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Aliases for SMTNL2 Gene

Aliases for SMTNL2 Gene

  • Smoothelin Like 2 2 3
  • Smoothelin-Like 2 2 5

External Ids for SMTNL2 Gene

Previous GeneCards Identifiers for SMTNL2 Gene

  • GC17P004435
  • GC17P004487

Summaries for SMTNL2 Gene

GeneCards Summary for SMTNL2 Gene

SMTNL2 (Smoothelin Like 2) is a Protein Coding gene. An important paralog of this gene is SPECC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMTNL2 Gene

Genomics for SMTNL2 Gene

Regulatory Elements for SMTNL2 Gene

Enhancers for SMTNL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMTNL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMTNL2 Gene

Chromosome:
17
Start:
4,583,981 bp from pter
End:
4,608,319 bp from pter
Size:
24,339 bases
Orientation:
Plus strand

Genomic View for SMTNL2 Gene

Genes around SMTNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMTNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMTNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMTNL2 Gene

Proteins for SMTNL2 Gene

  • Protein details for SMTNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAL5-SMTL2_HUMAN
    Recommended name:
    Smoothelin-like protein 2
    Protein Accession:
    Q2TAL5
    Secondary Accessions:
    • Q6ZVK6

    Protein attributes for SMTNL2 Gene

    Size:
    461 amino acids
    Molecular mass:
    50196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMTNL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMTNL2 Gene

Proteomics data for SMTNL2 Gene at MOPED

Post-translational modifications for SMTNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMTNL2 Gene

No data available for DME Specific Peptides for SMTNL2 Gene

Domains & Families for SMTNL2 Gene

Protein Domains for SMTNL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMTNL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TAL5

UniProtKB/Swiss-Prot:

SMTL2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the smoothelin family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the smoothelin family.
genes like me logo Genes that share domains with SMTNL2: view

No data available for Gene Families for SMTNL2 Gene

Function for SMTNL2 Gene

genes like me logo Genes that share phenotypes with SMTNL2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMTNL2 Gene

Localization for SMTNL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMTNL2 Gene COMPARTMENTS Subcellular localization image for SMTNL2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SMTNL2 Gene

Pathways & Interactions for SMTNL2 Gene

SuperPathways for SMTNL2 Gene

No Data Available

Interacting Proteins for SMTNL2 Gene

Gene Ontology (GO) - Biological Process for SMTNL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMTNL2 Gene

Drugs & Compounds for SMTNL2 Gene

No Compound Related Data Available

Transcripts for SMTNL2 Gene

Unigene Clusters for SMTNL2 Gene

Smoothelin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMTNL2 Gene

No ASD Table

Relevant External Links for SMTNL2 Gene

GeneLoc Exon Structure for
SMTNL2
ECgene alternative splicing isoforms for
SMTNL2

Expression for SMTNL2 Gene

mRNA expression in normal human tissues for SMTNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMTNL2 Gene

This gene is overexpressed in Muscle - Skeletal (x39.3).

Protein differential expression in normal tissues from HIPED for SMTNL2 Gene

This gene is overexpressed in Retina (19.3), Ovary (11.3), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SMTNL2 Gene



SOURCE GeneReport for Unigene cluster for SMTNL2 Gene Hs.441709

genes like me logo Genes that share expression patterns with SMTNL2: view

Protein tissue co-expression partners for SMTNL2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SMTNL2 Gene

Orthologs for SMTNL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMTNL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMTNL2 35
  • 86.73 (n)
  • 86.21 (a)
SMTNL2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMTNL2 35
  • 82.34 (n)
  • 78.37 (a)
SMTNL2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smtnl2 35
  • 84.58 (n)
  • 83.77 (a)
Smtnl2 16
Smtnl2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMTNL2 35
  • 94.07 (n)
  • 90.43 (a)
SMTNL2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smtnl2 35
  • 83.63 (n)
  • 83.77 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SMTNL2 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMTNL2 35
  • 61.05 (n)
  • 54.77 (a)
SMTNL2 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMTNL2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494968 35
  • 58.94 (n)
  • 54.41 (a)
zebrafish
(Danio rerio)
Actinopterygii smtnl 35
  • 56.21 (n)
  • 50 (a)
poldip2 36
  • 26 (a)
OneToMany
smtnl 36
  • 44 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6413 35
worm
(Caenorhabditis elegans)
Secernentea T15B12.1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10261 36
  • 42 (a)
ManyToMany
Species with no ortholog for SMTNL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMTNL2 Gene

ENSEMBL:
Gene Tree for SMTNL2 (if available)
TreeFam:
Gene Tree for SMTNL2 (if available)

Paralogs for SMTNL2 Gene

(2) SIMAP similar genes for SMTNL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMTNL2: view

Variants for SMTNL2 Gene

Sequence variations from dbSNP and Humsavar for SMTNL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12449695 - 4,592,445(+) CGGGG(A/G)CAGGT reference, missense
rs9916524 - 4,593,842(+) TCACG(C/T)GGTCT reference, missense
rs1038123 -- 4,591,516(-) CATTT(A/C)AGAGA intron-variant, upstream-variant-2KB
rs1038124 -- 4,591,195(-) CTGCC(A/G)TTGGG intron-variant, upstream-variant-2KB
rs1038125 -- 4,588,661(-) GGGTC(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMTNL2 Gene

Variant ID Type Subtype PubMed ID
dgv3050n71 CNV Loss 21882294
nsv907615 CNV Loss 21882294
nsv907616 CNV Loss 21882294
esv997031 CNV Deletion 20482838
nsv907617 CNV Loss 21882294
esv2715556 CNV Deletion 23290073

Variation tolerance for SMTNL2 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SMTNL2 Gene

Disorders for SMTNL2 Gene

Relevant External Links for SMTNL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMTNL2

No disorders were found for SMTNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMTNL2 Gene

Publications for SMTNL2 Gene

  1. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 67
  2. Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. (PMID: 23981301) Gordon E.A. … Bardwell L. (Cell. Signal. 2013) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SMTNL2 Gene

Sources for SMTNL2 Gene

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