNAP91 family.
Domain:
  • Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues).
  • Contains 1 ENTH (epsin N-terminal homology) domain.
Family:
  • Belongs to the PICALM/SNAP91 family.
genes like me logo Genes that share domains with SNAP91: view

No data available for Gene Families for SNAP91 Gene

Function for SNAP91 Gene

Molecular function for SNAP91 Gene

UniProtKB/Swiss-Prot Function:
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).

Gene Ontology (GO) - Molecular Function for SNAP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17762867
GO:0005545 1-phosphatidylinositol binding IEA --
GO:0019901 protein kinase binding ISS --
GO:0030276 clathrin binding IEA --
genes like me logo Genes that share ontologies with SNAP91: view
genes like me logo Genes that share phenotypes with SNAP91: view

Animal Model Products

CRISPR Products

miRNA for SNAP91 Gene

miRTarBase miRNAs that target SNAP91

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAP91 Gene

Localization for SNAP91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP91 Gene

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAP91 Gene COMPARTMENTS Subcellular localization image for SNAP91 gene
Compartment Confidence
cytosol 4
plasma membrane 4
cytoskeleton 2
nucleus 2
endosome 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNAP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005905 clathrin-coated pit IEA --
GO:0030136 clathrin-coated vesicle IEA --
genes like me logo Genes that share ontologies with SNAP91: view

Pathways & Interactions for SNAP91 Gene

genes like me logo Genes that share pathways with SNAP91: view

Pathways by source for SNAP91 Gene

Gene Ontology (GO) - Biological Process for SNAP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA --
GO:0015031 protein transport IEA --
GO:0048268 clathrin coat assembly IEA --
GO:2000369 regulation of clathrin-dependent endocytosis IMP 16254249
genes like me logo Genes that share ontologies with SNAP91: view

No data available for SIGNOR curated interactions for SNAP91 Gene

Drugs & Compounds for SNAP91 Gene

(1) Additional Compounds for SNAP91 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNAP91: view

Transcripts for SNAP91 Gene

Unigene Clusters for SNAP91 Gene

Synaptosomal-associated protein, 91kDa:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP91 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - -
SP2: -
SP3:

Relevant External Links for SNAP91 Gene

GeneLoc Exon Structure for
SNAP91
ECgene alternative splicing isoforms for
SNAP91

Expression for SNAP91 Gene

mRNA expression in normal human tissues for SNAP91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAP91 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.0), Brain - Cerebellar Hemisphere (x6.9), Brain - Anterior cingulate cortex (BA24) (x6.6), Brain - Cerebellum (x5.2), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for SNAP91 Gene

This gene is overexpressed in Brain (29.4), Frontal cortex (23.7), and Fetal Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNAP91 Gene



Protein tissue co-expression partners for SNAP91 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNAP91 Gene:

SNAP91

SOURCE GeneReport for Unigene cluster for SNAP91 Gene:

Hs.368046
genes like me logo Genes that share expression patterns with SNAP91: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SNAP91 Gene

Orthologs for SNAP91 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNAP91 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNAP91 34
  • 92.15 (n)
  • 93.89 (a)
SNAP91 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAP91 34
  • 88.24 (n)
  • 89.06 (a)
SNAP91 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snap91 34
  • 88.32 (n)
  • 91.43 (a)
Snap91 16
Snap91 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNAP91 34
  • 99.7 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Snap91 34
  • 87.96 (n)
  • 91.05 (a)
oppossum
(Monodelphis domestica)
Mammalia SNAP91 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAP91 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAP91 34
  • 82.84 (n)
  • 88.95 (a)
SNAP91 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAP91 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snap91 34
  • 76.03 (n)
  • 79.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.567 34
zebrafish
(Danio rerio)
Actinopterygii snap91 34
  • 64.1 (n)
  • 64.1 (a)
snap91 35
  • 57 (a)
OneToMany
SNAP91 (1 of 2) 35
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1779 34
fruit fly
(Drosophila melanogaster)
Insecta lap 36
  • 63 (a)
lap 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-11 36
  • 50 (a)
unc-11 35
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAP1801 35
  • 21 (a)
ManyToMany
YAP1802 35
  • 21 (a)
ManyToMany
YAP1802 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for SNAP91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAP91 Gene

ENSEMBL:
Gene Tree for SNAP91 (if available)
TreeFam:
Gene Tree for SNAP91 (if available)

Paralogs for SNAP91 Gene

Paralogs for SNAP91 Gene

Pseudogenes.org Pseudogenes for SNAP91 Gene

genes like me logo Genes that share paralogs with SNAP91: view

Variants for SNAP91 Gene

Sequence variations from dbSNP and Humsavar for SNAP91 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs798394 -- 83,556,397(+) AGAGA(A/G)AAGCA intron-variant
rs798395 -- 83,559,598(+) tagtc(C/T)gaagt intron-variant
rs813882 -- 83,700,509(-) TTAGT(A/G)AGTAA intron-variant
rs910681 -- 83,590,201(+) CTAAG(G/T)AAAAT intron-variant
rs953717 -- 83,637,674(+) TTTCA(A/G)GCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAP91 Gene

Variant ID Type Subtype PubMed ID
esv3323436 CNV insertion 20981092
nsv1025798 CNV gain 25217958
nsv1068710 OTHER inversion 25765185
nsv1153488 OTHER inversion 26484159
nsv5374 CNV insertion 18451855

Variation tolerance for SNAP91 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAP91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAP91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAP91 Gene

Disorders for SNAP91 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNAP91 Gene - From: OMIM

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SNAP91

Genetic Association Database (GAD)
SNAP91
Human Genome Epidemiology (HuGE) Navigator
SNAP91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAP91
genes like me logo Genes that share disorders with SNAP91: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAP91 Gene

Publications for SNAP91 Gene

  1. Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. (PMID: 12493563) Yao P.J. … Coleman P.D. (Neurobiol. Aging 2003) 2 3 22 65
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Novel cleft susceptibility genes in chromosome 6q. (PMID: 20511563) Letra A. … Vieira A.R. (J. Dent. Res. 2010) 3 46 65
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 65

Products for SNAP91 Gene

Sources for SNAP91 Gene

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