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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNAI1 Gene

protein-coding GIFtS: 62
GCID: GC20P048599

snail homolog 1 (Drosophila)

(Previous names: snail 1 (drosophila homolog), zinc finger protein )

Explore 48 diseases affiliated with
SNAI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Snail Homolog 1 (Drosophila)¹ ²		Protein Snail Homolog 1² ³
SNAH¹ ² ³		Snail 1 (Drosophila Homolog), Zinc Finger Protein¹
SLUGH2¹ ²		DJ710H13.1¹
SNA¹ ²		Snail 1 Homolog²
SNAIL¹ ²		Snail 1 Zinc Finger Protein²
SNAIL1¹ ²		Snail 1, Zinc Finger Protein²
Protein Sna² ³		Zinc Finger Protein SNAI1²

External Ids:	HGNC: 11128¹	Entrez Gene: 6615²	Ensembl: ENSG00000124216⁷	OMIM: 604238⁵	UniProtKB: O95863³

Export aliases for SNAI1 gene to outside databases

Previous GC identifers: GC20P048328 GC20P049237 GC20P049284 GC20P048032 GC20P045348

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNAI1:

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of

ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the

Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least

two variants of a similar processed pseudogene have been found on chromosome 2. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863

Function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of

embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene

promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits

to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and

SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B

promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself

Gene Wiki entry for SNAI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNAI1 gene promoter:
CREB AREB6 AP-1 ATF-2 SEF-1 (1) Nkx2-5 c-Jun Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNAI1 promoter sequence

Search SABiosciences Chromatin IP Primers for SNAI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNAI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.2

SNAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAI1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P048599: view genomic region (about GC identifiers)

Start:	48,599,513 bp from pter	End:	48,605,423 bp from pter
Size:	5,911 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863 (See protein sequence)

Recommended Name: Zinc finger protein SNAI1

Size: 264 amino acids; 29083 Da

Subunit: Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the

destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity). Interacts (via SNAG

domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3. Interacts (via

N-terminal region) with CSNK2A1. Interacts with EGR1 upon TPA induction. Interacts (via N-terminal region) with LATS2;

the interaction is dependent on LATS2 kinase activity but independent of SNAI1 Thr-203 phosphorylation. Interacts (via

zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import. Interacts (via zinc fingers) with KPNA1;

the interaction disrupts the transport complex with KPNB1 and prevents nuclear import increasing SNAI1 degradation in

the cytoplasm. Interacts (via zinc fingers) with KPNA2; the interaction, in combination with KPNB1, mediates nuclear

import. Interacts with KPNA4; this interaction mediates nuclear import. May interact (via zinc fingers) with IPO7.

Interacts (via zinc fingers) with PARP1; the interaction requires SNAI1 to be poly-ADP-ribosylated and

non-phosphorylated (active) by GSK3B. Interacts (via SNAG domain) with KDM1A; the interaction is necessary for the

down-regulation of dimethylated H3K4 mark and promoter activity of E-cadherin/CDH1, CDN7 and KRT8. Interacts with

TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular domain); the interactions induce SNAI1 degradation via

MDM2-mediated ubiquitination and inhibit SNAI1-induced cell invasion. Interacts with MDM2; the interaction promotes

SNAI1 ubiquitination. Interacts (via zinc fingers) with CSNK1E. Interacts with PAK1

Subcellular location: Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119)

it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and

ubiquitination involving BTRC occurs

Caution: The interaction with mouse KPNA2 may prevent SNAI1 nuclear import (PubMed:21454664)

1 PDB 3D structure from and Proteopedia for SNAI1:

2Y48 (3D)

Secondary accessions: B2R842 Q9P113 Q9UBP7 Q9UHH7

Explore the universe of human proteins at neXtProt for SNAI1: NX_O95863

Post-translational modifications:

Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by CSNK1E,

probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at Ser-100 and

Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the

nucleus. Phosphorylation at Ser-11 and Ser-92 positively regulates its functions in induction of EMT and cell

survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo pathway activation,

occurs in the nucleus and promotes nuclear retention and stabilization of total cellular protein level¹

Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination

requires previous GSK3B-mediated SNAI1 phosphorylation. Ubiquitination induced upon interaction with NOTCH1 or

TP53/p53 is mediated by MDM2¹

O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and

stabilizes the protein¹

ADP-ribosylation by PARP1 increases protein half-life and may be involved in TGFB-induced SNAI1 up-regulation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95863

SNAI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005976.2

ENSEMBL proteins:

ENSP00000244050

Human Recombinant Protein Products:

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	Novus Biologicals SNAI1 Proteins Novus Biologicals SNAI1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SNAI1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--

SNAI1 for ontologies About GeneDecksing

SNAI1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SNAI1
	R&D Systems Antibodies for SNAI1 (Snail)
	Cell Signaling Technology (CST) Antibodies for SNAI1 (Snail1)
	OriGene Antibodies (see all 3): SNAI1 OriGene Custom Antibody Services for SNAI1
	GenScript Custom Superior Antibodies Services for SNAI1
	Novus Biologicals SNAI1 Antibodies
	Abcam antibodies for SNAI1
	Uscn Antibodies for SNAI1
	ThermoFisher Antibody for SNAI1

Assay Products for SNAI1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for SNAI1 (Snail) (see all)
	GenScript Custom Assay Services for SNAI1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SNAI1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNAI1 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry O95863

ProtoNet protein and cluster: O95863

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863

Similarity: Belongs to the snail C2H2-type zinc-finger protein family

Similarity: Contains 4 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863

Function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of

embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene

promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits

to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and

SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B

promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself

Induction: Induced by TPA maximally by 2.5-fold at 4 hours, in HepG2 cells (at protein level)

Genatlas biochemistry entry for SNAI1:

zinc finger protein Drosophila snail 1 homolog,expressed in several fetal tissues with the highest expression in the

kidney,also transcribed in adult tissues,particularly in lung and placenta,heart,brain,liver,skeletal muscle

miRNA Products:		miRTarBase miRNAs that target SNAI1: hsa-mir-204 (MIRT004651)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNAI1
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAI1 (see all 33):
		hsa-miR-300 hsa-miR-1224-3p hsa-miR-128 hsa-miR-25 hsa-miR-30d hsa-miR-764 hsa-miR-4314 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: SNAI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNAI1 (see all 7) OriGene shRNA RFP: SNAI1 OriGene siRNA: SNAI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNAI1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SNAI1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: SNAI1 (NM_005985)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SNAI1
		Search LifeMap BioReagents cell lines for SNAI1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAI1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IDA	11912130
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--
GO:0019900	kinase binding	IPI	15448698
GO:0043565	sequence-specific DNA binding	IEA	--

SNAI1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for SNAI1: Snai1^tm1Grid Snai1^tm2.1Grid
     10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Snai1):

cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	mortality/aging	nervous system	normal	skeleton

SNAI1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion Tight junctions

Cell adhesion Tight junctions

1.00

Cell adhesion_Tight junctions

0.99

Development HGF signaling pathway

Development_HGF signaling pathway

0.78

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

0.23

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Neural Crest Differentiation

Neural Crest Differentiation

1.00

Validated targets of C-MYC transcriptional activation

Validated targets of C-MYC transcriptional activation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SNAI1

Cell adhesion Tight junctions

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SNAI1

	ILK Signaling
	Epithelial Adherens Junctions

1 Cell Signaling Technology (CST) Pathway for SNAI1

Wnt / Hedgehog / Notch

2 GeneGo (Thomson Reuters) Pathways for SNAI1

	Development HGF signaling pathway
	Cell adhesion Tight junctions

3 BioSystems Pathways for SNAI1

	Neural Crest Differentiation
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Validated targets of C-MYC transcriptional activation

1 Kegg Pathway (Kegg details for SNAI1):

Adherens junction

SNAI1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SNAI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for SNAI1 (O95863^{1, 2, 3} ENSP00000244050⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3C	P68431²^,³	MINT-7906344 I2D: score=2
HIST1H3D	P68431²^,³	MINT-7906344 I2D: score=2
HIST1H3E	P68431²^,³	MINT-7906344 I2D: score=2
HIST1H3F	P68431²^,³	MINT-7906344 I2D: score=2
HIST1H3G	P68431²^,³	MINT-7906344 I2D: score=2

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0001649	osteoblast differentiation	IEP	--
GO:0001707	mesoderm formation	ISS	--
GO:0001837	epithelial to mesenchymal transition	ISS	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--

SNAI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SNAI1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNAI1
1 Novoseek chemical compound relationship for SNAI1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	16.5	3	12579345 (2), 16142376 (1)

Search CenterWatch for drugs/clinical trials and news about SNAI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNAI1 gene:

NM_005985.3

Unigene Cluster for SNAI1:

Snail homolog 1 (Drosophila)

Hs.48029 [show with all ESTs]

Unigene Representative Sequence: NM_005985

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000244050(uc002xuz.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNAI1
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SNAI1 (see all 33):
		hsa-miR-300 hsa-miR-1224-3p hsa-miR-128 hsa-miR-25 hsa-miR-30d hsa-miR-764 hsa-miR-4314 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: SNAI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNAI1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNAI1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNAI1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SNAI1 (NM_005985)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAI1

Additional cDNA sequence:

AF125377.1 AF131208.1 AK313228.1 BC012910.1

2 DOTS entries:

DT.209334 DT.100791370

24/108 AceView cDNA sequences (see all 108):

CR591963 CR598990 BM741207 BX282556 CA307039 BU634421 AA465052 CR607902

BQ890143 BM717296 CR608397 CR603151 CR600523 CR594531 CR622459 CR614923

AL553239 AI679459 BQ022549 BU632427 CR596163 CR621605 BM678199 BE783301

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNAI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATTCCCTC

About this image

SNAI1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epiblast

Primordial Germ Cell Precursors

Germ Cells

Epiblast

Intraembryonic Epiblast Cells

Early Embryo

Head Mesenchyme

Prechordal Mesenchyme

Diencephalic Neural Crest Cells

Neural Crest

Head Mesenchyme

Prechordal Mesenchyme

Mesencephalic Neural Crest Cells

Neural Crest

Endocardium

Parietal Endoderm Cells

Extraembryonic Tissues

Neural Crest

Cardiac Neural Crest

Cardiac Neural Crest Cells

Neural Crest

Placenta

Chorion Frondosum

Primitive Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Placenta

Column Cytotrophoblast Layer

Column Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Somite

Cervical Central Dermomyotome

Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)

Extraembryonic Tissues

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

Neurospheres (Generation of neuros...)

Peripheral sensory neuron-like cells (Generation of neuros...)

Primordial germ cell-like cells (Reconstitution of mo...)

Definitive endoderm-like cells (A scalable, suspensi...)

Beating cell clusters (Spontaneous differen...)

See SNAI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNAI1

SOURCE GeneReport for Unigene cluster: Hs.48029

UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863

Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal

and epithelial cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including SNAI1 (see all 8):

Fibrosis in human mouse rat

Polycomb & Trithorax Complexes in human mouse rat

Cancer PathwayFinder in human mouse rat

Estrogen Receptor Signaling in human mouse rat

Notch Signaling Targets in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNAI1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNAI1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SNAI1 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	O12939_CHICK⁶	snail like protein	54(a)	1 ↔ 1	20(13845513-13848414)
lizard (Anolis carolinensis)	Reptilia	SNAI1⁶	--	53(a)	1 ↔ 1	4(147424944-147430075)
zebrafish (Danio rerio)	Actinopterygii	NM_130989.1²	--	81.14(n)		30182 NM_130989.1
fruit fly (Drosophila melanogaster)	Insecta	sna³	mesoderm cell fate commitment RNA polymerase II more	70(a) (best of 3)		2 35D2 --
worm (Caenorhabditis elegans)	Secernentea	K02D7.2³	zinc finger protein	60(a)		IV(311184-312352) --

ENSEMBL Gene Tree for SNAI1 (if available)
TreeFam Gene Tree for SNAI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SNAI1 gene

SCRT1² SNAI2² SCRT2² SNAI3²

8 SIMAP similar genes for SNAI1 using alignment to 1 protein entry: SNAI1_HUMAN:

SCRT2 SCRT1 SNAI2 SNAI3 ZNF323 ZNF84

ZSCAN5A ZNF702P

SNAI1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SNAI1
PGOHUM00000241098

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114837387^1,2		--	48597589(+)	`CAGCTC/TACTGT`	1	--	us2k¹		1		WA	118
rs141800299^1,2		--	48597649(+)	`TGAAGC/TTGCTG`	1	--	us2k¹		0	--	--	--	--
rs6020170^1,2	C,F,A,H,	--	48597659(+)	`GCTGAA/GACAAA`	1	--	us2k¹		22		NS EA NA WA CSA	2349
rs150557484^1,2		--	48597665(+)	`ACAAAC/GAATGA`	1	--	us2k¹		0	--	--	--	--
rs181535472^1,2		--	48597682(+)	`GCCAGC/TGTGAA`	1	--	us2k¹		0	--	--	--	--
rs76915494^1,2	C,F,	--	48597811(+)	`GAGGGA/GGAGAG`	1	--	us2k¹		1		EA	120
rs73274766^1,2	C,	--	48597988(+)	`CACGGG/AACGGG`	1	--	us2k¹		2		WA	120
rs140545997^1,2		--	48598001(+)	`GTATTA/CCGCTT`	1	--	us2k¹		0	--	--	--	--
rs8117462^1,2	C,F,	--	48598045(+)	`CTGCCC/TGCTCT`	1	--	us2k¹		3		WA CSA	122
rs78085311^1,2	F,	--	48598053(+)	`TCTCCA/GGCTAG`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for SNAI1 (48599513 - 48605423 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNAI1: --

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNAI1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SNAI1 for disorders           About GeneDecksing

OMIM gene information: 604238    OMIM disorders: --

20/48 diseases for SNAI1 (see all 48):    About MalaCards

inappropriate adh syndrome non-small cell lung carcinoma spindle cell carcinoma adenoid cystic carcinoma

oral squamous cell carcinoma squamous cell carcinoma embryonal rhabdomyosarcoma waardenburg's syndrome

synovial sarcoma adenoiditis neuroendocrine tumor renal cell carcinoma

craniosynostosis rhabdomyosarcoma pituitary tumor carcinoma

lung carcinoma crohn's disease breast cancer oral cancer

2 Novoseek disease relationships for SNAI1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer	36.2	2	16142376 (2)
breast cancer	28.6	4	18089802 (3)

Human Genome Epidemiology (HuGE) Navigator: SNAI1 (4 documents)

Export disorders for SNAI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SNAI1 gene, integrated from 9 sources (see all 195):
(articles sorted by number of sources associating them with SNAI1)

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Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P). (PubMed id 10585766)^{1, 2, 3} Paznekas W.A.... Jabs E.W. (1999)
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PubMed id 21952048)^{1, 2} Zhang K....Longmore G.D. (2012)
Poly(ADP-ribose)-dependent regulation of Snail1 prote in stability. (PubMed id 21577210)^{1, 2} RodrA-guez M.I....Oliver F.J. (2011)
Notch1 binds and induces degradation of Snail in hepa tocellular carcinoma. (PubMed id 22128911)^{1, 2} Lim S.O....Jung G. (2011)
Importin alpha protein acts as a negative regulator f or Snail protein nuclear import. (PubMed id 21454664)^{1, 2} Sekimoto T....Yoneda Y. (2011)
Phosphorylation of serine 11 and serine 92 as new pos itive regulators of human Snail1 function: potential involvement of casein kina se-2 and the cAMP-activated kinase protein kinase A. (PubMed id 19923321)^{1, 2} MacPherson M.R....Cano A. (2010)
Snail associates with EGR-1 and SP-1 to upregulate tr anscriptional activation of p15INK4b. (PubMed id 20121949)^{1, 2} Hu C.T....Wu W.S. (2010)
The hypoxia-controlled FBXL14 ubiquitin ligase target s SNAIL1 for proteasome degradation. (PubMed id 19955572)^{1, 2} ViA+as-Castells R....DA-az V.M. (2010)
Snail1 is stabilized by O-GlcNAc modification in hype rglycaemic condition. (PubMed id 20959806)^{1, 2} Park S.Y....Cho J.W. (2010)
Requirement of the histone demethylase LSD1 in Snai1- mediated transcriptional repression during epithelial-mesenchymal transition. (PubMed id 20562920)^{1, 2} Lin T....Lu J. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6615	HGNC: 11128	AceView: SNAI1	Ensembl:ENSG00000124216	euGenes: HUgn6615
ECgene: SNAI1	Kegg: 6615	H-InvDB: SNAI1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SNAI1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SNAI1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SNAI1 gene
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Patent Information for SNAI1 gene:
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GeneCards and IP:
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SNAI1 Gene

snail homolog 1 (Drosophila)

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SNAI1 Gene

snail homolog 1 (Drosophila)

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