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Aliases for SMR3A Gene

Aliases for SMR3A Gene

  • Submaxillary Gland Androgen Regulated Protein 3A 2 3 5
  • Proline Rich 5 (Salivary) 2 3
  • Proline-Rich Protein PBI 3 4
  • PROL5 3 4
  • PBI 3 4
  • Submaxillary Gland Androgen Regulated Protein 3 Homolog A (Mouse) 2
  • Submaxillary Gland Androgen Regulated Protein 3 Homolog A 3
  • Protein Homologous To Salivary Proline-Rich Protein P-B 3
  • Submaxillary Gland Androgen-Regulated Protein 3A 3
  • Proline- Rich Protein 5 3
  • Proline-Rich Protein 5 4
  • P-B1 3
  • PRL5 3

External Ids for SMR3A Gene

Previous HGNC Symbols for SMR3A Gene

  • PROL5

Previous GeneCards Identifiers for SMR3A Gene

  • GC04P071410
  • GC04U900478
  • GC04P071261
  • GC04P067028
  • GC04P071226

Summaries for SMR3A Gene

GeneCards Summary for SMR3A Gene

SMR3A (Submaxillary Gland Androgen Regulated Protein 3A) is a Protein Coding gene. An important paralog of this gene is SMR3B.

UniProtKB/Swiss-Prot for SMR3A Gene

  • May play a role in protection or detoxification.

Additional gene information for SMR3A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMR3A Gene

Genomics for SMR3A Gene

Regulatory Elements for SMR3A Gene


Genomic Location for SMR3A Gene

Chromosome:
4
Start:
70,360,761 bp from pter
End:
70,367,158 bp from pter
Size:
6,398 bases
Orientation:
Plus strand

Genomic View for SMR3A Gene

Genes around SMR3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMR3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMR3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMR3A Gene

Proteins for SMR3A Gene

  • Protein details for SMR3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99954-SMR3A_HUMAN
    Recommended name:
    Submaxillary gland androgen-regulated protein 3A
    Protein Accession:
    Q99954

    Protein attributes for SMR3A Gene

    Size:
    134 amino acids
    Molecular mass:
    14048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMR3A Gene

Post-translational modifications for SMR3A Gene

No Post-translational modifications

Other Protein References for SMR3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMR3A Gene

Domains & Families for SMR3A Gene

Gene Families for SMR3A Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SMR3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMR3A Gene

Graphical View of Domain Structure for InterPro Entry

Q99954

UniProtKB/Swiss-Prot:

SMR3A_HUMAN :
  • Belongs to the PROL1/PROL3 family.
Family:
  • Belongs to the PROL1/PROL3 family.
genes like me logo Genes that share domains with SMR3A: view

Function for SMR3A Gene

Molecular function for SMR3A Gene

UniProtKB/Swiss-Prot Function:
May play a role in protection or detoxification.
genes like me logo Genes that share phenotypes with SMR3A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SMR3A
  • Applied Biological Materials Clones for SMR3A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMR3A Gene

Localization for SMR3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMR3A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMR3A gene
Compartment Confidence
extracellular 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SMR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SMR3A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SMR3A Gene

Pathways & Interactions for SMR3A Gene

SuperPathways for SMR3A Gene

No Data Available

Interacting Proteins for SMR3A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000226460%0d%0a9606.ENSP00000343348%0d%0a
Selected Interacting proteins: Q99954-SMR3A_HUMAN ENSP00000226460 for SMR3A Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for SMR3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMR3A Gene

Drugs & Compounds for SMR3A Gene

No Compound Related Data Available

Transcripts for SMR3A Gene

mRNA/cDNA for SMR3A Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMR3A Gene

Submaxillary gland androgen regulated protein 3A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SMR3A
  • Applied Biological Materials Clones for SMR3A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SMR3A Gene

No ASD Table

Relevant External Links for SMR3A Gene

GeneLoc Exon Structure for
SMR3A
ECgene alternative splicing isoforms for
SMR3A

Expression for SMR3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMR3A Gene

mRNA differential expression in normal tissues according to GTEx for SMR3A Gene

This gene is overexpressed in Minor Salivary Gland (x23.9) and Thyroid (x22.1).

NURSA nuclear receptor signaling pathways regulating expression of SMR3A Gene:

SMR3A

SOURCE GeneReport for Unigene cluster for SMR3A Gene:

Hs.701334
genes like me logo Genes that share expression patterns with SMR3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMR3A Gene

Orthologs for SMR3A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SMR3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMR3A 34
  • 96 (a)
OneToOne
Species where no ortholog for SMR3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMR3A Gene

ENSEMBL:
Gene Tree for SMR3A (if available)
TreeFam:
Gene Tree for SMR3A (if available)

Paralogs for SMR3A Gene

Paralogs for SMR3A Gene

(1) SIMAP similar genes for SMR3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMR3A: view

Variants for SMR3A Gene

Sequence variations from dbSNP and Humsavar for SMR3A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000165653 -- 70,359,989(+) AGTTC(C/T)GCTCA upstream-variant-2KB
rs1000259349 -- 70,359,132(+) ATCCA(C/T)TACAA upstream-variant-2KB
rs1000440092 -- 70,365,749(+) ATGAA(C/T)CAGCT intron-variant
rs1000499343 -- 70,358,891(+) CTTTG(A/T)ATTTT upstream-variant-2KB
rs1000744034 -- 70,364,637(+) CTAAT(A/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMR3A Gene

Variant ID Type Subtype PubMed ID
dgv187e55 CNV loss 17911159
dgv196n111 CNV deletion 26073780
dgv321n21 CNV loss 19592680
dgv9127n54 CNV loss 21841781
dgv955e199 CNV deletion 23128226
esv2759259 CNV loss 17122850
esv2763367 CNV loss 21179565
esv34954 CNV loss 17911159
esv3600933 CNV loss 21293372
esv3893959 CNV loss 25118596
esv3893960 CNV loss 25118596
nsv1006332 CNV loss 25217958
nsv1012495 CNV gain 25217958
nsv10525 CNV loss 18304495
nsv441887 CNV loss 18776908
nsv461554 CNV loss 19166990
nsv470046 CNV loss 18288195
nsv517266 CNV loss 19592680
nsv822613 CNV loss 20364138
nsv829964 CNV gain 17160897

Variation tolerance for SMR3A Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMR3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMR3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMR3A Gene

Disorders for SMR3A Gene

Relevant External Links for SMR3A

Genetic Association Database (GAD)
SMR3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMR3A

No disorders were found for SMR3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMR3A Gene

Publications for SMR3A Gene

  1. Nucleotide sequence of gene PBI encoding a protein homologous to salivary proline-rich protein P-B. (PMID: 9354371) Isemura S … Saitoh E (Journal of biochemistry 1997) 2 3 4 22 60
  2. hSMR3A as a marker for patients with erectile dysfunction. (PMID: 17512016) Tong Y … Davies KP (The Journal of urology 2007) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Expression of Submaxillary Gland Androgen-regulated Protein 3A (SMR3A) in Adenoid Cystic Carcinoma of the Head and Neck. (PMID: 26851015) Thierauf J … Hess J (Anticancer research 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for SMR3A Gene

  • Addgene plasmids for SMR3A

Sources for SMR3A Gene

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