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Aliases for SNAP91 Gene

Aliases for SNAP91 Gene

  • Synaptosome Associated Protein 91kDa 2 3 5
  • Clathrin Coat-Associated Protein AP180 3 4
  • 91 KDa Synaptosomal-Associated Protein 3 4
  • Phosphoprotein F1-20 3 4
  • Synaptosomal-Associated Protein, 91 KDa (Mouse) Homolog 2
  • Synaptosomal-Associated Protein, 91kDa Homolog (Mouse) 2
  • Synaptosomal-Associated Protein, 91kDa Homolog 3
  • Synaptosomal-Associated Protein, 91kDa 2
  • Assembly Protein, 180kDa 3
  • KIAA0656 4
  • AP180 3
  • CALM 3

External Ids for SNAP91 Gene

Previous GeneCards Identifiers for SNAP91 Gene

  • GC06M084208
  • GC06M084258
  • GC06M084261
  • GC06M084319
  • GC06M081492
  • GC06M084262

Summaries for SNAP91 Gene

GeneCards Summary for SNAP91 Gene

SNAP91 (Synaptosome Associated Protein 91kDa) is a Protein Coding gene. Diseases associated with SNAP91 include leukemia, acute myeloid. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi. GO annotations related to this gene include protein kinase binding and clathrin binding. An important paralog of this gene is PICALM.

UniProtKB/Swiss-Prot for SNAP91 Gene

  • Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).

Gene Wiki entry for SNAP91 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP91 Gene

Genomics for SNAP91 Gene

Regulatory Elements for SNAP91 Gene

Genomic Location for SNAP91 Gene

Chromosome:
6
Start:
83,552,880 bp from pter
End:
83,709,691 bp from pter
Size:
156,812 bases
Orientation:
Minus strand

Genomic View for SNAP91 Gene

Genes around SNAP91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAP91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAP91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP91 Gene

Proteins for SNAP91 Gene

  • Protein details for SNAP91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60641-AP180_HUMAN
    Recommended name:
    Clathrin coat assembly protein AP180
    Protein Accession:
    O60641
    Secondary Accessions:
    • A8K0L7
    • E5RI02
    • Q5JX13
    • Q68DL9
    • Q6P9D3
    • Q9NTY7

    Protein attributes for SNAP91 Gene

    Size:
    907 amino acids
    Molecular mass:
    92502 Da
    Quaternary structure:
    • Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91 (By similarity).
    SequenceCaution:
    • Sequence=BAA31631.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB89292.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH18201.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SNAP91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAP91 Gene

Proteomics data for SNAP91 Gene at MOPED

Post-translational modifications for SNAP91 Gene

  • Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no evidence for direct Thr-310 phosphorylation (By similarity).
  • Glycosylation at Thr 310
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SNAP91 Gene

Domains & Families for SNAP91 Gene

Protein Domains for SNAP91 Gene

Graphical View of Domain Structure for InterPro Entry

O60641

UniProtKB/Swiss-Prot:

AP180_HUMAN :
  • Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues).
  • Belongs to the PICALM/SNAP91 family.
Domain:
  • Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues).
  • Contains 1 ENTH (epsin N-terminal homology) domain.
Family:
  • Belongs to the PICALM/SNAP91 family.
genes like me logo Genes that share domains with SNAP91: view

No data available for Gene Families for SNAP91 Gene

Function for SNAP91 Gene

Molecular function for SNAP91 Gene

UniProtKB/Swiss-Prot Function:
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).

Gene Ontology (GO) - Molecular Function for SNAP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding ISS --
genes like me logo Genes that share ontologies with SNAP91: view
genes like me logo Genes that share phenotypes with SNAP91: view

Animal Model Products

miRNA for SNAP91 Gene

miRTarBase miRNAs that target SNAP91

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAP91 Gene

Localization for SNAP91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP91 Gene

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAP91 Gene COMPARTMENTS Subcellular localization image for SNAP91 gene
Compartment Confidence
cytosol 4
plasma membrane 4
cytoskeleton 2
nucleus 2
endosome 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNAP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030136 clathrin-coated vesicle IEA --
genes like me logo Genes that share ontologies with SNAP91: view

Pathways & Interactions for SNAP91 Gene

genes like me logo Genes that share pathways with SNAP91: view

Pathways by source for SNAP91 Gene

Gene Ontology (GO) - Biological Process for SNAP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048268 clathrin coat assembly IEA --
genes like me logo Genes that share ontologies with SNAP91: view

No data available for SIGNOR curated interactions for SNAP91 Gene

Drugs & Compounds for SNAP91 Gene

(1) Additional Compounds for SNAP91 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNAP91: view

Transcripts for SNAP91 Gene

Unigene Clusters for SNAP91 Gene

Synaptosomal-associated protein, 91kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP91 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - -
SP2: -
SP3:

Relevant External Links for SNAP91 Gene

GeneLoc Exon Structure for
SNAP91
ECgene alternative splicing isoforms for
SNAP91

Expression for SNAP91 Gene

mRNA expression in normal human tissues for SNAP91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAP91 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.0), Brain - Cerebellar Hemisphere (x6.9), Brain - Anterior cingulate cortex (BA24) (x6.6), Brain - Cerebellum (x5.2), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for SNAP91 Gene

This gene is overexpressed in Brain (29.4), Frontal cortex (23.7), and Fetal Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAP91 Gene



SOURCE GeneReport for Unigene cluster for SNAP91 Gene Hs.368046

genes like me logo Genes that share expression patterns with SNAP91: view

Protein tissue co-expression partners for SNAP91 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SNAP91 Gene

Orthologs for SNAP91 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNAP91 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNAP91 35
  • 92.15 (n)
  • 93.89 (a)
SNAP91 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAP91 35
  • 88.24 (n)
  • 89.06 (a)
SNAP91 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snap91 35
  • 88.32 (n)
  • 91.43 (a)
Snap91 16
Snap91 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNAP91 35
  • 99.7 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Snap91 35
  • 87.96 (n)
  • 91.05 (a)
oppossum
(Monodelphis domestica)
Mammalia SNAP91 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAP91 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAP91 35
  • 82.84 (n)
  • 88.95 (a)
SNAP91 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAP91 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snap91 35
  • 76.03 (n)
  • 79.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.567 35
zebrafish
(Danio rerio)
Actinopterygii snap91 35
  • 64.1 (n)
  • 64.1 (a)
snap91 36
  • 57 (a)
OneToMany
SNAP91 (1 of 2) 36
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1779 35
fruit fly
(Drosophila melanogaster)
Insecta lap 37
  • 63 (a)
lap 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-11 37
  • 50 (a)
unc-11 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAP1801 36
  • 21 (a)
ManyToMany
YAP1802 36
  • 21 (a)
ManyToMany
YAP1802 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for SNAP91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAP91 Gene

ENSEMBL:
Gene Tree for SNAP91 (if available)
TreeFam:
Gene Tree for SNAP91 (if available)

Paralogs for SNAP91 Gene

Paralogs for SNAP91 Gene

Pseudogenes.org Pseudogenes for SNAP91 Gene

genes like me logo Genes that share paralogs with SNAP91: view

Variants for SNAP91 Gene

Sequence variations from dbSNP and Humsavar for SNAP91 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs60730 -- 83,663,339(+) cgaaa(A/G)ctgag intron-variant
rs63034 -- 83,641,517(+) GAAAA(C/T)AGCAG intron-variant
rs91894 -- 83,678,186(+) AACTT(C/G)AGGAG intron-variant
rs217284 -- 83,702,167(-) TCAAA(G/T)TCCTT intron-variant
rs217285 -- 83,702,134(-) AGTTT(A/C)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAP91 Gene

Variant ID Type Subtype PubMed ID
nsv5374 CNV Insertion 18451855
nsv886330 CNV Gain 21882294

Variation tolerance for SNAP91 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAP91 Gene

HapMap Linkage Disequilibrium report
SNAP91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAP91 Gene

Disorders for SNAP91 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNAP91 Gene - From: OMIM

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SNAP91

Genetic Association Database (GAD)
SNAP91
Human Genome Epidemiology (HuGE) Navigator
SNAP91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAP91
genes like me logo Genes that share disorders with SNAP91: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAP91 Gene

Publications for SNAP91 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. (PMID: 12493563) Yao P.J. … Coleman P.D. (Neurobiol. Aging 2003) 2 3 23
  3. The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide. (PMID: 19450545) Wu F. … Yao P.J. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling. (PMID: 12807910) Morgan J.R. … Lafer E.M. (J. Biol. Chem. 2003) 3 23
  5. ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. (PMID: 12847086) Krauss M. … Haucke V. (J. Cell Biol. 2003) 3 23

Products for SNAP91 Gene

Sources for SNAP91 Gene

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