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Aliases for SMR3A Gene

Aliases for SMR3A Gene

  • Submaxillary Gland Androgen Regulated Protein 3A 2 3
  • Proline Rich 5 (Salivary) 2 3
  • Proline-Rich Protein PBI 3 4
  • Proline-Rich Protein 5 3 4
  • PROL5 3 4
  • PBI 3 4
  • Submaxillary Gland Androgen Regulated Protein 3 Homolog A (Mouse) 2
  • Submaxillary Gland Androgen Regulated Protein 3 Homolog A 3
  • Protein Homologous To Salivary Proline-Rich Protein P-B 3
  • Submaxillary Gland Androgen-Regulated Protein 3A 3
  • Proline- Rich Protein 5 3
  • P-B1 3
  • PRL5 3

External Ids for SMR3A Gene

Previous HGNC Symbols for SMR3A Gene

  • PROL5

Previous GeneCards Identifiers for SMR3A Gene

  • GC04P071410
  • GC04U900478
  • GC04P071261
  • GC04P067028
  • GC04P071226

Summaries for SMR3A Gene

GeneCards Summary for SMR3A Gene

SMR3A (Submaxillary Gland Androgen Regulated Protein 3A) is a Protein Coding gene. An important paralog of this gene is SMR3B.

UniProtKB/Swiss-Prot for SMR3A Gene

  • May play a role in protection or detoxification.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMR3A Gene

Genomics for SMR3A Gene

Regulatory Elements for SMR3A Gene

Genomic Location for SMR3A Gene

Start:
70,360,761 bp from pter
End:
70,367,158 bp from pter
Size:
6,398 bases
Orientation:
Plus strand

Genomic View for SMR3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMR3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMR3A Gene

Proteins for SMR3A Gene

  • Protein details for SMR3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99954-SMR3A_HUMAN
    Recommended name:
    Submaxillary gland androgen-regulated protein 3A
    Protein Accession:
    Q99954
    Secondary Accessions:

    Protein attributes for SMR3A Gene

    Size:
    134 amino acids
    Molecular mass:
    14048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMR3A Gene

Proteomics data for SMR3A Gene at MOPED

Post-translational modifications for SMR3A Gene

No Post-translational modifications

Other Protein References for SMR3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMR3A Gene

Domains for SMR3A Gene

Protein Domains for SMR3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMR3A Gene

Graphical View of Domain Structure for InterPro Entry

Q99954

UniProtKB/Swiss-Prot:

SMR3A_HUMAN :
  • Q99954
Family:
  • Belongs to the PROL1/PROL3 family.
genes like me logo Genes that share domains with SMR3A: view

No data available for Gene Families for SMR3A Gene

Function for SMR3A Gene

Molecular function for SMR3A Gene

UniProtKB/Swiss-Prot Function: May play a role in protection or detoxification.

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMR3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMR3A Gene

Localization for SMR3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMR3A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMR3A Gene COMPARTMENTS Subcellular localization image for SMR3A gene
Compartment Confidence
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SMR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SMR3A: view

Pathways for SMR3A Gene

SuperPathways for SMR3A Gene

No Data Available

Interacting Proteins for SMR3A Gene

Gene Ontology (GO) - Biological Process for SMR3A Gene

None

No data available for Pathways by source for SMR3A Gene

Transcripts for SMR3A Gene

mRNA/cDNA for SMR3A Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMR3A Gene

Submaxillary gland androgen regulated protein 3A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMR3A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMR3A Gene

No ASD Table

Relevant External Links for SMR3A Gene

GeneLoc Exon Structure for
SMR3A
ECgene alternative splicing isoforms for
SMR3A

Expression for SMR3A Gene

mRNA expression in normal human tissues for SMR3A Gene

mRNA differential expression in normal tissues according to GTEx for SMR3A Gene

This gene is overexpressed in Minor Salivary Gland (23.9) and Thyroid (22.1).

SOURCE GeneReport for Unigene cluster for SMR3A Gene Hs.701334

genes like me logo Genes that share expressions with SMR3A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for SMR3A Gene

Orthologs for SMR3A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SMR3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMR3A 36
  • 96 (a)
OneToOne
Species with no ortholog for SMR3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMR3A Gene

ENSEMBL:
Gene Tree for SMR3A (if available)
TreeFam:
Gene Tree for SMR3A (if available)

Paralogs for SMR3A Gene

Paralogs for SMR3A Gene

Selected SIMAP similar genes for SMR3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMR3A: view

Variants for SMR3A Gene

Sequence variations from dbSNP and Humsavar for SMR3A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1383432 -- 70,363,945(-) GTTCA(A/C)GTTGT intron-variant
rs1383433 -- 70,360,304(-) CCCTG(C/T)TGTTA upstream-variant-2KB
rs1480754 -- 70,367,598(-) GTTTG(C/T)TAGAA downstream-variant-500B
rs1480755 -- 70,361,495(-) AATCC(A/G)TATAT intron-variant
rs1842472 -- 70,364,351(-) ATTCT(A/C)ATCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMR3A Gene

Variant ID Type Subtype PubMed ID
nsv829964 CNV Gain 17160897
nsv879467 CNV Loss 21882294
nsv461554 CNV Loss 19166990
nsv470046 CNV Loss 18288195
dgv321n21 CNV Loss 19592680
dgv1641e1 CNV Complex 17122850
dgv1642e1 CNV Complex 17122850
dgv187e55 CNV Loss 17911159
esv34954 CNV Loss 17911159
nsv10525 CNV Loss 18304495
nsv879468 CNV Loss 21882294
dgv5631n71 CNV Loss 21882294
dgv955e199 CNV Deletion 23128226
nsv822613 CNV Loss 20364138
essv4514 CNV CNV 17122850
nsv441887 CNV CNV 18776908
nsv517266 CNV Loss 19592680

Relevant External Links for SMR3A Gene

HapMap Linkage Disequilibrium report
SMR3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMR3A Gene

Disorders for SMR3A Gene

(1) University of Copenhagen DISEASES for SMR3A Gene

Relevant External Links for SMR3A

Genetic Association Database (GAD)
SMR3A
genes like me logo Genes that share disorders with SMR3A: view

No data available for UniProtKB/Swiss-Prot for SMR3A Gene

Publications for SMR3A Gene

  1. Nucleotide sequence of gene PBI encoding a protein homologous to salivary proline-rich protein P-B. (PMID: 9354371) Isemura S. … Saitoh E. (J. Biochem. 1997) 2 3 4 23
  2. hSMR3A as a marker for patients with erectile dysfunction. (PMID: 17512016) Tong Y. … Davies K.P. (J. Urol. 2007) 2 3
  3. The opiorphin gene (ProL1) and its homologues function in erectile physiology. (PMID: 18410445) Tong Y. … Davies K. (BJU Int. 2008) 3
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SMR3A Gene

Sources for SMR3A Gene

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