Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMURF1 Gene

protein-coding   GIFtS: 67
GCID: GC07M098627

SMAD Specific E3 Ubiquitin Protein Ligase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SMAD Specific E3 Ubiquitin Protein Ligase 11 2     E3 Ubiquitin-Protein Ligase SMURF12
SMAD Ubiquitination Regulatory Factor 12 3     Smad-Specific E3 Ubiquitin Ligase 12
hSMURF12 3     EC 6.3.2.-3
SMAD-Specific E3 Ubiquitin-Protein Ligase 12 3     KIAA16253
E3 Ubiquitin Ligase SMURF12     EC 6.3.28

External Ids:    HGNC: 168071   Entrez Gene: 571542   Ensembl: ENSG000001987427   OMIM: 6055685   UniProtKB: Q9HCE73   

Export aliases for SMURF1 gene to outside databases

Previous GC identifers: GC07M097159 GC07M098222 GC07M098236 GC07M098269 GC07M098463 GC07M093257


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SMURF1 Gene:
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone
morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell
signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different
isoforms.(provided by RefSeq, Dec 2010)

GeneCards Summary for SMURF1 Gene: 
SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) is a protein-coding gene. Diseases associated with SMURF1 include cerebral cavernous malformations-2, and wolfram syndrome, and among its related super-pathways are BMP signalling and regulation and Antigen processing: Ubiquitination & Proteasome degradation. GO annotations related to this gene include ubiquitin-protein ligase activity and activin binding. An important paralog of this gene is HERC1.

UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates
ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway.
Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA

Gene Wiki entry for SMURF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMURF1 gene promoter:
         STAT1   AML1a   Pax-5   ATF-2   STAT1beta   Evi-1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SMURF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SMURF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMURF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.1-q31.1

SMURF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMURF1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M098627:  view genomic region     (about GC identifiers)

Start:
98,625,058 bp from pter      End:
98,741,743 bp from pter
Size:
116,686 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 97,981,091-98,097,765     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase SMURF1  
Size: 757 amino acids; 86114 Da
Subunit: Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and
TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Sequence caution: Sequence=BAB13451.1; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for SMURF1:
2LAZ (3D)        2LB0 (3D)        2LB1 (3D)        2LTX (3D)        3PYC (3D)    
Secondary accessions: A4D279 B7ZMB6 B9EGV3 O75853 Q547Q3 Q9UJT8
Alternative splicing: 2 isoforms:  Q9HCE7-1   Q9HCE7-2   

Explore the universe of human proteins at neXtProt for SMURF1: NX_Q9HCE7

Explore proteomics data for SMURF1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome.
    Lys-383 is the primary ubiquitination site
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCE7

  • 4/23 DME Specific Peptides for SMURF1 (Q9HCE7) (see all 23)
     PLPPGWE  GFKALQG  LQINPDS  NPYYGLF 

    SMURF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SMURF1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186776.1  NP_065162.1  NP_851994.1  

    ENSEMBL proteins: 
     ENSP00000355326   ENSP00000354621  
    Reactome Protein details: Q9HCE7
    Human Recombinant Protein Products for SMURF1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SMURF1
    OriGene Protein Over-expression Lysate for SMURF1
    OriGene MassSpec for SMURF1 
    OriGene Custom Protein Services for SMURF1
    GenScript Custom Purified and Recombinant Proteins Services for SMURF1
    Novus Biologicals SMURF1 Proteins
    Novus Biologicals SMURF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SMURF1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11278251
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA12151385

    SMURF1 for ontologies           About GeneDecksing



    SMURF1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SMURF1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SMURF1  (SMURF1 iso3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SMURF1
    GenScript Custom Superior Antibodies Services for SMURF1
    Novus Biologicals SMURF1 Antibodies
    Abcam antibodies for SMURF1
    Cloud-Clone Corp. Antibodies for SMURF1 
    ThermoFisher Antibody for SMURF1
    LSBio Antibodies in human, mouse, rat for SMURF1 

    Assay Products for SMURF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SMURF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SMURF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SMURF1 
    Cloud-Clone Corp. CLIAs for SMURF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR024928 E3_ub_ligase_SMURF1
     IPR018029 C2_membr_targeting
     IPR001202 WW_dom
     IPR000569 HECT

    Graphical View of Domain Structure for InterPro Entry Q9HCE7

    ProtoNet protein and cluster: Q9HCE7

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7
    Domain: The C2 domain mediates membrane localization and substrate selection
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 2 WW domains


    SMURF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMUF1_HUMAN, Q9HCE7
    Function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates
    ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway.
    Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA10458166
    GO:0005515protein binding IPI15231748
    GO:0048185activin binding NAS16720724
    GO:0070411I-SMAD binding IPI11278251
    GO:0070412R-SMAD binding IPI11278251
         
    SMURF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SMURF1:
     Increased cell death in HCT116  Increased cell number in G1, a 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Smurf1):
     embryogenesis  hearing/vestibular/ear  limbs/digits/tail  mortality/aging  nervous system 
     normal  skeleton 

    SMURF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SMURF1: Smurf1tm1Wran Smurf1tm1Yez

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SMURF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SMURF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMURF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMURF1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMURF1
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate SMURF1 (see all 117):
    hsa-miR-194* hsa-miR-411* hsa-miR-323-3p hsa-miR-140-5p hsa-miR-15a hsa-miR-106a hsa-miR-218-1* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSMURF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SMURF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMURF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SMURF1
    Sirion Biotech Customized adenovirus for overexpression of SMURF1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SMURF1 (see all 13)
    OriGene ORF clones in mouse, rat for SMURF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SMURF1 (NM_001199847)
    Sino Biological Human cDNA Clone for SMURF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMURF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMURF1
    Sirion Biotech Customized lentivirus for stable overexpression of SMURF1 
                         Customized lentivirus expression plasmids for stable overexpression of SMURF1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SMURF1
    Search LifeMap BioReagents cell lines for SMURF1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMURF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SMURF1 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    Signaling by BMP0.35
    BMP receptor signaling0.31
    BMP signalling and regulation0.35
    2Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    3TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.90
    TGF-beta receptor signaling activates SMADs0.90
    4Immune System
    Immune System0.56
    Adaptive Immune System0.56
    5Development TGF-beta receptor signaling
    Development TGF-beta receptor signaling0.96

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for SMURF1
        Common schema of ubiquitination
    Signal transduction Activin A signaling regulation
    Development TGF-beta receptor signaling

    1 R&D Systems Pathway for SMURF1
        TGF-beta Signaling Pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMURF1
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis
    Epithelial Tight Junctions

    2 Cell Signaling Technology (CST) Pathways for SMURF1
        TGF-beta/Smad Signaling
    Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for SMURF1
        Signal transduction Activin A signaling regulation
    Development TGF-beta receptor signaling

    5 BioSystems Pathways for SMURF1
        BMP signalling and regulation
    TGF-beta Receptor Signaling Pathway
    Signaling events mediated by HDAC Class I
    TGF-beta receptor signaling
    BMP receptor signaling

    1 Sino Biological Pathway for SMURF1 
        TGF-beta Signaling Pathway

    5/10        Reactome Pathways for SMURF1 (see all 10)
        TGF-beta receptor signaling activates SMADs
    Adaptive Immune System
    Signaling by TGF-beta Receptor Complex
    Antigen processing: Ubiquitination & Proteasome degradation
    Signal Transduction


    3         Kegg Pathways  (Kegg details for SMURF1):
        Ubiquitin mediated proteolysis
    Endocytosis
    TGF-beta signaling pathway

    UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7
    Pathway: Protein modification; protein ubiquitination


    SMURF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMURF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/175 Interacting proteins for SMURF1 (Q9HCE72, 3 ENSP000003546214) via UniProtKB, MINT, STRING, and/or I2D (see all 175)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615862, 3, ENSP000004001754MINT-56527 MINT-8187339 MINT-8187355 I2D: score=3 STRING: ENSP00000400175
    SMAD3P840222, 3, ENSP000003329734MINT-61699 I2D: score=5 STRING: ENSP00000332973
    SMAD2Q157962, 3, ENSP000002621604MINT-60919 I2D: score=3 STRING: ENSP00000262160
    SMAD5Q997172, 3MINT-61822 I2D: score=3 
    PSME3P612892, 3, ENSP000002933624MINT-7894494 MINT-7894481 MINT-7894523 MINT-7894558 MINT-7894543 I2D: score=2 STRING: ENSP00000293362
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19937093
    GO:0006611protein export from nucleus IDA11278251
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007398ectoderm development TAS10458166
    GO:0016567protein ubiquitination IDA11278251

    SMURF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMURF1 (SMUF1)

    4 HMDB Compounds for SMURF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about SMURF1 / SMUF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SMURF1 gene (3 alternative transcripts): 
    NM_001199847.1  NM_020429.2  NM_181349.2  

    Unigene Cluster for SMURF1:

    SMAD specific E3 ubiquitin protein ligase 1
    Hs.189329  [show with all ESTs]
    Unigene Representative Sequence: NM_020429
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361368 ENST00000361125(uc003upu.2 uc003upv.2 uc003upt.3)
    ENST00000480055 ENST00000472627
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMURF1
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate SMURF1 (see all 117):
    hsa-miR-194* hsa-miR-411* hsa-miR-323-3p hsa-miR-140-5p hsa-miR-15a hsa-miR-106a hsa-miR-218-1* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSMURF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SMURF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMURF1
    Clone
    Products:
         
    OriGene clones in human, mouse for SMURF1 (see all 13)
    OriGene ORF clones in mouse, rat for SMURF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SMURF1 (NM_001199847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMURF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMURF1
    Sirion Biotech Customized lentivirus for stable overexpression of SMURF1 
                         Customized lentivirus expression plasmids for stable overexpression of SMURF1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SMURF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMURF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMURF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMURF1

    Additional mRNA sequence: 

    AB046845.1 AF199364.2 AF464850.1 AK057024.1 AK126471.1 AL137424.1 AL833673.1 AL834242.1 
    AY007164.1 BC008574.1 BC136804.1 BC144414.1 BC152468.1 

    20 DOTS entries:

    DT.215004  DT.95376369  DT.95315267  DT.121118917  DT.95376368  DT.100024798  DT.100781112  DT.40230689 
    DT.95246758  DT.40130690  DT.86847075  DT.91750284  DT.92059059  DT.97791117  DT.121118766  DT.40130811 
    DT.70103168  DT.91680089  DT.91985165  DT.95254959 

    24/170 AceView cDNA sequences (see all 170):

    AA362022 AL044740 Z45577 H81876 AW369262 BU173732 AA587907 AW078809 
    BM846776 CB130302 CK819607 BM667855 F04432 AK057024 Z41035 BM129625 
    NM_020429 BQ684594 BM981719 NM_181349 AI658899 AA745586 AB046845 BQ433092 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SMURF1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
    SP1:        -                                                                                                                                       
    SP2:                                                                                                                                                
    SP3:                                                              -     -                                                                           
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for SMURF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMURF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SMURF1 Expression
    About this image


    See SMURF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMURF1

    SOURCE GeneReport for Unigene cluster: Hs.189329
        SABiosciences Expression via Pathway-Focused PCR Arrays including SMURF1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Tight Junctions in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SMURF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMURF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMURF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMURF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMURF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SMURF1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smurf11 , 5 SMAD specific E3 ubiquitin protein ligase 11, 5 88.24(n)1
    98.63(a)1
      5 (84.83 cM)5
    757881  NM_001038627.11  NP_001033716.11 
     1448764955 
    chicken
    (Gallus gallus)
    Aves SMURF11 SMAD specific E3 ubiquitin protein ligase 1 84(n)
    98.07(a)
      416487  XM_414794.3  XP_414794.2 
    lizard
    (Anolis carolinensis)
    Reptilia SMURF16
    SMAD specific E3 ubiquitin protein ligase 1
    96(a)
    1 ↔ 1
    GL343725.1(106637-135204)
    African clawed frog
    (Xenopus laevis)
    Amphibia Smurf12 E3 ubiquitin ligase SMURF1 77.93(n)    AF169310.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb30b122 Danio rerio cDNA clone MGC66401 IMAGE5915182, complete more 77.63(n)    BC059201.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lack3 TGFbeta receptor signaling pathway
    ubiquitin-protein more
    71(a)     --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSP56
    E3 ubiquitin ligase of the NEDD4 family; involved ...
    36(a)
    1 → many
    V(410189-412618)


    ENSEMBL Gene Tree for SMURF1 (if available)
    TreeFam Gene Tree for SMURF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMURF1 gene
    HERC12  NEDD4L2  HECW22  HERC22  HECTD32  WWP22  HECW12  SMURF22  
    HUWE12  NEDD42  WWP12  ITCH2  
    12 SIMAP similar genes for SMURF1 using alignment to 2 protein entries:     SMUF1_HUMAN (see all proteins):
    DKFZp564H223    SMURF2    HUWE1    HECW1    NEDL1    HECW2
    NEDD4    DKFZp564G092    NEDD4L    ITCH    WWP2    WWP1

    SMURF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2338 SNPs in SMURF1 are shown (see all 2338)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829365691,2
    --98624661(+) GTGGCA/GCAAGC 3 -- int10--------
    rs38371031,2
    C--98624801(-) TTTTT-/TATTTT 3 -- int11Minor allele frequency- T:0.00CSA 2
    rs20109531,2
    C,F,A,H--98624832(+) TAACCG/AGTGCG 3 -- int129Minor allele frequency- A:0.40NS EA NA WA CSA 2917
    rs10070071,2
    C,F,A,H--98624877(+) TTTCCC/TGATAG 3 -- int129Minor allele frequency- T:0.13NA EA NS WA CSA 3111
    rs1172117991,2
    F--98624980(+) TTCCTG/ACTGCC 3 -- int11Minor allele frequency- A:0.03EA 120
    rs1876366961,2
    --98625084(+) TTGCAC/TATGTA 3 -- ut310--------
    rs2009003071,2
    C--98625206(+) TTTGA-/TTTTTG 3 -- ut310--------
    rs613264841,2
    C--98625213(+) TTTGAC/AATAGA 3 -- ut312Minor allele frequency- A:0.03WA 120
    rs93731,2
    C--98625257(+) TGATAA/CAAACA 3 -- ut312Minor allele frequency- C:0.00MN NA 186
    rs1924046411,2
    --98625287(+) TAGCAA/GCAATA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SMURF1 (98625058 - 98741743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SMURF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2621233CNV Deletion19546169
    nsv366204CNV Loss16902084
    esv25445CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing SMURF1:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing SMURF1
    DNA2.0 Custom Variant and Variant Library Synthesis for SMURF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605568    OMIM disorders: --

    16 diseases for SMURF1:    About MalaCards
    cerebral cavernous malformations-2    wolfram syndrome    cavernous malformation    cerebral cavernous malformation
    scleroderma    wilms tumor    cerebritis    ulcerative colitis
    periodontitis    pancreatic cancer    pancreatitis    colorectal cancer
    lung cancer    endotheliitis    breast cancer    neuronitis


    SMURF1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SMURF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 14657501 (1), 19458200 (1)
    cancer 0 5 18927080 (2)

    Genetic Association Database (GAD): SMURF1
    Human Genome Epidemiology (HuGE) Navigator: SMURF1 (1 document)

    Export disorders for SMURF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMURF1 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with SMURF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. (PubMed id 10458166)1, 2, 3 Zhu H.... Thomsen G.H. (1999)
    2. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)1, 2 Cui Y.... Zhang L. (2011)
    3. Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection. (PubMed id 21402695)1, 2 Lu K....He F. (2011)
    4. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PubMed id 20228798)1, 4 Franke A....Vatn M.H. (2010)
    5. Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. (PubMed id 19937093)1, 2 Li S....Zhang L. (2010)
    6. Single nucleotide polymorphisms in the Wnt and BMP pa thways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (2010)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    9. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    10. Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. (PubMed id 18927080)1, 9 Fukunaga E....Imamura T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57154 HGNC: 16807 AceView: SMURF1 Ensembl:ENSG00000198742 euGenes: HUgn57154
    ECgene: SMURF1 Kegg: 57154 H-InvDB: SMURF1

    (According to HUGE)
    About This Section
    HUGE: KIAA1625

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMURF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SMURF1 gene:
    Search GeneIP for patents involving SMURF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SMURF1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SMURF1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SMURF1  
     OriGene MassSpec something-or-other for SMURF1   OriGene clones in human, mouse for SMURF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SMURF1   OriGene Purified Protein for SMURF1  
     OriGene ORF clones in mouse, rat for SMURF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SMURF1   OriGene Custom Protein Services for SMURF1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMURF1
     QIAGEN SeqTarget long-range PCR primers for resequencing SMURF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMURF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMURF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMURF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMURF1
     GenScript Custom Purified and Recombinant Proteins Services for SMURF1 GenScript cDNA clones with any tag delivered in your preferred vector for SMURF1
     GenScript Custom Assay Services for SMURF1 GenScript Custom Superior Antibodies Services for SMURF1
     GenScript Custom overexpressing Cell Line Services for SMURF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SMURF1 
    (SMURF1 iso3)

     Regulatory tfbs in SMURF1 promoter
     Search Chromatin IP Primers for SMURF1
     RT2 qPCR Primer Assay in human, mouse, rat SMURF1
     GNC Network for SMURF1
     SABiosciences PCR Arrays including human, mouse, rat SMURF1
     Search Tocris compounds for SMURF1 (SMUF1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SMURF1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SMURF1 antibodies
     SMURF1 proteins
     SMURF1 lysates
     Antibodies for SMURF1
     See all of Abcam's Antibodies, Kits and Proteins for SMURF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SMURF1
     Antibodies for SMURF1
     ELISAs for SMURF1
     CLIAs for SMURF1
     Search LifeMap BioReagents cell lines for SMURF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMURF1
     SwitchGear 3'UTR luciferase reporter plasmids for SMURF1
     SwitchGear Promoter luciferase reporter plasmids for SMURF1
     ThermoFisher Antibody for SMURF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMURF1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SMURF1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SMURF1
    Customized:
     lentivirus for stable overexpression of SMURF1
     lentivirus expression plasmids for stable overexpression of SMURF1
     adenovirus for overexpression of SMURF1
     LSBio Antibodies in human, mouse, rat for SMURF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SMURF1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4