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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNAP91 Gene

protein-coding   GIFtS: 57
GCID: GC06M084319

synaptosomal-associated protein, 91kDa

(Previous names: synaptosomal-associated protein, 91 kDa (mouse) homolog,...)
 Explore 6 diseases affiliated with
SNAP91 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNAP91    

Aliases
for SNAP91 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synaptosomal-Associated Protein, 91kDa1 2     91 KDa Synaptosomal-Associated Protein2 3
AP1801 2     Synaptosomal-Associated Protein, 91 KDa (Mouse) Homolog1
CALM1 2     Synaptosomal-Associated Protein, 91kDa Homolog (Mouse)1
KIAA06561 3     Assembly Protein, 180kDa2
Clathrin Coat-Associated Protein AP1802 3     Clathrin Coat Assembly Protein AP1802
Phosphoprotein F1-202 3     Synaptosomal-Associated Protein, 91kDa Homolog2

External Ids:    HGNC: 149861   Entrez Gene: 98922   Ensembl: ENSG000000656097   OMIM: 6079235   UniProtKB: O606413   

Export aliases for SNAP91 gene to outside databases

Previous GC identifers: GC06M084208 GC06M084258 GC06M084261 GC06M081492


Summaries
for SNAP91 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AP180_HUMAN, O60641
Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.
Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins,
leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70
nm coats (By similarity)

Gene Wiki entry for SNAP91


Genomic Views
for SNAP91 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNAP91 gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   E2F-5   FOXD3   Nkx2-5   E2F-2   E2F   E2F-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNAP91 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNAP91

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAP91


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q15

SNAP91 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAP91 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M084319:  view genomic region     (about GC identifiers)

Start:
 84,262,599 bp from pter      End:
 84,419,410 bp from pter
Size:
 156,812 bases      Orientation:
 minus strand

Proteins
for SNAP91 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AP180_HUMAN, O60641 (See protein sequence)
Recommended Name: Clathrin coat assembly protein AP180  
Size: 907 amino acids; 92502 Da
Subunit: Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91 (By similarity)
Subcellular location: Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic
side (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma
membrane (By similarity)
Sequence caution: Sequence=BAA31631.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB89292.1; Type=Erroneous gene model prediction; Sequence=CAH18201.1; Type=Erroneous translation; Note=Wrong
choice of CDS;
Secondary accessions: A8K0L7 Q5JX13 Q68DL9 Q6P9D3 Q9NTY7
Alternative splicing: 3 isoforms:  O60641-1   O60641-2   O60641-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SNAP91: NX_O60641

Post-translational modifications:

  • Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no
    • evidence for direct Thr-310 phosphorylation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60641

    • SNAP91 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001229721.1  NP_001229722.1  NP_001229723.1  NP_001243646.1  NP_001243647.1  NP_055656.1  

    ENSEMBL proteins: 
     ENSP00000429776   ENSP00000358708   ENSP00000400459   ENSP00000195649   ENSP00000428511  
     ENSP00000428215   ENSP00000429937   ENSP00000428026   ENSP00000430255   ENSP00000428127  
     ENSP00000430071   ENSP00000358705   ENSP00000429700   ENSP00000429429   ENSP00000430441  
     ENSP00000358704   ENSP00000427959   ENSP00000431055   ENSP00000429950   ENSP00000428592  
     ENSP00000412492   ENSP00000413277  

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    Novus Biologicals SNAP91 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNAP91

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005905coated pit IEA--
    GO:0008021synaptic vesicle ----
    GO:0014069postsynaptic density ----
    GO:0030118clathrin coat IEA--


    SNAP91 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SNAP91

    Protein Domains /
    Families
    for SNAP91 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNAP91 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR014712 Clathrin_Pinositid-bd_GAT-like
     IPR008942 ENTH_VHS
     IPR013809 Epsin-like_N
     IPR011417 ANTH

    Graphical View of Domain Structure for InterPro Entry O60641

    ProtoNet protein and cluster: O60641

    2 Blocks protein families:
    IPB001026 Epsin N-terminal homology
    IPB013809 Epsin-like


    UniProtKB/Swiss-Prot: AP180_HUMAN, O60641
    Domain: Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic
    middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues)
    Similarity: Contains 1 ENTH (epsin N-terminal homology) domain


    Function
    for SNAP91 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AP180_HUMAN, O60641
    Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.
    Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins,
    leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70
    nm coats (By similarity)

    miRNA
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    hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-3161 hsa-miR-629 hsa-miR-3148 hsa-miR-92b hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmid: SNAP91 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNAP91 (see all 7)
    OriGene shRNA RFP: SNAP91
    OriGene siRNA: SNAP91
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNAP91

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding ----
    GO:00055451-phosphatidylinositol binding IEA--
    GO:0030276clathrin binding IEA--


    SNAP91 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SNAP91:
     Decreased viability with cispl 


    Pathways & Interactions
    for SNAP91 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin-dependent protein traffic
    		Transport_Clathrin-coated vesicle cycle0.66
    		wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SNAP91
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNAP91

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for SNAP91 (O606412, 3 ENSP000001956494) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP2A2O949733, ENSP000004132344I2D: score=2 STRING: ENSP00000413234
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    AP2B1P630103, ENSP000003144144I2D: score=1 STRING: ENSP00000314414
    NECAP1Q8NC963, ENSP000003417374I2D: score=1 STRING: ENSP00000341737
    EPS15P425663, ENSP000003607984I2D: score=2 STRING: ENSP00000360798
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007163establishment or maintenance of cell polarity ----
    GO:0007409axonogenesis ----
    GO:0030100regulation of endocytosis ----
    GO:0048268clathrin coat assembly IEA--
    GO:0051223regulation of protein transport ----


    SNAP91 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNAP91 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNAP91 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNAP91
    1 Novoseek chemical compound relationship for SNAP91 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 24.2 1 11239400 (1)

    Search CenterWatch for drugs/clinical trials and news about SNAP91 / AP180 

    Transcripts
    for SNAP91 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNAP91 gene (6 alternative transcripts): 
    NM_001242792.1  NM_001242793.1  NM_001242794.1  NM_001256717.1  NM_001256718.1  NM_014841.2  

    Unigene Cluster for SNAP91:

    Synaptosomal-associated protein, 91kDa
    Hs.368046  [show with all ESTs]
    Unigene Representative Sequence: CR749348
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000521485 ENST00000369694(uc003pka.3) ENST00000439399(uc011dze.2 uc003pkc.3 uc003pkd.3)
    ENST00000195649(uc011dzd.2) ENST00000520302 ENST00000521743(uc021zcf.1)
    ENST00000518312(uc003pkb.3) ENST00000520213 ENST00000523448 ENST00000521616(uc011dzf.1)
    ENST00000519133 ENST00000521931 ENST00000369691 ENST00000523780 ENST00000522248
    ENST00000519779 ENST00000518309 ENST00000369690

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAP91 (see all 33):
    hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-3161 hsa-miR-629 hsa-miR-3148 hsa-miR-92b hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmid: SNAP91 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SNAP91
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    Clone
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    Additional cDNA sequence: 

    AB014556.1 AF054993.1 AK289582.1 AK294556.1 AK294898.1 BC036650.1 BC044579.1 BC060818.1 
    CR749348.1 

    8 DOTS entries:

    DT.95299394  DT.452972  DT.121363316  DT.121363336  DT.91866138  DT.121363328  DT.92466379  DT.121363329 

    24/99 AceView cDNA sequences (see all 99):

    AA936082 AF054993 BE504881 F01567 F10915 F06489 AB014556 AA258526 
    AA804744 AL118818 BF514550 BM692846 AL079617 AV729020 F06335 BQ722787 
    F05703 CA865843 BF446414 F13317 AA421284 BM689980 BC036650 BM694987 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SNAP91    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:        -     -     -                                                                                                                                 
    SP2:                    -                                                                                                                                 
    SP3:                                                                                                                                                      


    ECgene alternative splicing isoforms for SNAP91

    Expression
    for SNAP91 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNAP91 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACGCCCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNAP91 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainChoroid PlexusBrain
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    EyeRetinaEye
    HeartRight VentricleHeart
    KidneyRenal VesicleKidney
    LimbLimb BudLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SNAP91 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNAP91

    SOURCE GeneReport for Unigene cluster: Hs.368046
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    In Situ
    Assay Products:     
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    Orthologs
    for SNAP91 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNAP91 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snap911 , 5 synaptosomal-associated protein 911, 5 89.69(n)1
    94.1(a)1    		   9 (46.58 cM)5
    206161  NM_013669.11  NP_038697.11 
     867659365 
    chicken
    (Gallus gallus)    		 Aves SNAP916
    		 synaptosomal-associated protein, 91kDa homolog
    		 87(a)
    		 1 ↔ 1
    		 3(80365762-80435518)
    lizard
    (Anolis carolinensis)    		 Reptilia SNAP916
    		 --
    		 77(a)
    		 1 ↔ 1
    		 1(197442638-197494748)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.5672 Xenopus laevis clathrin assembly protein AP180 (AP18 more 77.6(n)    AF182340.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5653841 clathrin coat assembly protein AP180-like 63.99(n)
    64.23(a)    		   565384  XM_688661.5  XP_693753.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta lap3 synaptic vesicle coating 63(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-111 , 3 Expression: neurons3
    Protein UNC-111    		 50(a)3
    52.47(n)1
    48.29(a)1    		   I(3799173-3805706)3
    1719521  NM_058827.21  NP_491228.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G352001 putative clathrin assembly protein 43.53(n)
    27.27(a)    		   833474  NM_122911.3  NP_198370.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g08033001 hypothetical protein 42.52(n)
    28.38(a)    		   4331047  NM_001054960.1  NP_001048425.1 


    ENSEMBL Gene Tree for SNAP91 (if available)
    TreeFam Gene Tree for SNAP91 (if available) 

    Paralogs
    for SNAP91 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNAP91 gene
    PICALM2  
    2 SIMAP similar genes for SNAP91 using alignment to 16 protein entries:     AP180_HUMAN (see all proteins):
    PICALM    CALM/AF10 fusion

    SNAP91 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SNAP91
    PGOHUM00000242097


    Genomic Variants
    for SNAP91 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2553 NCBI SNPs in SNAP91 are shown (see all 2553)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs77485521,2
    		A--81594035(+) TACTTC/TAAAAC 1 -- int10--------
    rs343779721,2
    		C,F--84262146(+) TTGGAC/AACAGG 6 -- int13Minor allele frequency- A:0.50NA 6
    rs1912840931,2
    		--84262190(+) GGTGGA/GGGGGA 6 -- int10--------
    rs1823812251,2
    		--84262220(+) GGAGAG/TATACC 6 -- int10--------
    rs1866951421,2
    		--84262263(+) ACCAAC/TATGGC 6 -- int10--------
    rs1912616231,2
    		--84262270(+) TGGCAC/TATGTA 6 -- int10--------
    rs747909391,2
    		C--84262281(+) TACATA/GTGTAA 6 -- int10--------
    rs1847956061,2
    		--84262478(+) TAATTC/TTTTAT 6 -- int10--------
    rs1887016051,2
    		--84262502(+) CTCTAC/TTGGCA 6 -- int10--------
    rs1456269311,2
    		--84262553(+) TGTGTC/TATTTG 6 -- int10--------

    HapMap Linkage Disequilibrium report for SNAP91 (84262599 - 84419410 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNAP91: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNAP91
    DNA2.0 Custom Variant and Variant Library Synthesis for SNAP91

    Disorders / Diseases
    for SNAP91 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNAP91 for disorders           About GeneDecksing

    OMIM gene information: 607923    OMIM disorders: --

    6 diseases for SNAP91:    About MalaCards
    myeloid leukemia    alzheimer's disease    pharyngitis    leukemia
    schizophrenia    neuronitis

    2 Novoseek disease relationships for SNAP91 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 48.1 3 10926122 (1), 11161218 (1), 15558718 (1)
    alzheimers disease 28 10 10579202 (8), 11124443 (1)

    Human Genome Epidemiology (HuGE) Navigator: SNAP91 (3 documents)

    Export disorders for SNAP91 gene to outside databases

    Publications
    for SNAP91 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNAP91 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with SNAP91)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. (PubMed id 12493563)1, 3, 9 Yao P.J....Coleman P.D. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. (PubMed id 10436022)1, 3 Tebar F.... Sorkin A. (1999)
    6. Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry. (PubMed id 10579202)1, 9 Yao P.J....Coleman P.D. (1999)
    7. The clathrin assembly protein AP180 regulates the gen eration of amyloid-beta peptide. (PubMed id 19450545)1, 9 Wu F....Yao P.J. (2009)
    8. Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling. (PubMed id 12807910)1, 9 Morgan J.R....Lafer E.M. (2003)
    9. ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. (PubMed id 12847086)1, 9 Krauss M.... Haucke V. (2003)
    10. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. (PubMed id 10430869)1, 9 Traub L.M....Fremont D.H. (1999)

    External Searches for SNAP91 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNAP91 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9892 HGNC: 14986 AceView: SNAP91 Ensembl:ENSG00000065609 euGenes: HUgn9892
    ECgene: SNAP91 H-InvDB: SNAP91

    Other Databases showing SNAP91 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0656

    Specialized Databases showing SNAP91 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNAP91 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNAP91 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNAP91 gene:
    Search GeneIP for patents involving SNAP91

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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