Aliases for SNAP25 Gene
External Ids for SNAP25 Gene
Previous Symbols for SNAP25 Gene
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SNAP25 Gene
SNAP25 (Synaptosomal-Associated Protein, 25kDa) is a Protein Coding gene. Diseases associated with SNAP25 include botulism and antisocial personality disorder. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include SNARE binding. An important paralog of this gene is SNAP23.
UniProtKB/Swiss-Prot for SNAP25 Gene
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF