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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNAP23 Gene

protein-coding   GIFtS: 64
GCID: GC15P042787

synaptosomal-associated protein, 23kDa

(Previous names: synaptosomal-associated protein, 23kD )
 Explore 12 diseases affiliated with
SNAP23 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNAP23    

Aliases
for SNAP23 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synaptosomal-Associated Protein, 23kDa1 2     Vesicle-Membrane Fusion Protein SNAP-232 3
HsT170161 2     SNAP-232 3
SNAP23A1 2     Synaptosomal-Associated Protein, 23kD1
SNAP23B1 2     Synaptosomal-Associated Protein 232

External Ids:    HGNC: 111311   Entrez Gene: 87732   Ensembl: ENSG000000925317   OMIM: 6025345   UniProtKB: O001613   

Export aliases for SNAP23 gene to outside databases

Previous GC identifers: GC15P038155 GC15P035683 GC15P040366 GC15P040503 GC15P040575 GC15P019635


Summaries
for SNAP23 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNAP23:
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein
termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with
SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general
membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most,
if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed
homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded
by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and
synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion
machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants
encoding different protein isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNP23_HUMAN, O00161
Function: Essential component of the high affinity receptor for the general membrane fusion machinery and an important
regulator of transport vesicle docking and fusion

Gene Wiki entry for SNAP23


Genomic Views
for SNAP23 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNAP23 gene promoter:
         COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNAP23 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNAP23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAP23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

SNAP23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAP23 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P042787:  view genomic region     (about GC identifiers)

Start:
 42,783,431 bp from pter      End:
 42,837,547 bp from pter
Size:
 54,117 bases      Orientation:
 plus strand

Proteins
for SNAP23 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNP23_HUMAN, O00161 (See protein sequence)
Recommended Name: Synaptosomal-associated protein 23  
Size: 211 amino acids; 23354 Da
Subunit: Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Binds simultaneously to
SNAPIN and SYN4. Found in a complex with VAMP8 and STX4 in pancreas. Interacts with STX1A and STX12 (By similarity).
Binds tightly to multiple syntaxins and synaptobrevins/VAMPs. Found in a complex with VAMP8 and STX1A
Subcellular location: Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse,
synaptosome. Note=Mainly localized to the plasma membrane
1 PDB 3D structure from and Proteopedia for SNAP23:
1NHL (3D)    
Secondary accessions: O00162 Q13602 Q6IAE3
Alternative splicing: 2 isoforms:  O00161-1   O00161-2   

Explore the universe of human proteins at neXtProt for SNAP23: NX_O00161

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00161

    • SNAP23 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003816.2  NP_570710.1  

    ENSEMBL proteins: 
     ENSP00000454214   ENSP00000454799   ENSP00000457535   ENSP00000249647   ENSP00000455339  
     ENSP00000455472   ENSP00000455652   ENSP00000458012   ENSP00000454842   ENSP00000456035  
     ENSP00000380327   ENSP00000456144   ENSP00000455102   ENSP00000456000   ENSP00000207062  
    Reactome Protein details: O00161
    Human Recombinant Protein Products: 
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    Novus Biologicals SNAP23 Proteins
    Novus Biologicals SNAP23 Lysates
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    ProSpec Recombinant Protein for SNAP23
    Uscn Proteins for SNAP23

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005792microsome ----
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--


    SNAP23 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SNAP23

    Protein Domains /
    Families
    for SNAP23 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNAP23 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000727 T_SNARE_dom
     IPR000928 SNAP-25

    Graphical View of Domain Structure for InterPro Entry O00161

    ProtoNet protein and cluster: O00161

    1 Blocks protein family: IPB000928 SNAP-25 family

    UniProtKB/Swiss-Prot: SNP23_HUMAN, O00161
    Similarity: Belongs to the SNAP-25 family
    Similarity: Contains 2 t-SNARE coiled-coil homology domains


    Function
    for SNAP23 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNP23_HUMAN, O00161
    Function: Essential component of the high affinity receptor for the general membrane fusion machinery and an important
    regulator of transport vesicle docking and fusion

    miRNA
    Products:            		miRTarBase miRNAs that target SNAP23:
    hsa-let-7b (MIRT001590)

    OriGene 3'-UTR Clone (see all 2): SNAP23
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNAP23
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAP23 (see all 25):
    hsa-let-7d hsa-miR-202 hsa-miR-1271 hsa-let-7c hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmid: SNAP23 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNAP23 (see all 7)
    OriGene shRNA RFP: SNAP23
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SNAP23 (NM_003825)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAP23 

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    Search LifeMap BioReagents cell lines for SNAP23

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514


    SNAP23 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for SNAP23:
     Decreased POU5F1-GFP protein e  Decreased Salmonella enterica   Increased Erk phosphorylation   Increased S DNA content 
     S arrest  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Snap23tm1.1Paro for SNAP23
         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Snap23):
     embryogenesis  mortality/aging  no phenotypic analysis 

    SNAP23 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SNAP23 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		Clathrin derived vesicle budding1.00
    		trans-Golgi Network Vesicle Budding1.00
    2Membrane Trafficking
    		Membrane Trafficking1.00
    		Translocation of GLUT4 to the Plasma Membrane0.32
    3wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    		wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)1.00
    		Regulation of CFTR activity (norm and CF)0.38
    4Fusion of GLUT4 Vesicle with the Plasma Membrane
    		Fusion of GLUT4 Vesicle with the Plasma Membrane1.00
    5Insulin Signaling
    		Insulin Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SNAP23
        Epithelial Tight Junctions

    3 GeneGo (Thomson Reuters) Pathways for SNAP23
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Regulation of CFTR activity (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)

    1 BioSystems Pathway for SNAP23 
        Insulin Signaling

    5        Reactome Pathways for SNAP23
        Membrane Trafficking
    Clathrin derived vesicle budding
    Translocation of GLUT4 to the Plasma Membrane
    trans-Golgi Network Vesicle Budding
    Fusion of GLUT4 Vesicle with the Plasma Membrane


    1         Kegg Pathway  (Kegg details for SNAP23):
        SNARE interactions in vesicular transport


    SNAP23 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNAP23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for SNAP23 (O001611, 2, 3 ENSP000002496474) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TLK1Q9UKI82, 3, ENSP000004110994MINT-17055 I2D: score=3 STRING: ENSP00000411099
    MATR3P432432, 3, ENSP000003543464MINT-8271740 I2D: score=2 STRING: ENSP00000354346
    WASH2PQ6VEQ52, 3MINT-8271762 I2D: score=1 
    STX11O755582, 3, ENSP000003565404MINT-8271751 I2D: score=6 STRING: ENSP00000356540
    NAPAP549201, 3, ENSP000002633544EBI-745000,EBI-749652 I2D: score=4 STRING: ENSP00000263354
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006903vesicle targeting TAS8663154
    GO:0006944cellular membrane fusion TAS10839363
    GO:0015031protein transport IEA--


    SNAP23 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNAP23 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNAP23 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNAP23
    9 Novoseek chemical compound relationships for SNAP23 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 54.1 4 15256361 (1), 9614185 (1), 10648404 (1)
    lipid 14.8 13 15542596 (3), 17922004 (2), 12376543 (2), 16439800 (1) (see all 6)
    cysteine 14.5 9 12551899 (3), 15542596 (2), 10329400 (1), 17575076 (1)
    glucose 9.4 9 10329959 (3), 10212832 (1), 17947242 (1), 19754436 (1) (see all 5)
    sucrose 5.95 1 12376543 (1)
    cholesterol 0 7 16439800 (1), 12376543 (1)
    atp 0 1 12494459 (1)
    chloride 0 1 12209004 (1)
    calcium 0 3 14993220 (3)

    Search CenterWatch for drugs/clinical trials and news about SNAP23 / SNP23 

    Transcripts
    for SNAP23 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNAP23 gene (2 alternative transcripts): 
    NM_003825.3  NM_130798.2  

    Unigene Cluster for SNAP23:

    Synaptosomal-associated protein, 23kDa
    Hs.728237  [show with all ESTs]
    Unigene Representative Sequence: NM_003825
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000568745 ENST00000561526 ENST00000568227 ENST00000568451 ENST00000563765
    ENST00000249647(uc001zpz.2 uc001zqa.2) ENST00000566141 ENST00000564153
    ENST00000567094 ENST00000568331 ENST00000566327 ENST00000563451 ENST00000566035
    ENST00000568859 ENST00000568514 ENST00000397138 ENST00000563873 ENST00000568841


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAP23 (see all 25):
    hsa-let-7d hsa-miR-202 hsa-miR-1271 hsa-let-7c hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-2115
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    Inhib. RNA
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    Additional cDNA sequence: 

    AJ011915.1 AK290152.1 AK313161.1 AK315279.1 BC000148.2 BC003686.1 BC022890.1 BT006916.1 
    CR457212.1 U55936.1 Y09567.1 Y09568.1 

    22 DOTS entries:

    DT.100814709  DT.92448105  DT.40237565  DT.100814711  DT.100814708  DT.121079622  DT.121079631  DT.100809878 
    DT.121079597  DT.92448107  DT.100814724  DT.100814727  DT.121079575  DT.95143265  DT.100814712  DT.121079598 
    DT.100715037  DT.121079633  DT.75175860  DT.121079645  DT.92419486  DT.95143255 

    24/327 AceView cDNA sequences (see all 327):

    AI110610 BU154597 AI564466 AW594203 BG541934 CA430112 AL080028 AL543279 
    AL559212 BM782600 AF062718 AA744963 AW173322 AW273418 AL552586 AA348054 
    AL550305 BI258743 CA413785 BQ878061 BU950516 CA309336 BM922295 NM_003825 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SNAP23 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c
    SP1:                                      -     -     -           -           -     -                 -     -                                             
    SP2:                                      -     -     -           -           -     -                 -     -     -     -     -     -                     
    SP3:                                      -     -     -           -           -     -                                                                     
    SP4:                                            -     -           -           -     -                 -     -                                             
    SP5:                                      -           -           -           -     -                                                                     


    ECgene alternative splicing isoforms for SNAP23

    Expression
    for SNAP23 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNAP23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTCAGATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SNAP23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNAP23

    SOURCE GeneReport for Unigene cluster: Hs.728237

    UniProtKB/Swiss-Prot: SNP23_HUMAN, O00161
    Tissue specificity: Ubiquitous. Highest levels where found in placenta

        SABiosciences Expression via Pathway-Focused PCR Array including SNAP23: 
              Diabetes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for SNAP23 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNAP23 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SNAP231 synaptosomal-associated protein, 23kDa 75.76(n)
    77.03(a)    		   423235  NM_001199666.1  NP_001186595.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 76(a)
    45(a)
    		 1 ↔ many
    1 ↔ many
    		 1(39852054-39859497)
    2(191348119-191348748)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AB033718.12   -- 76.28(n)    AB033718.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC045896.12   -- 74.13(n)   393159  BC045896.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Snap253 Golgi to plasma membrane transport t-SNARE 51(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y22F5A.33 SNAP-25 family 51(a)   V(10264006-10265432)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SNAP296
    SNAP306
    (see all 3)    		 synaptosomal-associated protein, 29kDa
    (see all 3)    		 16(a)
    16(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 5(2515587-2516694)
    1(4751581-4752844)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 SNARE domain containing protein, putative, express...
    SNARE domain containing protein, putative, express...
    (see all 3)    		 16(a)
    14(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 3(5859717-5862894)
    2(19438167-19440551)


    ENSEMBL Gene Tree for SNAP23 (if available)
    TreeFam Gene Tree for SNAP23 (if available) 

    Paralogs
    for SNAP23 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNAP23 gene
    SNAP252  
    1 SIMAP similar gene for SNAP23 using alignment to 12 protein entries:     SNP23_HUMAN (see all proteins):
    SNAP25

    SNAP23 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SNAP23
    PGOHUM00000247557 PGOHUM00000262446


    Genomic Variants
    for SNAP23 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/623 NCBI SNPs in SNAP23 are shown (see all 623)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs129126921,2
    		C,--42785550(+) TCTCTC/ATCTAT 2 -- us2k1 trp36Minor allele frequency- A:0.49NA WA 132
    rs25959371,2
    		C,--42785552(+) TCTCTA/CTATAT 2 -- us2k1 trp36Minor allele frequency- C:0.17NA WA 132
    rs770951481,2
    		F,--42785632(+) AGTACC/GCACCC 2 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1503866701,2
    		--42785703(+) AAAATC/TGTCCC 2 -- us2k10--------
    rs1808894671,2
    		--42785723(+) ACCACA/GGAATT 2 -- us2k10--------
    rs1860908851,2
    		--42785760(+) TGAACC/TAATGA 2 -- us2k10--------
    rs1449976511,2
    		--42785785(+) TTTCTC/TCACCT 2 -- us2k10--------
    rs1490729371,2
    		--42785860(+) TTTTTA/GCCCAT 2 -- us2k10--------
    rs1431351921,2
    		--42786003(+) AAGATA/GACCCC 2 -- us2k10--------
    rs1382809441,2
    		--42786018(+) TCAACC/TTCACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNAP23 (42783431 - 42837547 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNAP23: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNAP23
    DNA2.0 Custom Variant and Variant Library Synthesis for SNAP23

    Disorders / Diseases
    for SNAP23 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNAP23 for disorders           About GeneDecksing

    OMIM gene information: 602534    OMIM disorders: --

    12 diseases for SNAP23:    About MalaCards
    congenital dyserythropoietic anemia type i    congenital dyserythropoietic anemia    dyserythropoietic anemia    hemophagocytic lymphohistiocytosis
    insulin resistance    botulism    tetanus    anemia
    coloboma    pharyngitis    cholesterol    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for SNAP23:
    Botulism     Coloboma     Tetanus

    2 Novoseek disease relationships for SNAP23 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 42.8 2 19910495 (1), 9614185 (1)
    insulin resistance 8.93 3 19754436 (2)

    Human Genome Epidemiology (HuGE) Navigator: SNAP23 (2 documents)

    Export disorders for SNAP23 gene to outside databases

    Publications
    for SNAP23 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNAP23 gene, integrated from 9 sources (see all 151):
    (articles sorted by number of sources associating them with SNAP23)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. (PubMed id 9070898)1, 2, 3, 9 Mollinedo F. and Lazo P.A. (1997)
    2. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. (PubMed id 8663154)1, 2, 3, 9 Ravichandran V.... Roche P.A. (1996)
    3. Genomic organization, chromosomal localization, alternative splicing, and isoforms of human Synaptosome associated protein-23 gene implicated in vesicle-membrane fusion. (PubMed id 11354632)1, 2, 9 Lazo P.A.... Estivill X. (2001)
    4. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. (PubMed id 12556468)1, 2, 9 Freedman S.J....Eck M.J. (2003)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. (PubMed id 12130530)1, 2 Polgar J.... Reed G.L. (2002)
    8. Phosphorylation of SNAP-23 in activated human platelets. (PubMed id 12930825)1, 9 Polgar J....Reed G.L. (2003)
    9. Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. (PubMed id 11001914)1, 9 Martin-Martin B....Mollinedo F. (2000)
    10. Identification of three new splice variants of the SNARE protein SNAP-23. (PubMed id 11444845)1, 9 Shukla A....Dahl R. (2001)

    External Searches for SNAP23 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNAP23 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8773 HGNC: 11131 AceView: SNAP23 Ensembl:ENSG00000092531 euGenes: HUgn8773
    ECgene: SNAP23 Kegg: 8773 H-InvDB: SNAP23

    Other Databases showing SNAP23 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNAP23 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNAP23 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNAP23 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNAP23 gene:
    Search GeneIP for patents involving SNAP23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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