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Aliases for SMURF1 Gene

Aliases for SMURF1 Gene

  • SMAD Specific E3 Ubiquitin Protein Ligase 1 2 3 5
  • SMAD-Specific E3 Ubiquitin-Protein Ligase 1 3 4
  • HSMURF1 3 4
  • Smad Ubiquitination Regulatory Factor 1 3
  • SMAD Ubiquitination Regulatory Factor 1 4
  • Smad-Specific E3 Ubiquitin Ligase 1 3
  • E3 Ubiquitin Ligase SMURF1 3
  • EC 6.3.2.- 4
  • KIAA1625 4
  • EC 6.3.2 63

External Ids for SMURF1 Gene

Previous GeneCards Identifiers for SMURF1 Gene

  • GC07M097159
  • GC07M098222
  • GC07M098236
  • GC07M098269
  • GC07M098463
  • GC07M098627
  • GC07M093257

Summaries for SMURF1 Gene

Entrez Gene Summary for SMURF1 Gene

  • This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

GeneCards Summary for SMURF1 Gene

SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with SMURF1 include Colonic Benign Neoplasm. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and phospholipid binding. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for SMURF1 Gene

  • E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Wiki entry for SMURF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMURF1 Gene

Genomics for SMURF1 Gene

Regulatory Elements for SMURF1 Gene

Enhancers for SMURF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMURF1 on UCSC Golden Path with GeneCards custom track

Promoters for SMURF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMURF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMURF1 Gene

Chromosome:
7
Start:
99,027,435 bp from pter
End:
99,144,120 bp from pter
Size:
116,686 bases
Orientation:
Minus strand

Genomic View for SMURF1 Gene

Genes around SMURF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMURF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMURF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMURF1 Gene

Proteins for SMURF1 Gene

  • Protein details for SMURF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE7-SMUF1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase SMURF1
    Protein Accession:
    Q9HCE7
    Secondary Accessions:
    • A4D279
    • B7ZMB6
    • B9EGV3
    • O75853
    • Q547Q3
    • Q9UJT8

    Protein attributes for SMURF1 Gene

    Size:
    757 amino acids
    Molecular mass:
    86114 Da
    Quaternary structure:
    • Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation.
    SequenceCaution:
    • Sequence=BAB13451.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SMURF1 Gene

    Alternative splice isoforms for SMURF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMURF1 Gene

Proteomics data for SMURF1 Gene at MOPED

Post-translational modifications for SMURF1 Gene

  • Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site.
  • Ubiquitination at Lys 381 and Lys 383
  • Modification sites at PhosphoSitePlus

Other Protein References for SMURF1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SMURF1 (SMURF1)

Domains & Families for SMURF1 Gene

Protein Domains for SMURF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCE7

UniProtKB/Swiss-Prot:

SMUF1_HUMAN :
  • The C2 domain mediates membrane localization and substrate selection.
Domain:
  • The C2 domain mediates membrane localization and substrate selection.
  • Contains 1 C2 domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with SMURF1: view

No data available for Gene Families for SMURF1 Gene

Function for SMURF1 Gene

Molecular function for SMURF1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Enzyme Numbers (IUBMB) for SMURF1 Gene

Gene Ontology (GO) - Molecular Function for SMURF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA,TAS --
GO:0005543 phospholipid binding TAS 22020285
GO:0016874 ligase activity IEA --
GO:0048185 activin binding NAS 16720724
genes like me logo Genes that share ontologies with SMURF1: view
genes like me logo Genes that share phenotypes with SMURF1: view

Animal Models for SMURF1 Gene

MGI Knock Outs for SMURF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SMURF1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMURF1 Gene

Localization for SMURF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMURF1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMURF1 Gene COMPARTMENTS Subcellular localization image for SMURF1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
mitochondrion 3
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SMURF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11278251
GO:0005739 colocalizes_with mitochondrion IGI 22020285
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SMURF1: view

Pathways & Interactions for SMURF1 Gene

genes like me logo Genes that share pathways with SMURF1: view

UniProtKB/Swiss-Prot Q9HCE7-SMUF1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SMURF1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for SMURF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19937093
GO:0016567 protein ubiquitination IEA,IDA 11278251
GO:0030154 cell differentiation IDA 10458166
GO:0030509 BMP signaling pathway TAS --
GO:0030514 negative regulation of BMP signaling pathway TAS 10458166
genes like me logo Genes that share ontologies with SMURF1: view

Drugs & Compounds for SMURF1 Gene

(3) Drugs for SMURF1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for SMURF1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with SMURF1: view

Transcripts for SMURF1 Gene

Unigene Clusters for SMURF1 Gene

SMAD specific E3 ubiquitin protein ligase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMURF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7: -
SP8:

Relevant External Links for SMURF1 Gene

GeneLoc Exon Structure for
SMURF1
ECgene alternative splicing isoforms for
SMURF1

Expression for SMURF1 Gene

mRNA expression in normal human tissues for SMURF1 Gene

Protein differential expression in normal tissues from HIPED for SMURF1 Gene

This gene is overexpressed in Adipocyte (18.7), Placenta (15.8), Heart (11.5), and Uterus (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMURF1 Gene



SOURCE GeneReport for Unigene cluster for SMURF1 Gene Hs.189329

mRNA Expression by UniProt/SwissProt for SMURF1 Gene

Q9HCE7-SMUF1_HUMAN
Tissue specificity: Expressed in melanocytes (PubMed:23999003).
genes like me logo Genes that share expression patterns with SMURF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for SMURF1 Gene

Orthologs for SMURF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMURF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMURF1 35
  • 88.73 (n)
  • 98.15 (a)
SMURF1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMURF1 35
  • 89.48 (n)
  • 99.15 (a)
SMURF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smurf1 35
  • 88.24 (n)
  • 98.63 (a)
Smurf1 16
Smurf1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMURF1 35
  • 99.21 (n)
  • 100 (a)
SMURF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smurf1 35
  • 88.92 (n)
  • 98.76 (a)
oppossum
(Monodelphis domestica)
Mammalia SMURF1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMURF1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMURF1 35
  • 84.06 (n)
  • 98.08 (a)
SMURF1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMURF1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491582 35
  • 78.72 (n)
  • 90.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Smurf1 35
zebrafish
(Danio rerio)
Actinopterygii smurf1 35
  • 77.96 (n)
  • 92.18 (a)
wufb30b12 35
smurf1 36
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lack 37
  • 71 (a)
lack 36
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8479 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8773 36
  • 63 (a)
OneToMany
Species with no ortholog for SMURF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMURF1 Gene

ENSEMBL:
Gene Tree for SMURF1 (if available)
TreeFam:
Gene Tree for SMURF1 (if available)

Paralogs for SMURF1 Gene

Paralogs for SMURF1 Gene

(12) SIMAP similar genes for SMURF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMURF1: view

Variants for SMURF1 Gene

Sequence variations from dbSNP and Humsavar for SMURF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs13246077 - 99,042,170(+) CCGTA(G/T)AATAC reference, missense
rs941001 -- 99,137,562(-) TGCTT(A/T)CAGGA intron-variant
rs998848 -- 99,040,232(-) AAAGG(A/G)GATTT intron-variant
rs998849 -- 99,040,227(-) GGATT(C/T)TTTGG intron-variant
rs1003865 -- 99,039,696(-) GGACT(C/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMURF1 Gene

Variant ID Type Subtype PubMed ID
nsv366204 CNV Loss 16902084
esv2621233 CNV Deletion 19546169
esv25445 CNV Gain 19812545

Variation tolerance for SMURF1 Gene

Residual Variation Intolerance Score: 3.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SMURF1 Gene

Disorders for SMURF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SMURF1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SMURF1

Genetic Association Database (GAD)
SMURF1
Human Genome Epidemiology (HuGE) Navigator
SMURF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMURF1
genes like me logo Genes that share disorders with SMURF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SMURF1 Gene

Publications for SMURF1 Gene

  1. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. (PMID: 10458166) Zhu H. … Thomsen G.H. (Nature 1999) 2 3 4 67
  2. Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. (PMID: 18927080) Fukunaga E. … Imamura T. (J. Biol. Chem. 2008) 3 23
  3. Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. (PMID: 17190792) Sahai E. … Vial E. (J. Cell Biol. 2007) 3 23
  4. Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. (PMID: 17215250) Wang Q. … Chen D. (J. Biol. Chem. 2007) 3 23
  5. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. (PMID: 17576816) Chan M.C. … Hata A. (Mol. Cell. Biol. 2007) 3 23

Products for SMURF1 Gene

Sources for SMURF1 Gene

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