Aliases for SMURF1 Gene
External Ids for SMURF1 Gene
Previous GeneCards Identifiers for SMURF1 Gene
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
GeneCards Summary for SMURF1 Gene
SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with SMURF1 include Wolfram Syndrome and Colonic Benign Neoplasm. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Innate Immune System. GO annotations related to this gene include ligase activity and phospholipid binding. An important paralog of this gene is SMURF2.
UniProtKB/Swiss-Prot for SMURF1 Gene
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).