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Aliases for SMYD4 Gene

Aliases for SMYD4 Gene

  • SET And MYND Domain Containing 4 2 3
  • SET And MYND Domain-Containing Protein 4 3
  • EC 2.1.1.- 4
  • KIAA1936 4
  • ZMYND21 3

External Ids for SMYD4 Gene

Previous GeneCards Identifiers for SMYD4 Gene

  • GC00U911629
  • GC17M001891
  • GC17M001630
  • GC17M001682
  • GC17M001580

Summaries for SMYD4 Gene

GeneCards Summary for SMYD4 Gene

SMYD4 (SET And MYND Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

Gene Wiki entry for SMYD4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMYD4 Gene

Genomics for SMYD4 Gene

Regulatory Elements for SMYD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMYD4 Gene

1,779,485 bp from pter
1,830,634 bp from pter
51,150 bases
Minus strand

Genomic View for SMYD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMYD4 Gene

Proteins for SMYD4 Gene

  • Protein details for SMYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SET and MYND domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8N1P2
    • Q8NAT0
    • Q96LV4
    • Q96PV2

    Protein attributes for SMYD4 Gene

    804 amino acids
    Molecular mass:
    89225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMYD4 Gene

Proteomics data for SMYD4 Gene at MOPED

Post-translational modifications for SMYD4 Gene

  • Ubiquitination at Lys717
  • Modification sites at PhosphoSitePlus

Other Protein References for SMYD4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SMYD4

No data available for DME Specific Peptides for SMYD4 Gene

Domains for SMYD4 Gene

Gene Families for SMYD4 Gene

Protein Domains for SMYD4 Gene

Suggested Antigen Peptide Sequences for SMYD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 1 MYND-type zinc finger.
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with SMYD4: view

Function for SMYD4 Gene

Enzyme Numbers (IUBMB) for SMYD4 Gene

Gene Ontology (GO) - Molecular Function for SMYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008168 methyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SMYD4: view

Animal Model Products

miRNA for SMYD4 Gene

miRTarBase miRNAs that target SMYD4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMYD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SMYD4 Gene

Localization for SMYD4 Gene

Subcellular locations from

Jensen Localization Image for SMYD4 Gene COMPARTMENTS Subcellular localization image for SMYD4 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SMYD4 Gene

Pathways for SMYD4 Gene

SuperPathways for SMYD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with SMYD4: view

No data available for Pathways by source for SMYD4 Gene

Transcripts for SMYD4 Gene

mRNA/cDNA for SMYD4 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMYD4 Gene

SET and MYND domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMYD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMYD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
SP1: - - - -
SP2: -
SP3: -
SP4: -

Relevant External Links for SMYD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMYD4 Gene

mRNA expression in normal human tissues for SMYD4 Gene

Protein differential expression in normal tissues for SMYD4 Gene

This gene is overexpressed in Monocytes (18.6), Fetal gut (18.4), Bone (14.7), and Fetal ovary (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMYD4 Gene

SOURCE GeneReport for Unigene cluster for SMYD4 Gene Hs.514602

genes like me logo Genes that share expressions with SMYD4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for SMYD4 Gene

Orthologs for SMYD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMYD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMYD4 35
  • 81.69 (n)
  • 74.72 (a)
SMYD4 36
  • 74 (a)
(Canis familiaris)
Mammalia SMYD4 35
  • 82.07 (n)
  • 75.63 (a)
SMYD4 36
  • 75 (a)
(Mus musculus)
Mammalia Smyd4 35
  • 79.48 (n)
  • 72.49 (a)
Smyd4 16
Smyd4 36
  • 72 (a)
(Pan troglodytes)
Mammalia SMYD4 35
  • 98.92 (n)
  • 98.63 (a)
SMYD4 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Smyd4 35
  • 79.07 (n)
  • 73.68 (a)
(Monodelphis domestica)
Mammalia SMYD4 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia SMYD4 36
  • 55 (a)
(Gallus gallus)
Aves SMYD4 35
  • 58.48 (n)
  • 52.26 (a)
SMYD4 36
  • 51 (a)
(Anolis carolinensis)
Reptilia SMYD4 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smyd4 35
  • 53.21 (n)
  • 45.47 (a)
(Danio rerio)
Actinopterygii smyd4 35
  • 48.24 (n)
  • 39.58 (a)
smyd4 36
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008839 35
  • 44.08 (n)
  • 30.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7759 35
  • 42.87 (n)
  • 29.55 (a)
CG1868 36
  • 21 (a)
CG7759 36
  • 23 (a)
CG8378 36
  • 26 (a)
dao 36
  • 15 (a)
Smyd4 36
  • 22 (a)
Species with no ortholog for SMYD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMYD4 Gene

Gene Tree for SMYD4 (if available)
Gene Tree for SMYD4 (if available)

Paralogs for SMYD4 Gene

genes like me logo Genes that share paralogs with SMYD4: view

No data available for Paralogs for SMYD4 Gene

Variants for SMYD4 Gene

Sequence variations from dbSNP and Humsavar for SMYD4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11062 -- 1,779,718(+) GTCAC(A/G)GTTCA utr-variant-3-prime
rs719912 -- 1,824,382(-) TTACT(A/G)TGACT intron-variant
rs719913 -- 1,824,004(-) ccccc(C/T)tcaaa intron-variant
rs1133109 -- 1,779,990(-) CTGAT(A/C)TGCAG utr-variant-3-prime
rs1989260 -- 1,824,126(-) acctc(A/T)ggtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMYD4 Gene

Variant ID Type Subtype PubMed ID
nsv9490 CNV Loss 18304495
dgv3033n71 CNV Loss 21882294
nsv833335 CNV Gain+Loss 17160897
nsv1946 CNV Insertion 18451855
nsv907521 CNV Gain 21882294
esv33335 CNV Loss 17666407

Relevant External Links for SMYD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMYD4 Gene

Disorders for SMYD4 Gene

Relevant External Links for SMYD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SMYD4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SMYD4 Gene

Publications for SMYD4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for SMYD4 Gene

Sources for SMYD4 Gene

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