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SMYD3 Gene

protein-coding   GIFtS: 60
GCID: GC01M245912

SET And MYND Domain Containing 3

(Previous names: zinc finger, MYND domain containing 1)
(Previous symbols: ZNFN3A1, ZMYND1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET And MYND Domain Containing 31 2     KMT3E2
ZMYND11 2 3     bA74P14.12
ZNFN3A11 2 3     BA74P14.1 (Novel Protein)2
Zinc Finger, MYND Domain Containing 11 2     Histone-Lysine N-Methyltransferase SMYD32
Zinc Finger MYND Domain-Containing Protein 12 3     Zinc Finger Protein, Subfamily 3A (MYND Domain Containing), 12
SET And MYND Domain-Containing Protein 32 3     EC 2.1.18
EC 2.1.1.433 8     

External Ids:    HGNC: 155131   Entrez Gene: 647542   Ensembl: ENSG000001854207   OMIM: 6087835   UniProtKB: Q9H7B43   

Export aliases for SMYD3 gene to outside databases

Previous GC identifers: GC01M242118 GC01M242859 GC01M242239 GC01M243979 GC01M216300


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMYD3 Gene:
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction
with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for SMYD3 Gene:
SMYD3 (SET and MYND domain containing 3) is a protein-coding gene. GO annotations related to this gene include histone-lysine N-methyltransferase activity. An important paralog of this gene is SMYD1.

UniProtKB/Swiss-Prot: SMYD3_HUMAN, Q9H7B4
Function: Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and
tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an
RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences

Gene Wiki entry for SMYD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SMYD3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMYD3 promoter sequence
   Search Chromatin IP Primers for SMYD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMYD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

SMYD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMYD3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M245912:  view genomic region     (about GC identifiers)

Start:
245,912,642 bp from pter      End:
246,670,644 bp from pter
Size:
758,003 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SMYD3_HUMAN, Q9H7B4 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SMYD3  
Size: 428 amino acids; 49097 Da
Subunit: Interacts with HSPCA. Interacts with HELZ. Interacts with POLR2A; the interaction may be indirect and may
be mediated by HELZ
Sequence caution: Sequence=CAI14744.1; Type=Erroneous initiation; Sequence=CAI16628.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for SMYD3 (see all 7):
3MEK (3D)        3OXF (3D)        3OXG (3D)        3OXL (3D)        3PDN (3D)        3QWP (3D)    
Secondary accessions: A8K0P0 B1AN38 Q86TL8 Q8N5Z6 Q96AI5
Alternative splicing: 3 isoforms:  Q9H7B4-1   Q9H7B4-2   Q9H7B4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMYD3: NX_Q9H7B4

Explore proteomics data for SMYD3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys378, Lys391
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SMYD3 (Q9H7B4)
     NHSCDPN  QAIISSN 


    See SMYD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161212.1  NP_073580.1  

    ENSEMBL proteins: 
     ENSP00000419184   ENSP00000375712   ENSP00000408122   ENSP00000385380   ENSP00000394281  
     ENSP00000373637   ENSP00000444184  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    3 InterPro protein domains:
     IPR002893 Znf_MYND
     IPR001214 SET_dom
     IPR025805 Hist-Lys_N-MeTrfase_Smyd3

    Graphical View of Domain Structure for InterPro Entry Q9H7B4

    ProtoNet protein and cluster: Q9H7B4

    2 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: SMYD3_HUMAN, Q9H7B4
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 SET domain


    Find genes that share domains with SMYD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMYD3_HUMAN, Q9H7B4
    Function: Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and
    tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an
    RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Enzyme regulation: Histone methyltransferase activity strongly stimulated by HSPCA

         Enzyme Numbers (IUBMB): EC 2.1.1.431 2 EC 2.1.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0018024histone-lysine N-methyltransferase activity ISS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with SMYD3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SMYD3:
     Increased cell number in G1, a 

    Animal Models:
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    miRTarBase miRNAs that target SMYD3:
    hsa-mir-124-3p (MIRT004725)

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    3 qRT-PCR Assays for microRNAs that regulate SMYD3:
    hsa-miR-374b hsa-miR-377 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidSMYD3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMYD3_HUMAN, Q9H7B4: Cytoplasm. Nucleus. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in
    the nucleus at S phase and G2/M
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus3
    cytosol2
    mitochondrion2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SMYD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SMYD3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SMYD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMYD3 (Q9H7B42, 3 ENSP000003736374) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404252, 3, ENSP000004039484MINT-62527 I2D: score=4 STRING: ENSP00000403948
    ENSG00000237344P404252, 3, ENSP000003971774MINT-62527 I2D: score=4 STRING: ENSP00000397177
    PBX2P404252, 3, ENSP000003641904MINT-62527 I2D: score=4 STRING: ENSP00000364190
    ENSG00000206315P404252, 3MINT-62527 I2D: score=4 
    ENSG00000224952P404252, 3MINT-62527 I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMYD3

    1 HMDB Compound for SMYD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMYD3 gene (2 alternative transcripts): 
    NM_001167740.1  NM_022743.2  

    Unigene Cluster for SMYD3:

    SET and MYND domain containing 3
    Hs.567571  [show with all ESTs]
    Unigene Representative Sequence: AK023594
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000482592 ENST00000366516(uc001ibj.3) ENST00000366517 ENST00000490107(uc001ibl.3)
    ENST00000483072 ENST00000470510 ENST00000490322 ENST00000493441 ENST00000488153
    ENST00000492487 ENST00000391836 ENST00000464398 ENST00000453676 ENST00000462422
    ENST00000403792 ENST00000470863 ENST00000455277 ENST00000388985
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate SMYD3:
    hsa-miR-374b hsa-miR-377 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidSMYD3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SMYD3
      QuantiFast Probe-based Assays in human, mouse, rat SMYD3

    Additional mRNA sequence: 

    AB057595.1 AK023594.1 AK024733.1 AK289605.1 AY186742.1 BC017079.1 BC031010.1 BC107725.1 

    24 DOTS entries:

    DT.455368  DT.91831790  DT.95335612  DT.97845524  DT.91765722  DT.100788335  DT.40107402  DT.102838248 
    DT.97845525  DT.100781742  DT.91765718  DT.91765739  DT.100763282  DT.100788337  DT.40274023  DT.75110823 
    DT.121370536  DT.91765723  DT.91765732  DT.91800093  DT.91982495  DT.121370490  DT.91918798  DT.92051363 

    Selected AceView cDNA sequences (see all 212):

    CA441294 BX954846 Z41791 BX364216 AK023594 BG187961 CR600947 AB057595 
    BM921701 BI489494 AW013972 CR604227 AW962095 AI686325 AW027931 CR597338 
    CR621503 BG190654 W32866 AA351225 BC017079 BX341386 AI914351 BU734480 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMYD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGCAAAC
    SMYD3 Expression
    About this image

    SMYD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMYD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567571

    UniProtKB/Swiss-Prot: SMYD3_HUMAN, Q9H7B4
    Tissue specificity: Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and
    hepatocellular carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Array including SMYD3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMYD3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smyd31 , 5 SET and MYND domain containing 31, 5 87.31(n)1
    93.93(a)1
      1 (83.48 cM)5
    697261  NM_027188.31  NP_081464.11 
     1789519605 
    chicken
    (Gallus gallus)
    Aves SMYD31 SET and MYND domain containing 3 69.25(n)
    58.22(a)
      421489  XM_419536.3  XP_419536.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMYD36
    SET and MYND domain containing 3
    57(a)
    1 ↔ 1
    GL343534.1(426032-434049)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847649.12   -- 80.29(n)    BX847649.1 
    zebrafish
    (Danio rerio)
    Actinopterygii smyd31 SET and MYND domain containing 3 55.26(n)
    46.95(a)
      569507  NM_001037400.1  NP_001032477.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bzd1 Buzidau 44.81(n)
    31.65(a)
      44554  NM_080029.4  NP_524768.2 
    worm
    (Caenorhabditis elegans)
    Secernentea set-301 set-30 45.23(n)
    34.8(a)
      180772  NM_076449.4  NP_508850.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SDG371 SDG37 43.08(n)
    30.29(a)
      816300  NM_179638.1  NP_849969.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07042001 Os03g0704200 46.05(n)
    38.14(a)
      9266585  NM_001186674.1  NP_001173603.1 


    ENSEMBL Gene Tree for SMYD3 (if available)
    TreeFam Gene Tree for SMYD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMYD3 gene
    SMYD12  SMYD22  
    5 SIMAP similar genes for SMYD3 using alignment to 8 protein entries:     SMYD3_HUMAN (see all proteins):
    MSS51    SMYD4    SMYD2    SMYD1    DKFZp313O0925

    Find genes that share paralogs with SMYD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMYD3 (see all 18492)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165597391,2
    C,F--245912172(+) CACATT/CTGGCT 2 -- int11Minor allele frequency- C:0.01NA 120
    rs2003252831,2
    C--245912198(-) TTTTCC/TTNNNN 2 -- int10--------
    rs57823661,2
    C--245912200(+) CAAGG-/AAAAAA 2 -- int10--------
    rs1845381571,2
    --245912234(+) AAAATA/GCTGAT 2 -- int10--------
    rs1506857331,2
    --245912254(+) TTACAC/TAAAGA 2 -- int10--------
    rs1885132531,2
    --245912260(+) AAAGAA/GCTGTG 2 -- int10--------
    rs1158849301,2
    C,F--245912274(+) CATTCG/AAAAAA 2 -- int12Minor allele frequency- A:0.02WA NA 238
    rs745690911,2
    F--245912428(+) AAAGAT/CGACAT 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1812654231,2
    --245912471(+) TAAGTC/TTTTGC 2 -- int10--------
    rs1165026181,2
    F--245912590(+) ATGTTG/AGTATT 2 -- int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for SMYD3 (245912642 - 246162642 bp, first 250kb of SMYD3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SMYD3 (see all 152):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664400CNV Deletion23128226
    esv2727162CNV Deletion23290073
    esv2727351CNV Deletion23290073
    esv1098694CNV Deletion17803354
    esv2675120CNV Deletion23128226
    esv2727106CNV Deletion23290073
    esv2727062CNV Deletion23290073
    esv2727296CNV Deletion23290073
    esv2727363CNV Deletion23290073
    esv1404916CNV Deletion17803354

    Human Gene Mutation Database (HGMD): SMYD3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMYD3
    DNA2.0 Custom Variant and Variant Library Synthesis for SMYD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608783    OMIM disorders: --


    Find genes that share disorders with SMYD3           About GenesLikeMe

    2 Novoseek inferred disease relationships for SMYD3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 32.3 3 16687068 (2), 15235609 (1)
    cancer 24.6 9 15235609 (2), 19472189 (2), 17609160 (1), 16687068 (1) (see all 5)

    Genetic Association Database (GAD): SMYD3
    Human Genome Epidemiology (HuGE) Navigator: SMYD3 (5 documents)

    Export disorders for SMYD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMYD3 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with SMYD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PubMed id 15235609)1, 2, 9 Hamamoto R.... Nakamura Y. (Nat. Cell Biol. 2004)
    2. Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. (PubMed id 22419068)1, 2 Van Aller G.S.... Kruger R.G. (Epigenetics 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking. (PubMed id 18294291)1, 4 Wang H....He F. (Cancer Sci. 2008)
    5. SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population. (PubMed id 17431393)1, 4 Wang X.Q....Fan S.T. (Exp. Oncol. 2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. (PubMed id 16155568)1, 4 Tsuge M....Nakamura Y. (Nat. Genet. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Histone methyltransferase SMYD3 promotes MRTF-A-mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells. (PubMed id 24189459)1 Luo X.G....Zhang T.C. (Cancer Lett. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64754 HGNC: 15513 AceView: SMYD3 Ensembl:ENSG00000185420 euGenes: HUgn64754
    ECgene: SMYD3 H-InvDB: SMYD3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMYD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SMYD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SMYD3 gene:
    Search GeneIP for patents involving SMYD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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