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Aliases for SNAI1 Gene

Aliases for SNAI1 Gene

  • Snail Family Zinc Finger 1 2 3
  • Protein Snail Homolog 1 3 4
  • Protein Sna 3 4
  • SNAH 3 4
  • Snail 1 (Drosophila Homolog), Zinc Finger Protein 2
  • Snail Homolog 1 (Drosophila) 2
  • Snail 1, Zinc Finger Protein 3
  • Snail 1 Zinc Finger Protein 3
  • Zinc Finger Protein SNAI1 3
  • Snail 1 Homolog 3
  • Snail Homolog 1 3
  • DJ710H13.1 3
  • SLUGH2 3
  • SNAIL1 3
  • SNAIL 3
  • SNA 3

External Ids for SNAI1 Gene

Summaries for SNAI1 Gene

Entrez Gene Summary for SNAI1 Gene

  • The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAI1 Gene

SNAI1 (Snail Family Zinc Finger 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is SCRT2.

UniProtKB/Swiss-Prot for SNAI1 Gene

  • Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Gene Wiki entry for SNAI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAI1 Gene

Genomics for SNAI1 Gene

Genomic Location for SNAI1 Gene

Start:
49,982,976 bp from pter
End:
49,988,886 bp from pter
Size:
5,911 bases
Orientation:
Plus strand

Genomic View for SNAI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAI1 Gene

Regulatory Elements for SNAI1 Gene

Proteins for SNAI1 Gene

  • Protein details for SNAI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95863-SNAI1_HUMAN
    Recommended name:
    Zinc finger protein SNAI1
    Protein Accession:
    O95863
    Secondary Accessions:
    • B2R842
    • Q9P113
    • Q9UBP7
    • Q9UHH7

    Protein attributes for SNAI1 Gene

    Size:
    264 amino acids
    Molecular mass:
    29083 Da
    Quaternary structure:
    • Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3. Interacts (via N-terminal region) with CSNK2A1. Interacts with EGR1 upon TPA induction. Interacts (via N-terminal region) with LATS2; the interaction is dependent on LATS2 kinase activity but independent of SNAI1 Thr-203 phosphorylation. Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import. Interacts (via zinc fingers) with KPNA1; the interaction disrupts the transport complex with KPNB1 and prevents nuclear import increasing SNAI1 degradation in the cytoplasm. Interacts (via zinc fingers) with KPNA2; the interaction, in combination with KPNB1, mediates nuclear import. Interacts with KPNA4; this interaction mediates nuclear import. May interact (via zinc fingers) with IPO7. Interacts (via zinc fingers) with PARP1; the interaction requires SNAI1 to be poly-ADP-ribosylated and non-phosphorylated (active) by GSK3B. Interacts (via SNAG domain) with KDM1A; the interaction is necessary for the down-regulation of dimethylated H3K4 mark and promoter activity of E-cadherin/CDH1, CDN7 and KRT8. Interacts with TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular domain); the interactions induce SNAI1 degradation via MDM2-mediated ubiquitination and inhibit SNAI1-induced cell invasion. Interacts with MDM2; the interaction promotes SNAI1 ubiquitination. Interacts (via zinc fingers) with CSNK1E. Interacts with PAK1.

    Three dimensional structures from OCA and Proteopedia for SNAI1 Gene

neXtProt entry for SNAI1 Gene

Proteomics data for SNAI1 Gene at MOPED

Post-translational modifications for SNAI1 Gene

  • ADP-ribosylation by PARP1 increases protein half-life and may be involved in TGFB-induced SNAI1 up-regulation
  • O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein
  • Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by CSNK1E, probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at Ser-100 and Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the nucleus. Phosphorylation at Ser-11 and Ser-92 positively regulates its functions in induction of EMT and cell survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo pathway activation, occurs in the nucleus and promotes nuclear retention and stabilization of total cellular protein level.
  • Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. Ubiquitination induced upon interaction with NOTCH1 or TP53/p53 is mediated by MDM2
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys98, Lys137, and Lys146
  • Glycosylation at Ser112

Other Protein References for SNAI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNAI1 Gene

Domains for SNAI1 Gene

Gene Families for SNAI1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • SNAI :Snail homologs

Protein Domains for SNAI1 Gene

UniProtKB/Swiss-Prot:

SNAI1_HUMAN
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.:
    • O95863
Similarity:
  • Contains 4 C2H2-type zinc fingers.:
    • O95863
genes like me logo Genes that share domains with SNAI1: view

Function for SNAI1 Gene

Molecular function for SNAI1 Gene

GENATLAS Biochemistry: zinc finger protein Drosophila snail 1 homolog,expressed in several fetal tissues with the highest expression in the kidney,also transcribed in adult tissues,particularly in lung and placenta,heart,brain,liver,skeletal muscle
UniProtKB/Swiss-Prot Function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
UniProtKB/Swiss-Prot Induction: Induced by TPA maximally by 2.5-fold at 4 hours, in HepG2 cells (at protein level).

Gene Ontology (GO) - Molecular Function for SNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 11912130
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription --
GO:0005515 protein binding IPI 15448698
GO:0019900 kinase binding IPI 15448698
genes like me logo Genes that share ontologies with SNAI1: view
genes like me logo Genes that share phenotypes with SNAI1: view

Animal Models for SNAI1 Gene

MGI Knock Outs for SNAI1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SNAI1 Gene

Localization for SNAI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAI1 Gene

Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAI1 Gene COMPARTMENTS Subcellular localization image for SNAI1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for SNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with SNAI1: view

Pathways for SNAI1 Gene

genes like me logo Genes that share pathways with SNAI1: view

Pathways by source for SNAI1 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for SNAI1 Gene
2 Qiagen pathways for SNAI1 Gene
1 Cell Signaling Technology pathway for SNAI1 Gene

Gene Ontology (GO) - Biological Process for SNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001649 osteoblast differentiation IEP 20128911
GO:0001707 mesoderm formation ISS --
GO:0001837 epithelial to mesenchymal transition ISS --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
genes like me logo Genes that share ontologies with SNAI1: view

Compounds for SNAI1 Gene

(1) Novoseek inferred chemical compound relationships for SNAI1 Gene

Compound -log(P) Hits PubMed IDs
zinc 16.5 3
genes like me logo Genes that share compounds with SNAI1: view

Transcripts for SNAI1 Gene

mRNA/cDNA for SNAI1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNAI1 Gene

Snail homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAI1 Gene

No ASD Table

Relevant External Links for SNAI1 Gene

GeneLoc Exon Structure for
SNAI1
ECgene alternative splicing isoforms for
SNAI1

Expression for SNAI1 Gene

mRNA expression in normal human tissues for SNAI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAI1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (5.0).

SOURCE GeneReport for Unigene cluster for SNAI1 Gene Hs.48029

mRNA Expression by UniProt/SwissProt for SNAI1 Gene

O95863-SNAI1_HUMAN
Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
genes like me logo Genes that share expressions with SNAI1: view

Orthologs for SNAI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAI1 36
  • 98.83 (n)
  • 97.27 (a)
SNAI1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAI1 36
  • 86.87 (n)
  • 87.5 (a)
SNAI1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAI1 36
  • 88.75 (n)
  • 89.03 (a)
SNAI1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snai1 36
  • 84.97 (n)
  • 87.5 (a)
Snai1 16
Snai1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAI1 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAI1 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snai1 36
  • 85.23 (n)
  • 89.02 (a)
chicken
(Gallus gallus)
Aves SNAI1 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAI1 37
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 36
snai1a 37
  • 45 (a)
OneToMany
snai1b 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta esg 37
  • 25 (a)
ManyToMany
sna 37
  • 26 (a)
ManyToMany
wor 37
  • 21 (a)
ManyToMany
wor 38
  • 66 (a)
esg 38
  • 68 (a)
sna 38
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 37
  • 41 (a)
ManyToMany
K02D7.2 38
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8617 37
  • 45 (a)
OneToMany
Species with no ortholog for SNAI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SNAI1 Gene

ENSEMBL:
Gene Tree for SNAI1 (if available)
TreeFam:
Gene Tree for SNAI1 (if available)

Paralogs for SNAI1 Gene

Paralogs for SNAI1 Gene

Selected SIMAP similar genes for SNAI1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SNAI1 Gene

genes like me logo Genes that share paralogs with SNAI1: view

Variants for SNAI1 Gene

Sequence variations from dbSNP and Humsavar for SNAI1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1047920 -- 49,988,570(+) TGCCC(C/T)GAGCC utr-variant-3-prime
rs1063210 -- 49,984,272(+) CACAC(A/G)CTGCC synonymous-codon, reference
rs1063211 -- 49,988,448(+) CACAC(A/C)CCCCC utr-variant-3-prime
rs1543442 -- 49,988,262(+) TTCCC(A/G)TGGCC utr-variant-3-prime
rs2280812 -- 49,985,096(+) CCACT(C/G)AATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAI1 Gene

Variant ID Type Subtype PubMed ID
nsv912915 CNV Loss 21882294
nsv509776 CNV Insertion 20534489

Relevant External Links for SNAI1 Gene

HapMap Linkage Disequilibrium report
SNAI1
Human Gene Mutation Database (HGMD)
SNAI1

Disorders for SNAI1 Gene

(2) Novoseek inferred disease relationships for SNAI1 Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 36.2 2
breast cancer 28.6 3

Relevant External Links for SNAI1

Genetic Association Database (GAD)
SNAI1
Human Genome Epidemiology (HuGE) Navigator
SNAI1
genes like me logo Genes that share disorders with SNAI1: view

No data available for UniProtKB/Swiss-Prot for SNAI1 Gene

Publications for SNAI1 Gene

  1. Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P). (PMID: 10585766) Paznekas W.A. … Jabs E.W. (Genomics 1999) 2 3 4
  2. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. (PMID: 10655587) Batlle E. … Garcia de Herreros A. (Nat. Cell Biol. 2000) 3 4
  3. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. (PMID: 15448698) Zhou B.P. … Hung M.C. (Nat. Cell Biol. 2004) 3 4
  4. SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue. (PMID: 19802011) PeA+a C. … Bonilla F. (Oncogene 2009) 3 23
  5. Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer. (PMID: 19861116) Hoshino H. … Ishii H. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for SNAI1 Gene

  • Addgene plasmids for SNAI1

Sources for SNAI1 Gene

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