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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNAP91 Gene

protein-coding   GIFtS: 59
GCID: GC06M084319

Synaptosomal-Associated Protein, 91kDa

(Previous names: synaptosomal-associated protein, 91 kDa (mouse) homolog,...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptosomal-Associated Protein, 91kDa1 2     AP1802
Clathrin Coat-Associated Protein AP1802 3     CALM2
Phosphoprotein F1-202 3     Assembly Protein, 180kDa2
91 KDa Synaptosomal-Associated Protein2 3     Clathrin Coat Assembly Protein AP1802
Synaptosomal-Associated Protein, 91 KDa (Mouse) Homolog1     Synaptosomal-Associated Protein, 91kDa Homolog2
Synaptosomal-Associated Protein, 91kDa Homolog (Mouse)1     KIAA06563

External Ids:    HGNC: 149861   Entrez Gene: 98922   Ensembl: ENSG000000656097   OMIM: 6079235   UniProtKB: O606413   

Export aliases for SNAP91 gene to outside databases

Previous GC identifers: GC06M084208 GC06M084258 GC06M084261 GC06M081492


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SNAP91 Gene: 
SNAP91 (synaptosomal-associated protein, 91kDa) is a protein-coding gene. Diseases associated with SNAP91 include alzheimer's disease, and myeloid leukemia, and among its related super-pathways are Clathrin-dependent protein traffic. GO annotations related to this gene include clathrin binding and 1-phosphatidylinositol binding. An important paralog of this gene is PICALM.

UniProtKB/Swiss-Prot: AP180_HUMAN, O60641
Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.
Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins,
leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into
60-70 nm coats (By similarity)

Gene Wiki entry for SNAP91 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNAP91 gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   E2F-5   FOXD3   Nkx2-5   E2F-2   E2F   E2F-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNAP91 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNAP91

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAP91


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q15

SNAP91 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAP91 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M084319:  view genomic region     (about GC identifiers)

Start:
84,262,599 bp from pter      End:
84,419,410 bp from pter
Size:
156,812 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AP180_HUMAN, O60641 (See protein sequence)
Recommended Name: Clathrin coat assembly protein AP180  
Size: 907 amino acids; 92502 Da
Subunit: Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91 (By similarity)
Subcellular location: Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein;
Cytoplasmic side (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles
in the plasma membrane (By similarity)
Sequence caution: Sequence=BAA31631.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB89292.1; Type=Erroneous gene model prediction; Sequence=CAH18201.1; Type=Erroneous translation;
Note=Wrong choice of CDS;
Secondary accessions: A8K0L7 E5RI02 Q5JX13 Q68DL9 Q6P9D3 Q9NTY7
Alternative splicing: 4 isoforms:  O60641-1   O60641-2   O60641-3   O60641-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SNAP91: NX_O60641

Explore proteomics data for SNAP91 at MOPED 

Post-translational modifications:

  • UniProtKB: Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no
    evidence for direct Thr-310 phosphorylation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60641

  • SNAP91 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNAP91 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001229721.1  NP_001229722.1  NP_001229723.1  NP_001243646.1  NP_001243647.1  NP_055656.1  

    ENSEMBL proteins: 
     ENSP00000429776   ENSP00000358708   ENSP00000195649   ENSP00000400459   ENSP00000428215  
     ENSP00000428511   ENSP00000429937   ENSP00000428026   ENSP00000430255   ENSP00000428127  
     ENSP00000430071   ENSP00000358705   ENSP00000429700   ENSP00000429429   ENSP00000430441  
     ENSP00000358704   ENSP00000427959   ENSP00000431055   ENSP00000429950   ENSP00000428592  
     ENSP00000412492   ENSP00000413277  

    Human Recombinant Protein Products for SNAP91: 
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    Novus Biologicals SNAP91 Proteins
    Novus Biologicals SNAP91 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNAP91 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005905coated pit IEA--
    GO:0030118clathrin coat IEA--

    SNAP91 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR014712 Clathrin_Pinositid-bd_GAT-like
     IPR008942 ENTH_VHS
     IPR013809 Epsin-like_N
     IPR011417 ANTH_dom

    Graphical View of Domain Structure for InterPro Entry O60641

    ProtoNet protein and cluster: O60641

    2 Blocks protein domains:
    IPB001026 Epsin N-terminal homology
    IPB013809 Epsin-like


    UniProtKB/Swiss-Prot: AP180_HUMAN, O60641
    Domain: Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic
    middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues)
    Similarity: Belongs to the PICALM/SNAP91 family
    Similarity: Contains 1 ENTH (epsin N-terminal homology) domain


    SNAP91 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP180_HUMAN, O60641
    Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.
    Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins,
    leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into
    60-70 nm coats (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17762867
    GO:0005543phospholipid binding ----
    GO:00055451-phosphatidylinositol binding IEA--
    GO:0030276clathrin binding IEA--
         
    SNAP91 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SNAP91:
     Decreased viability with cispl 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNAP91 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNAP91 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSNAP91 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP91


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNAP91 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SNAP91
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNAP91

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for SNAP91 (O606412, 3 ENSP000001956494) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048268clathrin coat assembly IEA--

    SNAP91 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNAP91 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNAP91 (AP180)

    1 Novoseek inferred chemical compound relationship for SNAP91 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 24.2 1 11239400 (1)

    Search CenterWatch for drugs/clinical trials and news about SNAP91 / AP180

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNAP91 gene (6 alternative transcripts): 
    NM_001242792.1  NM_001242793.1  NM_001242794.1  NM_001256717.1  NM_001256718.1  NM_014841.2  

    Unigene Cluster for SNAP91:

    Synaptosomal-associated protein, 91kDa
    Hs.368046  [show with all ESTs]
    Unigene Representative Sequence: CR749348
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000521485 ENST00000369694(uc003pka.3) ENST00000195649(uc011dzd.2)
    ENST00000439399(uc011dze.2 uc003pkc.3 uc003pkd.3) ENST00000521743(uc021zcf.1)
    ENST00000520302 ENST00000518312(uc003pkb.3) ENST00000520213 ENST00000523448
    ENST00000521616(uc011dzf.1) ENST00000519133 ENST00000521931 ENST00000369691
    ENST00000523780 ENST00000522248 ENST00000519779 ENST00000518309 ENST00000369690


    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAP91 (see all 33):
    hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-3161 hsa-miR-629 hsa-miR-3148 hsa-miR-92b hsa-miR-203
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB014556.1 AF054993.1 AK289582.1 AK294556.1 AK294898.1 BC036650.1 BC044579.1 BC060818.1 
    CR749348.1 

    8 DOTS entries:

    DT.95299394  DT.452972  DT.121363316  DT.121363336  DT.91866138  DT.121363328  DT.92466379  DT.121363329 

    24/99 AceView cDNA sequences (see all 99):

    CB043922 BM692846 F06489 AF054993 BQ722787 AL118818 BM694987 AL079617 
    AA322365 CB118175 AA421284 AB014556 AA936082 AA804744 BC036650 F06335 
    BE504881 AL118840 AV729020 AA258526 BF446414 BM692219 CA865843 BF514550 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SNAP91    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:        -     -     -                                                                                                                                 
    SP2:                    -                                                                                                                                 
    SP3:                                                                                                                                                      


    ECgene alternative splicing isoforms for SNAP91

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNAP91 expression in normal human tissues (normalized intensities)      SNAP91 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGCCCTCT
    SNAP91 Expression
    About this image


    SNAP91 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 45 entries
             Thalamus
             Globus Pallidus   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
             autonomic/sympathetic/ganglion   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Human Neuron (HN)   

    See SNAP91 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNAP91

    SOURCE GeneReport for Unigene cluster: Hs.368046
        SABiosciences Custom PCR Arrays for SNAP91
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAP91
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP91

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNAP91 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snap911 , 5 synaptosomal-associated protein 911, 5 89.69(n)1
    94.1(a)1
      9 (46.58 cM)5
    206161  NM_013669.11  NP_038697.11 
     867659365 
    chicken
    (Gallus gallus)
    Aves SNAP916
    clathrin coat assembly protein AP180
    86(a)
    1 ↔ 1
    3(77046813-77117276)
    lizard
    (Anolis carolinensis)
    Reptilia SNAP916
    synaptosomal-associated protein, 91kDa
    79(a)
    1 ↔ 1
    1(197398527-197499422)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5672 Xenopus laevis clathrin assembly protein AP180 (AP18 more 77.6(n)    AF182340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5653841 clathrin coat assembly protein AP180-like 63.99(n)
    64.23(a)
      565384  XM_688661.5  XP_693753.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta lap3 synaptic vesicle coating 63(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-111 , 3 Expression: neurons3
    Protein UNC-111
    50(a)3
    52.47(n)1
    48.29(a)1
      I(3799173-3805706)3
    1719521  NM_058827.21  NP_491228.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAP1802(YGR241C)4 Protein involved in clathrin cage assembly; binds Pan1p more   --   7(976581-974875) 853157  NP_011757.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G352001 putative clathrin assembly protein 43.53(n)
    27.27(a)
      833474  NM_122911.3  NP_198370.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08033001 hypothetical protein 42.52(n)
    28.38(a)
      4331047  NM_001054960.1  NP_001048425.1 


    ENSEMBL Gene Tree for SNAP91 (if available)
    TreeFam Gene Tree for SNAP91 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNAP91 gene
    PICALM2  
    2 SIMAP similar genes for SNAP91 using alignment to 15 protein entries:     AP180_HUMAN (see all proteins):
    PICALM    CALM/AF10 fusion

    SNAP91 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SNAP91
    PGOHUM00000242097


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3028 SNPs in SNAP91 are shown (see all 3028)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343779721,2
    C,F--84262146(+) TTGGAC/AACAGG 6 -- int13Minor allele frequency- A:0.50NA 6
    rs1912840931,2
    --84262190(+) GGTGGA/GGGGGA 6 -- int10--------
    rs1823812251,2
    --84262220(+) GGAGAG/TATACC 6 -- int10--------
    rs1866951421,2
    --84262263(+) ACCAAC/TATGGC 6 -- int10--------
    rs1912616231,2
    --84262270(+) TGGCAC/TATGTA 6 -- int10--------
    rs747909391,2
    C--84262281(+) TACATA/GTGTAA 6 -- int10--------
    rs1847956061,2
    --84262478(+) TAATTC/TTTTAT 6 -- int10--------
    rs1887016051,2
    --84262502(+) CTCTAC/TTGGCA 6 -- int10--------
    rs1456269311,2
    --84262553(+) TGTGTC/TATTTG 6 -- int10--------
    rs10611821,2
    C,H--84262641(-) GCCCTC/TTGAGA 6 -- ut31 ese32Minor allele frequency- T:0.01NS NA 174

    HapMap Linkage Disequilibrium report for SNAP91 (84262599 - 84419410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNAP91:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5374CNV Insertion18451855
    nsv886330CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SNAP91

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607923    OMIM disorders: --

    5 diseases for SNAP91:    About MalaCards
    alzheimer's disease    myeloid leukemia    schizophrenia    leukemia
    neuronitis


    SNAP91 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for SNAP91 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 48.1 3 10926122 (1), 11161218 (1), 15558718 (1)
    alzheimers disease 28 10 10579202 (8), 11124443 (1)

    Genetic Association Database (GAD): SNAP91
    Human Genome Epidemiology (HuGE) Navigator: SNAP91 (3 documents)

    Export disorders for SNAP91 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNAP91 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with SNAP91)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. (PubMed id 12493563)1, 3, 9 Yao P.J....Coleman P.D. (2003)
    3. Novel cleft susceptibility genes in chromosome 6q. (PubMed id 20511563)1, 4 Letra A....Vieira A.R. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. (PubMed id 10436022)1, 3 Tebar F.... Sorkin A. (1999)
    9. Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry. (PubMed id 10579202)1, 9 Yao P.J....Coleman P.D. (1999)
    10. The clathrin assembly protein AP180 regulates the gen eration of amyloid-beta peptide. (PubMed id 19450545)1, 9 Wu F....Yao P.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9892 HGNC: 14986 AceView: SNAP91 Ensembl:ENSG00000065609 euGenes: HUgn9892
    ECgene: SNAP91 H-InvDB: SNAP91

    (According to HUGE)
    About This Section
    HUGE: KIAA0656

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNAP91 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNAP91 gene:
    Search GeneIP for patents involving SNAP91

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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