SMYD5 Gene
protein-coding GIFtS: 45
GCID: GC02P073441
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SMYD family member 5(Previous name: retinoic acid induced 15 )
(Previous symbol: RAI15)
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Aliases
for SMYD5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SMYD Family Member 51 2 | | Retinoic Acid Induced 151 2 | | RAI151 2 3 | | Retinoic Acid-Induced Protein 152 3 | | NN8-4AG1 2 | | Retinoic Acid Responsive2 | | RRG11 2 | | SET And MYND Domain-Containing Protein 52 | | ZMYND231 2 | | Protein NN8-4AG3 |
Export aliases for SMYD5 gene to outside databasesPrevious GC identifers: GC02P073399 GC02P073415 GC02P073353 GC02P073294 GC02P073177 |
Summaries
for SMYD5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SMYD5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMYD5 gene promoter:
HOXA9 GATA-2 NF-AT CREB NF-AT4 NF-AT2 deltaCREB NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMYD5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMYD5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.2 Ensembl cytogenetic band: 2p13.2 HGNC cytogenetic band: 2p12SMYD5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P073441: view genomic region
(about GC identifiers)
Start:
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73,441,350 bp from pter |
End:
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73,454,365 bp from pter |
Size:
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13,016 bases |
Orientation:
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plus strand |
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Proteins
for SMYD5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMYD5_HUMAN, Q6GMV2 (See
protein sequence)Recommended Name: SET and MYND domain-containing protein 5 Size: 418 amino acids; 47341 Da
Sequence caution: Sequence=AAH73806.1; Type=Erroneous initiation;
Secondary accessions: D6W5H3 Q13558Explore the universe of human proteins at neXtProt for SMYD5: NX_Q6GMV2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6GMV2
SMYD5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006053.2
ENSEMBL proteins: ENSP00000388195 ENSP00000374152 ENSP00000258100 ENSP00000412587
Human Recombinant Protein Products for SMYD5:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
SMYD5 for ontologies About GeneDecksing
SMYD5 Antibody Products:
Assay Products for SMYD5: |
Protein
Domains /
Families
for SMYD5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMYD5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6GMV2ProtoNet protein and cluster: Q6GMV2 2 Blocks protein families: IPB001214 Nuclear protein SET IPB002893 Zn-finger
UniProtKB/Swiss-Prot: SMYD5_HUMAN, Q6GMV2Similarity: Contains 1 MYND-type zinc fingerSimilarity: Contains 1 SET domain |
Function
for SMYD5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0046872 | metal ion binding |
IEA | -- |
SMYD5 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMYD5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMYD5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SMYD5 (NM_006062) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMYD5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMYD5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD5 |
|
Pathways & Interactions
for SMYD5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMYD5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5 Interacting proteins for SMYD5 (Q6GMV23 ENSP000003741524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
SMYD5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMYD5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMYD5
Search CenterWatch for drugs/clinical trials and news about SMYD5
|
Transcripts
for SMYD5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMYD5 gene: NM_006062.2 Unigene Cluster for SMYD5: SMYD family member 5 Hs.631882 [show with all ESTs]Unigene Representative Sequence: NM_0060628 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000413491 ENST00000389501(uc002siw.2 uc010yre.1) ENST00000258100
ENST00000443900 ENST00000474652 ENST00000491204 ENST00000477038 ENST00000486518
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMYD5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMYD5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SMYD5 (NM_006062) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMYD5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMYD5 |
Additional cDNA sequence: AK300779.1 AK301809.1 BC009484.2 BC073806.1 U50383.1 10 DOTS entries: DT.312414 DT.95366142 DT.92436136 DT.100776385 DT.100776388 DT.75103138 DT.97801940 DT.121005302 DT.75103137 DT.97810216 24/129 AceView cDNA sequences (see all 129): AA429828 BM558993 CR592310 BU931089 AW630396 AW206927 BU860400 CR592777 BM809072 CB140860 AL550113 BG680133 AI289458 AI884743 BU508174 NM_006062 BQ924929 AU123957 AA947499 AA379041 BU728161 BC073806 AL120821 BF434204
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SMYD5 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
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| SP1: | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMYD5
|
Expression
for SMYD5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMYD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCAGGTG
About this image
See SMYD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMYD5
SOURCE GeneReport for Unigene cluster: Hs.631882
SABiosciences Custom PCR Arrays for SMYD5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMYD5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SMYD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMYD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMYD5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD5 |
Orthologs
for SMYD5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMYD5 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for SMYD5 (if available)
TreeFam Gene Tree for SMYD5 (if available) |
Paralogs
for SMYD5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SMYD5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMYD5 (73441350 - 73454365 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMYD5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMYD5 |
|
Disorders
/ Diseases
for SMYD5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SMYD5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMYD5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SMYD5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. (PubMed id 8754834)1, 2, 3 Shago M. and Giguere V. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for SMYD5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SMYD5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMYD5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMYD5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SMYD5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SMYD5 gene:
Search GeneIP for patents involving SMYD5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMYD5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SMYD5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMYD5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMYD5 | | | OriGene Protein Over-expression Lysate for SMYD5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMYD5 | | OriGene 3'-UTR Clone for SMYD5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMYD5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMYD5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SMYD5 | | OriGene Custom Protein Services for SMYD5 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMYD5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMYD5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMYD5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMYD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMYD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMYD5 |
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| | | | Search Tocris compounds for SMYD5 |
| |  |  |  |  | | | | |
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 | | | SMYD5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD5 |
|  |  |  |  | | | | ThermoFisher Antibodies for SMYD5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMYD5 |
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