SMURF1 Gene
protein-coding GIFtS: 64
GCID: GC07M098627
|
|
SMAD specific E3 ubiquitin protein ligase 1
| |
Aliases
for SMURF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SMAD Specific E3 Ubiquitin Protein Ligase 11 2 | | E3 Ubiquitin Ligase SMURF12 | | KIAA16251 3 | | E3 Ubiquitin-Protein Ligase SMURF12 | | SMAD Ubiquitination Regulatory Factor 12 3 | | Smad-Specific E3 Ubiquitin Ligase 12 | | HSMURF11 | | EC 6.3.2.-3 | | SMAD-Specific E3 Ubiquitin-Protein Ligase 12 3 | | EC 6.3.28 |
Export aliases for SMURF1 gene to outside databasesPrevious GC identifers: GC07M097159 GC07M098222 GC07M098236 GC07M098269 GC07M098463 GC07M093257 |
Summaries
for SMURF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SMURF1:
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogeneticprotein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cellpolarity. Alternative splicing results in multiple transcript variants encoding different isoforms.(provided byRefSeq, Dec 2010)
UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7Function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediatesubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotesubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA
Gene Wiki entry for SMURF1
|
Genomic Views
for SMURF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMURF1 gene promoter:
STAT1 AML1a Pax-5 ATF-2 STAT1beta Evi-1 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMURF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMURF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.1-q31.1SMURF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M098627: view genomic region
(about GC identifiers)
Start:
|
98,625,061 bp from pter |
End:
|
98,741,723 bp from pter |
Size:
|
116,663 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 97,981,097-98,097,745 |
|
Proteins
for SMURF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase SMURF1 Size: 757 amino acids; 86114 Da
Subunit: Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 andTGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Sequence caution: Sequence=BAB13451.1; Type=Erroneous initiation;
5 PDB 3D structures from  and Proteopedia  for SMURF1:2LAZ (3D)
2LB0 (3D)
2LB1 (3D)
2LTX (3D)
3PYC (3D)
Secondary accessions: A4D279 B7ZMB6 B9EGV3 O75853 Q547Q3 Q9UJT8Alternative splicing: 2 isoforms: Q9HCE7-1 Q9HCE7-2 Explore the universe of human proteins at neXtProt for SMURF1: NX_Q9HCE7
Post-translational modifications:
Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383is the primary ubiquitination site1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCE7
4/23 DME Specific Peptides for SMURF1 (Q9HCE7) (see all 23)
SMURF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186776.1 NP_065162.1 NP_851994.1
ENSEMBL proteins: ENSP00000355326 ENSP00000354621 Reactome Protein details: Q9HCE7
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
SMURF1 for ontologies About GeneDecksing
SMURF1 Antibody Products:
Assay Products for SMURF1: |
Protein
Domains /
Families
for SMURF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMURF1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9HCE7ProtoNet protein and cluster: Q9HCE7 2 Blocks protein families: IPB000008 C2 domain IPB000569 HECT domain (Ubiquitin-protein ligase)
UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7Domain: The C2 domain mediates membrane localization and substrate selectionSimilarity: Contains 1 C2 domainSimilarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domainSimilarity: Contains 2 WW domains |
Function
for SMURF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7Function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediatesubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotesubiquitination and subsequent proteasomal degradation of TRAF family members and RHOAEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMURF1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMURF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SMURF1 (NM_001199847) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMURF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMURF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMURF1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SMURF1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SMURF1:
Animal Models:
Mouse knock-outs for SMURF1: Smurf1tm1Wran Smurf1tm1Yez
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Smurf1):
SMURF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SMURF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Signaling by BMP | | | 3 | Development_TGF-beta receptor signaling | | | 4 | Immune System | | | 5 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for SMURF1
1  R&D Systems Pathway for SMURF1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMURF1
2 
Cell Signaling Technology (CST) Pathways for SMURF1
2  GeneGo (Thomson Reuters) Pathways for SMURF1
5  BioSystems Pathways for SMURF1
5/13 
Reactome Pathways for SMURF1 (see all 13)
3 
Kegg Pathways (Kegg details for SMURF1):
UniProtKB/Swiss-Prot: SMUF1_HUMAN, Q9HCE7Pathway: Protein modification; protein ubiquitination
SMURF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMURF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/174 Interacting proteins for SMURF1 (Q9HCE72, 3 ENSP000003546214) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
SMURF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMURF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMURF1
4 HMDB Compounds for SMURF1 About this table
Search CenterWatch for drugs/clinical trials and news about SMURF1 / SMUF1
|
Transcripts
for SMURF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMURF1 gene (3 alternative transcripts): NM_001199847.1 NM_020429.2 NM_181349.2 Unigene Cluster for SMURF1: SMAD specific E3 ubiquitin protein ligase 1 Hs.189329 [show with all ESTs]Unigene Representative Sequence: NM_0204294 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361368 ENST00000361125(uc003upu.2 uc003upv.2 uc003upt.3)
ENST00000480055 ENST00000472627
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMURF1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMURF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SMURF1 (NM_001199847) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMURF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMURF1 |
Additional cDNA sequence: AB046845.1 AF199364.2 AF464850.1 AK057024.1 AK126471.1 AL137424.1 AL833673.1 AL834242.1 AY007164.1 BC008574.1 BC136804.1 BC144414.1 BC152468.1 20 DOTS entries: DT.215004 DT.95376369 DT.95315267 DT.121118917 DT.95376368 DT.100024798 DT.100781112 DT.40230689 DT.95246758 DT.40130690 DT.86847075 DT.91750284 DT.92059059 DT.97791117 DT.121118766 DT.40130811 DT.70103168 DT.91680089 DT.91985165 DT.95254959 24/170 AceView cDNA sequences (see all 170): AL833673 R47213 AI740575 BQ684864 AF464850 CK819607 F03673 BM667855 F04432 AA587907 AW078809 AW006036 BU173732 BG289217 AW369262 CB130302 Z45577 AL044740 AA362022 BX096429 AI830495 BQ684421 BU185077 H81876
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SMURF1 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMURF1
|
Expression
for SMURF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMURF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SMURF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMURF1
SOURCE GeneReport for Unigene cluster: Hs.189329
SABiosciences Expression via Pathway-Focused PCR Arrays including SMURF1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMURF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMURF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMURF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMURF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMURF1 |
Orthologs
for SMURF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SMURF1 gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SMURF11 |
SMAD specific E3 ubiquitin protein ligase 1 |
84(n)
98.07(a) |
|
416487 XM_414794.3 XP_414794.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SMURF16 |
-- |
93(a) |
1 ↔ 1 |
GL343725.1(106637-119703) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Smurf12 |
E3 ubiquitin ligase SMURF1 |
77.93(n) |
|
AF169310.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb30b122 |
Danio rerio cDNA clone MGC66401 IMAGE5915182, complete more |
77.63(n) |
|
BC059201.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
lack3 |
TGFbeta receptor signaling pathway
ubiquitin-protein more |
71(a) |
|
-- |
ENSEMBL Gene Tree for SMURF1 (if available)
TreeFam Gene Tree for SMURF1 (if available) |
Paralogs
for SMURF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SMURF1 gene
- NEDD4L2 HECW22 HACE12 WWP22 KIAA03172 SMURF22 HECW12 ITCH2
- NEDD42 WWP12
12 SIMAP similar genes for SMURF1 using alignment to 2 protein entries: SMUF1_HUMAN (see all proteins):DKFZp564H223 SMURF2 HUWE1 HECW1 NEDL1 HECW2
NEDD4 WWP2 DKFZp564G092 NEDD4L ITCH WWP1
SMURF1 for paralogs About GeneDecksing
|
Genomic Variants
for SMURF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMURF1 (98625061 - 98741723 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SMURF1
2 CNVs: 100049 70008 | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing SMURF1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMURF1 |
|
Disorders
/ Diseases
for SMURF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMURF1 for disorders About GeneDecksing
OMIM gene information: 605568
OMIM disorders: --
15  diseases for SMURF1: About MalaCardscerebral cavernous malformations-2 cerebral cavernous malformations cavernous malformation wolfram syndrome
ulcerative colitis wilms tumor cerebritis scleroderma
pancreatic cancer colorectal cancer lung cancer breast cancer
pancreatitis malaria neuronitis
2 Novoseek disease relationships for SMURF1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
2 |
14657501 (1), 19458200 (1) |
| cancer |
0 |
5 |
18927080 (2) |
Human Genome Epidemiology (HuGE) Navigator: SMURF1 (1 document)
Export disorders for SMURF1 gene to outside databases
|
Publications
for SMURF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMURF1 gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with SMURF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. (PubMed id 10458166)1, 2, 3 Zhu H.... Thomsen G.H. (1999)
- Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection. (PubMed id 21402695)1, 2 Lu K....He F. (2011)
- Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. (PubMed id 19937093)1, 2 Li S....Zhang L. (2010)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. (PubMed id 18927080)1, 9 Fukunaga E....Imamura T. (2008)
- Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. (PubMed id 12519765)1, 9 Tajima Y....Imamura T. (2003)
- Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. (PubMed id 16299379)1, 9 Shen R....Chen D. (2006)
- Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. (PubMed id 12151385)1, 9 Suzuki C....Miyazono K. (2002)
|
External Searches for SMURF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SMURF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMURF1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SMURF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SMURF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SMURF1 gene:
Search GeneIP for patents involving SMURF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SMURF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SMURF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMURF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMURF1 | | | OriGene Protein Over-expression Lysate for SMURF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMURF1 | | OriGene 3'-UTR Clone for SMURF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMURF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMURF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SMURF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SMURF1 | | OriGene Custom Protein Services for SMURF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMURF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMURF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMURF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMURF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMURF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMURF1 |
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| | Antibodies & Assays for SMURF1
(SMURF1 iso3) |
| | | | Search Tocris compounds for SMURF1 |
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 | | | SMURF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMURF1 |
|  |  |  | | | | ThermoFisher Antibody for SMURF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMURF1 |
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