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SMYD2 Gene

protein-coding   GIFtS: 57
GCID: GC01P214454

SET And MYND Domain Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SET And MYND Domain Containing 21 2     ZMYND142
Histone Methyltransferase SMYD22 3     N-Lysine Methyltransferase SMYD22
Lysine N-Methyltransferase 3C2 3     Zinc Finger, MYND Domain Containing 142
HSKM-B2 3     EC 2.1.1.-3
KMT3C2 3     EC 2.1.1.433
SET And MYND Domain-Containing Protein 22 3     

External Ids:    HGNC: 209821   Entrez Gene: 569502   Ensembl: ENSG000001434997   OMIM: 6106635   UniProtKB: Q9NRG43   

Export aliases for SMYD2 gene to outside databases

Previous GC identifers: GC01P211070 GC01P211511 GC01P210842 GC01P212521 GC01P185129


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMYD2 Gene:
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 (PubMed
16805913)).(supplied by OMIM, Nov 2008)

GeneCards Summary for SMYD2 Gene:
SMYD2 (SET and MYND domain containing 2) is a protein-coding gene. Diseases associated with SMYD2 include folliculitis, and papillary thyroid carcinoma. GO annotations related to this gene include protein-lysine N-methyltransferase activity and p53 binding. An important paralog of this gene is SMYD1.

UniProtKB/Swiss-Prot: SMYD2_HUMAN, Q9NRG4
Function: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including
p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36'
(H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53,
leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.
Monomethylates RB1 at 'Lys-860'




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMYD2 gene promoter:
         TBP   GR   NRSF form 1   GR-beta   Pax-2   Pax-2a   SRY   Pax-2b   TFIID   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMYD2 promoter sequence
   Search Chromatin IP Primers for SMYD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMYD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

SMYD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMYD2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P214454:  view genomic region     (about GC identifiers)

Start:
214,454,445 bp from pter      End:
214,510,477 bp from pter
Size:
56,033 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SMYD2_HUMAN, Q9NRG4 (See protein sequence)
Recommended Name: N-lysine methyltransferase SMYD2  
Size: 433 amino acids; 49688 Da
Subunit: Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 (By similarity). Interacts (via
MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1
Selected PDB 3D structures from and Proteopedia for SMYD2 (see all 7):
3RIB (3D)        3S7B (3D)        3S7D (3D)        3S7F (3D)        3S7J (3D)        3TG4 (3D)    
Secondary accessions: B2R9P9 Q4V765 Q5VSH9 Q96AI4

Explore the universe of human proteins at neXtProt for SMYD2: NX_Q9NRG4

Explore proteomics data for SMYD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SMYD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064582.2  
    ENSEMBL proteins: 
     ENSP00000355924   ENSP00000409822   ENSP00000388682  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    3 InterPro protein domains:
     IPR002893 Znf_MYND
     IPR001214 SET_dom
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry Q9NRG4

    ProtoNet protein and cluster: Q9NRG4

    2 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: SMYD2_HUMAN, Q9NRG4
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 SET domain


    SMYD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMYD2_HUMAN, Q9NRG4
    Function: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including
    p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36'
    (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53,
    leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.
    Monomethylates RB1 at 'Lys-860'
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Induction: Expression is repressed by CEBPA

         Enzyme Numbers (IUBMB): EC 2.1.1.431 EC 2.1.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding ISS--
    GO:0002039p53 binding IPI17108971
    GO:0005515protein binding IPI--
    GO:0016279protein-lysine N-methyltransferase activity IDA17108971
    GO:0046872metal ion binding IEA--
         
    SMYD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SMYD2:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Smyd2):
     cardiovascular system  homeostasis/metabolism 

    SMYD2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMYD2
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    miRNA
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    miRTarBase miRNAs that target SMYD2:
    hsa-mir-19b-3p (MIRT031254), hsa-mir-130b-3p (MIRT020273), hsa-mir-26b-5p (MIRT029735)

    Block miRNA regulation of human, mouse, rat SMYD2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SMYD2:
    hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmidSMYD2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMYD2_HUMAN, Q9NRG4: Cytoplasm, cytosol (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol ISS--

    SMYD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SMYD2 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 pathway
    p53 pathway
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SMYD2
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for SMYD2
        p53 pathway




    SMYD2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMYD2
    Interactions:

        GeneGlobe Interaction Network for SMYD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMYD2 (Q9NRG43 ENSP000003559244) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP11Q9UKA43, ENSP000000253014I2D: score=2 STRING: ENSP00000025301
    AXIN1O151693, ENSP000002623204I2D: score=2 STRING: ENSP00000262320
    GSK3BP498413, ENSP000003248064I2D: score=2 STRING: ENSP00000324806
    TP53P046373, ENSP000002693054I2D: score=2 STRING: ENSP00000269305
    AKAP9Q999963, ENSP000003485734I2D: score=1 STRING: ENSP00000348573
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP17108971
    GO:0006351transcription, DNA-templated IEA--
    GO:0008285negative regulation of cell proliferation ISS--
    GO:0010452histone H3-K36 methylation ----
    GO:0016571histone methylation ----

    SMYD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for SMYD2 (see all 15)     About this table
    CompoundAction CAS #
    3-Deazaneplanocin,DZNepBlocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro[102052-95-9]
    AZ505potent and highly selective inhibitor of the oncogenic protein SMYD2[1035227-43-0]
    BIX 01294BIX-01294 is a small molecule inhibitor of G9a and GLP[935693-62-2]
    ChaetocinHistone methyltransferase SUV39H1 inhibitor[28097-03-2]
    EntacaponeEntacapone inhibits catechol-O-methyltransferase(COMT)[130929-57-6]
    EPZ-6438potent and bio-available inhibitor of EZH2[1403254-99-8 ]
    EPZ004777potent, selective DOT1L inhibitor[1338466-77-5]
    EPZ005687potent inhibitor of EZH2[1396772-26-1]
    EPZ5676potent inhibitor of DOT1L histone methyltransferase[1380288-87-8]
    SGC 0946highly potent and selective DOT1 Lmethyltransferase inhibitor--

    Browse Tocris compounds for SMYD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SMYD2 gene: 
    NM_020197.2  

    Unigene Cluster for SMYD2:

    SET and MYND domain containing 2
    Hs.66170  [show with all ESTs]
    Unigene Representative Sequence: BC068511
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491455(uc021pix.1 uc009xdl.1) ENST00000471645 ENST00000460580(uc021piw.1)
    ENST00000366957 ENST00000484459 ENST00000416415 ENST00000415093
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SMYD2:
    hsa-miR-1179
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SMYD2
      QuantiFast Probe-based Assays in human, mouse, rat SMYD2

    Additional mRNA sequence: 

    AF070592.1 AF226053.1 AK090571.1 AK091590.1 AK098683.1 AK313868.1 BC017080.2 BC028104.1 
    BC039890.1 BC057793.1 BC068511.1 BC098133.1 BC098276.1 BC098335.1 

    13 DOTS entries:

    DT.446799  DT.95183994  DT.100032982  DT.91800781  DT.100819009  DT.100033037  DT.100819010  DT.40250753 
    DT.97858902  DT.100809597  DT.75140314  DT.444352  DT.91924949 

    Selected AceView cDNA sequences (see all 213):

    CR589978 CA434890 AI377234 CR592315 CR617804 BC028104 AI708404 CA411809 
    BC017080 BM740370 CF552077 CR622801 AI627479 BM466219 BM739135 AK098683 
    CA313122 R88886 AA804764 CR613242 BC039890 AW519313 H98065 AI692922 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMYD2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                            -                             -           -                     
    SP2:                                            -                       -     -     -     -                     
    SP3:              -                             -                                                               
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SMYD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMYD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTTGTAA
    SMYD2 Expression
    About this image

    SMYD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMYD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.66170
        Custom PCR Arrays for SMYD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SMYD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smyd21 , 5 SET and MYND domain containing 21, 5 87.3(n)1
    93.3(a)1
      1 (95.03 cM)5
    2268301  NM_026796.11  NP_081072.11 
     1898804925 
    chicken
    (Gallus gallus)
    Aves SMYD21 SET and MYND domain containing 2 80.83(n)
    86.14(a)
      421361  NM_001277571.1  NP_001264500.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMYD26
    SET and MYND domain containing 2
    82(a)
    1 ↔ 1
    1(239783017-239840918)
    African clawed frog
    (Xenopus laevis)
    Amphibia smyd2-prov2 HSKM-B protein 79.49(n)    BC044103.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc02f022 Transcribed sequence with moderate similarity to protein more 73.94(n)    57045208 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bzd6
    Buzidau
    21(a)
    1 → many
    X(2500712-2502700)
    worm
    (Caenorhabditis elegans)
    Secernentea set-146
    set-106
    (see all 4)
    Protein SET-10 (set-10) mRNA, complete cds
    (see all 4)
    21(a)
    18(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(10793575-10796294) WBGene00011068
    I(15027500-15030554) WBGene00009370


    ENSEMBL Gene Tree for SMYD2 (if available)
    TreeFam Gene Tree for SMYD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMYD2 gene
    SMYD12  SMYD32  
    3 SIMAP similar genes for SMYD2 using alignment to 5 protein entries:     SMYD2_HUMAN (see all proteins):
    SMYD1    DKFZp313O0925    SMYD3

    SMYD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMYD2 (see all 1227)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3691810171,2
    C--185127808(+) GTCCA-/CT/TTT
            
    TTTTT
    2 -- us2k1 cds11NA 2
    rs578544831,2
    C--185147949(+) ATATA-/TATA  
      TATACA
    CCATA
    1 -- int11Minor allele frequency- TATATATACA:0.00NA 2
    rs730903551,2
    C,F--214452578(+) GAGCAC/TGATGC 1 -- us2k12Minor allele frequency- T:0.21WA 120
    rs111202871,2
    C,F,A,H--214452666(+) GTCCAT/Cttttt 1 -- us2k1 trp35Minor allele frequency- C:0.20WA NA 10
    rs1924476071,2
    --214452774(+) CAAGCA/GATTCT 1 -- us2k10--------
    rs1118472791,2
    C,F--214452795(+) CCTCCC/TGAGTA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs343341091,2
    C--214452825(+) ACCACC/GACACC 1 -- us2k12Minor allele frequency- G:0.25NA 4
    rs1901477851,2
    --214452897(+) ACTCTC/TGACCT 1 -- us2k10--------
    rs1491066721,2
    --214452912(+) TGATCC/TGCCTA 1 -- us2k10--------
    rs1818135571,2
    --214452945(+) GATTAC/TAGGCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SMYD2 (214454445 - 214510477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SMYD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668267CNV Deletion23128226
    esv2722595CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMYD2
    DNA2.0 Custom Variant and Variant Library Synthesis for SMYD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610663    OMIM disorders: --

    8 diseases for SMYD2:    
    About MalaCards
    folliculitis    papillary thyroid carcinoma    esophageal squamous cell carcinoma    retinoblastoma
    thyroiditis    esophagitis    squamous cell carcinoma    colorectal cancer


    SMYD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SMYD2
    Human Genome Epidemiology (HuGE) Navigator: SMYD2 (1 document)

    Export disorders for SMYD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMYD2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with SMYD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis of substrate methylation and inhibition of SMYD2. (PubMed id 21782458)1, 2 Ferguson A.D....Keen N. (Structure 2011)
    2. Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation. (PubMed id 21880715)1, 2 Wang L....Zhao K. (J. Biol. Chem. 2011)
    3. Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins. (PubMed id 21724641)1, 2 Xu S....Ding J. (J Mol Cell Biol 2011)
    4. Methylation of the retinoblastoma tumor suppressor by SMYD2. (PubMed id 20870719)1, 2 Saddic L.A.... Sage J. (J. Biol. Chem. 2010)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. (PubMed id 18065756)1, 2 Abu-Farha M....Figeys D. (Mol. Cell. Proteomics 2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Repression of p53 activity by Smyd2-mediated methylation. (PubMed id 17108971)1, 2 Huang J.... Berger S.L. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56950 HGNC: 20982 AceView: SMYD2 Ensembl:ENSG00000143499 euGenes: HUgn56950
    ECgene: SMYD2 H-InvDB: SMYD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMYD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SMYD2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMYD2 gene:
    Search GeneIP for patents involving SMYD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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