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Aliases for SMYD5 Gene

Aliases for SMYD5 Gene

  • SMYD Family Member 5 2 3 5
  • Retinoic Acid-Induced Protein 15 3 4
  • Retinoic Acid Induced 15 2 3
  • RAI15 3 4
  • Retinoic Acid Responsive 3
  • Protein NN8-4AG 4
  • EC 2.1.1.- 4
  • NN8-4AG 3
  • ZMYND23 3
  • RRG1 3

External Ids for SMYD5 Gene

Previous HGNC Symbols for SMYD5 Gene

  • RAI15

Previous GeneCards Identifiers for SMYD5 Gene

  • GC02P073399
  • GC02P073415
  • GC02P073353
  • GC02P073294
  • GC02P073441
  • GC02P073177

Summaries for SMYD5 Gene

GeneCards Summary for SMYD5 Gene

SMYD5 (SMYD Family Member 5) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMYD5 Gene

Genomics for SMYD5 Gene

Regulatory Elements for SMYD5 Gene

Enhancers for SMYD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMYD5 on UCSC Golden Path with GeneCards custom track

Promoters for SMYD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMYD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMYD5 Gene

73,214,222 bp from pter
73,227,237 bp from pter
13,016 bases
Plus strand

Genomic View for SMYD5 Gene

Genes around SMYD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMYD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMYD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMYD5 Gene

Proteins for SMYD5 Gene

  • Protein details for SMYD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SET and MYND domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • D6W5H3
    • Q13558

    Protein attributes for SMYD5 Gene

    418 amino acids
    Molecular mass:
    47341 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH73806.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SMYD5 Gene

Proteomics data for SMYD5 Gene at MOPED

Post-translational modifications for SMYD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMYD5 Gene

Antibody Products

  • Abcam antibodies for SMYD5

No data available for DME Specific Peptides for SMYD5 Gene

Domains & Families for SMYD5 Gene

Gene Families for SMYD5 Gene

Protein Domains for SMYD5 Gene

Suggested Antigen Peptide Sequences for SMYD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 1 MYND-type zinc finger.
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with SMYD5: view

Function for SMYD5 Gene

Enzyme Numbers (IUBMB) for SMYD5 Gene

Gene Ontology (GO) - Molecular Function for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with SMYD5: view
genes like me logo Genes that share phenotypes with SMYD5: view

Animal Models for SMYD5 Gene

MGI Knock Outs for SMYD5:

Animal Model Products

miRNA for SMYD5 Gene

miRTarBase miRNAs that target SMYD5

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMYD5 Gene

Localization for SMYD5 Gene

Subcellular locations from

Jensen Localization Image for SMYD5 Gene COMPARTMENTS Subcellular localization image for SMYD5 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SMYD5 Gene

Pathways & Interactions for SMYD5 Gene

SuperPathways for SMYD5 Gene

No Data Available

Pathways by source for SMYD5 Gene

1 GeneTex pathway for SMYD5 Gene

Gene Ontology (GO) - Biological Process for SMYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SMYD5: view

No data available for SIGNOR curated interactions for SMYD5 Gene

Drugs & Compounds for SMYD5 Gene

No Compound Related Data Available

Transcripts for SMYD5 Gene

Unigene Clusters for SMYD5 Gene

SMYD family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMYD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -

Relevant External Links for SMYD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMYD5 Gene

mRNA expression in normal human tissues for SMYD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SMYD5 Gene

This gene is overexpressed in Adrenal (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMYD5 Gene

SOURCE GeneReport for Unigene cluster for SMYD5 Gene Hs.631882

genes like me logo Genes that share expression patterns with SMYD5: view

Protein tissue co-expression partners for SMYD5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMYD5 Gene

Orthologs for SMYD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMYD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMYD5 35
  • 91.95 (n)
  • 96.41 (a)
SMYD5 36
  • 96 (a)
(Canis familiaris)
Mammalia SMYD5 35
  • 92.98 (n)
  • 97.37 (a)
SMYD5 36
  • 97 (a)
(Mus musculus)
Mammalia Smyd5 35
  • 87.18 (n)
  • 90.38 (a)
Smyd5 16
Smyd5 36
  • 90 (a)
(Pan troglodytes)
Mammalia SMYD5 35
  • 99.44 (n)
  • 99.52 (a)
SMYD5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Smyd5 35
  • 89.21 (n)
  • 94.48 (a)
(Ornithorhynchus anatinus)
Mammalia SMYD5 36
  • 51 (a)
(Gallus gallus)
Aves SMYD5 35
  • 77.45 (n)
  • 80.6 (a)
SMYD5 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SMYD5 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smyd5 35
  • 75.46 (n)
  • 79.86 (a)
Str.8196 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8640 35
(Danio rerio)
Actinopterygii smyd5 35
  • 69.64 (n)
  • 73.49 (a)
smyd5 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003552 35
  • 53.39 (n)
  • 49.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3353 35
  • 54.24 (n)
  • 48.34 (a)
CG3353 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3716 36
  • 46 (a)
Species with no ortholog for SMYD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMYD5 Gene

Gene Tree for SMYD5 (if available)
Gene Tree for SMYD5 (if available)

Paralogs for SMYD5 Gene

No data available for Paralogs for SMYD5 Gene

Variants for SMYD5 Gene

Sequence variations from dbSNP and Humsavar for SMYD5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1560393 -- 73,214,600(-) GGGCT(A/G)GCCGA intron-variant, utr-variant-5-prime
rs1048138 -- 73,227,147(+) GGGTT(C/T)TTACT utr-variant-3-prime
rs3188114 -- 73,227,128(+) GTCTG(A/G)CCCCT utr-variant-3-prime
rs3764991 -- 73,225,517(+) GTTTG(A/C/G/T)GTTGC intron-variant
rs6757079 -- 73,219,398(+) GGGAG(A/G)gggac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMYD5 Gene

Variant ID Type Subtype PubMed ID
nsv2776 CNV Loss 18451855

Variation tolerance for SMYD5 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SMYD5 Gene

Disorders for SMYD5 Gene

Relevant External Links for SMYD5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMYD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMYD5 Gene

Publications for SMYD5 Gene

  1. Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. (PMID: 8754834) Shago M. … Giguere V. (Mol. Cell. Biol. 1996) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SMYD5 Gene

Sources for SMYD5 Gene