Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SMURF2 Gene

Aliases for SMURF2 Gene

  • SMAD Specific E3 Ubiquitin Protein Ligase 2 2 3
  • SMAD-Specific E3 Ubiquitin-Protein Ligase 2 3 4
  • SMAD Ubiquitination Regulatory Factor 2 3 4
  • HSMURF2 3 4
  • E3 Ubiquitin-Protein Ligase SMURF2 3
  • E3 Ubiquitin Ligase SMURF2 3
  • EC 6.3.2.- 4
  • EC 6.3.2 64

External Ids for SMURF2 Gene

Summaries for SMURF2 Gene

GeneCards Summary for SMURF2 Gene

SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include identical protein binding and SMAD binding. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for SMURF2 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Gene Wiki entry for SMURF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMURF2 Gene

Genomics for SMURF2 Gene

Genomic Location for SMURF2 Gene

Start:
64,542,282 bp from pter
End:
64,662,268 bp from pter
Size:
119,987 bases
Orientation:
Minus strand

Genomic View for SMURF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMURF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMURF2 Gene

Regulatory Elements for SMURF2 Gene

Proteins for SMURF2 Gene

  • Protein details for SMURF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAU4-SMUF2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase SMURF2
    Protein Accession:
    Q9HAU4
    Secondary Accessions:
    • Q52LL1
    • Q9H260

    Protein attributes for SMURF2 Gene

    Size:
    748 amino acids
    Molecular mass:
    86196 Da
    Quaternary structure:
    • Interacts (via WW domains) with SMAD1. Interacts (via WW domains) with SMAD2 (via PY-motif). Interacts (via WW domains) with SMAD3 (via PY-motif). Interacts with SMAD6. Interacts with SMAD7 (via PY-motif) and TGFBR1; SMAD7 recruits SMURF2 to the TGF-beta receptor and regulates its degradation. Does not interact with SMAD4; SMAD4 lacks a PY-motif. Interacts with AIMP1. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase.

    Three dimensional structures from OCA and Proteopedia for SMURF2 Gene

neXtProt entry for SMURF2 Gene

Proteomics data for SMURF2 Gene at MOPED

Post-translational modifications for SMURF2 Gene

  • Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMURF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SMURF2 Gene

Protein Domains for SMURF2 Gene

UniProtKB/Swiss-Prot:

SMUF2_HUMAN
Domain:
  • The second and third WW domains are responsible for interaction with the PY-motif of R-SMAD (SMAD1, SMAD2 and SMAD3):
    • Q9HAU4
  • The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain:
    • Q9HAU4
  • Contains 1 C2 domain.:
    • Q9HAU4
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.:
    • Q9HAU4
  • Contains 3 WW domains.:
    • Q9HAU4
genes like me logo Genes that share domains with SMURF2: view

No data available for Gene Families for SMURF2 Gene

Function for SMURF2 Gene

Molecular function for SMURF2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activated by NDFIP1- and NDFIP2-binding
UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Enzyme Numbers (IUBMB) for SMURF2 Gene

Gene Ontology (GO) - Molecular Function for SMURF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005160 transforming growth factor beta receptor binding IEA --
GO:0005515 protein binding IPI 14755250
GO:0016874 ligase activity IEA --
GO:0042802 identical protein binding IPI 15231748
genes like me logo Genes that share ontologies with SMURF2: view
genes like me logo Genes that share phenotypes with SMURF2: view

Animal Models for SMURF2 Gene

MGI Knock Outs for SMURF2:

miRNA for SMURF2 Gene

miRTarBase miRNAs that target SMURF2

No data available for Transcription Factor Targeting and HOMER Transcription for SMURF2 Gene

Localization for SMURF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMURF2 Gene

Nucleus. Cytoplasm. Cell membrane. Membrane raft. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMURF2 Gene COMPARTMENTS Subcellular localization image for SMURF2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
mitochondrion 3
peroxisome 2
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SMURF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 14755250
GO:0005634 nucleus NAS 11163210
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SMURF2: view

Pathways for SMURF2 Gene

genes like me logo Genes that share pathways with SMURF2: view

Pathways by source for SMURF2 Gene

1 R&D Systems pathway for SMURF2 Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SMURF2 Gene
2 Cell Signaling Technology pathways for SMURF2 Gene

UniProtKB/Swiss-Prot Q9HAU4-SMUF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SMURF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IDA 14755250
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SMURF2: view

Compounds for SMURF2 Gene

(4) HMDB Compounds for SMURF2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with SMURF2: view

Transcripts for SMURF2 Gene

Unigene Clusters for SMURF2 Gene

SMAD specific E3 ubiquitin protein ligase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMURF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - -
SP2:
SP3:

Relevant External Links for SMURF2 Gene

GeneLoc Exon Structure for
SMURF2
ECgene alternative splicing isoforms for
SMURF2

Expression for SMURF2 Gene

mRNA expression in normal human tissues for SMURF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMURF2 Gene

SOURCE GeneReport for Unigene cluster for SMURF2 Gene Hs.515011

mRNA Expression by UniProt/SwissProt for SMURF2 Gene

Q9HAU4-SMUF2_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with SMURF2: view

Orthologs for SMURF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMURF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMURF2 36
  • 99.82 (n)
  • 100 (a)
SMURF2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMURF2 36
  • 94.26 (n)
  • 99.18 (a)
SMURF2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMURF2 36
  • 95.3 (n)
  • 99.33 (a)
mouse
(Mus musculus)
Mammalia Smurf2 36
  • 92.07 (n)
  • 99.2 (a)
Smurf2 16
Smurf2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMURF2 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Smurf2 36
  • 91.49 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves SMURF2 36
  • 86.76 (n)
  • 98.13 (a)
SMURF2 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMURF2 37
  • 97 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii smurf2 36
  • 76.02 (n)
  • 92.51 (a)
smurf2 37
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011242 36
  • 57.8 (n)
  • 62.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta lack 36
  • 60.25 (n)
  • 64.57 (a)
lack 37
  • 44 (a)
OneToMany
lack 38
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8773 37
  • 66 (a)
OneToMany
Species with no ortholog for SMURF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMURF2 Gene

ENSEMBL:
Gene Tree for SMURF2 (if available)
TreeFam:
Gene Tree for SMURF2 (if available)

Paralogs for SMURF2 Gene

Paralogs for SMURF2 Gene

genes like me logo Genes that share paralogs with SMURF2: view

Variants for SMURF2 Gene

Sequence variations from dbSNP and Humsavar for SMURF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9916 -- 64,542,465(-) GTATT(A/T)GTATT utr-variant-3-prime
rs1991402 -- 64,617,212(-) TTACT(A/G)TATCT intron-variant
rs1991403 -- 64,617,173(-) GCAGA(A/G)CACCC intron-variant
rs2162545 -- 64,619,020(+) ggata(A/C)taaga intron-variant
rs2288339 -- 64,556,214(-) TGGCC(C/T)CTGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMURF2 Gene

Variant ID Type Subtype PubMed ID
nsv908686 CNV Gain 21882294
nsv908687 CNV Loss 21882294
esv2656677 CNV Deletion 23128226

Relevant External Links for SMURF2 Gene

HapMap Linkage Disequilibrium report
SMURF2

Disorders for SMURF2 Gene

No disorders were found for SMURF2 Gene.

No data available for UniProtKB/Swiss-Prot for SMURF2 Gene

Publications for SMURF2 Gene

  1. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. (PMID: 14562029) Subramaniam V. … Seth A.K. (Br. J. Cancer 2003) 3 4 23
  2. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. (PMID: 11158580) Zhang Y. … Derynck R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  3. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. (PMID: 16061177) Ogunjimi A.A. … Wrana J.L. (Mol. Cell 2005) 3 4 23
  4. An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. (PMID: 16641086) Chong P.A. … Forman-Kay J.D. (J. Biol. Chem. 2006) 3 4 23
  5. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. (PMID: 17719543) Wiesner S. … Forman-Kay J.D. (Cell 2007) 3 4 23

Products for SMURF2 Gene

Sources for SMURF2 Gene

Back to Top

Content