SMU1 Gene
protein-coding GIFtS : 50
GCID: GC09 M033041
smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
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Aliasesfor SMU1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Smu-1 Suppressor Of Mec-8 And Unc-52 Homolog (C. Elegans) 1 2 FLJ108051 BWD1 2 RP11-54K16.32 SMU-11 2 Brain-Enriched WD-Repeat Protein2 FSAP571 Functional Spliceosome-Associated Protein 572 Smu-1 Suppressor Of Mec-8 And Unc-52 Protein Homolog2 3 WD40 Repeat-Containing Protein SMU12
Export aliases for SMU1 gene to outside databases Previous GC identifers: GC09M033038 GC09M033039 GC09M033000
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Summariesfor SMU1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for SMU1
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Genomic Viewsfor SMU1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008413.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SMU1 gene promoter: Elk-1 AML1a XBP-1 LCR-F1 USF-1 COMP1 FOXO4 Zic1 IRF-7A ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for SMU1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SMU1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9p12 Ensembl cytogenetic band: 9p21.1 HGNC cytogenetic band: 9p12 SMU1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M033041: view genomic region
(about GC identifiers )
Start:
33,041,762 bp from pter
End:
33,076,714 bp from pter
Size:
34,953 bases
Orientation:
minus strand
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Proteinsfor SMU1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SMU1_HUMAN, Q2TAY7 (See
protein sequence )Recommended Name: WD40 repeat-containing protein SMU1 Size : 513 amino acids; 57544 Da
Subcellular location : Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions : Q9BU59 Q9HA96 Q9NVD1Explore the universe of human proteins at neXtProt for SMU1: NX_Q2TAY7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q2TAY7 SMU1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060695.2 ENSEMBL proteins: ENSP00000380336 ENSP00000443639 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
SMU1 for ontologies About GeneDecksing SMU1 Antibody Products: Assay Products for SMU1:
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Protein
Domains / Familiesfor SMU1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SMU1 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q2TAY7 ProtoNet protein and cluster: Q2TAY7
2 Blocks protein families : IPB006594 Lissencephaly type-1-like homology motif IPB006595 CTLH UniProtKB/Swiss-Prot: SMU1_HUMAN, Q2TAY7 Similarity : Belongs to the WD repeat SMU1 familySimilarity : Contains 1 CTLH domainSimilarity : Contains 1 LisH domainSimilarity : Contains 6 WD repeats
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Functionfor SMU1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMU1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMU1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SMU1 (NM_018225 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMU1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMU1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMU1
10 GenomeRNAi human phenotypes for SMU1 :
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Pathways & Interactionsfor SMU1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMU1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)5/22 Interacting proteins for SMU1 (Q2TAY7 2 , 3 ENSP00000380336 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 22 )About this table
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Drugs & Compoundsfor SMU1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SMU1 Search CenterWatch for drugs/clinical trials and news about SMU1
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Transcriptsfor SMU1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SMU1 gene: NM_018225.2 Unigene Cluster for SMU1:
Smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) Hs.655351 [show with all ESTs ] Unigene Representative Sequence: NM_018225 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000397149 (uc003zsf.1 uc011lnu.1 ) ENST00000536631 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMU1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMU1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SMU1 (NM_018225 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMU1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMU1
Additional cDNA sequence: AK001667.1 AK001732.1 AK022032.1 AK225559.1 AK225587.1 AK304767.1 AL512690.1 BC002876.2 BC110654.1 EF011613.1
9 DOTS entries : DT.210659 DT.97791059
DT.92432544 DT.100645609 DT.95302517 DT.121172181 DT.100806369 DT.121379223 DT.40129659 24/608 AceView cDNA sequences (see all 608 ):
T54764 H43230 AU133267 BU072057 BU184731 BQ356499 CR595641 CR605922 BF115891 H65818 AA055900 BF116182 BU676424 BG939277 AI379343 BX093840 AA419607 BM971747 CA396269 CA444682 BU076050 CB241604 AW575684 AU133137 GeneLoc Exon Structure
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Expression for SMU1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SMU1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCCGGCCCAT
About this image SMU1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Metanephros Kidney Reproductive System Mesonephros Reproductive System Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SMU1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SMU1 SOURCE GeneReport for Unigene cluster: Hs.655351 SABiosciences Custom PCR Arrays for SMU1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SMU1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SMU1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SMU1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SMU1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMU1
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Orthologsfor SMU1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMU1 gene from 9/34 species (see all 34 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Smu11 , 5
smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)1, 5
91.36(n) 1 100(a) 1
 
4 (20.46 cM) 5 74255 1 NM_021535.4 1 NP_067510.3 1 40736542 5
chicken (Gallus gallus)
Aves
SMU11
smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
83.95(n) 99.61(a)
 
427377 NM_001007979.1 NP_001007980.1
lizard (Anolis carolinensis)
Reptilia
SMU16
--
99(a)
1 ↔ 1
GL343257.1(110035-124101)
African clawed frog (Xenopus laevis)
Amphibia
Xl.77092
Xenopus laevis transcribed sequence with moderate similarity more
81.39(n)
 
BU910616.1
zebrafish (Danio rerio)
Actinopterygii
zgc561472
hypothetical protein MGC56147
80.61(n)
 
393168 BC045945.1
fruit fly (Drosophila melanogaster)
Insecta
CG54511
CG5451
68.24(n) 78.59(a)
 
42272 NM_142509.4 NP_650766.1
worm (Caenorhabditis elegans)
Secernentea
smu-11
Protein SMU-1
59.34(n) 62.77(a)
 
173175 NM_060878.4 NP_493279.1
thale cress (Arabidopsis thaliana)
eudicotyledons
SMU11
WD40 repeat-containing protein SMU1
63.08(n) 64.97(a)
 
843707 NM_106031.3 NP_177513.2
rice (Oryza sativa)
Liliopsida
Os.11132
Oryza sativa (japonica cultivar-group) P0426D06.17 more
70.67(n)
 
AK121409.1
ENSEMBL Gene Tree for SMU1 (if available)TreeFam Gene Tree for SMU1 (if available)
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Paralogsfor SMU1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SMU1 gene WDR61 2 APAF1 2 8 SIMAP similar genes for SMU1 using alignment to 3 protein entries: SMU1_HUMAN (see all proteins ):WSB1 GNB5 WDR48 POC1B WDR61 WDR5 PF20 WDR5B
SMU1 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for SMU1 PGOHUM00000259500
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Genomic Variantsfor SMU1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SMU1 (33041762 - 33076714 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SMU1 2 Indels : 29149 47709
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SMU1
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Disorders
/ Diseasesfor SMU1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SMU1 for disorders About GeneDecksing 2 diseases for SMU1 : About MalaCards lissencephaly malaria Human Genome Epidemiology (HuGE) Navigator: SMU1 (1 document)Export disorders for SMU1 gene to outside databases
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Publicationsfor SMU1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SMU1 gene, integrated from 9 sources (see all 23 ): (articles sorted by number of sources associating them with SMU1) Utopia : connect your pdf to the dynamic world of online information
Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans. (PubMed id 11438655) 1 , 3, 9 Spike C.A....Herman R.K. (2001) Cloning and molecular characterization of a novel gene encoding a WD-repeat protein expressed in restricted areas of adult rat brain. (PubMed id 11410362) 1 , 3, 9 Di Benedetto A.J....Glavan B.J. (2001) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Global landscape of HIV-human protein complexes. (PubMed id 22190034) 1 Jager S....Krogan N.J. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326) 1 Tsai Y.C....Cristea I.M. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011)
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External Searches for SMU1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SMU1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SMU1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SMU1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SMU1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SMU1 gene: Search GeneIP for patents involving SMU1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SMU1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SMU1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SMU1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SMU1 OriGene Protein Over-expression Lysate for SMU1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SMU1 OriGene 3'-UTR Clone for SMU1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMU1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMU1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SMU1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SMU1 OriGene Custom Protein Services for SMU1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMU1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SMU1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SMU1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SMU1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SMU1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SMU1
Search Tocris compounds for SMU1
SMU1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMU1
Search ThermoFisher Antibodies for SMU1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMU1
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Aliases for SMU1
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Expression for SMU1
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