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SMYD4 Gene

protein-coding   GIFtS: 50
GCID: GC17M001682

SET And MYND Domain Containing 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET And MYND Domain Containing 41 2
ZMYND212
SET And MYND Domain-Containing Protein 42
EC 2.1.1.-3
KIAA19363

External Ids:    HGNC: 210671   Entrez Gene: 1148262   Ensembl: ENSG000001865327   UniProtKB: Q8IYR23   

Export aliases for SMYD4 gene to outside databases

Previous GC identifers: GC00U911629 GC17M001891 GC17M001630 GC17M001580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SMYD4 Gene:
SMYD4 (SET and MYND domain containing 4) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity.

Gene Wiki entry for SMYD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMYD4 gene promoter:
         MAZR   NF-YA   CBF-C   FAC1   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SMYD4 promoter sequence
   Search Chromatin IP Primers for SMYD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMYD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

SMYD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMYD4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001682:  view genomic region     (about GC identifiers)

Start:
1,682,779 bp from pter      End:
1,733,928 bp from pter
Size:
51,150 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SMYD4_HUMAN, Q8IYR2 (See protein sequence)
Recommended Name: SET and MYND domain-containing protein 4  
Size: 804 amino acids; 89225 Da
Secondary accessions: Q8N1P2 Q8NAT0 Q96LV4 Q96PV2

Explore the universe of human proteins at neXtProt for SMYD4: NX_Q8IYR2

Explore proteomics data for SMYD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys717
  • Modification sites at PhosphoSitePlus

  • See SMYD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443160.2  
    ENSEMBL proteins: 
     ENSP00000304360   ENSP00000460921   ENSP00000459819   ENSP00000461089   ENSP00000459129  

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    Cloud-Clone Corp. Proteins for SMYD4

     
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    Search eBioscience for ELISAs for SMYD4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type

    3 InterPro protein domains:
     IPR002893 Znf_MYND
     IPR001214 SET_dom
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry Q8IYR2

    ProtoNet protein and cluster: Q8IYR2

    2 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: SMYD4_HUMAN, Q8IYR2
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 SET domain


    Find genes that share domains with SMYD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008168methyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with SMYD4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMYD4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMYD4

    miRNA
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    miRTarBase miRNAs that target SMYD4:
    hsa-mir-744-5p (MIRT037610)

    Block miRNA regulation of human, mouse, rat SMYD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMYD4 (see all 25):
    hsa-miR-495 hsa-miR-15a hsa-miR-1260b hsa-miR-374a hsa-miR-340 hsa-miR-4314 hsa-miR-424 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidSMYD4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SMYD4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SMYD4 (NM_052928)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    golgi apparatus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMYD4
    Interactions:

        Search GeneGlobe Interaction Network for SMYD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SMYD4 (Q8IYR23 ENSP000003043604) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ELAVL2ENSP000003694604STRING: ENSP00000369460
    ELAVL3ENSP000003521624STRING: ENSP00000352162
    ELAVL4ENSP000003495944STRING: ENSP00000349594
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMYD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMYD4 gene: 
    NM_052928.2  

    Unigene Cluster for SMYD4:

    SET and MYND domain containing 4
    Hs.514602  [show with all ESTs]
    Unigene Representative Sequence: NM_052928
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305513(uc002ftm.4) ENST00000491788(uc002ftn.1) ENST00000476292
    ENST00000570368 ENST00000571854 ENST00000573937 ENST00000576633
    miRNA
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    Block miRNA regulation of human, mouse, rat SMYD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMYD4 (see all 25):
    hsa-miR-495 hsa-miR-15a hsa-miR-1260b hsa-miR-374a hsa-miR-340 hsa-miR-4314 hsa-miR-424 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidSMYD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SMYD4
    Predesigned siRNA for gene silencing in human, mouse, rat SMYD4
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SMYD4 (NM_052928)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMYD4
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      QuantiTect SYBR Green Assays in human, mouse, rat SMYD4
      QuantiFast Probe-based Assays in human, mouse, rat SMYD4

    Additional mRNA sequence: 

    AK057769.1 AK095369.1 AL137345.1 BC035077.2 

    5 DOTS entries:

    DT.97768980  DT.407661  DT.100745153  DT.102824463  DT.95264472 

    1 AceView cDNA sequence:

    BX644502 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SMYD4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
    SP1:              -           -                                                           -                       -         
    SP2:                                                                                      -                                 
    SP3:                          -                                                                                             
    SP4:              -                                                                                                         
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for SMYD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMYD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SMYD4 Expression
    About this image

    SMYD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMYD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514602
        Custom PCR Arrays for SMYD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SMYD4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smyd41 , 5 SET and MYND domain containing 41, 5 79.48(n)1
    72.49(a)1
      11 (45.82 cM)5
    3198221  NM_001102611.11  NP_001096081.11 
     753484335 
    chicken
    (Gallus gallus)
    Aves SMYD41 SET and MYND domain containing 4 58.48(n)
    52.26(a)
      417562  NM_001030715.1  NP_001025886.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMYD46
    SET and MYND domain containing 4
    50(a)
    1 ↔ 1
    GL343393.1(46106-58914)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia smyd41 SET and MYND domain containing 4 53.21(n)
    45.47(a)
      779741  NM_001078820.1  NP_001072288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI673196.12   -- 77.36(n)    BI673196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77591 CG7759 42.87(n)
    29.55(a)
      36234  NM_165831.2  NP_725048.1 


    ENSEMBL Gene Tree for SMYD4 (if available)
    TreeFam Gene Tree for SMYD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMYD4 gene
    Selected SIMAP similar genes for SMYD4 using alignment to 5 protein entries:     SMYD4_HUMAN (see all proteins) (see all similar genes):
    HDGFRP2    LSM12    EEF1E1    EIF3G    C12orf76    KIAA1651
    ARL6IP5    IK    MRPL45    COQ5    VPS33A    EIF3K
    GBGT1    ZNF257    DPP9    FRG1    ARIH1    CALCOCO2

    Find genes that share paralogs with SMYD4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMYD4 (see all 1336)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887651051,2
    --1682350(+) CTGGCA/GAATGC 1 -- int10--------
    rs1930668031,2
    --1682421(+) GGTTGC/TGGTGA 1 -- int10--------
    rs72147041,2
    C,A--1682422(+) gttgcA/Ggtgaa 1 -- int10--------
    rs72182691,2
    C,F,A,H--1682427(+) ggtgaG/Accaag 1 -- int19Minor allele frequency- A:0.32NA WA CSA 19
    rs557608571,2
    C--1682492(+) AAAAA-/AGGGCC 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1417390961,2
    C--1682519(+) GCTCAC/TGCCTG 1 -- int10--------
    rs110786361,2
    C,F,A,H--1682557(+) CACCTA/GAGGCC 1 -- int18Minor allele frequency- G:0.44NA WA EA 370
    rs1462573081,2
    --1682591(+) AACATA/CGTGAA 1 -- int10--------
    rs1484567251,2
    --1682726(+) AAGATC/TGCGCC 1 -- int10--------
    rs1858382911,2
    --1682727(+) AGATCA/GCGCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SMYD4 (1682779 - 1733928 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SMYD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1946CNV Insertion18451855
    dgv3033n71CNV Loss21882294
    esv33335CNV Loss17666407
    nsv9490CNV Loss18304495
    nsv907521CNV Gain21882294
    nsv833335CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMYD4
    DNA2.0 Custom Variant and Variant Library Synthesis for SMYD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SMYD4           About GenesLikeMe

    Genetic Association Database (GAD): SMYD4
    Human Genome Epidemiology (HuGE) Navigator: SMYD4 (1 document)

    Export disorders for SMYD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMYD4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SMYD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
    7. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)1 O'Seaghdha C.M....KAPttgen A. (Hum. Mol. Genet. 2010)
    8. Identification of Smyd4 as a potential tumor suppressor gene involved in breast cancer development. (PubMed id 19383909)1 Hu L....Zhu Y.J. (Cancer Res. 2009)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114826 HGNC: 21067 AceView: SMYD4.1 Ensembl:ENSG00000186532 euGenes: HUgn114826
    ECgene: SMYD4 H-InvDB: SMYD4

    (According to HUGE)
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    HUGE: KIAA1936

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMYD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMYD4 gene:
    Search GeneIP for patents involving SMYD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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