SMR3B Gene
protein-coding GIFtS: 45
GCID: GC04P071283
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submaxillary gland androgen regulated protein 3B(Previous names: proline rich 3, submaxillary gland androgen regulated protein...)
(Previous symbol: PROL3)
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Aliases
for SMR3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Submaxillary Gland Androgen Regulated Protein 3B1 2 | | Proline-Rich Protein 32 3 | | PRL31 2 3 5 | | SMR1B2 5 | | PROL31 2 3 | | Submaxillary Gland Androgen Regulated Protein 3 Homolog B (Mouse)1 | | PBII2 3 5 | | Salivary Proline-Rich Protein2 | | P-B1 2 | | Submaxillary Gland Androgen Regulated Protein 3 Homolog B2 | | Proline Rich 31 2 | | Submaxillary Gland Androgen-Regulated Protein 3B2 | | Proline-Rich Peptide P-B2 3 | | |
Export aliases for SMR3B gene to outside databasesPrevious GC identifers: GC04P071430 GC04P067051 |
Summaries
for SMR3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SMR3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMR3B gene promoter:
PPAR-gamma1 FOXD3 PPAR-gamma2 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMR3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMR3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.3 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3SMR3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P071283: view genomic region
(about GC identifiers)
Start:
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71,235,810 bp from pter |
End:
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71,255,961 bp from pter |
Size:
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20,152 bases |
Orientation:
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plus strand |
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Proteins
for SMR3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMR3B_HUMAN, P02814 (See
protein sequence)Recommended Name: Submaxillary gland androgen-regulated protein 3B precursor Size: 79 amino acids; 8188 Da
Subcellular location: Secreted
Secondary accessions: B7ZMG7 Q9UBN0 Q9UCT0Explore the universe of human proteins at neXtProt for SMR3B: NX_P02814
Post-translational modifications:
P-A and D1A are probably degradation products of P-B1
View neXtProt modification sites for NX_P02814
SMR3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006676.1
ENSEMBL proteins: ENSP00000423138 ENSP00000302400
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SMR3B for ontologies About GeneDecksing
SMR3B Antibody Products:
Assay Products for SMR3B: |
Protein
Domains /
Families
for SMR3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMR3B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P02814ProtoNet protein and cluster: P02814 UniProtKB/Swiss-Prot: SMR3B_HUMAN, P02814Similarity: Belongs to the PROL1/PROL3 family |
Function
for SMR3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SMR3B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMR3B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMR3B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SMR3B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SMR3B:
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Pathways & Interactions
for SMR3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMR3B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/29 Interacting proteins for SMR3B (P028143 ENSP000003024004) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
SMR3B for ontologies About GeneDecksing
|
Drugs & Compounds
for SMR3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMR3B
Search CenterWatch for drugs/clinical trials and news about SMR3B
|
Transcripts
for SMR3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMR3B gene: NM_006685.3 Unigene Cluster for SMR3B: Submaxillary gland androgen regulated protein 3B Hs.650650 [show with all ESTs]Unigene Representative Sequence: CB9844373 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504825 ENST00000304915(uc011cas.2 uc003hfh.3) ENST00000508027
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SMR3B (NM_006685) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMR3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMR3B |
Additional cDNA sequence: BC015327.1 BC094707.1 BC144529.1 D29833.2 15 DOTS entries: DT.100671853 DT.100681404 DT.121249580 DT.100893690 DT.100683735 DT.101982742 DT.441491 DT.100893688 DT.100893695 DT.121249353 DT.121249498 DT.121249589 DT.121249307 DT.121249524 DT.100893691 24/310 AceView cDNA sequences (see all 310): BP334673 BX487855 BP335048 CB956402 BP334508 CB985408 CB957114 BX487931 CB987447 BP335117 CB986024 BP334822 BX487127 CB957829 BM480401 BX487539 BP334492 BC015327 BP333858 BP334445 CB956361 BX487314 CB956330 CB957954
GeneLoc Exon Structure
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Expression
for SMR3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMR3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGACATAAC
About this image
See SMR3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMR3B
SOURCE GeneReport for Unigene cluster: Hs.650650
UniProtKB/Swiss-Prot: SMR3B_HUMAN, P02814Tissue specificity: Secreted into saliva by submaxillary gland. Not expressed in heart, brain, lung, liver, skeletalmuscle, Kidney, pancreas or placenta
SABiosciences Custom PCR Arrays for SMR3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMR3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SMR3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMR3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMR3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMR3B |
Orthologs
for SMR3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SMR3B (if available)
TreeFam Gene Tree for SMR3B (if available) |
Paralogs
for SMR3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SMR3B gene
- PROL12 SMR3A2
2 SIMAP similar genes for SMR3B using alignment to 2 protein entries: SMR3B_HUMAN (see all proteins):SMR3A PROL1
SMR3B for paralogs About GeneDecksing
|
Genomic Variants
for SMR3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SMR3B
4 CNVs: 38565 9001 32618 2529 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMR3B |
|
Disorders
/ Diseases
for SMR3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMR3B for disorders About GeneDecksing
OMIM gene information: 611593
OMIM disorders: --
1  disease for SMR3B: About MalaCardspancytopenia
Export disorders for SMR3B gene to outside databases
|
Publications
for SMR3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMR3B gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SMR3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and sequence analysis of cDNA coding for the precursor of the human salivary proline-rich peptide P-B. (PubMed id 7982889)1, 2, 3, 9 Isemura S. and Saito E. (1994)
- Isolation and amino acid sequences of proline-rich peptides of human whole saliva. (PubMed id 479131)1, 2, 3 Isemura S....Sanada K. (1979)
- Nucleotide sequence of gene PBII encoding salivary proline-rich protein P-B. (PubMed id 10731710)1, 2, 9 Isemura S. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva. (PubMed id 1747107)1, 2 Ramasubbu N....Levine M.J. (1991)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Structural features contributing to complex formation between glycogen phosphorylase and phosphorylase kinase. (PubMed id 10423233)9 Xu Y.H. and Carlson G.M. (1999)
- Tissue distribution and nucleotide sequence of bovine mRNA for salivary proline-rich protein P-B. (PubMed id 15353243)9 Isemura S....Sanada K. (2004)
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External Searches for SMR3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SMR3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMR3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMR3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SMR3B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SMR3B gene:
Search GeneIP for patents involving SMR3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMR3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SMR3B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMR3B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMR3B | | | OriGene Protein Over-expression Lysate for SMR3B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMR3B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for SMR3B |
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 | | | SMR3B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMR3B |
|  |  |  | | | | Search ThermoFisher Antibodies for SMR3B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMR3B |
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