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Aliases for SNAP23 Gene

Aliases for SNAP23 Gene

  • Synaptosome Associated Protein 23 2 3 5
  • Vesicle-Membrane Fusion Protein SNAP-23 3 4
  • Synaptosomal-Associated Protein, 23kDa 2 3
  • SNAP-23 3 4
  • Synaptosomal-Associated Protein, 23kD 3
  • Synaptosome Associated Protein 23kDa 3
  • Synaptosomal-Associated Protein 23 3
  • HsT17016 3
  • SNAP23A 3
  • SNAP23B 3

External Ids for SNAP23 Gene

Previous GeneCards Identifiers for SNAP23 Gene

  • GC15P038155
  • GC15P035683
  • GC15P040366
  • GC15P040503
  • GC15P040575
  • GC15P042787
  • GC15P019635

Summaries for SNAP23 Gene

Entrez Gene Summary for SNAP23 Gene

  • Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAP23 Gene

SNAP23 (Synaptosome Associated Protein 23) is a Protein Coding gene. Diseases associated with SNAP23 include Tetanus and Chief Cell Adenoma. Among its related pathways are Innate Immune System and Clathrin derived vesicle budding. GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is SNAP25.

UniProtKB/Swiss-Prot for SNAP23 Gene

  • Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

Gene Wiki entry for SNAP23 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP23 Gene

Genomics for SNAP23 Gene

Regulatory Elements for SNAP23 Gene

Enhancers for SNAP23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G042497 1.5 Ensembl ENCODE dbSUPER 8.8 +8.4 8375 4.3 HDGF PKNOX1 CREB3L1 ARNT FEZF1 TCF12 GTF3C2 FOS MEF2D SMARCA4 LRRC57 GANC HAUS2 TUBGCP4 LOC105370795 RPAP1 CDAN1 LCMT2 RPS3AP47 MAPKBP1
GH15G042493 1.7 FANTOM5 ENCODE dbSUPER 3.8 +4.1 4072 3.7 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 LRRC57 HAUS2 GANC TMEM87A ZSCAN29 SNAP23 ADAL TTBK2 ENSG00000261684
GH15G042461 0.5 ENCODE dbSUPER 11.3 -29.7 -29658 0.4 LRRC57 SNAP23 CAPN3 GANC TMEM87A GC15P042438 ZNF106
GH15G042619 0.5 ENCODE 10.8 +128.5 128504 1.1 RAD51 ZBTB33 FEZF1 CHD7 EZH2 STARD9 HAUS2 LRRC57 SNAP23 GANC TMEM87A EIF4EBP2P2 PIR61026
GH15G042056 1.7 FANTOM5 Ensembl ENCODE 1.8 -433.6 -433575 2.0 PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 GLIS2 GATA2 ZNF143 CDAN1 MAPKBP1 PLA2G4D PLA2G4E ENSG00000260814 LRRC57 EHD4 MGA SNAP23 TMEM87A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNAP23 on UCSC Golden Path with GeneCards custom track

Promoters for SNAP23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075763 -333 1801 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5

Transcription factor binding sites by QIAGEN in the SNAP23 gene promoter:

Genomic Location for SNAP23 Gene

Chromosome:
15
Start:
42,491,233 bp from pter
End:
42,545,356 bp from pter
Size:
54,124 bases
Orientation:
Plus strand

Genomic View for SNAP23 Gene

Genes around SNAP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP23 Gene

Proteins for SNAP23 Gene

  • Protein details for SNAP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00161-SNP23_HUMAN
    Recommended name:
    Synaptosomal-associated protein 23
    Protein Accession:
    O00161
    Secondary Accessions:
    • O00162
    • Q13602
    • Q6IAE3

    Protein attributes for SNAP23 Gene

    Size:
    211 amino acids
    Molecular mass:
    23354 Da
    Quaternary structure:
    • Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (PubMed:12556468). Found in a complex with VAMP8 and STX1A (PubMed:12130530). Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (By similarity).

    Three dimensional structures from OCA and Proteopedia for SNAP23 Gene

    Alternative splice isoforms for SNAP23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAP23 Gene

Post-translational modifications for SNAP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNAP23 Gene

Domains & Families for SNAP23 Gene

Gene Families for SNAP23 Gene

Protein Domains for SNAP23 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAP23 Gene

Graphical View of Domain Structure for InterPro Entry

O00161

UniProtKB/Swiss-Prot:

SNP23_HUMAN :
  • Belongs to the SNAP-25 family.
Family:
  • Belongs to the SNAP-25 family.
genes like me logo Genes that share domains with SNAP23: view

Function for SNAP23 Gene

Molecular function for SNAP23 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

Gene Ontology (GO) - Molecular Function for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12773094
GO:0019905 syntaxin binding IPI 16677249
genes like me logo Genes that share ontologies with SNAP23: view
genes like me logo Genes that share phenotypes with SNAP23: view

Animal Models for SNAP23 Gene

MGI Knock Outs for SNAP23:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAP23 Gene

Localization for SNAP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP23 Gene

Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Mainly localized to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAP23 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
lysosome 5
cytosol 3
endosome 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 18457912
GO:0005886 plasma membrane IEA,TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with SNAP23: view

Pathways & Interactions for SNAP23 Gene

genes like me logo Genes that share pathways with SNAP23: view

Gene Ontology (GO) - Biological Process for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002553 histamine secretion by mast cell IMP 18253931
GO:0006810 transport IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006903 vesicle targeting TAS 8663154
genes like me logo Genes that share ontologies with SNAP23: view

No data available for SIGNOR curated interactions for SNAP23 Gene

Drugs & Compounds for SNAP23 Gene

(7) Drugs for SNAP23 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SNAP23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNAP23: view

Transcripts for SNAP23 Gene

Unigene Clusters for SNAP23 Gene

Synaptosomal-associated protein, 23kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP23 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - -
SP9:
SP10: -
SP11: - - -

Relevant External Links for SNAP23 Gene

GeneLoc Exon Structure for
SNAP23
ECgene alternative splicing isoforms for
SNAP23

Expression for SNAP23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAP23 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SNAP23 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4) and Platelet (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNAP23 Gene



Protein tissue co-expression partners for SNAP23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNAP23 Gene:

SNAP23

SOURCE GeneReport for Unigene cluster for SNAP23 Gene:

Hs.511149

mRNA Expression by UniProt/SwissProt for SNAP23 Gene:

O00161-SNP23_HUMAN
Tissue specificity: Ubiquitous. Highest levels where found in placenta.

Evidence on tissue expression from TISSUES for SNAP23 Gene

  • Blood(4.6)
  • Liver(4.3)
  • Nervous system(3.4)
  • Kidney(2.4)
  • Lung(2.4)
  • Spleen(2.4)
  • Intestine(2.2)
  • Muscle(2.2)
  • Adrenal gland(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with SNAP23: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAP23 Gene

Orthologs for SNAP23 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAP23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAP23 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia SNAP23 34 35
  • 91 (n)
cow
(Bos Taurus)
Mammalia SNAP23 34 35
  • 89.26 (n)
mouse
(Mus musculus)
Mammalia Snap23 34 16 35
  • 88.41 (n)
rat
(Rattus norvegicus)
Mammalia Snap23 34
  • 87.78 (n)
oppossum
(Monodelphis domestica)
Mammalia SNAP23 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAP23 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAP23 34 35
  • 75.76 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia snap23 34
  • 70.41 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:56072 34
  • 63.64 (n)
SNAP23 (1 of 2) 35
  • 54 (a)
OneToMany
SNAP23 (2 of 2) 35
  • 38 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Snap25 36 35
  • 51 (a)
Snap24 35
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y22F5A.3 36
  • 51 (a)
ric-4 35
  • 41 (a)
ManyToMany
aex-4 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6593 35
  • 57 (a)
OneToMany
Species where no ortholog for SNAP23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAP23 Gene

ENSEMBL:
Gene Tree for SNAP23 (if available)
TreeFam:
Gene Tree for SNAP23 (if available)

Paralogs for SNAP23 Gene

Paralogs for SNAP23 Gene

Pseudogenes.org Pseudogenes for SNAP23 Gene

genes like me logo Genes that share paralogs with SNAP23: view

Variants for SNAP23 Gene

Sequence variations from dbSNP and Humsavar for SNAP23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000021467 -- 42,502,725(+) CTTGA(A/G)CCCCG intron-variant
rs1000063744 -- 42,493,242(+) GAGGC(C/T)GAGGT intron-variant
rs1000123406 -- 42,500,000(+) ACTAG(C/G)TGGAC intron-variant
rs1000221779 -- 42,531,630(+) TTCTT(C/T)TTTGT intron-variant, utr-variant-3-prime
rs1000327909 -- 42,523,497(+) AAAAA(A/G)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAP23 Gene

Variant ID Type Subtype PubMed ID
esv2761870 CNV loss 21179565
esv3636272 CNV loss 21293372
esv3636274 CNV loss 21293372
nsv1508 CNV insertion 18451855
nsv528725 CNV gain 19592680
nsv832987 CNV gain 17160897

Variation tolerance for SNAP23 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAP23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAP23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAP23 Gene

Disorders for SNAP23 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SNAP23 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tetanus
  • clostridial tetanus
chief cell adenoma
  • chief cell adenoma of parathyroid gland
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SNAP23

Genetic Association Database (GAD)
SNAP23
Human Genome Epidemiology (HuGE) Navigator
SNAP23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAP23
genes like me logo Genes that share disorders with SNAP23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAP23 Gene

Publications for SNAP23 Gene

  1. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. (PMID: 9070898) Mollinedo F. … Lazo P.A. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 64
  2. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. (PMID: 8663154) Ravichandran V. … Roche P.A. (J. Biol. Chem. 1996) 2 3 4 22 64
  3. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. (PMID: 12556468) Freedman S.J. … Eck M.J. (J. Biol. Chem. 2003) 3 4 22 64
  4. Genomic organization, chromosomal localization, alternative splicing, and isoforms of human Synaptosome associated protein-23 gene implicated in vesicle-membrane fusion. (PMID: 11354632) Lazo P.A. … Estivill X. (Hum. Genet. 2001) 3 4 22 64
  5. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 64

Products for SNAP23 Gene

Sources for SNAP23 Gene

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