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Aliases for SNAI3 Gene

Aliases for SNAI3 Gene

  • Snail Family Transcriptional Repressor 3 2 3 5
  • Zinc Finger Protein 293 2 3 4
  • Snail Family Zinc Finger 3 2 3
  • Protein Snail Homolog 3 3 4
  • ZNF293 3 4
  • Snail Homolog 3 (Drosophila) 2
  • Zinc Finger Protein SNAI3 3
  • Snail Homolog 3 3
  • SNAIL3 3
  • Zfp293 3
  • SMUC 3

External Ids for SNAI3 Gene

Previous HGNC Symbols for SNAI3 Gene

  • ZNF293

Previous GeneCards Identifiers for SNAI3 Gene

  • GC16U900013
  • GC16M088447
  • GC16M088488
  • GC16M087271
  • GC16M088744
  • GC16M074438

Summaries for SNAI3 Gene

Entrez Gene Summary for SNAI3 Gene

  • SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SNAI3 Gene

SNAI3 (Snail Family Transcriptional Repressor 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and copper ion binding. An important paralog of this gene is SNAI2.

UniProtKB/Swiss-Prot for SNAI3 Gene

  • Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5-CAGGTG-3 and 5-CACCTG-3 (By similarity).

Additional gene information for SNAI3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAI3 Gene

Genomics for SNAI3 Gene

Regulatory Elements for SNAI3 Gene

Enhancers for SNAI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H088615 1.6 FANTOM5 ENCODE dbSUPER 13.6 +68.0 68001 5 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 GATA2 CYBA IL17C ZC3H18 SNAI3 MVD RNF166 ZFPM1
GH16H088698 1.8 FANTOM5 ENCODE dbSUPER 10.2 -16.3 -16339 9 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 RNF166 ZC3H18 ANKRD11 CTU2 ENSG00000268218 LINC00304 SNAI3-AS1 ENSG00000259877 BANP SNAI3
GH16H089313 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 6 -634.1 -634111 14 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 CDK10 DBNDD1 ZNF276 ANKRD11 LOC100287036 SPG7 SNAI3 GAS8-AS1 TUBB3 RPL13
GH16H089112 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.9 -431.9 -431946 11 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ELK1 FOS RUNX3 ACSF3 GALNS TRAPPC2L RNF166 TUBB3 CYBA SNAI3 ENSG00000259877 ENSG00000260279 SLC22A31
GH16H088624 0.6 dbSUPER 11.6 +61.3 61281 1 OSR2 SCRT2 KLF9 ZBTB33 RUNX3 BATF CYBA MVD ZC3H18 SNAI3 IL17C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNAI3 on UCSC Golden Path with GeneCards custom track

Promoters for SNAI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089562 193 1001 HDGF ATF1 ARID4B SIN3A DMAP1 GLIS2 ATF7 SP3 SP5 GTF2B

Genomic Location for SNAI3 Gene

Chromosome:
16
Start:
88,677,682 bp from pter
End:
88,686,493 bp from pter
Size:
8,812 bases
Orientation:
Minus strand

Genomic View for SNAI3 Gene

Genes around SNAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAI3 Gene

Proteins for SNAI3 Gene

  • Protein details for SNAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNW1-SNAI3_HUMAN
    Recommended name:
    Zinc finger protein SNAI3
    Protein Accession:
    Q3KNW1
    Secondary Accessions:
    • Q86SU5

    Protein attributes for SNAI3 Gene

    Size:
    292 amino acids
    Molecular mass:
    32474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNAI3 Gene

Post-translational modifications for SNAI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAI3 Gene

Domains & Families for SNAI3 Gene

Gene Families for SNAI3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SNAI3 Gene

Suggested Antigen Peptide Sequences for SNAI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KNW1

UniProtKB/Swiss-Prot:

SNAI3_HUMAN :
  • Binds E-box via C2H2-type zinc finger domain.
  • Belongs to the snail C2H2-type zinc-finger protein family.
Domain:
  • Binds E-box via C2H2-type zinc finger domain.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SNAI3: view

Function for SNAI3 Gene

Molecular function for SNAI3 Gene

UniProtKB/Swiss-Prot Function:
Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5-CAGGTG-3 and 5-CACCTG-3 (By similarity).

Phenotypes From GWAS Catalog for SNAI3 Gene

Gene Ontology (GO) - Molecular Function for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SNAI3: view
genes like me logo Genes that share phenotypes with SNAI3: view

Animal Models for SNAI3 Gene

MGI Knock Outs for SNAI3:

Animal Model Products

CRISPR Products

miRNA for SNAI3 Gene

miRTarBase miRNAs that target SNAI3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNAI3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAI3 Gene

Localization for SNAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAI3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAI3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with SNAI3: view

Pathways & Interactions for SNAI3 Gene

SuperPathways for SNAI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SNAI3: view

No data available for Pathways by source and SIGNOR curated interactions for SNAI3 Gene

Drugs & Compounds for SNAI3 Gene

No Compound Related Data Available

Transcripts for SNAI3 Gene

mRNA/cDNA for SNAI3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNAI3 Gene

Snail homolog 3 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNAI3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SNAI3 Gene

No ASD Table

Relevant External Links for SNAI3 Gene

GeneLoc Exon Structure for
SNAI3
ECgene alternative splicing isoforms for
SNAI3

Expression for SNAI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAI3 Gene

mRNA differential expression in normal tissues according to GTEx for SNAI3 Gene

This gene is overexpressed in Whole Blood (x15.6) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for SNAI3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNAI3 Gene



Protein tissue co-expression partners for SNAI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNAI3 Gene:

SNAI3

SOURCE GeneReport for Unigene cluster for SNAI3 Gene:

Hs.673548

Evidence on tissue expression from TISSUES for SNAI3 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with SNAI3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAI3 Gene

Orthologs for SNAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAI3 33 34
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia SNAI3 33 34
  • 83.85 (n)
cow
(Bos Taurus)
Mammalia SNAI3 33 34
  • 80.54 (n)
rat
(Rattus norvegicus)
Mammalia Snai3 33
  • 77.58 (n)
mouse
(Mus musculus)
Mammalia Snai3 33 16 34
  • 77.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SNAI3 34
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAI3 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAI3 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snai3 33
  • 58.43 (n)
zebrafish
(Danio rerio)
Actinopterygii snai3 33 34
  • 56.49 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6891 33
fruit fly
(Drosophila melanogaster)
Insecta sna 34
  • 29 (a)
ManyToMany
esg 34
  • 28 (a)
ManyToMany
wor 34
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 34
  • 46 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8617 34
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15314 33
Species where no ortholog for SNAI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAI3 Gene

ENSEMBL:
Gene Tree for SNAI3 (if available)
TreeFam:
Gene Tree for SNAI3 (if available)

Paralogs for SNAI3 Gene

Paralogs for SNAI3 Gene

(9) SIMAP similar genes for SNAI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNAI3: view

Variants for SNAI3 Gene

Sequence variations from dbSNP and Humsavar for SNAI3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000023767 -- 88,688,459(+) CAACT(G/T)GCCCC upstream-variant-2KB
rs1000170032 -- 88,686,842(+) CGGAG(A/C)ATGAC nc-transcript-variant, upstream-variant-2KB
rs1000216828 -- 88,683,765(+) TTGGC(C/T)AGACT intron-variant
rs1000306676 -- 88,679,066(+) CTGGG(A/T)CCTTG intron-variant
rs1000565822 -- 88,683,963(+) TCACA(A/G)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAI3 Gene

Variant ID Type Subtype PubMed ID
dgv3064n100 CNV gain 25217958
nsv1065973 CNV loss 25217958
nsv471113 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv819188 CNV gain 19587683
nsv819380 CNV gain 19587683
nsv833325 CNV loss 17160897
nsv833327 CNV loss 17160897
nsv952070 CNV deletion 24416366

Variation tolerance for SNAI3 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNAI3 Gene

Human Gene Mutation Database (HGMD)
SNAI3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAI3 Gene

Disorders for SNAI3 Gene

Relevant External Links for SNAI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAI3

No disorders were found for SNAI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNAI3 Gene

Publications for SNAI3 Gene

  1. Identification and characterization of human SNAIL3 (SNAI3) gene in silico. (PMID: 12579345) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 22 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. (PMID: 24638100) Gras B … Ansieau S (PloS one 2014) 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for SNAI3 Gene

Sources for SNAI3 Gene

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