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Aliases for SMYD5 Gene

Aliases for SMYD5 Gene

  • SMYD Family Member 5 2 3 5
  • Retinoic Acid-Induced Protein 15 3 4
  • Retinoic Acid Induced 15 2 3
  • RAI15 3 4
  • SET And MYND Domain-Containing Protein 5 3
  • Retinoic Acid Responsive 3
  • Protein NN8-4AG 4
  • EC 2.1.1.- 4
  • NN8-4AG 3
  • ZMYND23 3
  • RRG1 3

External Ids for SMYD5 Gene

Previous HGNC Symbols for SMYD5 Gene

  • RAI15

Previous GeneCards Identifiers for SMYD5 Gene

  • GC02P073399
  • GC02P073415
  • GC02P073353
  • GC02P073294
  • GC02P073441
  • GC02P073177

Summaries for SMYD5 Gene

GeneCards Summary for SMYD5 Gene

SMYD5 (SMYD Family Member 5) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMYD5 Gene

Genomics for SMYD5 Gene

Regulatory Elements for SMYD5 Gene

Enhancers for SMYD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F073175 1.7 FANTOM5 Ensembl ENCODE 21 -37.6 -37568 3.2 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SMYD5 SFXN5 DUSP11 PRADC1 ENSG00000273245 NOTO SPR EMX1 CCT7 EGR4
GH02F073069 1.1 ENCODE 24.5 -143.3 -143284 3.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SMYD5 DUSP11 ENSG00000273245 ENSG00000272702 DGUOK-AS1 RAB11FIP5 GC02M073103 PIR43769 LOC105374800
GH02F073892 1.7 FANTOM5 Ensembl ENCODE 12.4 +679.5 679528 3.2 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 STAMBP SEMA4F SMYD5 ACTG2 C2orf81 MTHFD2 DGUOK TET3 DCTN1 BOLA3
GH02F073968 1.4 Ensembl ENCODE 14.8 +756.8 756779 5.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SEMA4F C2orf81 LOC107985899 KRT18P26 RPSAP28 SMYD5 DGUOK-AS1 DCTN1 DGUOK WBP1
GH02F073699 1.4 Ensembl ENCODE 14.8 +487.0 486995 3.9 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 TPRKB SMYD5 ENSG00000272702 DUSP11 SEMA4F NAT8B ALMS1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMYD5 on UCSC Golden Path with GeneCards custom track

Promoters for SMYD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000592831 278 1801 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 KLF13 SP3

Genomic Location for SMYD5 Gene

Chromosome:
2
Start:
73,214,222 bp from pter
End:
73,227,237 bp from pter
Size:
13,016 bases
Orientation:
Plus strand

Genomic View for SMYD5 Gene

Genes around SMYD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMYD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMYD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMYD5 Gene

Proteins for SMYD5 Gene

  • Protein details for SMYD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GMV2-SMYD5_HUMAN
    Recommended name:
    SET and MYND domain-containing protein 5
    Protein Accession:
    Q6GMV2
    Secondary Accessions:
    • D6W5H3
    • Q13558

    Protein attributes for SMYD5 Gene

    Size:
    418 amino acids
    Molecular mass:
    47341 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH73806.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SMYD5 Gene

Post-translational modifications for SMYD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMYD5 Gene

No data available for DME Specific Peptides for SMYD5 Gene

Domains & Families for SMYD5 Gene

Gene Families for SMYD5 Gene

Protein Domains for SMYD5 Gene

Suggested Antigen Peptide Sequences for SMYD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GMV2

UniProtKB/Swiss-Prot:

SMYD5_HUMAN :
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 1 MYND-type zinc finger.
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Similarity:
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with SMYD5: view

Function for SMYD5 Gene

Enzyme Numbers (IUBMB) for SMYD5 Gene

Gene Ontology (GO) - Molecular Function for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SMYD5: view
genes like me logo Genes that share phenotypes with SMYD5: view

Animal Models for SMYD5 Gene

MGI Knock Outs for SMYD5:

Animal Model Products

miRNA for SMYD5 Gene

miRTarBase miRNAs that target SMYD5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMYD5 Gene

Localization for SMYD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMYD5 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SMYD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SMYD5 Gene

Pathways & Interactions for SMYD5 Gene

SuperPathways for SMYD5 Gene

SuperPathway Contained pathways
1 PKMTs methylate histone lysines
genes like me logo Genes that share pathways with SMYD5: view

Pathways by source for SMYD5 Gene

1 GeneTex pathway for SMYD5 Gene
1 BioSystems pathway for SMYD5 Gene

Gene Ontology (GO) - Biological Process for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with SMYD5: view

No data available for SIGNOR curated interactions for SMYD5 Gene

Transcripts for SMYD5 Gene

Unigene Clusters for SMYD5 Gene

SMYD family member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMYD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SMYD5 Gene

GeneLoc Exon Structure for
SMYD5
ECgene alternative splicing isoforms for
SMYD5

Expression for SMYD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMYD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SMYD5 Gene

This gene is overexpressed in Adrenal (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SMYD5 Gene



Protein tissue co-expression partners for SMYD5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SMYD5 Gene:

SMYD5

SOURCE GeneReport for Unigene cluster for SMYD5 Gene:

Hs.631882
genes like me logo Genes that share expression patterns with SMYD5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMYD5 Gene

Orthologs for SMYD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMYD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMYD5 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia SMYD5 34 35
  • 92.98 (n)
cow
(Bos Taurus)
Mammalia SMYD5 34 35
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Smyd5 34
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Smyd5 34 16 35
  • 87.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SMYD5 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMYD5 34 35
  • 77.45 (n)
lizard
(Anolis carolinensis)
Reptilia SMYD5 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smyd5 34
  • 75.46 (n)
Str.8196 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8640 34
zebrafish
(Danio rerio)
Actinopterygii smyd5 34 35
  • 69.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3353 34 35
  • 54.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003552 34
  • 53.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3716 35
  • 46 (a)
OneToOne
Species where no ortholog for SMYD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMYD5 Gene

ENSEMBL:
Gene Tree for SMYD5 (if available)
TreeFam:
Gene Tree for SMYD5 (if available)

Paralogs for SMYD5 Gene

No data available for Paralogs for SMYD5 Gene

Variants for SMYD5 Gene

Sequence variations from dbSNP and Humsavar for SMYD5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10177179 -- 73,221,545(+) GCACC(A/G)CTTTT intron-variant
rs1048138 -- 73,227,147(+) GGGTT(C/T)TTACT utr-variant-3-prime
rs111443677 -- 73,222,084(+) TTCCT(A/G)CCACT intron-variant
rs111903710 -- 73,224,727(+) GATGC(A/C)GAGTC intron-variant
rs111928263 -- 73,220,811(+) TTCCT(G/T)TATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMYD5 Gene

Variant ID Type Subtype PubMed ID
nsv2776 CNV deletion 18451855

Variation tolerance for SMYD5 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMYD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMYD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMYD5 Gene

Disorders for SMYD5 Gene

Relevant External Links for SMYD5

Genetic Association Database (GAD)
SMYD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMYD5

No disorders were found for SMYD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMYD5 Gene

Publications for SMYD5 Gene

  1. Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. (PMID: 8754834) Shago M. … Giguere V. (Mol. Cell. Biol. 1996) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for SMYD5 Gene

Sources for SMYD5 Gene

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