SMUG1 Gene
protein-coding GIFtS: 56
GCID: GC12M054575
|
|
single-strand-selective monofunctional uracil-DNA glycosylase...
| |
Aliases
for SMUG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 11 2 | | Single-Strand Selective Monofunctional Uracil DNA Glycosylase2 | | FDG1 2 | | EC 3.2.2.-3 | | HMUDG1 2 | | EC 3.2.28 | | UNG31 2 | | |
Export aliases for SMUG1 gene to outside databasesPrevious GC identifers: GC12P054236 GC12M054687 GC12M054290 GC12M052862 GC12M052863 GC12M052864 GC12M051612 |
Summaries
for SMUG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SMUG1:
This gene encodes a protein that participates in base excision repair by removing uracil from single- anddouble-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature isknown for some but not all of the variants. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: SMUG1_HUMAN, Q53HV7Function: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as amonofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNAsubstrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U),5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. Thegeneral order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at thelow salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA
Gene Wiki entry for SMUG1
|
Genomic Views
for SMUG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMUG1 gene promoter:
c-Fos NF-1 NF-1/L AP-1 p53 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMUG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMUG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.11-q13.3 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.11-q13.3SMUG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M054575: view genomic region
(about GC identifiers)
Start:
|
54,558,529 bp from pter |
End:
|
54,582,778 bp from pter |
Size:
|
24,250 bases |
Orientation:
|
minus strand |
|
Proteins
for SMUG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMUG1_HUMAN, Q53HV7 (See
protein sequence)Recommended Name: Single-strand selective monofunctional uracil DNA glycosylase Size: 270 amino acids; 29862 Da
Subcellular location: Nucleus
Secondary accessions: A8K2K9 O95862 Q0D2M0 Q8NB71 Q9BWC8Alternative splicing: 2 isoforms: Q53HV7-1 Q53HV7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SMUG1: NX_Q53HV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53HV7
4/5 DME Specific Peptides for SMUG1 (Q53HV7) (see all 5)
SMUG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001230716.1 NP_001230717.1 NP_001230718.1 NP_001230719.1 NP_001230720.1 NP_055126.1
ENSEMBL proteins: ENSP00000426440 ENSP00000421206 ENSP00000421139 ENSP00000421894 ENSP00000338606 ENSP00000424191 ENSP00000423629 ENSP00000243112 ENSP00000384828 ENSP00000425974 ENSP00000423083 ENSP00000423457 ENSP00000426278 ENSP00000421790 ENSP00000427547 ENSP00000425426 Reactome Protein details: Q53HV7
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SMUG1 for ontologies About GeneDecksing
SMUG1 Antibody Products:
Assay Products for SMUG1: |
Protein
Domains /
Families
for SMUG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMUG1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q53HV7ProtoNet protein and cluster: Q53HV7 1 Blocks protein family: IPB005122 Uracil-DNA glycosylase superfamily
|
Function
for SMUG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SMUG1_HUMAN, Q53HV7Function: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as amonofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNAsubstrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U),5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. Thegeneral order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at thelow salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNAEnzyme Numbers (IUBMB): EC 3.2.22 EC 3.2.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMUG1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMUG1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SMUG1 (NM_014311) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMUG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMUG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMUG1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SMUG1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SMUG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Base-Excision Repair, AP Site Formation | | | 2 | Resolution of Abasic Sites (AP sites) | | | 3 | Fluoropyrimidine Activity | | | 4 | Nucleotide Excision Repair | | | 5 | Chks in Checkpoint Regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SMUG1
1  BioSystems Pathway for SMUG1
5/12 
Reactome Pathways for SMUG1 (see all 12)
1  PharmGKB Pathway for SMUG1
1 
Kegg Pathway (Kegg details for SMUG1):
SMUG1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMUG1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for SMUG1 (Q53HV71, 3 ENSP000003386064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SMUG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMUG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SMUG1 for compounds About GeneDecksing
 Browse Tocris compounds for SMUG1
6 Novoseek chemical compound relationships for SMUG1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SMUG1
|
Transcripts
for SMUG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMUG1 gene (6 alternative transcripts): NM_001243787.1 NM_001243788.1 NM_001243789.1 NM_001243790.1 NM_001243791.1 NM_014311.2 Unigene Clusters for SMUG1: Single-strand-selective monofunctional uracil-DNA glycosylase 1 Hs.632721 [show with all ESTs], Hs.731659 [show with all ESTs]Unigene Representative Sequences: AK091468, NM_01431118/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000509864 ENST00000511854 ENST00000506595 ENST00000514685(uc001sfb.4)
ENST00000505128(uc021qyn.1 uc001sfe.2) ENST00000337581(uc001sfg.2 uc001sff.2)
ENST00000508394(uc009znf.2 uc001sfd.4) ENST00000513838(uc001sfc.4)
ENST00000243112 ENST00000505662 ENST00000401977 ENST00000514196 ENST00000511522
ENST00000504338 ENST00000509078 ENST00000507904 ENST00000503447 ENST00000504797
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMUG1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMUG1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SMUG1 (NM_014311) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMUG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMUG1 |
Additional cDNA sequence: AF125182.1 AK001235.1 AK001789.1 AK222473.1 AK290274.1 BC000417.2 BC088352.1 BC105607.1 NR_045039.1 19 DOTS entries: DT.97843066 DT.447493 DT.100799789 DT.91765937 DT.91765932 DT.95324538 DT.100799787 DT.97843065 DT.100799784 DT.100799782 DT.91765933 DT.95277788 DT.95277795 DT.100688433 DT.100799786 DT.121145711 DT.95309958 DT.102830322 DT.91765938 24/188 AceView cDNA sequences (see all 188): BE222680 AA337554 AI286191 AL543196 AA247823 BM751457 T31349 NM_014311 F07519 AU124270 AI421211 BU190546 CR595676 CR609554 BM459018 BQ959462 BE277425 CD245413 BE048761 Z42793 Z38938 BE858784 AA456610 BE256109
GeneLoc Exon Structure
5/27 Alternative Splicing Database (ASD) splice patterns (SP) for SMUG1 (see all 27) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | |
| ExUns: | 9c | · | 9d | · | 9e | · | 9f | · | 9g | · | 9h | · | 9i | · | 9j | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMUG1
|
Expression
for SMUG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMUG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTAAGAG
About this image
See SMUG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMUG1
SOURCE GeneReport for Unigene clusters: Hs.632721 Hs.731659
SABiosciences Expression via Pathway-Focused PCR Array including SMUG1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMUG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMUG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMUG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMUG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMUG1 |
Orthologs
for SMUG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SMUG1 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Smug11 , 5 |
single-strand selective monofunctional uracil DNA glycosylase1, 5 |
85.84(n)1
90.23(a)1 |
|
15 (58.20 cM)5
717261 NM_027885.31 NP_082161.21
1031533075 |
chicken
(Gallus gallus) |
Aves |
SMUG11 |
single-strand-selective monofunctional uracil-DNA glycosylase more |
66.67(n)
67.49(a) |
|
431025 XM_428577.3 XP_428577.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SMUG16 |
-- |
66(a) |
1 ↔ 1 |
2(71543661-71547058) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.336982 |
Xenopus laevis single-strand selective monofunctional more |
78.9(n) |
|
AF125181.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5709011 |
similar to single-strand selective monofunctional uracil more |
63.37(n)
63.79(a) |
|
570901 XM_694432.5 XP_699524.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG52851 , 3 |
single-strand selective uracil DNA
N-glycosylase3
CG52851 |
43(a)3
49.72(n)1
43.16(a)1 |
|
89F13
420781 NM_142352.21 NP_650609.11 |
ENSEMBL Gene Tree for SMUG1 (if available)
TreeFam Gene Tree for SMUG1 (if available) |
Paralogs
for SMUG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SMUG1 gene
SMUG1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SMUG1
PGOHUM00000235055
|
Genomic Variants
for SMUG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMUG1 (54558529 - 54582778 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMUG1: --
Human Gene Mutation Database (HGMD): SMUG1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMUG1 |
|
Disorders
/ Diseases
for SMUG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMUG1 for disorders About GeneDecksing
OMIM gene information: 607753
OMIM disorders: --
20/21  diseases for SMUG1 (see all 21): About MalaCardsgraft versus host disease malignant pleural mesothelioma lymphatic system disease aphasia
familial colorectal cancer osteomyelitis colorectal cancer multiple sclerosis
brain disease sarcoidosis hepatocellular carcinoma esophageal cancer
thyroid cancer dementia meningioma breast cancer
esophagitis tuberculosis immunodeficiency thyroiditis
19 diseases from the University of Copenhagen DISEASES database for SMUG1:Lung cancer Lymphoma Carcinoma Thyroid cancer
Breast cancer Esophageal cancer Malignant glioma Cervical cancer
Heart disease Brain disease Colorectal cancer Melanoma
Sarcoidosis Alzheimer's disease Osteomyelitis Sarcoma
Vascular disease Pancreatic cancer Ovarian cancer Human Genome Epidemiology (HuGE) Navigator: SMUG1 (6 documents)
Export disorders for SMUG1 gene to outside databases
|
Publications
for SMUG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMUG1 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with SMUG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors. (PubMed id 10074426)1, 2, 3, 9 Haushalter K.A.... Verdine G.L. (1999)
- Definitive identification of mammalian 5-hydroxymethyluracil DNA N- glycosylase activity as SMUG1. (PubMed id 11526119)1, 2, 3 Boorstein R.J.... Teebor G.W. (2001)
- Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions. (PubMed id 12718543)1, 2, 9 Masaoka A.... Ide H. (2003)
- Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. (PubMed id 15466595)1, 2, 9 Matsubara M....Ide H. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. (PubMed id 12161446)1, 2 Kavli B.... Slupphaug G. (2002)
- Insights from xanthine and uracil DNA glycosylase activities of bacterial and human SMUG1: switching SMUG1 to UDG. (PubMed id 18835277)1, 9 Mi R....Cao W. (2009)
- Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. (PubMed id 17537817)1, 9 Pettersen H.S....Kavli B. (2007)
- Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. (PubMed id 19403629)1, 9 Chanson A....Mason J.B. (2009)
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External Searches for SMUG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SMUG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SMUG1 gene
(According to HUGE)
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Specialized Databases showing SMUG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SMUG1 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/smug1/ |
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About This Section
| Patent Information for SMUG1 gene:
Search GeneIP for patents involving SMUG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SMUG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for SMUG1 | | OriGene shRNA RFP for SMUG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMUG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMUG1 | | | OriGene Protein Over-expression Lysate for SMUG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMUG1 | | OriGene 3'-UTR Clone for SMUG1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMUG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMUG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SMUG1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SMUG1 | | OriGene Custom Protein Services for SMUG1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMUG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMUG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMUG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMUG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMUG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMUG1 |
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| | | | Search Tocris compounds for SMUG1 |
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 | | | SMUG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMUG1 |
|  |  |  | | | | ThermoFisher Antibodies for SMUG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMUG1 |
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