SNAP29 Gene
protein-coding GIFtS: 55
GCID: GC22P021213
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synaptosomal-associated protein, 29kDa(Previous names: synaptosomal-associated protein, 29kD )
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Aliases
for SNAP29 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synaptosomal-Associated Protein, 29kDa1 2 | | Vesicle-Membrane Fusion Protein SNAP-292 3 | | SNAP-291 2 3 | | Synaptosomal-Associated Protein, 29kD1 | | CEDNIK1 2 5 | | Synaptosomal-Associated Protein 292 | | Soluble 29 KDa NSF Attachment Protein2 3 | | |
Export aliases for SNAP29 gene to outside databasesPrevious GC identifers: GC22P017912 GC22P019537 GC22P004481 |
Summaries
for SNAP29 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNAP29:
This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Twoother members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediatesynaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly tomultiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While theprotein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiplepolyadenylation sites has been noted for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721Function: Involved in multiple membrane trafficking steps
Gene Wiki entry for SNAP29
|
Genomic Views
for SNAP29 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNAP29 gene promoter:
Max1 SREBP-1c HNF-4alpha1 SREBP-1b Meis-1b SREBP-1a Meis-1a c-Myc Meis-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNAP29
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAP29 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21SNAP29 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P021213: view genomic region
(about GC identifiers)
Start:
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21,213,271 bp from pter |
End:
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21,245,502 bp from pter |
Size:
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32,232 bases |
Orientation:
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plus strand |
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Proteins
for SNAP29 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721 (See
protein sequence)Recommended Name: Synaptosomal-associated protein 29 Size: 258 amino acids; 28970 Da
Subunit: Binds tightly to multiple syntaxins
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome.Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion iscytoplasmicExplore the universe of human proteins at neXtProt for SNAP29: NX_O95721
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95721
SNAP29 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004773.1
ENSEMBL proteins: ENSP00000215730 ENSP00000411095
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
SNAP29 for ontologies About GeneDecksing
SNAP29 Antibody Products:
Assay Products for SNAP29: |
Protein
Domains /
Families
for SNAP29 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNAP29 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95721ProtoNet protein and cluster: O95721 1 Blocks protein family: IPB000928 SNAP-25 family
UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721Similarity: Belongs to the SNAP-25 familySimilarity: Contains 1 t-SNARE coiled-coil homology domain |
Function
for SNAP29 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721Function: Involved in multiple membrane trafficking steps Genatlas biochemistry entry for SNAP29:synaptosomal-associated protein
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNAP29
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP29 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SNAP29 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Snap29):
SNAP29 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SNAP29 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SNAP29):
SNAP29 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNAP29
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/49 Interacting proteins for SNAP29 (O957213 ENSP000002157304) via UniProtKB, MINT, STRING, and/or I2D (see all 49)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SNAP29 for ontologies About GeneDecksing
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Drugs & Compounds
for SNAP29 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNAP29
Search CenterWatch for drugs/clinical trials and news about SNAP29 / SNP29
|
Transcripts
for SNAP29 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNAP29 gene: NM_004782.3 Unigene Cluster for SNAP29: Synaptosomal-associated protein, 29kDa Hs.108002 [show with all ESTs]Unigene Representative Sequence: NM_0047823 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000215730(uc011ahw.2) ENST00000490458 ENST00000439214
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNAP29 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNAP29
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNAP29 (NM_004782) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNAP29 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAP29 |
Additional cDNA sequence: AF115436.1 AK024704.1 BC009715.1 BT007357.1 CR456582.1 12 DOTS entries: DT.40220884 DT.97843911 DT.100023916 DT.213968 DT.101963487 DT.100694683 DT.120668179 DT.95239399 DT.40288090 DT.91689216 DT.120668443 DT.95163571 24/200 AceView cDNA sequences (see all 200): BQ013299 T16605 AI979050 AA393083 BM811557 CF243176 CK300815 BU633768 BQ011955 BM797105 AI031711 CB241202 BU506819 BQ013429 AA987813 AW955747 AA045540 AI224907 AI382727 AI017738 CR456582 AA865974 CD678985 AI497809
GeneLoc Exon Structure
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Expression
for SNAP29 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNAP29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACTGGGTC
About this image
See SNAP29 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNAP29
SOURCE GeneReport for Unigene cluster: Hs.108002
UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721Tissue specificity: Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas
SABiosciences Custom PCR Arrays for SNAP29
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNAP29
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP29 |
Orthologs
for SNAP29 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNAP29 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for SNAP29 (if available)
TreeFam Gene Tree for SNAP29 (if available) |
Paralogs
for SNAP29 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SNAP29 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNAP29 (21213271 - 21245502 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNAP29: --
Human Gene Mutation Database (HGMD): SNAP29
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNAP29 |
|
Disorders
/ Diseases
for SNAP29 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNAP29 for disorders About GeneDecksing
OMIM gene information: 604202
OMIM disorders: 609528
UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721
Defects in SNAP29 are the cause of CEDNIK syndrome (CEDNIK) [MIM:609528]. CEDNIK is a neurocutaneous syndromecharacterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma
9  diseases for SNAP29: About MalaCardscerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome cerebral dysgenesis keratoderma ichthyosis
neuropathy cerebritis schizophrenia neuronitis
keratitis
Genetic Association Database (GAD): SNAP29
Human Genome Epidemiology (HuGE) Navigator: SNAP29 (3 documents)
Export disorders for SNAP29 gene to outside databases
|
Publications
for SNAP29 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNAP29 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with SNAP29) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Three novel proteins of the syntaxin/SNAP-25 family. (PubMed id 9852078)1, 2, 3 Steegmaier M....Scheller R.H. (1998)
- A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma. (PubMed id 15968592)1, 2 Sprecher E.... Mandel H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Polymorphism in SNAP29 gene promoter region associated with schizophrenia. (PubMed id 11317222)1, 4 Saito T....Lachman H.M. (2001)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I....O'Brien K.P. (1999)
- SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission. (PubMed id 11707603)1, 9 Su Q....Sheng Z.H. (2001)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for SNAP29 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SNAP29 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNAP29 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNAP29 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNAP29 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SNAP29 gene:
Search GeneIP for patents involving SNAP29
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNAP29 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNAP29 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNAP29 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAP29 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNAP29 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAP29 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNAP29 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAP29 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAP29 |
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