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Aliases for SMTNL1 Gene

Aliases for SMTNL1 Gene

  • Smoothelin-Like 1 2 3
  • Calponin Homology-Associated Smooth Muscle Protein 2 3
  • CHASM 3 6
  • Smoothelin-Like Protein 1 3

External Ids for SMTNL1 Gene

Previous GeneCards Identifiers for SMTNL1 Gene

  • GC11P057066
  • GC11P057309
  • GC11P053658

Summaries for SMTNL1 Gene

Entrez Gene Summary for SMTNL1 Gene

  • SMTNL1, which is a member of the smoothelin (SMTN; MIM 602127) family, regulates contraction and relaxation of skeletal and smooth muscle fibers and mediates vascular adaptation to exercise (Wooldridge et al., 2008 [PubMed 18310078]).[supplied by OMIM, Dec 2010]

GeneCards Summary for SMTNL1 Gene

SMTNL1 (Smoothelin-Like 1) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding. An important paralog of this gene is SMTNL2.

UniProtKB/Swiss-Prot for SMTNL1 Gene

  • Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMTNL1 Gene

Genomics for SMTNL1 Gene

Regulatory Elements for SMTNL1 Gene

Genomic Location for SMTNL1 Gene

57,537,571 bp from pter
57,550,274 bp from pter
12,704 bases
Plus strand

Genomic View for SMTNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMTNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMTNL1 Gene

Proteins for SMTNL1 Gene

  • Protein details for SMTNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Smoothelin-like protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SMTNL1 Gene

    457 amino acids
    Molecular mass:
    48953 Da
    Quaternary structure:
    • Interacts with PPP1R12A.

neXtProt entry for SMTNL1 Gene

Proteomics data for SMTNL1 Gene at MOPED

Post-translational modifications for SMTNL1 Gene

  • Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMTNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMTNL1 Gene

Domains for SMTNL1 Gene

Protein Domains for SMTNL1 Gene


Suggested Antigen Peptide Sequences for SMTNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A8MU46
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the smoothelin family.
genes like me logo Genes that share domains with SMTNL1: view

No data available for Gene Families for SMTNL1 Gene

Function for SMTNL1 Gene

Molecular function for SMTNL1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).

Gene Ontology (GO) - Molecular Function for SMTNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0008157 protein phosphatase 1 binding --
genes like me logo Genes that share ontologies with SMTNL1: view
genes like me logo Genes that share phenotypes with SMTNL1: view

Animal Models for SMTNL1 Gene

MGI Knock Outs for SMTNL1:

miRNA for SMTNL1 Gene

miRTarBase miRNAs that target SMTNL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SMTNL1 Gene

Localization for SMTNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMTNL1 Gene

Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SMTNL1 Gene COMPARTMENTS Subcellular localization image for SMTNL1 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMTNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0031430 M band IEA --
GO:0031674 I band IEA --
GO:0043292 contractile fiber IDA 20634291
genes like me logo Genes that share ontologies with SMTNL1: view

Pathways for SMTNL1 Gene

SuperPathways for SMTNL1 Gene

No Data Available

Interacting Proteins for SMTNL1 Gene

Gene Ontology (GO) - Biological Process for SMTNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014823 response to activity --
GO:0018105 peptidyl-serine phosphorylation --
GO:0042493 response to drug --
GO:0045907 positive regulation of vasoconstriction ISS --
GO:0045908 negative regulation of vasodilation ISS --
genes like me logo Genes that share ontologies with SMTNL1: view

No data available for Pathways by source for SMTNL1 Gene

Transcripts for SMTNL1 Gene

mRNA/cDNA for SMTNL1 Gene

(20) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMTNL1 Gene

Smoothelin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMTNL1 Gene

No ASD Table

Relevant External Links for SMTNL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMTNL1 Gene

mRNA expression in normal human tissues for SMTNL1 Gene

mRNA differential expression in normal tissues according to GTEx for SMTNL1 Gene

This gene is overexpressed in Muscle - Skeletal (46.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SMTNL1 Gene

SOURCE GeneReport for Unigene cluster for SMTNL1 Gene Hs.68756

mRNA Expression by UniProt/SwissProt for SMTNL1 Gene

Tissue specificity: Expressed in striated muscles, specifically in type 2a fibers (at protein level).
genes like me logo Genes that share expressions with SMTNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SMTNL1 Gene

Orthologs for SMTNL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMTNL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMTNL1 35
  • 98.72 (n)
  • 98.18 (a)
  • 98 (a)
(Bos Taurus)
Mammalia SMTNL1 35
  • 74.62 (n)
  • 67.25 (a)
  • 67 (a)
(Canis familiaris)
Mammalia SMTNL1 35
  • 79.49 (n)
  • 73.25 (a)
  • 70 (a)
(Mus musculus)
Mammalia Smtnl1 35
  • 77.19 (n)
  • 70.61 (a)
Smtnl1 16
Smtnl1 36
  • 69 (a)
(Monodelphis domestica)
Mammalia SMTNL1 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
(Rattus norvegicus)
Mammalia Smtnl1 35
  • 77.66 (n)
  • 70.74 (a)
(Gallus gallus)
Aves SMTNL1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia SMTNL1 36
  • 43 (a)
(Danio rerio)
Actinopterygii smtna 36
  • 31 (a)
smtnl1 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea T15B12.1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10261 36
  • 37 (a)
Species with no ortholog for SMTNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SMTNL1 Gene

Gene Tree for SMTNL1 (if available)
Gene Tree for SMTNL1 (if available)

Paralogs for SMTNL1 Gene

Selected SIMAP similar genes for SMTNL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SMTNL1: view

Variants for SMTNL1 Gene

Sequence variations from dbSNP and Humsavar for SMTNL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8890 -- 57,550,167(+) AGCCA(C/T)GGCCC utr-variant-3-prime
rs514385 -- 57,538,538(+) CTCCT(C/T)GGCTG intron-variant
rs525637 -- 57,538,046(+) ttttg(A/C/G)cattt intron-variant
rs554569 -- 57,544,094(-) accAT(C/G)GCTCT intron-variant
rs1124942 -- 57,549,443(-) ATGGG(A/C/T)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMTNL1 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897

Relevant External Links for SMTNL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMTNL1 Gene

Disorders for SMTNL1 Gene

No disorders were found for SMTNL1 Gene.

No data available for UniProtKB/Swiss-Prot for SMTNL1 Gene

Publications for SMTNL1 Gene

  1. Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. (PMID: 15327999) Borman M.A. … Haystead T.A. (FEBS Lett. 2004) 2 3
  2. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. (PMID: 18310078) Wooldridge A.A. … Haystead T.A. (J. Biol. Chem. 2008) 3 4
  3. Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. (PMID: 20634291) Lontay B. … Haystead T.A. (J. Biol. Chem. 2010) 3 4
  4. Mapping and functional characterization of the murine smoothelin-like 1 promoter. (PMID: 21352594) Ulke-LemAce A. … MacDonald J.A. (BMC Mol. Biol. 2011) 3
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for SMTNL1 Gene

Sources for SMTNL1 Gene

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