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SNAI1 Gene

protein-coding   GIFtS: 63
GCID: GC20P048599

Snail Family Zinc Finger 1

(Previous names: snail 1 (drosophila homolog), zinc finger protein, snail...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Snail Family Zinc Finger 11 2     SNAIL2
Protein Sna2 3     SNAIL12
Protein Snail Homolog 12 3     dJ710H13.12
SNAH2 3     Snail 1 Homolog2
Snail 1 (Drosophila Homolog), Zinc Finger Protein1     Snail 1 Zinc Finger Protein2
Snail Homolog 1 (Drosophila)1     Snail 1, Zinc Finger Protein2
SLUGH22     Snail Homolog 12
SNA2     Zinc Finger Protein SNAI12

External Ids:    HGNC: 111281   Entrez Gene: 66152   Ensembl: ENSG000001242167   OMIM: 6042385   UniProtKB: O958633   

Export aliases for SNAI1 gene to outside databases

Previous GC identifers: GC20P048328 GC20P049237 GC20P049284 GC20P048032 GC20P045348


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNAI1 Gene:
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the
expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally
similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the
developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SNAI1 Gene:
SNAI1 (snail family zinc finger 1) is a protein-coding gene. Diseases associated with SNAI1 include waardenburg syndrome type iid, and inappropriate adh syndrome. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and sequence-specific DNA binding. An important paralog of this gene is SCRT1.

UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863
Function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of
embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene
promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it
recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates
with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by
binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself

Gene Wiki entry for SNAI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNAI1 gene promoter:
         CREB   AREB6   AP-1   ATF-2   SEF-1 (1)   Nkx2-5   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNAI1 promoter sequence
   Search Chromatin IP Primers for SNAI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNAI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.2

SNAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAI1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P048599:  view genomic region     (about GC identifiers)

Start:
48,599,513 bp from pter      End:
48,605,423 bp from pter
Size:
5,911 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863 (See protein sequence)
Recommended Name: Zinc finger protein SNAI1  
Size: 264 amino acids; 29083 Da
Subunit: Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the
destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity). Interacts (via SNAG
domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3. Interacts (via
N-terminal region) with CSNK2A1. Interacts with EGR1 upon TPA induction. Interacts (via N-terminal region) with
LATS2; the interaction is dependent on LATS2 kinase activity but independent of SNAI1 Thr-203 phosphorylation.
Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import. Interacts (via zinc
fingers) with KPNA1; the interaction disrupts the transport complex with KPNB1 and prevents nuclear import
increasing SNAI1 degradation in the cytoplasm. Interacts (via zinc fingers) with KPNA2; the interaction, in
combination with KPNB1, mediates nuclear import. Interacts with KPNA4; this interaction mediates nuclear import.
May interact (via zinc fingers) with IPO7. Interacts (via zinc fingers) with PARP1; the interaction requires
SNAI1 to be poly-ADP-ribosylated and non-phosphorylated (active) by GSK3B. Interacts (via SNAG domain) with
KDM1A; the interaction is necessary for the down-regulation of dimethylated H3K4 mark and promoter activity of
E-cadherin/CDH1, CDN7 and KRT8. Interacts with TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular
domain); the interactions induce SNAI1 degradation via MDM2-mediated ubiquitination and inhibit SNAI1-induced
cell invasion. Interacts with MDM2; the interaction promotes SNAI1 ubiquitination. Interacts (via zinc fingers)
with CSNK1E. Interacts with PAK1
Caution: The interaction with mouse KPNA2 may prevent SNAI1 nuclear import (PubMed:21454664)
1 PDB 3D structure from and Proteopedia for SNAI1:
2Y48 (3D)    
Secondary accessions: B2R842 Q9P113 Q9UBP7 Q9UHH7

Explore the universe of human proteins at neXtProt for SNAI1: NX_O95863

Explore proteomics data for SNAI1 at MOPED

Post-translational modifications: 

  • Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by
    CSNK1E, probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at
    Ser-100 and Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased
    accumulation in the nucleus. Phosphorylation at Ser-11 and Ser-92 positively regulates its functions in induction
    of EMT and cell survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo
    pathway activation, occurs in the nucleus and promotes nuclear retention and stabilization of total cellular
    protein level1
  • Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered
    ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. Ubiquitination induced upon interaction
    with NOTCH1 or TP53/p53 is mediated by MDM21
  • O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and
    stabilizes the protein1
  • ADP-ribosylation by PARP1 increases protein half-life and may be involved in TGFB-induced SNAI1 up-regulation1
  • Ubiquitination2 at Lys98, Lys137, Lys146
  • Glycosylation2 at Ser112
  • Modification sites at PhosphoSitePlus

  • See SNAI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005976.2  
    ENSEMBL proteins: 
     ENSP00000244050  

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNAI1

    SNAI1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNAI1
    R&D Systems Antibodies for SNAI1 (Snail)
    Cell Signaling Technology (CST) Antibodies for SNAI1  (Snail1)
    OriGene Antibodies for SNAI1
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    Abcam antibodies for SNAI1
    Cloud-Clone Corp. Antibodies for SNAI1
    ThermoFisher Antibody for SNAI1
    LSBio Antibodies in human, mouse, rat for SNAI1

    SNAI1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SNAI1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNAI1
    Cloud-Clone Corp. CLIAs for SNAI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SNAI: Snail homologs
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O95863

    ProtoNet protein and cluster: O95863

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863
    Similarity: Belongs to the snail C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    SNAI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNAI1_HUMAN, O95863
    Function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of
    embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene
    promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it
    recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates
    with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by
    binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself
    Induction: Induced by TPA maximally by 2.5-fold at 4 hours, in HepG2 cells (at protein level)

         Genatlas biochemistry entry for SNAI1:
    zinc finger protein Drosophila snail 1 homolog,expressed in several fetal tissues with the highest expression in
    the kidney,also transcribed in adult tissues,particularly in lung and placenta,heart,brain,liver,skeletal muscle

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA11912130
    GO:0005515protein binding IPI15448698
    GO:0019900kinase binding IPI15448698
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    SNAI1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Snai1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  mortality/aging  nervous system  normal  skeleton 

    SNAI1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SNAI1: Snai1tm1Grid Snai1tm2.1Grid

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNAI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNAI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNAI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNAI1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNAI1:
    hsa-mir-26b-5p (MIRT029897), hsa-mir-335-5p (MIRT018418), hsa-mir-153-3p (MIRT007098), hsa-mir-204-5p (MIRT004651), hsa-mir-124-3p (MIRT022882)

    Block miRNA regulation of human, mouse, rat SNAI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNAI1 (see all 33):
    hsa-miR-300 hsa-miR-1224-3p hsa-miR-128 hsa-miR-25 hsa-miR-30d hsa-miR-764 hsa-miR-4314 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSNAI1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SNAI1
    Predesigned siRNA for gene silencing in human, mouse, rat SNAI1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SNAI1

    Clone
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    OriGene clones in human, mouse for SNAI1 (see all 6)
    OriGene ORF clones in mouse, rat for SNAI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNAI1 (NM_005985)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNAI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNAI1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNAI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNAI1_HUMAN, O95863: Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and
    Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction
    motif and ubiquitination involving BTRC occurs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    SNAI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNAI1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    ILK Signaling0.49
    2PAK Pathway
    Epithelial Adherens Junctions0.36
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SNAI1
        ILK Signaling
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for SNAI1
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for SNAI1
        Development HGF signaling pathway
    Cell adhesion Tight junctions

    3 BioSystems Pathways for SNAI1
        Neural Crest Differentiation
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    Validated targets of C-MYC transcriptional activation


    1 Kegg Pathway  (Kegg details for SNAI1):
        Adherens junction


    SNAI1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SNAI1 (see all 8): 
              Fibrosis in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Notch Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SNAI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNAI1 (O958631, 2, 3 ENSP000002440504) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684312, 3MINT-7906344 I2D: score=2 
    HIST1H3DP684312, 3MINT-7906344 I2D: score=2 
    HIST1H3EP684312, 3MINT-7906344 I2D: score=2 
    HIST1H3FP684312, 3MINT-7906344 I2D: score=2 
    HIST1H3GP684312, 3MINT-7906344 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001649osteoblast differentiation IEP--
    GO:0001707mesoderm formation ISS--
    GO:0001837epithelial to mesenchymal transition ISS--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    SNAI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNAI1

    1 Novoseek inferred chemical compound relationship for SNAI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 16.5 3 12579345 (2), 16142376 (1)



    SNAI1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for SNAI1 gene: 
    NM_005985.3  

    Unigene Cluster for SNAI1:

    Snail homolog 1 (Drosophila)
    Hs.48029  [show with all ESTs]
    Unigene Representative Sequence: NM_005985
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244050(uc002xuz.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSNAI1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: SNAI1 (NM_005985)
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      QuantiTect SYBR Green Assays in human, mouse, rat SNAI1
      QuantiFast Probe-based Assays in human, mouse, rat SNAI1

    Additional mRNA sequence: 

    AF125377.1 AF131208.1 AK313228.1 BC012910.1 

    2 DOTS entries:

    DT.209334  DT.100791370 

    Selected AceView cDNA sequences (see all 108):

    BM741207 BU632427 CR600523 BX282556 BC012910 CR607902 CR598990 CR591963 
    CR621605 NM_005985 BQ890143 BX324558 AL553239 BE783301 CR622459 CR594531 
    AA465052 BU634421 CA307039 CR614923 AI218759 CR596163 BM717296 CR608397 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SNAI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTCCCTC
    SNAI1 Expression
    About this image


    SNAI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 5 entries
             Cranial Neural Crest Cells Cranial Neural Crest
             Neurospheres
     
     Neurons (Uncategorized)
             Peripheral sensory neuron-like cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
             Head Mesenchyme
    SNAI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNAI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48029

    UniProtKB/Swiss-Prot: SNAI1_HUMAN, O95863
    Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Expressed in
    mesenchymal and epithelial cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SNAI1 (see all 8): 
              Fibrosis in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Notch Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SNAI1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snai11 , 5 snail homolog 1 (Drosophila)1, 5 84.97(n)1
    87.5(a)1
      2 (87.33 cM)5
    206131  NM_011427.21  NP_035557.11 
     1675381955 
    chicken
    (Gallus gallus)
    Aves SNAI16
    Gallus gallus snail homolog 1 (Drosophila) (SNAI1)...
    57(a)
    1 ↔ 1
    20(14136361-14139739)
    lizard
    (Anolis carolinensis)
    Reptilia SNAI16
    snail family zinc finger 1
    52(a)
    1 ↔ 1
    4(147401359-147431805)
    zebrafish
    (Danio rerio)
    Actinopterygii NM_130989.12   -- 81.14(n)   30182  NM_130989.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sna3 mesoderm cell fate commitment RNA
    polymerase II more
    70(a)
    (best of 3)
      2 35D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea K02D7.23 zinc finger protein 60(a)   IV(311184-312352)   --


    ENSEMBL Gene Tree for SNAI1 (if available)
    TreeFam Gene Tree for SNAI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNAI1 gene
    SCRT12  SNAI22  SNAI32  SCRT22  
    8 SIMAP similar genes for SNAI1 using alignment to 1 protein entry:     SNAI1_HUMAN:
    SCRT2    SCRT1    SNAI2    SNAI3    ZNF323    ZNF84
    ZSCAN5A    ZNF702P

    SNAI1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SNAI1
    PGOHUM00000241098


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNAI1 (see all 206)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148373871,2
    C,F--48597589(+) CAGCTC/TACTGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1418002991,2
    --48597649(+) TGAAGC/TTGCTG 1 -- us2k10--------
    rs60201701,2
    C,F,A,H--48597659(+) GCTGAA/GACAAA 1 -- us2k122Minor allele frequency- G:0.40NS EA NA WA CSA 2349
    rs1505574841,2
    --48597665(+) ACAAAC/GAATGA 1 -- us2k10--------
    rs1815354721,2
    --48597682(+) GCCAGC/TGTGAA 1 -- us2k10--------
    rs769154941,2
    C,F--48597811(+) GAGGGA/GGAGAG 1 -- us2k11Minor allele frequency- G:0.19EA 120
    rs732747661,2
    C,F--48597988(+) CACGGG/AACGGG 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1405459971,2
    --48598001(+) GTATTA/CCGCTT 1 -- us2k10--------
    rs81174621,2
    C,F--48598045(+) CTGCCC/TGCTCT 1 -- us2k13Minor allele frequency- T:0.11WA CSA 122
    rs780853111,2
    C,F--48598053(+) TCTCCA/GGCTAG 1 -- us2k11Minor allele frequency- G:0.03EA 120

    HapMap Linkage Disequilibrium report for SNAI1 (48599513 - 48605423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNAI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509776CNV Insertion20534489
    nsv912915CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNAI1
    DNA2.0 Custom Variant and Variant Library Synthesis for SNAI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604238    OMIM disorders: --

    Selected diseases for SNAI1 (see all 54):    
    About MalaCards
    waardenburg syndrome type iid    inappropriate adh syndrome    embryonal rhabdomyosarcoma    spindle cell carcinoma
    waardenburg's syndrome    phaeochromocytoma    adenoid cystic carcinoma    pharyngitis
    synovial sarcoma    craniosynostosis    adenoiditis    rhabdomyosarcoma
    oral squamous cell carcinoma    pituitary tumors    oral cancer    neuroendocrine tumor
    hypoxia    hyperglycemia    choroiditis    diabetic nephropathy


    SNAI1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SNAI1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 36.2 2 16142376 (2)
    breast cancer 28.6 4 18089802 (3)

    Genetic Association Database (GAD): SNAI1
    Human Genome Epidemiology (HuGE) Navigator: SNAI1 (4 documents)

    Export disorders for SNAI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNAI1 gene, integrated from 10 sources (see all 245):
    (articles sorted by number of sources associating them with SNAI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P). (PubMed id 10585766)1, 2, 3 Paznekas W.A.... Jabs E.W. (Genomics 1999)
    2. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PubMed id 21952048)1, 2 Zhang K.... Longmore G.D. (EMBO J. 2012)
    3. Poly(ADP-ribose)-dependent regulation of Snail1 protein stability. (PubMed id 21577210)1, 2 Rodriguez M.I.... Oliver F.J. (Oncogene 2011)
    4. Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. (PubMed id 22128911)1, 2 Lim S.O....Jung G. (BMC Biol. 2011)
    5. Importin alpha protein acts as a negative regulator for Snail protein nuclear import. (PubMed id 21454664)1, 2 Sekimoto T.... Yoneda Y. (J. Biol. Chem. 2011)
    6. Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. (PubMed id 19923321)1, 2 MacPherson M.R.... Cano A. (Mol. Biol. Cell 2010)
    7. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    8. p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. (PubMed id 20385133)1, 2 Lim S.O.... Jung G. (FEBS Lett. 2010)
    9. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PubMed id 20121949)1, 2 Hu C.T.... Wu W.S. (FEBS J. 2010)
    10. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. (PubMed id 19955572)1, 2 Vinas-Castells R....Diaz V.M. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6615 HGNC: 11128 AceView: SNAI1 Ensembl:ENSG00000124216 euGenes: HUgn6615
    ECgene: SNAI1 Kegg: 6615 H-InvDB: SNAI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNAI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SNAI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNAI1 gene:
    Search GeneIP for patents involving SNAI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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