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Aliases for SMTNL2 Gene

Aliases for SMTNL2 Gene

  • Smoothelin Like 2 2 3 5
  • Smoothelin-Like 2 2

External Ids for SMTNL2 Gene

Previous GeneCards Identifiers for SMTNL2 Gene

  • GC17P004435
  • GC17P004487

Summaries for SMTNL2 Gene

GeneCards Summary for SMTNL2 Gene

SMTNL2 (Smoothelin Like 2) is a Protein Coding gene. An important paralog of this gene is SMTN.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMTNL2 Gene

Genomics for SMTNL2 Gene

Regulatory Elements for SMTNL2 Gene

Enhancers for SMTNL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SMTNL2 on UCSC Golden Path with GeneCards custom track

Promoters for SMTNL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMTNL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMTNL2 Gene

4,583,981 bp from pter
4,608,319 bp from pter
24,339 bases
Plus strand

Genomic View for SMTNL2 Gene

Genes around SMTNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMTNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMTNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMTNL2 Gene

Proteins for SMTNL2 Gene

  • Protein details for SMTNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Smoothelin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6ZVK6

    Protein attributes for SMTNL2 Gene

    461 amino acids
    Molecular mass:
    50196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMTNL2 Gene


neXtProt entry for SMTNL2 Gene

Post-translational modifications for SMTNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMTNL2 Gene

No data available for DME Specific Peptides for SMTNL2 Gene

Domains & Families for SMTNL2 Gene

Protein Domains for SMTNL2 Gene


Suggested Antigen Peptide Sequences for SMTNL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the smoothelin family.
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the smoothelin family.
genes like me logo Genes that share domains with SMTNL2: view

No data available for Gene Families for SMTNL2 Gene

Function for SMTNL2 Gene

genes like me logo Genes that share phenotypes with SMTNL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMTNL2 Gene

Localization for SMTNL2 Gene

Subcellular locations from

Jensen Localization Image for SMTNL2 Gene COMPARTMENTS Subcellular localization image for SMTNL2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SMTNL2 Gene

Pathways & Interactions for SMTNL2 Gene

SuperPathways for SMTNL2 Gene

No Data Available

Interacting Proteins for SMTNL2 Gene

Gene Ontology (GO) - Biological Process for SMTNL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMTNL2 Gene

Drugs & Compounds for SMTNL2 Gene

No Compound Related Data Available

Transcripts for SMTNL2 Gene

Unigene Clusters for SMTNL2 Gene

Smoothelin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMTNL2 Gene

No ASD Table

Relevant External Links for SMTNL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMTNL2 Gene

mRNA expression in normal human tissues for SMTNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMTNL2 Gene

This gene is overexpressed in Muscle - Skeletal (x39.3).

Protein differential expression in normal tissues from HIPED for SMTNL2 Gene

This gene is overexpressed in Retina (19.3), Ovary (11.3), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SMTNL2 Gene

Protein tissue co-expression partners for SMTNL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMTNL2 Gene:


SOURCE GeneReport for Unigene cluster for SMTNL2 Gene:

genes like me logo Genes that share expression patterns with SMTNL2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SMTNL2 Gene

Orthologs for SMTNL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMTNL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMTNL2 34
  • 86.73 (n)
  • 86.21 (a)
  • 87 (a)
(Canis familiaris)
Mammalia SMTNL2 34
  • 82.34 (n)
  • 78.37 (a)
  • 80 (a)
(Mus musculus)
Mammalia Smtnl2 34
  • 84.58 (n)
  • 83.77 (a)
Smtnl2 16
Smtnl2 35
  • 85 (a)
(Pan troglodytes)
Mammalia SMTNL2 34
  • 94.07 (n)
  • 90.43 (a)
  • 93 (a)
(Rattus norvegicus)
Mammalia Smtnl2 34
  • 83.63 (n)
  • 83.77 (a)
(Ornithorhynchus anatinus)
Mammalia SMTNL2 35
  • 63 (a)
(Gallus gallus)
Aves SMTNL2 34
  • 61.05 (n)
  • 54.77 (a)
  • 52 (a)
(Anolis carolinensis)
Reptilia SMTNL2 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494968 34
  • 58.94 (n)
  • 54.41 (a)
(Danio rerio)
Actinopterygii smtnl 34
  • 56.21 (n)
  • 50 (a)
poldip2 35
  • 26 (a)
smtnl 35
  • 44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6413 34
(Caenorhabditis elegans)
Secernentea T15B12.1 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10261 35
  • 42 (a)
Species where no ortholog for SMTNL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMTNL2 Gene

Gene Tree for SMTNL2 (if available)
Gene Tree for SMTNL2 (if available)

Paralogs for SMTNL2 Gene

(2) SIMAP similar genes for SMTNL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMTNL2: view

Variants for SMTNL2 Gene

Sequence variations from dbSNP and Humsavar for SMTNL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12449695 - 4,592,445(+) CGGGG(A/G)CAGGT reference, missense
rs9916524 - 4,593,842(+) TCACG(C/T)GGTCT reference, missense
rs1038123 -- 4,591,516(-) CATTT(A/C)AGAGA intron-variant, upstream-variant-2KB
rs1038124 -- 4,591,195(-) CTGCC(A/G)TTGGG intron-variant, upstream-variant-2KB
rs1038125 -- 4,588,661(-) GGGTC(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMTNL2 Gene

Variant ID Type Subtype PubMed ID
esv2715556 CNV deletion 23290073
esv997031 CNV deletion 20482838
nsv1061858 CNV gain 25217958
nsv1153877 CNV deletion 26484159
nsv574273 CNV gain 21841781

Variation tolerance for SMTNL2 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMTNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMTNL2 Gene

Disorders for SMTNL2 Gene

Relevant External Links for SMTNL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMTNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMTNL2 Gene

Publications for SMTNL2 Gene

  1. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 65
  2. Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. (PMID: 23981301) Gordon E.A. … Bardwell L. (Cell. Signal. 2013) 3 65
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 65
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65

Products for SMTNL2 Gene

Sources for SMTNL2 Gene