Aliases for SNAP29 Gene
External Ids for SNAP29 Gene
Previous GeneCards Identifiers for SNAP29 Gene
This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SNAP29 Gene
SNAP29 (Synaptosome Associated Protein 29kDa) is a Protein Coding gene. Diseases associated with SNAP29 include cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome and muscular dystrophy-dystroglycanopathy , type a, 5. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. GO annotations related to this gene include syntaxin binding and SNAP receptor activity.
UniProtKB/Swiss-Prot for SNAP29 Gene
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.