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Aliases for SNAI3 Gene

Aliases for SNAI3 Gene

  • Snail Family Zinc Finger 3 2 3
  • Zinc Finger Protein 293 2 3 4
  • Protein Snail Homolog 3 3 4
  • Zfp293 3 6
  • ZNF293 3 4
  • SNAIL3 3 6
  • SMUC 3 6
  • Snail Homolog 3 (Drosophila) 2
  • Zinc Finger Protein SNAI3 3
  • Snail Homolog 3 3

External Ids for SNAI3 Gene

Previous HGNC Symbols for SNAI3 Gene

  • ZNF293

Previous GeneCards Identifiers for SNAI3 Gene

  • GC16U900013
  • GC16M088447
  • GC16M088488
  • GC16M087271
  • GC16M088744
  • GC16M074438

Summaries for SNAI3 Gene

Entrez Gene Summary for SNAI3 Gene

  • SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SNAI3 Gene

SNAI3 (Snail Family Zinc Finger 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and copper ion binding. An important paralog of this gene is SCRT2.

UniProtKB/Swiss-Prot for SNAI3 Gene

  • Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5-CAGGTG-3 and 5-CACCTG-3 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAI3 Gene

Genomics for SNAI3 Gene

Regulatory Elements for SNAI3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNAI3 Gene

Start:
88,677,682 bp from pter
End:
88,687,264 bp from pter
Size:
9,583 bases
Orientation:
Minus strand

Genomic View for SNAI3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAI3 Gene

Proteins for SNAI3 Gene

  • Protein details for SNAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNW1-SNAI3_HUMAN
    Recommended name:
    Zinc finger protein SNAI3
    Protein Accession:
    Q3KNW1
    Secondary Accessions:
    • Q86SU5

    Protein attributes for SNAI3 Gene

    Size:
    292 amino acids
    Molecular mass:
    32474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNAI3 Gene

Proteomics data for SNAI3 Gene at MOPED

Post-translational modifications for SNAI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAI3 Gene

Domains for SNAI3 Gene

Gene Families for SNAI3 Gene

HGNC:
  • SNAI :Snail homologs
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for SNAI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KNW1

UniProtKB/Swiss-Prot:

SNAI3_HUMAN :
  • Q3KNW1
Domain:
  • Binds E-box via C2H2-type zinc finger domain.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SNAI3: view

Function for SNAI3 Gene

Molecular function for SNAI3 Gene

UniProtKB/Swiss-Prot Function: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5-CAGGTG-3 and 5-CACCTG-3 (By similarity).

Gene Ontology (GO) - Molecular Function for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005507 copper ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with SNAI3: view

Phenotypes for SNAI3 Gene

MGI mutant phenotypes for SNAI3:
inferred from 3 alleles
genes like me logo Genes that share phenotypes with SNAI3: view

Animal Models for SNAI3 Gene

MGI Knock Outs for SNAI3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SNAI3 Gene

Localization for SNAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAI3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAI3 Gene COMPARTMENTS Subcellular localization image for SNAI3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with SNAI3: view

Pathways for SNAI3 Gene

SuperPathways for SNAI3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SNAI3: view

No data available for Pathways by source for SNAI3 Gene

Transcripts for SNAI3 Gene

mRNA/cDNA for SNAI3 Gene

(32) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNAI3 Gene

Snail homolog 3 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNAI3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SNAI3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAI3 Gene

No ASD Table

Relevant External Links for SNAI3 Gene

GeneLoc Exon Structure for
SNAI3
ECgene alternative splicing isoforms for
SNAI3

Expression for SNAI3 Gene

mRNA expression in normal human tissues for SNAI3 Gene

mRNA differential expression in normal tissues according to GTEx for SNAI3 Gene

This gene is overexpressed in Whole Blood (15.6) and Muscle - Skeletal (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNAI3 Gene

SOURCE GeneReport for Unigene cluster for SNAI3 Gene Hs.673548

genes like me logo Genes that share expressions with SNAI3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SNAI3 Gene

Orthologs for SNAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAI3 35
  • 99.2 (n)
  • 97.95 (a)
SNAI3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAI3 35
  • 80.54 (n)
  • 73.78 (a)
SNAI3 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAI3 35
  • 83.85 (n)
  • 78.01 (a)
SNAI3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snai3 35
  • 77.47 (n)
  • 72.47 (a)
Snai3 16
Snai3 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAI3 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAI3 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snai3 35
  • 77.58 (n)
  • 70.73 (a)
lizard
(Anolis carolinensis)
Reptilia SNAI3 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snai3 35
  • 58.43 (n)
  • 52.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6891 35
zebrafish
(Danio rerio)
Actinopterygii snai3 35
  • 56.49 (n)
  • 52.67 (a)
snai3 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta esg 36
  • 28 (a)
ManyToMany
sna 36
  • 29 (a)
ManyToMany
wor 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 36
  • 46 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15314 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8617 36
  • 49 (a)
OneToMany
Species with no ortholog for SNAI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAI3 Gene

ENSEMBL:
Gene Tree for SNAI3 (if available)
TreeFam:
Gene Tree for SNAI3 (if available)

Paralogs for SNAI3 Gene

Paralogs for SNAI3 Gene

Selected SIMAP similar genes for SNAI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNAI3: view

Variants for SNAI3 Gene

Sequence variations from dbSNP and Humsavar for SNAI3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs745326 -- 88,688,837(+) CCCAT(C/G)TGCCT upstream-variant-2KB
rs880970 -- 88,688,461(-) GGGGG(A/G)CAAGT upstream-variant-2KB
rs2340961 -- 88,688,566(+) TCAGC(A/C/G)TCCCC upstream-variant-2KB
rs4287555 -- 88,688,917(+) GGTTA(C/G)AGTTC upstream-variant-2KB
rs4782421 -- 88,687,950(+) agaaG(A/C)CCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNAI3 Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907255 CNV Loss 21882294
nsv833325 CNV Loss 17160897
nsv907268 CNV Loss 21882294
dgv2977n71 CNV Loss 21882294
dgv2978n71 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
nsv907283 CNV Loss 21882294
dgv2981n71 CNV Loss 21882294
nsv471113 CNV Loss 18288195
nsv833327 CNV Loss 17160897
nsv819188 CNV Gain 19587683
dgv2982n71 CNV Loss 21882294
dgv2983n71 CNV Loss 21882294
nsv907296 CNV Loss 21882294
nsv819380 CNV Gain 19587683

Relevant External Links for SNAI3 Gene

HapMap Linkage Disequilibrium report
SNAI3
Human Gene Mutation Database (HGMD)
SNAI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAI3 Gene

Disorders for SNAI3 Gene

No disorders were found for SNAI3 Gene.

No data available for UniProtKB/Swiss-Prot for SNAI3 Gene

Publications for SNAI3 Gene

  1. Identification and characterization of human SNAIL3 (SNAI3) gene in silico. (PMID: 12579345) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. (PMID: 14673164) Peinado H. … Cano A. (Mol. Cell. Biol. 2004) 3
  4. Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. (PMID: 24638100) Gras B. … Ansieau S. (PLoS ONE 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SNAI3 Gene

Sources for SNAI3 Gene

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