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Aliases for SMR3B Gene

Aliases for SMR3B Gene

  • Submaxillary Gland Androgen Regulated Protein 3B 2 3 5
  • Proline-Rich Peptide P-B 3 4
  • Proline-Rich Protein 3 3 4
  • Proline Rich 3 2 3
  • PROL3 3 4
  • PRL3 3 4
  • PBII 3 4
  • Submaxillary Gland Androgen Regulated Protein 3 Homolog B (Mouse) 2
  • Submaxillary Gland Androgen Regulated Protein 3 Homolog B 3
  • Salivary Proline-Rich Protein 3
  • SMR1B 3
  • P-B 3

External Ids for SMR3B Gene

Previous HGNC Symbols for SMR3B Gene

  • PROL3

Previous GeneCards Identifiers for SMR3B Gene

  • GC04P071430
  • GC04P071283
  • GC04P067051
  • GC04P071237

Summaries for SMR3B Gene

GeneCards Summary for SMR3B Gene

SMR3B (Submaxillary Gland Androgen Regulated Protein 3B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMR3B Gene

Genomics for SMR3B Gene

Regulatory Elements for SMR3B Gene

Genomic Location for SMR3B Gene

Chromosome:
4
Start:
70,370,093 bp from pter
End:
70,390,244 bp from pter
Size:
20,152 bases
Orientation:
Plus strand

Genomic View for SMR3B Gene

Genes around SMR3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMR3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMR3B Gene

Proteins for SMR3B Gene

  • Protein details for SMR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02814-SMR3B_HUMAN
    Recommended name:
    Submaxillary gland androgen-regulated protein 3B
    Protein Accession:
    P02814
    Secondary Accessions:
    • B7ZMG7
    • Q9UBN0
    • Q9UCT0

    Protein attributes for SMR3B Gene

    Size:
    79 amino acids
    Molecular mass:
    8188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMR3B Gene

Proteomics data for SMR3B Gene at MOPED

Post-translational modifications for SMR3B Gene

Other Protein References for SMR3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMR3B Gene

Domains & Families for SMR3B Gene

Protein Domains for SMR3B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMR3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02814

UniProtKB/Swiss-Prot:

SMR3B_HUMAN :
  • Belongs to the PROL1/PROL3 family.
Family:
  • Belongs to the PROL1/PROL3 family.
genes like me logo Genes that share domains with SMR3B: view

No data available for Gene Families for SMR3B Gene

Function for SMR3B Gene

genes like me logo Genes that share phenotypes with SMR3B: view

Animal Model Products

CRISPR Products

miRNA for SMR3B Gene

miRTarBase miRNAs that target SMR3B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMR3B Gene

Localization for SMR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMR3B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMR3B Gene COMPARTMENTS Subcellular localization image for SMR3B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
vacuole 2
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SMR3B Gene

Pathways & Interactions for SMR3B Gene

SuperPathways for SMR3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMR3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMR3B Gene

Drugs & Compounds for SMR3B Gene

No Compound Related Data Available

Transcripts for SMR3B Gene

Unigene Clusters for SMR3B Gene

Submaxillary gland androgen regulated protein 3B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMR3B Gene

No ASD Table

Relevant External Links for SMR3B Gene

GeneLoc Exon Structure for
SMR3B
ECgene alternative splicing isoforms for
SMR3B

Expression for SMR3B Gene

mRNA expression in normal human tissues for SMR3B Gene

mRNA differential expression in normal tissues according to GTEx for SMR3B Gene

This gene is overexpressed in Minor Salivary Gland (x27.5), Testis (x10.1), and Pituitary (x5.0).

Protein differential expression in normal tissues from HIPED for SMR3B Gene

This gene is overexpressed in Salivary gland (53.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMR3B Gene



SOURCE GeneReport for Unigene cluster for SMR3B Gene Hs.650650

mRNA Expression by UniProt/SwissProt for SMR3B Gene

P02814-SMR3B_HUMAN
Tissue specificity: Secreted into saliva by submaxillary gland. Not expressed in heart, brain, lung, liver, skeletal muscle, Kidney, pancreas or placenta.
genes like me logo Genes that share expression patterns with SMR3B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SMR3B Gene

Orthologs for SMR3B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SMR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMR3B 36
  • 60 (a)
OneToOne
Species with no ortholog for SMR3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMR3B Gene

ENSEMBL:
Gene Tree for SMR3B (if available)
TreeFam:
Gene Tree for SMR3B (if available)

Paralogs for SMR3B Gene

(2) SIMAP similar genes for SMR3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMR3B: view

No data available for Paralogs for SMR3B Gene

Variants for SMR3B Gene

Sequence variations from dbSNP and Humsavar for SMR3B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1480750 -- 70,382,338(-) AAAGC(A/G)GGAAA upstream-variant-2KB
rs1480751 -- 70,382,190(-) GTTCC(C/T)TTTGC upstream-variant-2KB
rs1814013 -- 70,387,764(-) CCAAG(A/T)TGATG intron-variant
rs2233586 -- 70,384,591(+) CACAC(A/T)TCTTT intron-variant
rs2233587 -- 70,384,600(+) TTATA(C/G)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMR3B Gene

Variant ID Type Subtype PubMed ID
nsv829964 CNV Gain 17160897
nsv879467 CNV Loss 21882294
nsv461554 CNV Loss 19166990
nsv470046 CNV Loss 18288195
dgv321n21 CNV Loss 19592680
dgv1642e1 CNV Complex 17122850
dgv187e55 CNV Loss 17911159
nsv10525 CNV Loss 18304495
dgv5631n71 CNV Loss 21882294
dgv955e199 CNV Deletion 23128226
nsv822613 CNV Loss 20364138
essv4514 CNV CNV 17122850
nsv441887 CNV CNV 18776908

Variation tolerance for SMR3B Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMR3B Gene

HapMap Linkage Disequilibrium report
SMR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMR3B Gene

Disorders for SMR3B Gene

Relevant External Links for SMR3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMR3B

No disorders were found for SMR3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMR3B Gene

Publications for SMR3B Gene

  1. Molecular cloning and sequence analysis of cDNA coding for the precursor of the human salivary proline-rich peptide P-B. (PMID: 7982889) Isemura S. … Saito E. (J. Biochem. 1994) 2 3 4 23 67
  2. Nucleotide sequence of gene PBII encoding salivary proline-rich protein P-B. (PMID: 10731710) Isemura S. (J. Biochem. 2000) 3 23
  3. Isolation and amino acid sequences of proline-rich peptides of human whole saliva. (PMID: 479131) Isemura S. … Sanada K. (J. Biochem. 1979) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SMR3B Gene

Sources for SMR3B Gene

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