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SNAP29 Gene

protein-coding   GIFtS: 57
GCID: GC22P021213

Synaptosomal-Associated Protein, 29kDa

(Previous names: synaptosomal-associated protein, 29kD)
  See SNAP29-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptosomal-Associated Protein, 29kDa1 2     CEDNIK2 5
Soluble 29 KDa NSF Attachment Protein1 2 3     Synaptosomal-Associated Protein, 29kD1
Vesicle-Membrane Fusion Protein SNAP-292 3     Synaptosomal-Associated Protein 292
SNAP-292 3     

External Ids:    HGNC: 111331   Entrez Gene: 93422   Ensembl: ENSG000000999407   OMIM: 6042025   UniProtKB: O957213   

Export aliases for SNAP29 gene to outside databases

Previous GC identifers: GC22P017912 GC22P019537 GC22P004481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNAP29 Gene:
This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps.
Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and
mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene
binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the
plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the
cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNAP29 Gene:
SNAP29 (synaptosomal-associated protein, 29kDa) is a protein-coding gene. Diseases associated with SNAP29 include cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome. GO annotations related to this gene include SNAP receptor activity.

UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721
Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins
for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex,
an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in
autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably
involved in multiple membrane trafficking steps

Gene Wiki entry for SNAP29 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNAP29 gene promoter:
         Max1   SREBP-1c   HNF-4alpha1   SREBP-1b   Meis-1b   SREBP-1a   Meis-1a   c-Myc   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNAP29 promoter sequence
   Search Chromatin IP Primers for SNAP29

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNAP29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

SNAP29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAP29 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021213:  view genomic region     (about GC identifiers)

Start:
21,213,271 bp from pter      End:
21,245,506 bp from pter
Size:
32,236 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721 (See protein sequence)
Recommended Name: Synaptosomal-associated protein 29  
Size: 258 amino acids; 28970 Da
Subunit: Interacts with multiple syntaxins including STX6 (By similarity). Forms a SNARE complex, composed of
VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome

Explore the universe of human proteins at neXtProt for SNAP29: NX_O95721

Explore proteomics data for SNAP29 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113, Lys126
  • Modification sites at PhosphoSitePlus

  • See SNAP29 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004773.1  
    ENSEMBL proteins: 
     ENSP00000215730   ENSP00000411095  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000928 SNAP-25
     IPR000727 T_SNARE_dom

    Graphical View of Domain Structure for InterPro Entry O95721

    ProtoNet protein and cluster: O95721

    1 Blocks protein domain: IPB000928 SNAP-25 family

    UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721
    Similarity: Belongs to the SNAP-25 family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Find genes that share domains with SNAP29           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNP29_HUMAN, O95721
    Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins
    for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex,
    an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in
    autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably
    involved in multiple membrane trafficking steps

         Genatlas biochemistry entry for SNAP29:
    synaptosomal-associated protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity TAS10839363
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SNAP29           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Snap29):
     mortality/aging 

    Find genes that share phenotypes with SNAP29           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SNAP29

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNAP29:
    hsa-mir-505-3p (MIRT041037), hsa-mir-7-5p (MIRT025633), hsa-mir-155-5p (MIRT001499)

    Block miRNA regulation of human, mouse, rat SNAP29 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNAP29 (see all 23):
    hsa-miR-3685 hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-607 hsa-miR-539 hsa-miR-340 hsa-miR-221 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSNAP29 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNP29_HUMAN, O95721: Cytoplasm. Membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome.
    Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is
    cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane4
    cytosol3
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005886plasma membrane TAS9852078
    GO:0030054cell junction IEA--

    Find genes that share ontologies with SNAP29           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNAP29 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    SNARE interactions in vesicular transport0.40


    Find genes that share SuperPaths with SNAP29           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SNAP29):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNAP29
    Interactions:

        GeneGlobe Interaction Network for SNAP29

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNAP29 (O957213 ENSP000002157304) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EHD1Q9H4M93, ENSP000003205164I2D: score=4 STRING: ENSP00000320516
    NSFP464593, ENSP000003812934I2D: score=3 STRING: ENSP00000381293
    STX12Q86Y823, ENSP000003630544I2D: score=2 STRING: ENSP00000363054
    VAMP7P518093, ENSP000002864484I2D: score=2 STRING: ENSP00000286448
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000046autophagic vacuole fusion IMP--
    GO:0006887exocytosis TAS10839363
    GO:0006903vesicle targeting TAS9852078
    GO:0015031protein transport IEA--
    GO:0061025membrane fusion TAS10839363

    Find genes that share ontologies with SNAP29           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNAP29 (SNP29)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNAP29 gene: 
    NM_004782.3  

    Unigene Cluster for SNAP29:

    Synaptosomal-associated protein, 29kDa
    Hs.108002  [show with all ESTs]
    Unigene Representative Sequence: NM_004782
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215730(uc011ahw.2) ENST00000490458 ENST00000439214
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SNAP29 (see all 23):
    hsa-miR-3685 hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-607 hsa-miR-539 hsa-miR-340 hsa-miR-221 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSNAP29 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF115436.1 AK024704.1 BC009715.1 BT007357.1 CR456582.1 

    12 DOTS entries:

    DT.40220884  DT.97843911  DT.100023916  DT.213968  DT.101963487  DT.100694683  DT.120668179  DT.95239399 
    DT.40288090  DT.91689216  DT.120668443  DT.95163571 

    Selected AceView cDNA sequences (see all 200):

    CB241202 BM797105 CK300815 AA865974 CF243176 CR456582 AA076457 CD678985 
    AI017738 AI497809 BU506819 BU633768 AI979050 BU556768 BM811557 BQ013429 
    AI031711 CR617204 AA810150 BQ013299 AW955747 AI420718 AA045540 T16605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNAP29 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTGGGTC
    SNAP29 Expression
    About this image


    SNAP29 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SNAP29 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNAP29 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.108002

    UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721
    Tissue specificity: Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SNAP29 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snap291 , 5 synaptosomal-associated protein 291, 5 84.24(n)1
    83.72(a)1
      16 (10.79 cM)5
    674741  NM_023348.41  NP_075837.31 
     174060035 
    chicken
    (Gallus gallus)
    Aves SNAP291 synaptosomal-associated protein, 29kDa 67.89(n)
    64.63(a)
      416766  NM_001030652.1  NP_001025823.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNAP296
    synaptosomal-associated protein, 29kDa
    63(a)
    1 ↔ 1
    GL343282.1(915852-924473)
    African clawed frog
    (Xenopus laevis)
    Amphibia snap29-prov2 synaptosomal-associated protein, 29kDa 72.25(n)    BC041208.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.186292 Transcribed sequence with weak similarity to protein more 76.44(n)    AL916631.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta usnp1 ubisnap 47.4(n)
    35.44(a)
      37774  NM_079107.3  NP_523831.1 
    worm
    (Caenorhabditis elegans)
    Secernentea snap-291 snap-29 40.76(n)
    29.41(a)
      176233  NM_066539.7  NP_498940.1 


    ENSEMBL Gene Tree for SNAP29 (if available)
    TreeFam Gene Tree for SNAP29 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNAP29 (see all 769)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871635291,2
    --5157435(+) TTTTTG/TTAAGT 1 -- int10--------
    rs1903391131,2
    --5157508(+) ATGTAA/CTGAGC 1 -- int10--------
    rs1171369911,2
    C,F--5157524(+) TTTCTT/GTTTGG 1 -- int12Minor allele frequency- G:0.04NA EA 240
    rs1142359251,2
    F--5157603(+) GTTGTT/CTACAC 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1780701,2
    C,F,A,H--5157623(+) AGTCTA/GTTTGC 1 -- int124Minor allele frequency- G:0.32EA NA NS WA 2486
    rs1379156511,2
    --5157634(+) ATCCTA/GCTTGG 1 -- int10--------
    rs1816695791,2
    --5157854(+) TCAAAC/TGTGAT 1 -- int10--------
    rs1494713051,2
    --5157875(+) GCCACC/TGCCAG 1 -- int10--------
    rs1169395131,2
    F--5157876(+) CCACCG/ACCAGC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1160467321,2
    F--5157884(+) AGCACA/GTCCTC 1 -- int11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for SNAP29 (21213271 - 21245506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SNAP29:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724009CNV Deletion23290073
    esv2678175CNV Deletion23128226
    nsv436864CNV Insertion17901297
    nsv834141CNV Loss17160897
    nsv834140CNV Loss17160897
    nsv523162CNV Loss19592680
    nsv914418CNV Gain21882294
    nsv914419CNV Gain21882294
    nsv914390CNV Gain21882294

    Human Gene Mutation Database (HGMD): SNAP29
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604202   
    OMIM disorders: 609528  
    UniProtKB/Swiss-Prot: SNP29_HUMAN, O95721
  • Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK) [MIM:609528]:
    A neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar
    keratoderma. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for SNAP29:    
    About MalaCards
    cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome


    Find genes that share disorders with SNAP29           About GenesLikeMe

    Genetic Association Database (GAD): SNAP29
    Human Genome Epidemiology (HuGE) Navigator: SNAP29 (3 documents)

    Export disorders for SNAP29 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNAP29 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SNAP29)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel proteins of the syntaxin/SNAP-25 family. (PubMed id 9852078)1, 2, 3 Steegmaier M....Scheller R.H. (J. Biol. Chem. 1998)
    2. [Genetic analysis of genitourinary malformations]. (PubMed id 19350501)1, 4 Zhang J.S....Li-Ling J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma. (PubMed id 15968592)1, 2 Sprecher E.... Mandel H. (Am. J. Hum. Genet. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. Polymorphism in SNAP29 gene promoter region associated with schizophrenia. (PubMed id 11317222)1, 4 Saito T....Lachman H.M. (Mol. Psychiatry 2001)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I.... Wright H. (Nature 1999)
    9. SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission. (PubMed id 11707603)1, 9 Su Q....Sheng Z.H. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9342 HGNC: 11133 AceView: SNAP29 Ensembl:ENSG00000099940 euGenes: HUgn9342
    ECgene: SNAP29 Kegg: 9342 H-InvDB: SNAP29

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNAP29 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNAP29 gene:
    Search GeneIP for patents involving SNAP29

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from genOway)
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