Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNAI3 Gene

Aliases for SNAI3 Gene

  • Snail Family Transcriptional Repressor 3 2 3 5
  • Zinc Finger Protein 293 2 3 4
  • Snail Family Zinc Finger 3 2 3
  • Protein Snail Homolog 3 3 4
  • ZNF293 3 4
  • Snail Homolog 3 (Drosophila) 2
  • Zinc Finger Protein SNAI3 3
  • Snail Homolog 3 3
  • SNAIL3 3
  • Zfp293 3
  • SMUC 3

External Ids for SNAI3 Gene

Previous HGNC Symbols for SNAI3 Gene

  • ZNF293

Previous GeneCards Identifiers for SNAI3 Gene

  • GC16U900013
  • GC16M088447
  • GC16M088488
  • GC16M087271
  • GC16M088744
  • GC16M074438

Summaries for SNAI3 Gene

Entrez Gene Summary for SNAI3 Gene

  • SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SNAI3 Gene

SNAI3 (Snail Family Transcriptional Repressor 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and copper ion binding. An important paralog of this gene is SNAI2.

UniProtKB/Swiss-Prot for SNAI3 Gene

  • Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5-CAGGTG-3 and 5-CACCTG-3 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAI3 Gene

Genomics for SNAI3 Gene

Regulatory Elements for SNAI3 Gene

Enhancers for SNAI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F088615 1.4 FANTOM5 ENCODE 13.6 +68.0 68001 5.5 HDGF PKNOX1 MLX CREB3L1 SIN3A ARID4B FEZF1 DMAP1 YY1 FOS CYBA IL17C ZC3H18 SNAI3 MVD RNF166 ZFPM1
GH16F088698 1.6 FANTOM5 ENCODE 10.2 -16.3 -16339 9.4 MLX CREB3L1 FEZF1 DMAP1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D RNF166 CTU2 SNAI3-AS1 SNAI3 ZNF778 ENSG00000260121 PIEZO1 CDK10 ZC3H18 APRT
GH16F089313 2 VISTA FANTOM5 Ensembl ENCODE 5.9 -634.5 -634517 15.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 YY1 FOS ZNF263 SP5 LOC100289580 ENSG00000259877 TRAPPC2L CTU2 FAM157C ENSG00000261172 AFG3L1P CDK10 DBNDD1 ZNF276
GH16F089112 1.7 FANTOM5 Ensembl ENCODE 5.9 -431.9 -431946 11.3 HDGF PKNOX1 CREB3L1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 FOS ACSF3 ENSG00000259877 CTU2 TRAPPC2L GALNS RNF166 TUBB3 CYBA SNAI3 ENSG00000260279
GH16F088633 1.7 FANTOM5 Ensembl ENCODE 3.6 +50.9 50871 4.9 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF143 ZNF207 ZNF263 CYBA CTU2 ENSG00000259877 RNF166 ZC3H18 SNAI3 CBFA2T3 ZFPM1 ACSF3 IL17C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNAI3 on UCSC Golden Path with GeneCards custom track

Promoters for SNAI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001507474 293 1601 ATF1 ARID4B DMAP1 ZNF48 GLIS2 FOS SP3 SP5 GTF2B NFYC

Genomic Location for SNAI3 Gene

Chromosome:
16
Start:
88,677,682 bp from pter
End:
88,686,493 bp from pter
Size:
8,812 bases
Orientation:
Minus strand

Genomic View for SNAI3 Gene

Genes around SNAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAI3 Gene

Proteins for SNAI3 Gene

  • Protein details for SNAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNW1-SNAI3_HUMAN
    Recommended name:
    Zinc finger protein SNAI3
    Protein Accession:
    Q3KNW1
    Secondary Accessions:
    • Q86SU5

    Protein attributes for SNAI3 Gene

    Size:
    292 amino acids
    Molecular mass:
    32474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNAI3 Gene

Post-translational modifications for SNAI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAI3 Gene

Domains & Families for SNAI3 Gene

Suggested Antigen Peptide Sequences for SNAI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KNW1

UniProtKB/Swiss-Prot:

SNAI3_HUMAN :
  • Binds E-box via C2H2-type zinc finger domain.
  • Belongs to the snail C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Binds E-box via C2H2-type zinc finger domain.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SNAI3: view

Function for SNAI3 Gene

Molecular function for SNAI3 Gene

UniProtKB/Swiss-Prot Function:
Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5-CAGGTG-3 and 5-CACCTG-3 (By similarity).

Gene Ontology (GO) - Molecular Function for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SNAI3: view
genes like me logo Genes that share phenotypes with SNAI3: view

Animal Models for SNAI3 Gene

MGI Knock Outs for SNAI3:

Animal Model Products

miRNA for SNAI3 Gene

miRTarBase miRNAs that target SNAI3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAI3 Gene

Localization for SNAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAI3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAI3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with SNAI3: view

Pathways & Interactions for SNAI3 Gene

SuperPathways for SNAI3 Gene

No Data Available

Interacting Proteins for SNAI3 Gene

Gene Ontology (GO) - Biological Process for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SNAI3: view

No data available for Pathways by source and SIGNOR curated interactions for SNAI3 Gene

Transcripts for SNAI3 Gene

mRNA/cDNA for SNAI3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNAI3 Gene

Snail homolog 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAI3 Gene

No ASD Table

Relevant External Links for SNAI3 Gene

GeneLoc Exon Structure for
SNAI3
ECgene alternative splicing isoforms for
SNAI3

Expression for SNAI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNAI3 Gene

mRNA differential expression in normal tissues according to GTEx for SNAI3 Gene

This gene is overexpressed in Whole Blood (x15.6) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for SNAI3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNAI3 Gene



Protein tissue co-expression partners for SNAI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNAI3 Gene:

SNAI3

SOURCE GeneReport for Unigene cluster for SNAI3 Gene:

Hs.673548
genes like me logo Genes that share expression patterns with SNAI3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SNAI3 Gene

Orthologs for SNAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAI3 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia SNAI3 34 35
  • 83.85 (n)
cow
(Bos Taurus)
Mammalia SNAI3 34 35
  • 80.54 (n)
rat
(Rattus norvegicus)
Mammalia Snai3 34
  • 77.58 (n)
mouse
(Mus musculus)
Mammalia Snai3 34 16 35
  • 77.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SNAI3 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAI3 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAI3 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snai3 34
  • 58.43 (n)
zebrafish
(Danio rerio)
Actinopterygii snai3 34 35
  • 56.49 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6891 34
fruit fly
(Drosophila melanogaster)
Insecta sna 35
  • 29 (a)
ManyToMany
esg 35
  • 28 (a)
ManyToMany
wor 35
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 35
  • 46 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8617 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15314 34
Species where no ortholog for SNAI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAI3 Gene

ENSEMBL:
Gene Tree for SNAI3 (if available)
TreeFam:
Gene Tree for SNAI3 (if available)

Paralogs for SNAI3 Gene

Paralogs for SNAI3 Gene

(9) SIMAP similar genes for SNAI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNAI3: view

Variants for SNAI3 Gene

Sequence variations from dbSNP and Humsavar for SNAI3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10540733 -- 88,680,086(+) AAAAA(-/A)GTGTG intron-variant
rs11076698 -- 88,686,285(+) GCCCC(G/T)CAGGG intron-variant
rs111515044 -- 88,687,427(+) CTGGG(G/T)GGCCT intron-variant, upstream-variant-2KB
rs111890506 -- 88,679,538(+) GGGTG(C/G)ATCAC intron-variant
rs112033718 -- 88,681,628(+) GGGAA(C/G/T)GTCAC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SNAI3 Gene

Variant ID Type Subtype PubMed ID
nsv952070 CNV deletion 24416366
nsv833327 CNV loss 17160897
nsv833325 CNV loss 17160897
nsv819380 CNV gain 19587683
nsv819188 CNV gain 19587683
nsv482951 CNV loss 15286789
nsv471113 CNV loss 18288195
nsv1065973 CNV loss 25217958
dgv3064n100 CNV gain 25217958

Variation tolerance for SNAI3 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAI3 Gene

Human Gene Mutation Database (HGMD)
SNAI3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAI3 Gene

Disorders for SNAI3 Gene

Relevant External Links for SNAI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAI3

No disorders were found for SNAI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAI3 Gene

Publications for SNAI3 Gene

  1. Identification and characterization of human SNAIL3 (SNAI3) gene in silico. (PMID: 12579345) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 22 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. (PMID: 24638100) Gras B. … Ansieau S. (PLoS ONE 2014) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. (PMID: 14673164) Peinado H. … Cano A. (Mol. Cell. Biol. 2004) 3 64

Products for SNAI3 Gene

Sources for SNAI3 Gene

Content
Loading form....