Aliases for SMYD3 Gene
External Ids for SMYD3 Gene
Previous HGNC Symbols for SMYD3 Gene
Previous GeneCards Identifiers for SMYD3 Gene
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for SMYD3 Gene
SMYD3 (SET And MYND Domain Containing 3) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II core binding. An important paralog of this gene is SMYD1.
UniProtKB/Swiss-Prot for SMYD3 Gene
Histone methyltransferase. Specifically methylates Lys-4 of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates Lys-5 of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5-CCCTCC-3 or 5-GAGGGG-3 sequences (PubMed:15235609).