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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNAI3 Gene

protein-coding   GIFtS: 46
GCID: GC16M088744

Snail Family Zinc Finger 3

(Previous names: zinc finger protein 293, snail homolog 3 (Drosophila))
(Previous symbol: ZNF293)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Snail Family Zinc Finger 31 2     Snail Homolog 3 (Drosophila)1
Zinc Finger Protein 2931 2 3     Zfp2932
ZNF2931 2 3     Snail Homolog 32
Protein Snail Homolog 32 3     Zinc Finger Protein SNAI32
SMUC2 5     ZFP2935
SNAIL32 5     

External Ids:    HGNC: 184111   Entrez Gene: 3339292   Ensembl: ENSG000001856697   OMIM: 6127415   UniProtKB: Q3KNW13   

Export aliases for SNAI3 gene to outside databases

Previous GC identifers: GC16U900013 GC16M088447 GC16M088488 GC16M087271 GC16M074438


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNAI3 Gene:
SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal
formation during embryogenesis (Katoh and Katoh, 2003 (PubMed 12579345)).(supplied by OMIM, Apr 2009)

GeneCards Summary for SNAI3 Gene: 
SNAI3 (snail family zinc finger 3) is a protein-coding gene. Diseases associated with SNAI3 include waardenburg syndrome type iid, and waardenburg's syndrome. GO annotations related to this gene include copper ion binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SNAI1.

UniProtKB/Swiss-Prot: SNAI3_HUMAN, Q3KNW1
Function: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation
of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and
5'-CACCTG-3' (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010542.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNAI3 gene promoter:
         Egr-3   Tal-1   Pax-5   LCR-F1   AP-2gamma   E47   YY1   PPAR-gamma2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNAI3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNAI3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAI3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

SNAI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAI3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M088744:  view genomic region     (about GC identifiers)

Start:
88,744,090 bp from pter      End:
88,752,901 bp from pter
Size:
8,812 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNAI3_HUMAN, Q3KNW1 (See protein sequence)
Recommended Name: Zinc finger protein SNAI3  
Size: 292 amino acids; 32474 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q86SU5

Explore the universe of human proteins at neXtProt for SNAI3: NX_Q3KNW1

Explore proteomics data for SNAI3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3KNW1

  • SNAI3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNAI3 Protein Expression
    REFSEQ proteins: NP_840101.1  
    ENSEMBL proteins: 
     ENSP00000327968  

    Human Recombinant Protein Products for SNAI3: 
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    Novus Biologicals SNAI3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNAI3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    SNAI3 for ontologies           About GeneDecksing



    SNAI3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SNAI: Snail homologs
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR002355 Cu_oxidase_Cu_BS
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q3KNW1

    ProtoNet protein and cluster: Q3KNW1

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: SNAI3_HUMAN, Q3KNW1
    Domain: Binds E-box via C2H2-type zinc finger domain (By similarity)
    Similarity: Belongs to the snail C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    SNAI3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNAI3_HUMAN, Q3KNW1
    Function: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation
    of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and
    5'-CACCTG-3' (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005507copper ion binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding ----
         
    SNAI3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Snai3):
     normal 

    SNAI3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Snai3tm2.1Grid for SNAI3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNAI3 
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    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAI3 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidSNAI3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAI3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNAI3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SNAI3 (Q3KNW13 ENSP000003279684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    SNAI3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNAI3

    Search CenterWatch for drugs/clinical trials and news about SNAI3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNAI3 gene: 
    NM_178310.3  

    Unigene Cluster for SNAI3:

    Snail homolog 3 (Drosophila)
    Hs.673548  [show with all ESTs]
    Unigene Representative Sequence: NM_178310
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332281(uc002flj.3)
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAI3 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidSNAI3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNAI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAI3
    Sirion Biotech Customized lentivirus for stable overexpression of SNAI3 
                         Customized lentivirus expression plasmids for stable overexpression of SNAI3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNAI3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAI3

    Additional mRNA sequence: 

    BC041461.1 BC107058.2 

    1 DOTS entry:

    DT.99973068 

    24/32 AceView cDNA sequences (see all 32):

    BU430306 BC015583 BM723048 BM713291 AI343397 BX117011 AA350678 AA350679 
    BQ225207 AI339613 AA824376 BU951543 AY203928 BM677498 BM547936 AK094837 
    AI095822 BQ446432 AI432314 BE379377 BI522767 BU951292 AI635994 BQ067930 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNAI3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACACACACG
    SNAI3 Expression
    About this image


    See SNAI3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNAI3

    SOURCE GeneReport for Unigene cluster: Hs.673548
        SABiosciences Expression via Pathway-Focused PCR Arrays including SNAI3: 
              Cancer PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAI3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SNAI3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snai31 , 5 snail homolog 3 (Drosophila)1, 5 78.75(n)1
    74.56(a)1
      8 (71.07 cM)5
    309271  NM_013914.21  NP_038942.11 
     1224542065 
    lizard
    (Anolis carolinensis)
    Reptilia SNAI36
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343670.1(138316-145351)
    zebrafish
    (Danio rerio)
    Actinopterygii snai31 snail homolog 3 56.27(n)
    52.09(a)
      567724  NM_001077385.1  NP_001070853.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154466
    sna6
    (see all 5)
    snail
    (see all 5)
    8(a)
    27(a)
    (see all 5)
    possible ortholog
    many ↔ many
    (see all 5)
    X(20970378-20973233)
    2L(15476593-15478269)
    worm
    (Caenorhabditis elegans)
    Secernentea K02D7.26
    Protein K02D7.2
    43(a)
    possible ortholog
    IV(311512-313697)


    ENSEMBL Gene Tree for SNAI3 (if available)
    TreeFam Gene Tree for SNAI3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNAI3 gene
    SNAI12  SCRT12  SNAI22  SCRT22  
    9 SIMAP similar genes for SNAI3 using alignment to 1 protein entry:     SNAI3_HUMAN:
    ZNF846    SCRT1    SNAI1    SNAI2    ZNF844    ZNF137P
    ZNF323    PLZF    ZNF833P

    SNAI3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/31 SNPs in SNAI3 are shown (see all 31)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125961041,2
    C,A,H--88754144(+) TCTCTC/ACAAAA 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs1472896581,2
    C--88754144(+) TCTCT-/ACAAAA 1 -- us2k10--------
    rs1831151281,2
    --88754218(+) CAGGAC/TGCTGA 1 -- us2k10--------
    rs796922951,2
    --88754224(+) GCTGAA/GGAGGG 1 -- us2k10--------
    rs125971381,2
    H--88754337(+) aaaatA/Taaaaa 1 -- us2k1 tfbs30--------
    rs1126493091,2
    C--88754337(+) AAATT-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1866656031,2
    --88754338(+) AAATTA/TAAAAA 1 -- us2k10--------
    rs1391466111,2
    --88754490(+) CTGCAA/TGCATG 1 -- us2k10--------
    rs1912724321,2
    --88754493(+) CAAGCA/GTGGCC 1 -- us2k10--------
    rs1834024721,2
    C--88754510(+) CACCAC/TGCCGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNAI3 (88744090 - 88752901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for SNAI3 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv907283CNV Loss21882294
    nsv471113CNV Loss18288195
    nsv833327CNV Loss17160897
    nsv907278CNV Loss21882294
    dgv2977n71CNV Loss21882294
    nsv907268CNV Loss21882294
    nsv907255CNV Loss21882294
    dgv2978n71CNV Loss21882294
    dgv2979n71CNV Loss21882294
    nsv907226CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SNAI3
    DNA2.0 Custom Variant and Variant Library Synthesis for SNAI3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612741    OMIM disorders: --

    2 diseases for SNAI3:    About MalaCards
    waardenburg syndrome type iid    waardenburg's syndrome


    SNAI3 for disorders           About GeneDecksing


    Export disorders for SNAI3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNAI3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SNAI3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human SNAIL3 (SNAI3) gene in silico. (PubMed id 12579345)1, 3, 9 Katoh M. and Katoh M. (2003)
    2. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. (PubMed id 14673164)1 Peinado H....Cano A. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 333929 HGNC: 18411 AceView: MGC23284 Ensembl:ENSG00000185669 euGenes: HUgn333929
    ECgene: SNAI3 H-InvDB: SNAI3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNAI3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNAI3 gene:
    Search GeneIP for patents involving SNAI3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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