Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNAP91 Gene

protein-coding   GIFtS: 60
GCID: GC06M084262

Synaptosomal-Associated Protein, 91kDa

(Previous names: synaptosomal-associated protein, 91 kDa (mouse) homolog,...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Synaptosomal-Associated Protein, 91kDa1 2     AP1802
Clathrin Coat-Associated Protein AP1802 3     CALM2
Phosphoprotein F1-202 3     Assembly Protein, 180kDa2
91 KDa Synaptosomal-Associated Protein2 3     Clathrin Coat Assembly Protein AP1802
Synaptosomal-Associated Protein, 91 KDa (Mouse) Homolog1     Synaptosomal-Associated Protein, 91kDa Homolog2
Synaptosomal-Associated Protein, 91kDa Homolog (Mouse)1     KIAA06563

External Ids:    HGNC: 149861   Entrez Gene: 98922   Ensembl: ENSG000000656097   OMIM: 6079235   UniProtKB: O606413   

Export aliases for SNAP91 gene to outside databases

Previous GC identifers: GC06M084208 GC06M084258 GC06M084261 GC06M084319 GC06M081492


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SNAP91 Gene:
SNAP91 (synaptosomal-associated protein, 91kDa) is a protein-coding gene. GO annotations related to this gene include clathrin binding and 1-phosphatidylinositol binding. An important paralog of this gene is PICALM.

UniProtKB/Swiss-Prot: AP180_HUMAN, O60641
Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.
Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins,
leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into
60-70 nm coats (By similarity)

Gene Wiki entry for SNAP91 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNAP91 gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   E2F-5   FOXD3   Nkx2-5   E2F-2   E2F   E2F-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNAP91 promoter sequence
   Search Chromatin IP Primers for SNAP91

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNAP91


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q15

SNAP91 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAP91 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M084262:  view genomic region     (about GC identifiers)

Start:
84,262,599 bp from pter      End:
84,419,410 bp from pter
Size:
156,812 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AP180_HUMAN, O60641 (See protein sequence)
Recommended Name: Clathrin coat assembly protein AP180  
Size: 907 amino acids; 92502 Da
Subunit: Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91 (By similarity)
Sequence caution: Sequence=BAA31631.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB89292.1; Type=Erroneous gene model prediction; Sequence=CAH18201.1; Type=Erroneous translation;
Note=Wrong choice of CDS;
Secondary accessions: A8K0L7 E5RI02 Q5JX13 Q68DL9 Q6P9D3 Q9NTY7
Alternative splicing: 4 isoforms:  O60641-1   O60641-2   O60641-3   O60641-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SNAP91: NX_O60641

Explore proteomics data for SNAP91 at MOPED

Post-translational modifications: 

  • Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no
    evidence for direct Thr-310 phosphorylation (By similarity)1
  • Glycosylation2 at Thr310
  • Modification sites at PhosphoSitePlus

  • See SNAP91 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001229721.1  NP_001229722.1  NP_001229723.1  NP_001243646.1  NP_001243647.1  NP_055656.1  

    ENSEMBL proteins: 
     ENSP00000429776   ENSP00000358708   ENSP00000195649   ENSP00000400459   ENSP00000428215  
     ENSP00000428511   ENSP00000429937   ENSP00000428026   ENSP00000430255   ENSP00000428127  
     ENSP00000430071   ENSP00000358705   ENSP00000429700   ENSP00000429429   ENSP00000430441  
     ENSP00000358704   ENSP00000427959   ENSP00000431055   ENSP00000429950   ENSP00000428592  
     ENSP00000412492   ENSP00000413277  

    SNAP91 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SNAP91
    OriGene Protein Over-expression Lysate for SNAP91
    OriGene MassSpec for SNAP91
    OriGene Custom Protein Services for SNAP91
    GenScript Custom Purified and Recombinant Proteins Services for SNAP91
    Novus Biologicals SNAP91 Proteins
    Novus Biologicals SNAP91 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNAP91

     
    Search eBioscience for Proteins for SNAP91 

     
    antibodies-online proteins for SNAP91 (4 products) 

     
    Search antibodies-online for peptides for SNAP91

    SNAP91 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SNAP91
    Novus Biologicals SNAP91 Antibodies
    Abcam antibodies for SNAP91
    Cloud-Clone Corp. Antibodies for SNAP91
    Search ThermoFisher Antibodies for SNAP91
    antibodies-online antibodies for SNAP91 (21 products) 

    SNAP91 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNAP91
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNAP91
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNAP91
    Cloud-Clone Corp. CLIAs for SNAP91
    Search eBioscience for ELISAs for SNAP91 
    antibodies-online kits for SNAP91 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR011417 ANTH_dom
     IPR014712 Clathrin_Pinositid-bd_GAT-like
     IPR008942 ENTH_VHS
     IPR013809 Epsin-like_N

    Graphical View of Domain Structure for InterPro Entry O60641

    ProtoNet protein and cluster: O60641

    2 Blocks protein domains:
    IPB001026 Epsin N-terminal homology
    IPB013809 Epsin-like


    UniProtKB/Swiss-Prot: AP180_HUMAN, O60641
    Domain: Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic
    middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues)
    Similarity: Belongs to the PICALM/SNAP91 family
    Similarity: Contains 1 ENTH (epsin N-terminal homology) domain


    Find genes that share domains with SNAP91           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP180_HUMAN, O60641
    Function: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.
    Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins,
    leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into
    60-70 nm coats (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17762867
    GO:0005543phospholipid binding ----
    GO:00055451-phosphatidylinositol binding IEA--
    GO:0030276clathrin binding IEA--
         
    Find genes that share ontologies with SNAP91           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SNAP91:
     Decreased viability with cispl 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SNAP91

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNAP91:
    hsa-mir-26b-5p (MIRT029749), hsa-mir-335-5p (MIRT018431)

    Block miRNA regulation of human, mouse, rat SNAP91 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNAP91 (see all 33):
    hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-3161 hsa-miR-629 hsa-miR-3148 hsa-miR-92b hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidSNAP91 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNAP91
    Predesigned siRNA for gene silencing in human, mouse, rat SNAP91

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNAP91

    Clone
    Products:
         
    OriGene clones in human, mouse for SNAP91 (see all 9)
    OriGene ORF clones in mouse, rat for SNAP91
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNAP91 (NM_014841)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNAP91
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAP91

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNAP91
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNAP91 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP91

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12032) for SNAP91 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AP180_HUMAN, O60641: Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein;
    Cytoplasmic side (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles
    in the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005905coated pit IEA--
    GO:0030118clathrin coat IEA--

    Find genes that share ontologies with SNAP91           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SNAP91 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SNAP91
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNAP91
    Interactions:

        GeneGlobe Interaction Network for SNAP91

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNAP91 (O606411, 2, 3 ENSP000001956494) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0048268clathrin coat assembly IEA--

    Find genes that share ontologies with SNAP91           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNAP91 (AP180)

    1 Novoseek inferred chemical compound relationship for SNAP91 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 24.2 1 11239400 (1)



    Find genes that share compounds with SNAP91           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNAP91 gene (6 alternative transcripts): 
    NM_001242792.1  NM_001242793.1  NM_001242794.1  NM_001256717.1  NM_001256718.1  NM_014841.2  

    Unigene Cluster for SNAP91:

    Synaptosomal-associated protein, 91kDa
    Hs.368046  [show with all ESTs]
    Unigene Representative Sequence: CR749348
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000521485 ENST00000369694(uc003pka.3) ENST00000195649(uc011dzd.2)
    ENST00000439399(uc011dze.2 uc003pkc.3 uc003pkd.3) ENST00000521743(uc021zcf.1)
    ENST00000520302 ENST00000518312(uc003pkb.3) ENST00000520213 ENST00000523448
    ENST00000521616(uc011dzf.1) ENST00000519133 ENST00000521931 ENST00000369691
    ENST00000523780 ENST00000522248 ENST00000519779 ENST00000518309 ENST00000369690

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNAP91 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNAP91 (see all 33):
    hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-3161 hsa-miR-629 hsa-miR-3148 hsa-miR-92b hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidSNAP91 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNAP91
    Predesigned siRNA for gene silencing in human, mouse, rat SNAP91
    Clone
    Products:
         
    OriGene clones in human, mouse for SNAP91 (see all 9)
    OriGene ORF clones in mouse, rat for SNAP91
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNAP91 (NM_014841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNAP91
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAP91
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SNAP91
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNAP91
      QuantiTect SYBR Green Assays in human, mouse, rat SNAP91
      QuantiFast Probe-based Assays in human, mouse, rat SNAP91
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12032) for SNAP91 

    Additional mRNA sequence: 

    AB014556.1 AF054993.1 AK289582.1 AK294556.1 AK294898.1 BC036650.1 BC044579.1 BC060818.1 
    CR749348.1 

    8 DOTS entries:

    DT.95299394  DT.452972  DT.121363316  DT.121363336  DT.91866138  DT.121363328  DT.92466379  DT.121363329 

    Selected AceView cDNA sequences (see all 99):

    AL118818 F01567 AA936082 F05703 BM694987 AL079617 AL118840 BF514550 
    AA322365 BF446414 F10915 AV729020 F06335 BM692846 BM692219 BE504881 
    AF054993 AB014556 AA421284 BQ722787 CA865843 F06489 CB118175 AA804744 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SNAP91    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:        -     -     -                                                                                                                                 
    SP2:                    -                                                                                                                                 
    SP3:                                                                                                                                                      


    ECgene alternative splicing isoforms for SNAP91

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNAP91 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGCCCTCT
    SNAP91 Expression
    About this image


    SNAP91 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebellum
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
    SNAP91 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNAP91 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368046
        Custom PCR Arrays for SNAP91
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SNAP91
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNAP91
    QuantiTect SYBR Green Assays in human, mouse, rat SNAP91
    QuantiFast Probe-based Assays in human, mouse, rat SNAP91
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP91

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNAP91 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snap911 , 5 synaptosomal-associated protein 911, 5 88.32(n)1
    91.43(a)1
      9 (46.58 cM)5
    206161  NM_013669.21  NP_038697.11 
     867659365 
    chicken
    (Gallus gallus)
    Aves SNAP911 synaptosomal-associated protein, 91kDa homolog (mouse) 82.84(n)
    88.95(a)
      428635  NM_001012951.1  NP_001012969.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNAP916
    synaptosomal-associated protein, 91kDa
    79(a)
    1 ↔ 1
    1(197398527-197499422)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5672 Xenopus laevis clathrin assembly protein AP180 (AP18 more 77.6(n)    AF182340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snap911 synaptosomal-associated protein 91 64.1(n)
    64.1(a)
      565384  XM_688661.6  XP_693753.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta lap3 synaptic vesicle coating 63(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-113 Expression: neurons 50(a)   I(3799173-3805706)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAP1802(YGR241C)4 Protein involved in clathrin cage assembly; binds Pan1p more   --   7(976581-974875) 853157  NP_011757.1 


    ENSEMBL Gene Tree for SNAP91 (if available)
    TreeFam Gene Tree for SNAP91 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNAP91 gene
    PICALM2  
    2 SIMAP similar genes for SNAP91 using alignment to 15 protein entries:     AP180_HUMAN (see all proteins):
    PICALM    CALM/AF10 fusion

    Find genes that share paralogs with SNAP91           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SNAP91
    PGOHUM00000242097


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNAP91 (see all 3028)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343779721,2
    C,F--84262146(+) TTGGAC/AACAGG 6 -- int13Minor allele frequency- A:0.50NA 6
    rs1912840931,2
    --84262190(+) GGTGGA/GGGGGA 6 -- int10--------
    rs1823812251,2
    --84262220(+) GGAGAG/TATACC 6 -- int10--------
    rs1866951421,2
    --84262263(+) ACCAAC/TATGGC 6 -- int10--------
    rs1912616231,2
    --84262270(+) TGGCAC/TATGTA 6 -- int10--------
    rs747909391,2
    C--84262281(+) TACATA/GTGTAA 6 -- int10--------
    rs1847956061,2
    --84262478(+) TAATTC/TTTTAT 6 -- int10--------
    rs1887016051,2
    --84262502(+) CTCTAC/TTGGCA 6 -- int10--------
    rs1456269311,2
    --84262553(+) TGTGTC/TATTTG 6 -- int10--------
    rs10611821,2
    C,H--84262641(-) GCCCTC/TTGAGA 6 -- ut31 ese32Minor allele frequency- T:0.01NS NA 174

    HapMap Linkage Disequilibrium report for SNAP91 (84262599 - 84419410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNAP91:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5374CNV Insertion18451855
    nsv886330CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNAP91
    DNA2.0 Custom Variant and Variant Library Synthesis for SNAP91

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607923    OMIM disorders: --


    Find genes that share disorders with SNAP91           About GenesLikeMe

    2 Novoseek inferred disease relationships for SNAP91 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 48.1 3 10926122 (1), 11161218 (1), 15558718 (1)
    alzheimers disease 28 10 10579202 (8), 11124443 (1)

    Genetic Association Database (GAD): SNAP91
    Human Genome Epidemiology (HuGE) Navigator: SNAP91 (3 documents)

    Export disorders for SNAP91 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNAP91 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with SNAP91)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. (PubMed id 12493563)1, 3, 9 Yao P.J....Coleman P.D. (Neurobiol. Aging 2003)
    3. Novel cleft susceptibility genes in chromosome 6q. (PubMed id 20511563)1, 4 Letra A....Vieira A.R. (J. Dent. Res. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. (PubMed id 10436022)1, 3 Tebar F.... Sorkin A. (Mol. Biol. Cell 1999)
    9. Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry. (PubMed id 10579202)1, 9 Yao P.J....Coleman P.D. (Neuroscience 1999)
    10. The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide. (PubMed id 19450545)1, 9 Wu F....Yao P.J. (Biochem. Biophys. Res. Commun. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9892 HGNC: 14986 AceView: SNAP91 Ensembl:ENSG00000065609 euGenes: HUgn9892
    ECgene: SNAP91 H-InvDB: SNAP91

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0656

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNAP91 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNAP91 gene:
    Search GeneIP for patents involving SNAP91

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SNAP91  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SNAP91  
     OriGene MassSpec for SNAP91   OriGene clones in human, mouse for SNAP91  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNAP91   OriGene Purified Protein for SNAP91  
     OriGene ORF clones in mouse, rat for SNAP91   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNAP91   OriGene Custom Protein Services for SNAP91  

     
     
     Block miRNA regulation of human, mouse, rat SNAP91 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNAP91
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNAP91 Predesigned siRNA for gene silencing in human, mouse, rat SNAP91
     QuantiFast Probe-based Assays in human, mouse, rat SNAP91 QuantiTect SYBR Green Assays in human, mouse, rat SNAP91
     Custom PCR Arrays for SNAP91 Search Chromatin IP Primers for SNAP91
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNAP91  GeneGlobe Interaction Network for SNAP91
     Regulatory tfbs in SNAP91 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNAP91 GenScript cDNA clones with any tag delivered in your preferred vector for SNAP91
     GenScript Custom Assay Services for SNAP91 GenScript Custom overexpressing Cell Line Services for SNAP91
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SNAP91 (AP180)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNAP91 antibodies
     SNAP91 proteins
     SNAP91 lysates
     Antibodies for SNAP91
     See all of Abcam's Antibodies, Kits and Proteins for SNAP91
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SNAP91
     Antibodies for SNAP91
     ELISAs for SNAP91
     CLIAs for SNAP91



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNAP91
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP91
     SwitchGear 3'UTR luciferase reporter plasmids for SNAP91
     SwitchGear Promoter luciferase reporter plasmids for SNAP91
     Search ThermoFisher Antibodies for SNAP91
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAP91
     Browse compounds at ApexBio
     Search Addgene for plasmids for SNAP91
      Search eBioscience for proteins for SNAP91
      Search eBioscience for elisas for SNAP91
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SNAP91
     antibodies-online antibodies for SNAP91 (21 products)
     antibodies-online kits for SNAP91 (6 products)
      Search antibodies-online for peptides for SNAP91
     antibodies-online proteins for SNAP91 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNAP91 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4