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Aliases for SMURF1 Gene

Aliases for SMURF1 Gene

  • SMAD Specific E3 Ubiquitin Protein Ligase 1 2 3
  • SMAD-Specific E3 Ubiquitin-Protein Ligase 1 3 4
  • HSMURF1 3 4
  • Smad Ubiquitination Regulatory Factor 1 3
  • SMAD Ubiquitination Regulatory Factor 1 4
  • Smad-Specific E3 Ubiquitin Ligase 1 3
  • E3 Ubiquitin-Protein Ligase SMURF1 3
  • E3 Ubiquitin Ligase SMURF1 3
  • EC 6.3.2.- 4
  • KIAA1625 4
  • EC 6.3.2 64

External Ids for SMURF1 Gene

Summaries for SMURF1 Gene

Entrez Gene Summary for SMURF1 Gene

  • This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

GeneCards Summary for SMURF1 Gene

SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin-protein transferase activity and activin binding. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for SMURF1 Gene

  • E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.

Gene Wiki entry for SMURF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMURF1 Gene

Genomics for SMURF1 Gene

Genomic Location for SMURF1 Gene

99,027,435 bp from pter
99,144,120 bp from pter
116,686 bases
Minus strand

Genomic View for SMURF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMURF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMURF1 Gene

Regulatory Elements for SMURF1 Gene

Proteins for SMURF1 Gene

  • Protein details for SMURF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase SMURF1
    Protein Accession:
    Secondary Accessions:
    • A4D279
    • B7ZMB6
    • B9EGV3
    • O75853
    • Q547Q3
    • Q9UJT8

    Protein attributes for SMURF1 Gene

    757 amino acids
    Molecular mass:
    86114 Da
    Quaternary structure:
    • Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation.
    • Sequence=BAB13451.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SMURF1 Gene

    Alternative splice isoforms for SMURF1 Gene


neXtProt entry for SMURF1 Gene

Proteomics data for SMURF1 Gene at MOPED

Post-translational modifications for SMURF1 Gene

  • Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys381 and Lys383

Other Protein References for SMURF1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SMURF1 Gene

Protein Domains for SMURF1 Gene


  • The C2 domain mediates membrane localization and substrate selection.:
    • Q9HCE7
  • Contains 1 C2 domain.:
    • Q9HCE7
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.:
    • Q9HCE7
  • Contains 2 WW domains.:
    • Q9HCE7
genes like me logo Genes that share domains with SMURF1: view

No data available for Gene Families for SMURF1 Gene

Function for SMURF1 Gene

Molecular function for SMURF1 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.

Enzyme Numbers (IUBMB) for SMURF1 Gene

Gene Ontology (GO) - Molecular Function for SMURF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 10458166
GO:0005515 protein binding IPI 15231748
GO:0005543 phospholipid binding TAS 22020285
GO:0016874 ligase activity IEA --
GO:0048185 activin binding NAS 16720724
genes like me logo Genes that share ontologies with SMURF1: view
genes like me logo Genes that share phenotypes with SMURF1: view

Animal Models for SMURF1 Gene

MGI Knock Outs for SMURF1:

miRNA for SMURF1 Gene

miRTarBase miRNAs that target SMURF1

No data available for Transcription Factor Targeting and HOMER Transcription for SMURF1 Gene

Localization for SMURF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMURF1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for SMURF1 Gene COMPARTMENTS Subcellular localization image for SMURF1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 4
mitochondrion 3
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SMURF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11278251
GO:0005739 colocalizes_with mitochondrion IGI 22020285
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SMURF1: view

Pathways for SMURF1 Gene

genes like me logo Genes that share pathways with SMURF1: view

UniProtKB/Swiss-Prot Q9HCE7-SMUF1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SMURF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19937093
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006611 protein export from nucleus IDA 11278251
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007398 ectoderm development TAS 10458166
genes like me logo Genes that share ontologies with SMURF1: view

Compounds for SMURF1 Gene

(4) HMDB Compounds for SMURF1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with SMURF1: view

Transcripts for SMURF1 Gene

Unigene Clusters for SMURF1 Gene

SMAD specific E3 ubiquitin protein ligase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMURF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP3: - -
SP6: - -
SP7: -

Relevant External Links for SMURF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMURF1 Gene

mRNA expression in normal human tissues for SMURF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMURF1 Gene

SOURCE GeneReport for Unigene cluster for SMURF1 Gene Hs.189329

genes like me logo Genes that share expressions with SMURF1: view

Orthologs for SMURF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMURF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMURF1 36
  • 99.21 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SMURF1 36
  • 88.73 (n)
  • 98.15 (a)
  • 91 (a)
(Canis familiaris)
Mammalia SMURF1 36
  • 89.48 (n)
  • 99.15 (a)
  • 96 (a)
(Mus musculus)
Mammalia Smurf1 36
  • 88.24 (n)
  • 98.63 (a)
Smurf1 16
Smurf1 37
  • 99 (a)
(Monodelphis domestica)
Mammalia SMURF1 37
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia SMURF1 37
  • 92 (a)
(Rattus norvegicus)
Mammalia Smurf1 36
  • 88.92 (n)
  • 98.76 (a)
(Gallus gallus)
Aves SMURF1 36
  • 84.06 (n)
  • 98.08 (a)
  • 96 (a)
(Anolis carolinensis)
Reptilia SMURF1 37
  • 96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Smurf1 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491582 36
  • 78.72 (n)
  • 90.96 (a)
(Danio rerio)
Actinopterygii smurf1 36
  • 77.96 (n)
  • 92.18 (a)
smurf1 37
  • 92 (a)
wufb30b12 36
fruit fly
(Drosophila melanogaster)
Insecta lack 37
  • 42 (a)
lack 38
  • 71 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8479 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8773 37
  • 63 (a)
Species with no ortholog for SMURF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMURF1 Gene

Gene Tree for SMURF1 (if available)
Gene Tree for SMURF1 (if available)

Paralogs for SMURF1 Gene

Paralogs for SMURF1 Gene

Selected SIMAP similar genes for SMURF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMURF1: view

Variants for SMURF1 Gene

Sequence variations from dbSNP and Humsavar for SMURF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3294 -- 99,050,742(+) ATAGT(C/G)TTGGA intron-variant
rs219797 -- 99,052,428(+) GGCCC(A/C/G/T)GAGTC synonymous-codon, reference
rs219798 -- 99,052,476(+) CATGG(C/T)GTCAC intron-variant
rs219799 -- 99,055,915(+) gagct(A/G)agatc intron-variant
rs219826 -- 99,049,516(+) GCATT(C/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMURF1 Gene

Variant ID Type Subtype PubMed ID
nsv366204 CNV Loss 16902084
esv2621233 CNV Deletion 19546169
esv25445 CNV Gain 19812545

Relevant External Links for SMURF1 Gene

HapMap Linkage Disequilibrium report

Disorders for SMURF1 Gene

(2) Novoseek inferred disease relationships for SMURF1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
cancer 0 2

Relevant External Links for SMURF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SMURF1: view

No data available for UniProtKB/Swiss-Prot for SMURF1 Gene

Publications for SMURF1 Gene

  1. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. (PMID: 10458166) Zhu H. … Thomsen G.H. (Nature 1999) 2 3 4
  2. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. (PMID: 15761148) Ozdamar B. … Wrana J.L. (Science 2005) 3 23
  3. Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. (PMID: 15817471) MorAcn A. … Moustakas A. (J. Biol. Chem. 2005) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. (PMID: 19937093) Li S. … Zhang L. (Mol. Cell. Biochem. 2010) 3 4

Products for SMURF1 Gene

Sources for SMURF1 Gene

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