SMR3A Gene
protein-coding GIFtS: 39
GCID: GC04P071261
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submaxillary gland androgen regulated protein 3A(Previous names: proline rich 5 (salivary), submaxillary gland androgen...)
(Previous symbol: PROL5)
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Aliases
for SMR3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Submaxillary Gland Androgen Regulated Protein 3A1 2 | | Submaxillary Gland Androgen Regulated Protein 3 Homolog A (Mouse)1 | | PBI1 2 3 | | P-B12 | | PROL51 2 3 | | Proline- Rich Protein 52 | | PRL51 2 | | Protein Homologous To Salivary Proline-Rich Protein P-B2 | | Proline Rich 5 (Salivary)1 2 | | Submaxillary Gland Androgen Regulated Protein 3 Homolog A2 | | Proline-Rich Protein 52 3 | | Submaxillary Gland Androgen-Regulated Protein 3A2 | | Proline-Rich Protein PBI2 3 | | |
Export aliases for SMR3A gene to outside databasesPrevious GC identifers: GC04P071410 GC04U900478 GC04P067028 |
Summaries
for SMR3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SMR3A_HUMAN, Q99954Function: May play a role in protection or detoxification (By similarity)
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Genomic Views
for SMR3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMR3A gene promoter:
HFH-3 HNF-4alpha2 CUTL1 HNF-4alpha1 FOXL1 FOXI1 POU2F1 FOXO4 POU2F1a Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMR3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMR3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.3 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3SMR3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P071261: view genomic region
(about GC identifiers)
Start:
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71,226,478 bp from pter |
End:
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71,232,875 bp from pter |
Size:
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6,398 bases |
Orientation:
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plus strand |
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Proteins
for SMR3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMR3A_HUMAN, Q99954 (See
protein sequence)Recommended Name: Submaxillary gland androgen-regulated protein 3A precursor Size: 134 amino acids; 14048 Da
Subcellular location: Secreted (Potential)Explore the universe of human proteins at neXtProt for SMR3A: NX_Q99954
SMR3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036522.3
ENSEMBL proteins: ENSP00000226460
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
SMR3A for ontologies About GeneDecksing
SMR3A Antibody Products:
Assay Products for SMR3A: |
Protein
Domains /
Families
for SMR3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q99954 UniProtKB/Swiss-Prot: SMR3A_HUMAN, Q99954Similarity: Belongs to the PROL1/PROL3 family |
Function
for SMR3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SMR3A_HUMAN, Q99954Function: May play a role in protection or detoxification (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SMR3A (NM_012390) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMR3A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMR3A |
|
Pathways & Interactions
for SMR3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMR3A
|
Drugs & Compounds
for SMR3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMR3A
Search CenterWatch for drugs/clinical trials and news about SMR3A
|
Transcripts
for SMR3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SMR3A gene: NM_012390.3 Unigene Cluster for SMR3A: Submaxillary gland androgen regulated protein 3A Hs.701334 [show with all ESTs]Unigene Representative Sequence: CK4301791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000226460(uc003hfg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SMR3A (NM_012390) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMR3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMR3A |
Additional cDNA sequence: AK312075.1 BC140927.1 3 DOTS entries: DT.121249370 DT.100893691 DT.121249589
GeneLoc Exon Structure
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Expression
for SMR3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMR3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SMR3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMR3A
SOURCE GeneReport for Unigene cluster: Hs.701334
SABiosciences Custom PCR Arrays for SMR3A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMR3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMR3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMR3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMR3A |
Orthologs
for SMR3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SMR3A (if available)
TreeFam Gene Tree for SMR3A (if available) |
Paralogs
for SMR3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SMR3A gene
- SMR3B2 PROL12
1 SIMAP similar gene for SMR3A using alignment to 2 protein entries: SMR3A_HUMAN (see all proteins):SMR3B
SMR3A for paralogs About GeneDecksing
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Genomic Variants
for SMR3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SMR3A
6 CNVs: 38565 51454 9002 9001 32618 2529 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMR3A |
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Disorders
/ Diseases
for SMR3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMR3A for disorders About GeneDecksing
1  disease for SMR3A: About MalaCardsscheuermann's disease
1 disease from the University of Copenhagen DISEASES database for SMR3A:Scheuermann's disease Export disorders for SMR3A gene to outside databases
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Publications
for SMR3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMR3A gene integrated from 9 sources:
(articles sorted by number of sources associating them with SMR3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nucleotide sequence of gene PBI encoding a protein homologous to salivary proline-rich protein P-B. (PubMed id 9354371)1, 2, 3, 9 Isemura S. and Saitoh E. (1997)
- hSMR3A as a marker for patients with erectile dysfunction. (PubMed id 17512016)1, 3 Tong Y....Davies K.P. (2007)
- The opiorphin gene (ProL1) and its homologues function in erectile physiology. (PubMed id 18410445)1 Tong Y....Davies K. (2008)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. (PubMed id 15851553)1 Ozyildirim A.M....Laurie G.W. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SMR3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SMR3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMR3A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMR3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SMR3A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SMR3A gene:
Search GeneIP for patents involving SMR3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMR3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SMR3A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMR3A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMR3A | | | OriGene Protein Over-expression Lysate for SMR3A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMR3A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMR3A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMR3A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMR3A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMR3A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMR3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMR3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMR3A |
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| | | | Search Tocris compounds for SMR3A |
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 | | | SMR3A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for SMR3A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMR3A |
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