Aliases for SMURF1 Gene
External Ids for SMURF1 Gene
Previous GeneCards Identifiers for SMURF1 Gene
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
GeneCards Summary for SMURF1 Gene
SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with SMURF1 include Cerebral Cavernous Malformations-2 and Colonic Benign Neoplasm. Among its related pathways are Hedgehog Pathway and SMAD Signaling Network. GO annotations related to this gene include ligase activity and phospholipid binding. An important paralog of this gene is SMURF2.
UniProtKB/Swiss-Prot for SMURF1 Gene
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).