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Aliases for SNAI2 Gene

Aliases for SNAI2 Gene

  • Snail Family Zinc Finger 2 2 3
  • SLUG 3 4 6
  • Protein Snail Homolog 2 3 4
  • WS2D 3 6
  • Slug Homolog, Zinc Finger Protein (Chicken) 2
  • Slug (Chicken Homolog), Zinc Finger Protein 3
  • Neural Crest Transcription Factor SLUG 3
  • Neural Crest Transcription Factor Slug 4
  • Snail Homolog 2 (Drosophila) 2
  • Zinc Finger Protein SNAI2 3
  • Snail Homolog 2 3
  • SLUGH1 3
  • SNAIL2 3
  • SLUGH 4

External Ids for SNAI2 Gene

Previous HGNC Symbols for SNAI2 Gene

  • SLUG

Previous GeneCards Identifiers for SNAI2 Gene

  • GC08M049834
  • GC08M049553
  • GC08M049880
  • GC08M049992
  • GC08M045294
  • GC08M049830

Summaries for SNAI2 Gene

Entrez Gene Summary for SNAI2 Gene

  • This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAI2 Gene

SNAI2 (Snail Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with SNAI2 include waardenburg syndrome, type 2d and piebald trait, snai2-related. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SCRT2.

UniProtKB/Swiss-Prot for SNAI2 Gene

  • Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Gene Wiki entry for SNAI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAI2 Gene

Genomics for SNAI2 Gene

Regulatory Elements for SNAI2 Gene

Genomic Location for SNAI2 Gene

Start:
48,917,677 bp from pter
End:
48,921,740 bp from pter
Size:
4,064 bases
Orientation:
Minus strand

Genomic View for SNAI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAI2 Gene

Proteins for SNAI2 Gene

  • Protein details for SNAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43623-SNAI2_HUMAN
    Recommended name:
    Zinc finger protein SNAI2
    Protein Accession:
    O43623
    Secondary Accessions:
    • B2R6P6
    • Q53FC1

    Protein attributes for SNAI2 Gene

    Size:
    268 amino acids
    Molecular mass:
    29986 Da
    Quaternary structure:
    • Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7.

neXtProt entry for SNAI2 Gene

Proteomics data for SNAI2 Gene at MOPED

Post-translational modifications for SNAI2 Gene

  • GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SNAI2 (Snail2)

No data available for DME Specific Peptides for SNAI2 Gene

Domains for SNAI2 Gene

Gene Families for SNAI2 Gene

HGNC:
  • SNAI :Snail homologs
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for SNAI2 Gene

Suggested Antigen Peptide Sequences for SNAI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43623

UniProtKB/Swiss-Prot:

SNAI2_HUMAN :
  • O43623
Domain:
  • Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SNAI2: view

Function for SNAI2 Gene

Molecular function for SNAI2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Gene Ontology (GO) - Molecular Function for SNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 10866665
GO:0003682 chromatin binding IEA --
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IDA 10518215
genes like me logo Genes that share ontologies with SNAI2: view
genes like me logo Genes that share phenotypes with SNAI2: view

Animal Models for SNAI2 Gene

MGI Knock Outs for SNAI2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SNAI2 Gene

Localization for SNAI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAI2 Gene

Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAI2 Gene COMPARTMENTS Subcellular localization image for SNAI2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19756381
GO:0005634 nucleus IDA 10866665
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SNAI2: view

Pathways for SNAI2 Gene

genes like me logo Genes that share pathways with SNAI2: view

Pathways by source for SNAI2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SNAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18663143
GO:0001649 osteoblast differentiation IEP 20128911
GO:0001837 epithelial to mesenchymal transition IMP 17984306
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation ISS --
GO:0003273 cell migration involved in endocardial cushion formation ISS --
genes like me logo Genes that share ontologies with SNAI2: view

Compounds for SNAI2 Gene

(4) Novoseek inferred chemical compound relationships for SNAI2 Gene

Compound -log(P) Hits PubMed IDs
matrigel 32.2 1
estrogen 26.2 2
zinc 21.8 6
tyrosine 0 1
genes like me logo Genes that share compounds with SNAI2: view

Transcripts for SNAI2 Gene

mRNA/cDNA for SNAI2 Gene

(150) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNAI2 Gene

Snail homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNAI2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAI2 Gene

No ASD Table

Relevant External Links for SNAI2 Gene

GeneLoc Exon Structure for
SNAI2
ECgene alternative splicing isoforms for
SNAI2

Expression for SNAI2 Gene

mRNA expression in normal human tissues for SNAI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SNAI2 Gene Hs.360174

mRNA Expression by UniProt/SwissProt for SNAI2 Gene

O43623-SNAI2_HUMAN
Tissue specificity: Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).
genes like me logo Genes that share expressions with SNAI2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein expression for SNAI2 Gene

Orthologs for SNAI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAI2 35
  • 99.88 (n)
  • 100 (a)
SNAI2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAI2 35
  • 87.81 (n)
  • 93.66 (a)
SNAI2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAI2 35
  • 94.78 (n)
  • 97.39 (a)
SNAI2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snai2 35
  • 90.05 (n)
  • 95.52 (a)
Snai2 16
Snai2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAI2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAI2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snai2 35
  • 90.05 (n)
  • 94.78 (a)
chicken
(Gallus gallus)
Aves SNAI2 35
  • 85.7 (n)
  • 93.66 (a)
SNAI2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAI2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia snai2-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slug 35
snai2 35
  • 79.32 (n)
  • 89.85 (a)
zebrafish
(Danio rerio)
Actinopterygii idibd5003 35
snai2 35
  • 72.4 (n)
  • 83.2 (a)
snai2 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta esg 36
  • 29 (a)
ManyToMany
sna 36
  • 31 (a)
ManyToMany
wor 36
  • 24 (a)
ManyToMany
wor 37
  • 76 (a)
CG17181 37
  • 50 (a)
esg 37
  • 79 (a)
sna 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 35
  • 56.19 (n)
  • 57.14 (a)
K02D7.2 36
  • 46 (a)
ManyToMany
K02D7.2 37
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8617 36
  • 50 (a)
OneToMany
Species with no ortholog for SNAI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAI2 Gene

ENSEMBL:
Gene Tree for SNAI2 (if available)
TreeFam:
Gene Tree for SNAI2 (if available)

Paralogs for SNAI2 Gene

Paralogs for SNAI2 Gene

genes like me logo Genes that share paralogs with SNAI2: view

Variants for SNAI2 Gene

Sequence variations from dbSNP and Humsavar for SNAI2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2735446 -- 48,923,234(-) ACACT(C/T)TTCTT upstream-variant-2KB
rs2735447 -- 48,923,221(-) TTGTG(A/G)ATAGA upstream-variant-2KB
rs2735448 -- 48,923,151(-) TATAT(C/T)TGTAA upstream-variant-2KB
rs2735449 -- 48,923,092(-) CTGCT(C/T)TCATA upstream-variant-2KB
rs2735450 -- 48,922,748(-) CTTTT(C/G)TCTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNAI2 Gene

Variant ID Type Subtype PubMed ID
nsv890854 CNV Gain 21882294

Relevant External Links for SNAI2 Gene

HapMap Linkage Disequilibrium report
SNAI2
Human Gene Mutation Database (HGMD)
SNAI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAI2 Gene

Disorders for SNAI2 Gene

(2) OMIM Diseases for SNAI2 Gene (602150)

UniProtKB/Swiss-Prot

SNAI2_HUMAN
  • Waardenburg syndrome 2D (WS2D) [MIM:608890]: WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. {ECO:0000269 PubMed:12444107}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Piebald trait (PBT) [MIM:172800]: Autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. {ECO:0000269 PubMed:12955764}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SNAI2 Gene

(22) Novoseek inferred disease relationships for SNAI2 Gene

Disease -log(P) Hits PubMed IDs
waardenburgs syndrome 70.9 1
piebaldism 58.1 4
metastasis 56.8 20
tumors 45.9 26
ovarian carcinoma 45.4 3

Relevant External Links for SNAI2

Genetic Association Database (GAD)
SNAI2
Human Genome Epidemiology (HuGE) Navigator
SNAI2
genes like me logo Genes that share disorders with SNAI2: view

Publications for SNAI2 Gene

  1. Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8. (PMID: 9337409) Rhim H. … Pavan W.J. (Mamm. Genome 1997) 2 3 23
  2. The SLUG zinc-finger protein represses E-cadherin in breast cancer. (PMID: 11912130) Hajra K.M. … Fearon E.R. (Cancer Res. 2002) 3 4 23
  3. SLUG (SNAI2) deletions in patients with Waardenburg disease. (PMID: 12444107) Sanchez-Martin M. … Sanchez-Garcia I. (Hum. Mol. Genet. 2002) 3 4 23
  4. Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. (PMID: 16707493) Turner F.E. … Hotchin N.A. (J. Biol. Chem. 2006) 3 4 23
  5. Human SLUG gene organization, expression, and chromosome map location on 8q. (PMID: 9721220) Cohen M.E. … Jabs E.W. (Genomics 1998) 2 3 4

Products for SNAI2 Gene

  • Addgene plasmids for SNAI2

Sources for SNAI2 Gene

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