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Aliases for SNAP25 Gene

Aliases for SNAP25 Gene

  • Synaptosomal-Associated Protein, 25kDa 2 3
  • Resistance To Inhibitors Of Cholinesterase 4 Homolog 2 3
  • Synaptosomal-Associated Protein, 25kD 2 3
  • Super Protein 3 4
  • SNAP-25 3 4
  • SNAP 3 4
  • SUP 3 4
  • Synaptosomal-Associated 25 KDa Protein 4
  • Synaptosomal-Associated Protein 25 3
  • DJ1068F16.2 3
  • BA416N4.2 3
  • RIC-4 3
  • RIC4 3
  • SEC9 3

External Ids for SNAP25 Gene

Previous HGNC Symbols for SNAP25 Gene

  • SNAP

Previous GeneCards Identifiers for SNAP25 Gene

  • GC20P010187
  • GC20P010194
  • GC20P010147
  • GC20P010199
  • GC20P010151

Summaries for SNAP25 Gene

Entrez Gene Summary for SNAP25 Gene

  • Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAP25 Gene

SNAP25 (Synaptosomal-Associated Protein, 25kDa) is a Protein Coding gene. Diseases associated with SNAP25 include botulism and antisocial personality disorder. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include SNARE binding. An important paralog of this gene is SNAP23.

UniProtKB/Swiss-Prot for SNAP25 Gene

  • t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF

Gene Wiki entry for SNAP25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP25 Gene

Genomics for SNAP25 Gene

Regulatory Elements for SNAP25 Gene

Transcription factor binding sites by QIAGEN in the SNAP25 gene promoter:

Genomic Location for SNAP25 Gene

Start:
10,218,694 bp from pter
End:
10,307,418 bp from pter
Size:
88,725 bases
Orientation:
Plus strand

Genomic View for SNAP25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP25 Gene

Proteins for SNAP25 Gene

  • Protein details for SNAP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60880-SNP25_HUMAN
    Recommended name:
    Synaptosomal-associated protein 25
    Protein Accession:
    P60880
    Secondary Accessions:
    • B2RAU4
    • D3DW16
    • D3DW17
    • P13795
    • P36974
    • P70557
    • P70558
    • Q53EM2
    • Q5U0B5
    • Q8IXK3
    • Q96FM2
    • Q9BR45

    Protein attributes for SNAP25 Gene

    Size:
    206 amino acids
    Molecular mass:
    23315 Da
    Quaternary structure:
    • Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with CENPF, TRIM9, RIMS1, SNAPIN, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1 (By similarity). Associates with the BLOC-1 complex. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with EQTN (By similarity).
    Miscellaneous:
    • When cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85, Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead

    Three dimensional structures from OCA and Proteopedia for SNAP25 Gene

    Alternative splice isoforms for SNAP25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAP25 Gene

Proteomics data for SNAP25 Gene at MOPED

Post-translational modifications for SNAP25 Gene

  • Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAP25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAP25 Gene

Domains for SNAP25 Gene

Protein Domains for SNAP25 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60880

UniProtKB/Swiss-Prot:

SNP25_HUMAN :
  • P60880
Domain:
  • Contains 2 t-SNARE coiled-coil homology domains.
Family:
  • Belongs to the SNAP-25 family.
genes like me logo Genes that share domains with SNAP25: view

No data available for Gene Families for SNAP25 Gene

Function for SNAP25 Gene

Molecular function for SNAP25 Gene

GENATLAS Biochemistry: synaptosomal-associated protein 1,25kDa,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein,palmitoylated in vivo for the binding to syntaxin
UniProtKB/Swiss-Prot Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF

Gene Ontology (GO) - Molecular Function for SNAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 11438518
GO:0017075 syntaxin-1 binding IPI 12730201
GO:0048306 calcium-dependent protein binding ISS --
genes like me logo Genes that share ontologies with SNAP25: view
genes like me logo Genes that share phenotypes with SNAP25: view

Animal Models for SNAP25 Gene

MGI Knock Outs for SNAP25:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SNAP25 Gene

Localization for SNAP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP25 Gene

Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAP25 Gene COMPARTMENTS Subcellular localization image for SNAP25 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
plasma membrane 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SNAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005802 trans-Golgi network IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with SNAP25: view

Pathways for SNAP25 Gene

genes like me logo Genes that share pathways with SNAP25: view

Gene Ontology (GO) - Biological Process for SNAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001504 neurotransmitter uptake NAS 8760387
GO:0006112 energy reserve metabolic process TAS --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0010975 regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with SNAP25: view

Compounds for SNAP25 Gene

(1) HMDB Compounds for SNAP25 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6

(1) Drugbank Compounds for SNAP25 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Botulinum Toxin Type A
  • BoNT/A
93384-43-1 target inhibitor

(27) Novoseek inferred chemical compound relationships for SNAP25 Gene

Compound -log(P) Hits PubMed IDs
toxin-s 48.4 2
calcium 48.2 60
mastoparan 45.8 3
n-ethylmaleimide 38 1
catecholamine 37.3 6
genes like me logo Genes that share compounds with SNAP25: view

Transcripts for SNAP25 Gene

Unigene Clusters for SNAP25 Gene

Synaptosomal-associated protein, 25kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP25 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: -
SP11:

Relevant External Links for SNAP25 Gene

GeneLoc Exon Structure for
SNAP25
ECgene alternative splicing isoforms for
SNAP25

Expression for SNAP25 Gene

mRNA expression in normal human tissues for SNAP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAP25 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.1), Brain - Cerebellar Hemisphere (8.0), Brain - Anterior cingulate cortex (BA24) (6.6), Brain - Cerebellum (4.4), Brain - Amygdala (4.3), Brain - Hippocampus (4.3), and Brain - Cortex (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAP25 Gene

SOURCE GeneReport for Unigene cluster for SNAP25 Gene Hs.167317

mRNA Expression by UniProt/SwissProt for SNAP25 Gene

P60880-SNP25_HUMAN
Tissue specificity: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum
genes like me logo Genes that share expressions with SNAP25: view

Orthologs for SNAP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAP25 35
  • 99.68 (n)
  • 100 (a)
SNAP25 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAP25 35
  • 96.28 (n)
  • 100 (a)
SNAP25 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAP25 35
  • 97.41 (n)
  • 100 (a)
SNAP25 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snap25 35
  • 95.15 (n)
  • 100 (a)
Snap25 16
Snap25 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAP25 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAP25 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snap25 35
  • 94.66 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SNAP25 35
  • 90.78 (n)
  • 100 (a)
SNAP25 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAP25 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia snap25-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snap25 35
  • 87.7 (n)
  • 95.63 (a)
Str.15491 35
zebrafish
(Danio rerio)
Actinopterygii snap25a 35
  • 84.15 (n)
  • 93.14 (a)
snap25a 36
  • 94 (a)
OneToMany
snap25b 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Snap24 35
  • 64.2 (n)
  • 60.1 (a)
Snap24 36
  • 56 (a)
ManyToMany
Snap25 36
  • 57 (a)
ManyToMany
Snap24 37
  • 57 (a)
Snap25 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea aex-4 36
  • 18 (a)
ManyToMany
ric-4 36
  • 46 (a)
ManyToMany
Y22F5A.3 37
  • 53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8011 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6593 36
  • 65 (a)
OneToMany
Species with no ortholog for SNAP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAP25 Gene

ENSEMBL:
Gene Tree for SNAP25 (if available)
TreeFam:
Gene Tree for SNAP25 (if available)

Paralogs for SNAP25 Gene

Paralogs for SNAP25 Gene

Selected SIMAP similar genes for SNAP25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNAP25: view

Variants for SNAP25 Gene

Sequence variations from dbSNP and Humsavar for SNAP25 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3223 -- 10,297,724(-) AGGGG(C/T)TACAG intron-variant
rs8636 -- 10,307,094(+) GGCTA(C/T)GTTTT utr-variant-3-prime
rs362547 -- 10,264,491(+) TTCTT(C/T)AGCCA intron-variant
rs362548 -- 10,266,167(+) TTCTG(A/G)TGATT intron-variant
rs362549 -- 10,289,242(+) CCTGG(A/G)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAP25 Gene

Variant ID Type Subtype PubMed ID
nsv522874 CNV Loss 19592680
nsv833919 CNV Gain 17160897
nsv912660 CNV Gain 21882294
esv2674016 CNV Deletion 23128226
nsv3290 CNV Insertion 18451855
nsv828687 CNV Loss 20364138

Relevant External Links for SNAP25 Gene

HapMap Linkage Disequilibrium report
SNAP25
Human Gene Mutation Database (HGMD)
SNAP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAP25 Gene

Disorders for SNAP25 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SNAP25 Gene including...

Search for SNAP25 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SNAP25 Gene

(17) Novoseek inferred disease relationships for SNAP25 Gene

Disease -log(P) Hits PubMed IDs
tetanus 74.3 11
botulism 71.6 2
attention-deficit hyperactivity disorder 42.8 6
paralysis 37.5 4
schizophrenia 32.6 20

Relevant External Links for SNAP25

Genetic Association Database (GAD)
SNAP25
Human Genome Epidemiology (HuGE) Navigator
SNAP25
genes like me logo Genes that share disorders with SNAP25: view

No data available for UniProtKB/Swiss-Prot for SNAP25 Gene

Publications for SNAP25 Gene

  1. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PMID: 8760387) Jagadish M.N. … Ward C.W. (Biochem. J. 1996) 3 4 23
  2. The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes. (PMID: 10692432) Gerona R.R. … Martin T.F. (J. Biol. Chem. 2000) 2 3 23
  3. The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia. (PMID: 15823421) MA1ller D.J. … Kennedy J.L. (Neurosci. Lett. 2005) 3 23 48
  4. The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts. (PMID: 16801949) Gosso M.F. … Posthuma D. (Mol. Psychiatry 2006) 3 23 48
  5. Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics. (PMID: 18347838) Spellmann I. … Riedel M. (Eur Arch Psychiatry Clin Neurosci 2008) 3 23 48

Products for SNAP25 Gene

Sources for SNAP25 Gene

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