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Aliases for SMYD5 Gene

Aliases for SMYD5 Gene

  • SMYD Family Member 5 2 3 5
  • Retinoic Acid-Induced Protein 15 3 4
  • Retinoic Acid Induced 15 2 3
  • RAI15 3 4
  • SET And MYND Domain-Containing Protein 5 3
  • Retinoic Acid Responsive 3
  • Protein NN8-4AG 4
  • EC 2.1.1.- 4
  • NN8-4AG 3
  • ZMYND23 3
  • RRG1 3

External Ids for SMYD5 Gene

Previous HGNC Symbols for SMYD5 Gene

  • RAI15

Previous GeneCards Identifiers for SMYD5 Gene

  • GC02P073399
  • GC02P073415
  • GC02P073353
  • GC02P073294
  • GC02P073441
  • GC02P073177

Summaries for SMYD5 Gene

GeneCards Summary for SMYD5 Gene

SMYD5 (SMYD Family Member 5) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMYD5 Gene

Genomics for SMYD5 Gene

Regulatory Elements for SMYD5 Gene

Enhancers for SMYD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G073175 1.7 FANTOM5 Ensembl ENCODE 21 -37.6 -37568 3.2 HDGF FOXA2 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SMYD5 SFXN5 DUSP11 PRADC1 ENSG00000273245 NOTO SPR EMX1 CCT7 EGR4
GH02G073892 2 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +679.5 679528 3.2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 DUSP11 PCGF1 STAMBP SEMA4F ENSG00000273245 SMYD5 ACTG2 MTHFD2 CCDC142 DGUOK
GH02G073191 0.8 ENCODE 21.9 -22.4 -22356 1.5 FOXA2 ARID4B RAD21 DNMT3B RARA ZNF366 THAP11 CEBPB NFYC CEBPA SMYD5 RAB11FIP5 PRADC1 SFXN5 SPR EMX1 CCT7 GC02P073186 NOTO
GH02G073384 1.4 FANTOM5 ENCODE 12.5 +171.9 171854 2.3 HDGF MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 ZNF263 DUSP11 ALMS1P1 ENSG00000273245 DGUOK-AS1 SMYD5 FBXO41 ALMS1 GNG5P4
GH02G073062 1.3 Ensembl ENCODE 12.5 -150.3 -150342 3.3 PKNOX1 MLX ARID4B SIN3A ZNF48 ZNF121 SLC30A9 GLIS2 ZNF766 ZNF143 SMYD5 FBXO41 EMX1 RAB11FIP5 LOC105374800 GC02M073108 PIR43769
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMYD5 on UCSC Golden Path with GeneCards custom track

Promoters for SMYD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119037 278 1401 HDGF FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for SMYD5 Gene

Chromosome:
2
Start:
73,214,222 bp from pter
End:
73,227,237 bp from pter
Size:
13,016 bases
Orientation:
Plus strand

Genomic View for SMYD5 Gene

Genes around SMYD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMYD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMYD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMYD5 Gene

Proteins for SMYD5 Gene

  • Protein details for SMYD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GMV2-SMYD5_HUMAN
    Recommended name:
    SET and MYND domain-containing protein 5
    Protein Accession:
    Q6GMV2
    Secondary Accessions:
    • D6W5H3
    • Q13558

    Protein attributes for SMYD5 Gene

    Size:
    418 amino acids
    Molecular mass:
    47341 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH73806.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SMYD5 Gene

Post-translational modifications for SMYD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMYD5 Gene

No data available for DME Specific Peptides for SMYD5 Gene

Domains & Families for SMYD5 Gene

Gene Families for SMYD5 Gene

Protein Domains for SMYD5 Gene

Suggested Antigen Peptide Sequences for SMYD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GMV2

UniProtKB/Swiss-Prot:

SMYD5_HUMAN :
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with SMYD5: view

Function for SMYD5 Gene

Enzyme Numbers (IUBMB) for SMYD5 Gene

Gene Ontology (GO) - Molecular Function for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SMYD5: view
genes like me logo Genes that share phenotypes with SMYD5: view

Animal Models for SMYD5 Gene

MGI Knock Outs for SMYD5:

Animal Model Products

miRNA for SMYD5 Gene

miRTarBase miRNAs that target SMYD5

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMYD5 Gene

Localization for SMYD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMYD5 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SMYD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SMYD5 Gene

Pathways & Interactions for SMYD5 Gene

SuperPathways for SMYD5 Gene

SuperPathway Contained pathways
1 PKMTs methylate histone lysines
genes like me logo Genes that share pathways with SMYD5: view

Pathways by source for SMYD5 Gene

1 GeneTex pathway for SMYD5 Gene
1 BioSystems pathway for SMYD5 Gene

Gene Ontology (GO) - Biological Process for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with SMYD5: view

No data available for SIGNOR curated interactions for SMYD5 Gene

Drugs & Compounds for SMYD5 Gene

No Compound Related Data Available

Transcripts for SMYD5 Gene

Unigene Clusters for SMYD5 Gene

SMYD family member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMYD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SMYD5 Gene

GeneLoc Exon Structure for
SMYD5
ECgene alternative splicing isoforms for
SMYD5

Expression for SMYD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMYD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SMYD5 Gene

This gene is overexpressed in Adrenal (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SMYD5 Gene



Protein tissue co-expression partners for SMYD5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SMYD5 Gene:

SMYD5

SOURCE GeneReport for Unigene cluster for SMYD5 Gene:

Hs.631882

Evidence on tissue expression from TISSUES for SMYD5 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SMYD5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMYD5 Gene

Orthologs for SMYD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMYD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMYD5 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia SMYD5 34 35
  • 92.98 (n)
cow
(Bos Taurus)
Mammalia SMYD5 34 35
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Smyd5 34
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Smyd5 34 16 35
  • 87.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SMYD5 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMYD5 34 35
  • 77.45 (n)
lizard
(Anolis carolinensis)
Reptilia SMYD5 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smyd5 34
  • 75.46 (n)
Str.8196 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8640 34
zebrafish
(Danio rerio)
Actinopterygii smyd5 34 35
  • 69.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3353 34 35
  • 54.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003552 34
  • 53.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3716 35
  • 46 (a)
OneToOne
Species where no ortholog for SMYD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMYD5 Gene

ENSEMBL:
Gene Tree for SMYD5 (if available)
TreeFam:
Gene Tree for SMYD5 (if available)

Paralogs for SMYD5 Gene

No data available for Paralogs for SMYD5 Gene

Variants for SMYD5 Gene

Sequence variations from dbSNP and Humsavar for SMYD5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000074679 -- 73,219,650(+) GTGCT(A/G)GGATT intron-variant
rs1000294311 -- 73,213,425(+) AATCT(G/T)ACAGA upstream-variant-2KB
rs1000345079 -- 73,225,271(+) TTTGT(A/G)GGTTT intron-variant
rs1000662523 -- 73,224,655(+) ACAGC(A/G)AGTTG intron-variant
rs1000963312 -- 73,226,700(+) ACCCT(C/T)TCTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SMYD5 Gene

Variant ID Type Subtype PubMed ID
nsv2776 CNV deletion 18451855

Variation tolerance for SMYD5 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMYD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMYD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMYD5 Gene

Disorders for SMYD5 Gene

Relevant External Links for SMYD5

Genetic Association Database (GAD)
SMYD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMYD5

No disorders were found for SMYD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMYD5 Gene

Publications for SMYD5 Gene

  1. Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. (PMID: 8754834) Shago M. … Giguere V. (Mol. Cell. Biol. 1996) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for SMYD5 Gene

Sources for SMYD5 Gene

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