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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMYD1 Gene

protein-coding   GIFtS: 54
GCID: GC02P088367

SET And MYND Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SET And MYND Domain Containing 11 2     ZMYND222
SET And MYND Domain-Containing Protein 12 3     CD8 Beta Opposite2
BOP2     Histone-Lysine N-Methyltransferase SMYD12
KMT3D2     Zinc Finger, MYND Domain Containing 182
ZMYND182     EC 2.1.1.433

External Ids:    HGNC: 209861   Entrez Gene: 1505722   Ensembl: ENSG000001155937   OMIM: 6068465   UniProtKB: Q8NB123   

Export aliases for SMYD1 gene to outside databases

Previous GC identifers: GC02P088252 GC02P088269 GC02P088206 GC02P087289


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SMYD1 Gene: 
SMYD1 (SET and MYND domain containing 1) is a protein-coding gene. Diseases associated with SMYD1 include axenfeld-rieger syndrome, and hypoplastic left heart syndrome. GO annotations related to this gene include DNA binding and transcription corepressor activity. An important paralog of this gene is SMYD2.

UniProtKB/Swiss-Prot: SMYD1_HUMAN, Q8NB12
Function: Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation.
Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMYD1 gene promoter:
         HOXA9   HOXA9B   Elk-1   POU6F1 (c2)   GATA-1   MEF-2A   HOXA5   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMYD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SMYD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMYD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.1

SMYD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMYD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P088367:  view genomic region     (about GC identifiers)

Start:
88,367,299 bp from pter      End:
88,412,906 bp from pter
Size:
45,608 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMYD1_HUMAN, Q8NB12 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SMYD1  
Size: 490 amino acids; 56617 Da
Subunit: Interacts with HDAC1, HDAC2 and HDAC3 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: A0AV30 A6NE13

Explore the universe of human proteins at neXtProt for SMYD1: NX_Q8NB12

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NB12

  • SMYD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_938015.1  
    ENSEMBL proteins: 
     ENSP00000393453   ENSP00000407888   ENSP00000387482  

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    Novus Biologicals SMYD1 Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for SMYD1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    SMYD1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SMYD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZMYND: Zinc fingers, MYND-type
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    2 InterPro protein domains:
     IPR002893 Znf_MYND
     IPR001214 SET_dom

    Graphical View of Domain Structure for InterPro Entry Q8NB12

    ProtoNet protein and cluster: Q8NB12

    2 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: SMYD1_HUMAN, Q8NB12
    Domain: The SET domain is split between the S-sequence (residues 1-49) and the core SET domain (residues 181-258),
    however the two segments still come together to form a conserved SET domain fold (By similarity)
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 SET domain


    SMYD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMYD1_HUMAN, Q8NB12
    Function: Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation.
    Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Induction: By serum response factor SRF and myogenin. SRF binds to the CArG site and MYOG binds to the E-box
    element on SMYD1 promoter

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
    GO:0018024histone-lysine N-methyltransferase activity IEA--
         
    SMYD1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Smyd1):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 
     muscle 

    SMYD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Smyd1tm1Dsr for SMYD1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SMYD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SMYD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMYD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMYD1 

    miRNA
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    hsa-miR-3678-3p hsa-miR-1298 hsa-miR-765 hsa-miR-3120-3p hsa-miR-888 hsa-miR-373* hsa-miR-664 hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidSMYD1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SMYD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Heart Development
    Heart Development


    1 BioSystems Pathway for SMYD1
        Heart Development



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMYD1

    3 Interacting proteins for SMYD1 (Q8NB123) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC3O153793I2D: score=2 
    HDAC1Q135473I2D: score=1 
    HDAC2Q927693I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007507heart development IEA--
    GO:0010831positive regulation of myotube differentiation IDA19783823
    GO:0035914skeletal muscle cell differentiation IEA--

    SMYD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMYD1

    Search CenterWatch for drugs/clinical trials and news about SMYD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SMYD1 gene: 
    NM_198274.3  

    Unigene Cluster for SMYD1:

    SET and MYND domain containing 1
    Hs.516176  [show with all ESTs]
    Unigene Representative Sequence: NM_198274
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419482(uc002ssq.2 uc002ssr.3 uc002sss.3) ENST00000444564
    ENST00000438570 ENST00000468008
    miRNA
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    hsa-miR-3678-3p hsa-miR-1298 hsa-miR-765 hsa-miR-3120-3p hsa-miR-888 hsa-miR-373* hsa-miR-664 hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidSMYD1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: SMYD1 (NM_198274)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMYD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMYD1
    Sirion Biotech Customized lentivirus for stable overexpression of SMYD1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMYD1

    Additional mRNA sequence: 

    AF086123.1 AK022290.1 AK091724.1 AL832035.1 AY518933.1 AY518934.1 BC017915.1 BC126191.1 
    BX647878.1 

    4 DOTS entries:

    DT.306345  DT.454717  DT.100747244  DT.120946134 

    24/65 AceView cDNA sequences (see all 65):

    AI004011 AA248334 BX500817 AI078564 AI079318 F30640 AK022290 AL832035 
    W95588 AU147602 CF552718 BQ918532 AX747145 AI015235 BC017915 BF575127 
    BX647878 C04066 NM_198274 BX103184 AJ572108 AI014299 AI420970 BF790590 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SMYD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:              -                                                                                 
    SP2:                                                  -                                             
    SP3:                                                                                                
    SP4:              -           -     -     -     -     -     -     -     -     -     -     -         


    ECgene alternative splicing isoforms for SMYD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMYD1 expression in normal human tissues (normalized intensities)      SMYD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTGTATT
    SMYD1 Expression
    About this image


    SMYD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             vastus lateralis   
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen

    Genevestigator expression for SMYD1

    SOURCE GeneReport for Unigene cluster: Hs.516176

    UniProtKB/Swiss-Prot: SMYD1_HUMAN, Q8NB12
    Tissue specificity: Expression seems mostly restricted to heart and skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMYD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SMYD1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smyd11 , 5 SET and MYND domain containing 11, 5 89.45(n)1
    94.13(a)1
      6 (32.14 cM)5
    121801  NM_009762.21  NP_033892.21 
     712139405 
    chicken
    (Gallus gallus)
    Aves SMYD11 SET and MYND domain containing 1 78.69(n)
    82.06(a)
      373960  NM_204155.1  NP_989486.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMYD16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    6(59317036-59360113)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.18172 Xenopus laevis transcribed sequence with weak similarity more 77.51(n)    BJ073212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570461612   -- 78.48(n)    57046161 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bzd6
    Buzidau
    22(a)
    1 → many
    X(2500712-2502700)
    worm
    (Caenorhabditis elegans)
    Secernentea set-146
    set-186
    (see all 4)
    Protein SET-18, isoform b
    (see all 4)
    18(a)
    16(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(10793575-10796299)
    I(10590720-10593962)


    ENSEMBL Gene Tree for SMYD1 (if available)
    TreeFam Gene Tree for SMYD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMYD1 gene
    SMYD22  SMYD32  
    3 SIMAP similar genes for SMYD1 using alignment to 4 protein entries:     SMYD1_HUMAN (see all proteins):
    DKFZp313O0925    SMYD2    SMYD3

    SMYD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1049 SNPs in SMYD1 are shown (see all 1049)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118911231,2
    C,F,H--88365338(+) GTCTCA/GATCTC 1 -- us2k16Minor allele frequency- G:0.21NA 14
    rs1421397571,2
    --88365414(+) CCGGCC/TTCTTT 1 -- us2k10--------
    rs1882415741,2
    --88365516(+) AAGTTA/GTTTTG 1 -- us2k10--------
    rs1511574151,2
    C--88365534(+) GTGTAC/TATCAG 1 -- us2k10--------
    rs1922587561,2
    --88365580(+) GTATTC/GTTACC 1 -- us2k10--------
    rs1848371121,2
    --88366208(+) CCTGGC/TAGCAG 1 -- us2k10--------
    rs601210221,2
    C--88366494(+) TTATT-/TAT   
       TTATT
    AATTT
    1 -- us2k11Minor allele frequency- TATTTATT:0.00NA 2
    rs1896095721,2
    --88366529(+) GTCGCC/TCAGGC 1 -- us2k10--------
    rs1914055071,2
    --88366556(+) GATCTC/TGGCTC 1 -- us2k10--------
    rs1452049351,2
    --88366856(+) GGCCCA/GTCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SMYD1 (88367299 - 88412906 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SMYD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv61n16CNV Deletion17901297
    nsv874581CNV Gain21882294
    nsv834289CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606846    OMIM disorders: --

    3 diseases for SMYD1:    About MalaCards
    axenfeld-rieger syndrome    hypoplastic left heart syndrome    tetralogy of fallot

    2 diseases from the University of Copenhagen DISEASES database for SMYD1:
    Axenfeld-Rieger syndrome     Hypoplastic left heart syndrome

    SMYD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SMYD1
    Human Genome Epidemiology (HuGE) Navigator: SMYD1 (1 document)

    Export disorders for SMYD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMYD1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SMYD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin. (PubMed id 19783823)1, 2 Li D....Liu M. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. (PubMed id 11923873)1, 3 Gottlieb P.D....Srivastava D. (2002)
    6. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    8. Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding protein. (PubMed id 19162039)1 Yang J. and Everett A.D. (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150572 HGNC: 20986 AceView: SMYD1 Ensembl:ENSG00000115593 euGenes: HUgn150572
    ECgene: SMYD1 H-InvDB: SMYD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMYD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SMYD1 gene:
    Search GeneIP for patents involving SMYD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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