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Aliases for SNAP47 Gene

Aliases for SNAP47 Gene

  • Synaptosomal-Associated Protein, 47kDa 2 3
  • Synaptosomal-Associated 47 KDa Protein 3 4
  • Epididymis Luminal Protein 170 3 4
  • C1orf142 3 4
  • SNAP-47 3 4
  • HEL170 3 4
  • SVAP1 3 4
  • Chromosome 1 Open Reading Frame 142 2
  • Synaptosomal-Associated Protein 47 3

External Ids for SNAP47 Gene

Previous HGNC Symbols for SNAP47 Gene

  • C1orf142

Previous GeneCards Identifiers for SNAP47 Gene

  • GC01P225984
  • GC01P227917
  • GC01P198439

Summaries for SNAP47 Gene

GeneCards Summary for SNAP47 Gene

SNAP47 (Synaptosomal-Associated Protein, 47kDa) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics.

UniProtKB/Swiss-Prot for SNAP47 Gene

  • Plays a role in intracellular membrane fusion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP47 Gene

Genomics for SNAP47 Gene

Regulatory Elements for SNAP47 Gene

Genomic Location for SNAP47 Gene

Start:
227,728,539 bp from pter
End:
227,781,231 bp from pter
Size:
52,693 bases
Orientation:
Plus strand

Genomic View for SNAP47 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAP47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP47 Gene

Proteins for SNAP47 Gene

  • Protein details for SNAP47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SQN1-SNP47_HUMAN
    Recommended name:
    Synaptosomal-associated protein 47
    Protein Accession:
    Q5SQN1
    Secondary Accessions:
    • B6EDE0
    • Q5HYB5
    • Q5TBZ3
    • Q8N558
    • Q8TB31
    • Q8TCW8
    • Q8WV46
    • Q96CQ3
    • Q96FE1
    • Q96I66
    • Q96NU3
    • Q9BT10
    • Q9BVB2

    Protein attributes for SNAP47 Gene

    Size:
    464 amino acids
    Molecular mass:
    52562 Da
    Quaternary structure:
    • Forms a complex containing SNAP47, VAMP2 and STX1A (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6.
    SequenceCaution:
    • Sequence=BAB70779.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SNAP47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAP47 Gene

Proteomics data for SNAP47 Gene at MOPED

Post-translational modifications for SNAP47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNAP47 Gene

Domains for SNAP47 Gene

Protein Domains for SNAP47 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAP47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SQN1

UniProtKB/Swiss-Prot:

SNP47_HUMAN :
  • Q5SQN1
Domain:
  • Contains 2 t-SNARE coiled-coil homology domains.
Family:
  • Belongs to the SVAP1 family.
genes like me logo Genes that share domains with SNAP47: view

No data available for Gene Families for SNAP47 Gene

Function for SNAP47 Gene

Molecular function for SNAP47 Gene

UniProtKB/Swiss-Prot Function: Plays a role in intracellular membrane fusion.

Gene Ontology (GO) - Molecular Function for SNAP47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 19546860
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SNAP47: view

Phenotypes for SNAP47 Gene

genes like me logo Genes that share phenotypes with SNAP47: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNAP47

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNAP47 Gene

Localization for SNAP47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP47 Gene

Endomembrane system. Cytoplasm, perinuclear region. Note=Appears to be exclusively membrane-bound. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAP47 Gene COMPARTMENTS Subcellular localization image for SNAP47 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SNAP47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane --
GO:0030425 dendrite IEA --
GO:0031083 colocalizes_with BLOC-1 complex IDA 19546860
genes like me logo Genes that share ontologies with SNAP47: view

Pathways for SNAP47 Gene

genes like me logo Genes that share pathways with SNAP47: view

Pathways by source for SNAP47 Gene

1 KEGG pathway for SNAP47 Gene

Gene Ontology (GO) - Biological Process for SNAP47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016082 synaptic vesicle priming IBA --
GO:0031629 synaptic vesicle fusion to presynaptic membrane IBA --
GO:0060291 long-term synaptic potentiation IEA --
genes like me logo Genes that share ontologies with SNAP47: view

Transcripts for SNAP47 Gene

Unigene Clusters for SNAP47 Gene

Synaptosomal-associated protein, 47kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNAP47

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP47 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for SNAP47 Gene

GeneLoc Exon Structure for
SNAP47
ECgene alternative splicing isoforms for
SNAP47

Expression for SNAP47 Gene

mRNA expression in normal human tissues for SNAP47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAP47 Gene

SOURCE GeneReport for Unigene cluster for SNAP47 Gene Hs.325081

genes like me logo Genes that share expressions with SNAP47: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNAP47 Gene

Orthologs for SNAP47 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAP47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAP47 35
  • 99.5 (n)
  • 99.35 (a)
SNAP47 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAP47 35
  • 80.11 (n)
  • 77.57 (a)
SNAP47 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
SNAP47 35
  • 78.47 (n)
  • 74.94 (a)
mouse
(Mus musculus)
Mammalia Snap47 35
  • 74.43 (n)
  • 68.2 (a)
Snap47 16
Snap47 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAP47 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snap47 35
  • 76.4 (n)
  • 73.44 (a)
chicken
(Gallus gallus)
Aves SNAP47 35
  • 67.15 (n)
  • 60.91 (a)
SNAP47 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAP47 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.20482 35
snap47 35
  • 59.5 (n)
  • 50 (a)
snap47 36
  • 48 (a)
OneToOne
Species with no ortholog for SNAP47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAP47 Gene

ENSEMBL:
Gene Tree for SNAP47 (if available)
TreeFam:
Gene Tree for SNAP47 (if available)

Paralogs for SNAP47 Gene

No data available for Paralogs for SNAP47 Gene

Variants for SNAP47 Gene

Sequence variations from dbSNP and Humsavar for SNAP47 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs730684 -- 227,766,254(+) CCAGA(C/T)GTAGG intron-variant
rs748405 -- 227,759,733(+) AAAGC(A/G)GTTGG intron-variant
rs754223 -- 227,776,465(-) AGAGG(C/T)GAGGC intron-variant
rs754224 -- 227,775,790(+) GCAGG(G/T)CTTCC intron-variant
rs912072 -- 227,760,634(-) CAGCC(C/T)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAP47 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv515496 CNV Loss 19592680
nsv873249 CNV Loss 21882294
esv2724217 CNV Deletion 23290073
esv8091 CNV Gain 19470904

Relevant External Links for SNAP47 Gene

HapMap Linkage Disequilibrium report
SNAP47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAP47 Gene

Disorders for SNAP47 Gene

No disorders were found for SNAP47 Gene.

No data available for UniProtKB/Swiss-Prot for SNAP47 Gene

Publications for SNAP47 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. (PMID: 16621800) Holt M. … Jahn R. (J. Biol. Chem. 2006) 2 3
  3. The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. (PMID: 19546860) Ghiani C.A. … Dell'Angelica E.C. (Mol. Psychiatry 2010) 3 4
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for SNAP47 Gene

Sources for SNAP47 Gene

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