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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SMPX Gene

protein-coding GIFtS: 44
GCID: GC0XM021634

small muscle protein, X-linked

Explore 7 diseases affiliated with
SMPX via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Small Muscle Protein, X-Linked¹ ²
Stretch-Responsive Skeletal Muscle Protein² ³
DFNX4²
Small Muscular Protein²
SRMX³

External Ids:	HGNC: 11122¹	Entrez Gene: 23676²	Ensembl: ENSG00000091482⁷	OMIM: 300226⁵	UniProtKB: Q9UHP9³

Export aliases for SMPX gene to outside databases

Previous GC identifers: GC0XM020298 GC0XM020922 GC0XM021085 GC0XM021483 GC0XM019465

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SMPX:

This gene encodes a small protein that has no known functional domains. Mutations in this gene are a cause of X-linked

deafness-4, and the encoded protein may play a role in the maintenance of inner ear cells subjected to mechanical

stress. Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: SMPX_HUMAN, Q9UHP9

Function: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional

states during growth, adaptation, and repair (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SMPX gene promoter:
STAT5B C/EBPbeta POU3F1 FOXL1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 FOXO1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMPX promoter sequence

Search SABiosciences Chromatin IP Primers for SMPX

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMPX

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.1 Ensembl cytogenetic band: Xp22.12 HGNC cytogenetic band: Xp22.2-p22.1

SMPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMPX gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM021634: view genomic region (about GC identifiers)

Start:	21,724,090 bp from pter	End:	21,776,281 bp from pter
Size:	52,192 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SMPX_HUMAN, Q9UHP9 (See protein sequence)

Recommended Name: Small muscular protein

Size: 88 amino acids; 9559 Da

Caution: It is uncertain whether Met-1 or Met-3 is the initiator

Secondary accessions: B1AWX2

Explore the universe of human proteins at neXtProt for SMPX: NX_Q9UHP9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UHP9

SMPX Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055147.1

ENSEMBL proteins:

ENSP00000368808

Human Recombinant Protein Products for SMPX:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: SMPX OriGene Protein Over-expression Lysate: SMPX OriGene Custom Protein Services for SMPX
	GenScript Custom Purified and Recombinant Proteins Services for SMPX
	Novus Biologicals SMPX Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SMPX

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005927	muscle tendon junction	IEA	--
GO:0031430	M band	IEA	--
GO:0043034	costamere	IEA	--

SMPX for ontologies About GeneDecksing

SMPX Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for SMPX
	Novus Biologicals SMPX Antibodies
	Abcam antibodies for SMPX
	Uscn Antibodies for SMPX
	ThermoFisher Antibodies for SMPX

Assay Products for SMPX:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SMPX
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SMPX

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9UHP9

UniProtKB/Swiss-Prot: SMPX_HUMAN, Q9UHP9

Similarity: Belongs to the SMPX family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SMPX_HUMAN, Q9UHP9

Function: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional

states during growth, adaptation, and repair (By similarity)

Genatlas biochemistry entry for SMPX:

striated muscle protein X,expressed in muscle and heart

Phenotypes:
1 GenomeRNAi human phenotype for SMPX:

Increased gamma-H2AX phosphory

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Smpx):

no phenotypic analysis

normal

SMPX for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Smpx^tm1Rph for SMPX

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SMPX

miRNA Products:		OriGene 3'-UTR Clone: SMPX Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMPX
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SMPX:
		hsa-miR-3163 hsa-miR-485-3p hsa-miR-410 hsa-miR-4282
		SwitchGear 3'UTR luciferase reporter plasmid: SMPX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMPX (see all 7) OriGene shRNA RFP: SMPX OriGene siRNA: SMPX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMPX
		Sirion Biotech Custom design and validation of potent shRNA sequences against SMPX

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SMPX
			Sirion Biotech Customized adenovirus for overexpression of SMPX Sirion Biotech Customized adenovirus for potent knockdown of SMPX

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPX (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPX OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SMPX (NM_014332)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMPX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPX

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SMPX
		Search LifeMap BioReagents cell lines for SMPX
		Sirion Biotech Customized stable knockdown cell line services for SMPX Sirion Biotech Customized inducible knockdown cell line services for SMPX Sirion Biotech Customized stable overexpressing cell line services for SMPX Sirion Biotech Customized inducible overexpressing cell line services for SMPX

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SMPX

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SMPX

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006941	striated muscle contraction	TAS	10598820

SMPX for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SMPX for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SMPX
1 Novoseek chemical compound relationship for SMPX gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydrogen	0	1	15005633 (1)

Search CenterWatch for drugs/clinical trials and news about SMPX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SMPX gene:

NM_014332.2

Unigene Cluster for SMPX:

Small muscle protein, X-linked

Hs.86492 [show with all ESTs]

Unigene Representative Sequence: NR_045617

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379494(uc022btv.1 uc004daa.3) ENST00000494525

miRNA Products:		OriGene 3'-UTR Clone: SMPX Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMPX
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SMPX:
		hsa-miR-3163 hsa-miR-485-3p hsa-miR-410 hsa-miR-4282
		SwitchGear 3'UTR luciferase reporter plasmid: SMPX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMPX (see all 7) OriGene shRNA RFP: SMPX OriGene siRNA: SMPX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMPX
		Sirion Biotech Custom design and validation of potent shRNA sequences against SMPX

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPX (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPX OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SMPX (NM_014332)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMPX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPX

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SMPX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPX

Additional cDNA sequence:

AF129505.1 AJ250584.1 AK312134.1 BC005948.1 NR_045617.1

3 DOTS entries:

DT.413492 DT.91831685 DT.121282744

24/46 AceView cDNA sequences (see all 46):

AJ250584 BM697544 AF129505 AI355906 AI090520 AI381720 NM_014332 AI190689

AI333485 BU735731 AI355905 AW170011 BM717052 BC005948 AI355904 BF791178

BE856875 BX116016 F16837 BX502872 AA211521 AI824667 W07478 F36800

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SMPX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATGTCGA

About this image

SMPX expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Myocardium

Foregut Endoderm Cells

Endoderm

Epicardium

Mesenchymal Condensate Cells

Bone, Cartilage

Bone

Heart

Limb

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Cardiomyocyte-like progenitor cells (Derivation of cardio...)

Beating cell clusters (Spontaneous differen...)

See SMPX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMPX

SOURCE GeneReport for Unigene cluster: Hs.86492

UniProtKB/Swiss-Prot: SMPX_HUMAN, Q9UHP9

Tissue specificity: Preferentially and abundantly expressed in heart and skeletal muscle

SABiosciences Custom PCR Arrays for SMPX

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SMPX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPX

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SMPX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SMPX gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Smpx^{1 , 5}	small muscle protein, X-linked^{1, 5}	85.1(n)¹ 87.06(a)¹		X (72.67 cM)⁵ 66106¹ NM_025357.3¹ NP_079633.1¹ 157698910⁵
chicken (Gallus gallus)	Aves	SMPX¹	small muscle protein, X-linked	76.74(n) 81.4(a)		771780 XM_001234018.2 XP_001234019.1
lizard (Anolis carolinensis)	Reptilia	SMPX⁶	--	76(a)	1 ↔ 1	3(124547685-124554654)
African clawed frog (Xenopus laevis)	Amphibia	MGC64235²	hypothetical protein MGC64235	76.97(n)		AF343894.1
zebrafish (Danio rerio)	Actinopterygii	smpx¹	small muscle protein, X-linked	67.89(n) 71.95(a)		431732 NM_001002185.1 NP_001002185.1

ENSEMBL Gene Tree for SMPX (if available)
TreeFam Gene Tree for SMPX (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183763795^1,2		--	21723757(+)	`TACTTC/TATTGT`	2	--	ds500¹		0	--	--	--	--
rs140527961^1,2		--	21723904(+)	`ATCCAA/TTTCCT`	2	--	ds500¹		0	--	--	--	--
rs145808515^1,2		--	21723957(+)	`TTTTAC/GCCATG`	2	--	ds500¹		0	--	--	--	--
rs12848589^1,2	C,F,H	--	21724039(+)	`TCTCCA/GGGTTT`	2	--	ds500¹		7		NA NS EA	514
rs191715076^1,2		--	21724341(+)	`AAAATG/TAAGAT`	2	--	nc-transcript-variantut3¹		0	--	--	--	--
rs184731985^1,2		--	21724367(+)	`GCCAAC/TTAGAA`	2	--	nc-transcript-variantut3¹		0	--	--	--	--
rs189668874^1,2		--	21724849(+)	`GTGGGA/GCCAGA`	2	--	int¹		0	--	--	--	--
rs181612609^1,2		--	21724878(+)	`GAGGGC/TGGTTC`	2	--	int¹		0	--	--	--	--
rs185203053^1,2		--	21725204(+)	`TCATCG/TCCCCA`	2	--	int¹		0	--	--	--	--
rs200739484^1,2		--	21725254(+)	`TTTGA-/CTCTCTG`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SMPX (21724090 - 21776281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMPX: --
Human Gene Mutation Database (HGMD): SMPX

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMPX

DNA2.0 Custom Variant and Variant Library Synthesis for SMPX

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SMPX for disorders About GeneDecksing

OMIM gene information: 300226 OMIM disorders: --

UniProtKB/Swiss-Prot: SMPX_HUMAN, Q9UHP9

Defects in SMPX are the cause of deafness X-linked type 4 (DFNX4) [MIM:300066]. A non-syndromic form of

sensorineural, progressive hearing loss with postlingual onset. In affected males, the auditory impairment affects

initially high-frequency hearing. It later evolves to become severe to profound and affects all frequencies. Carrier

females manifest moderate hearing impairment in the high frequencies

7 diseases for SMPX: About MalaCards

friedreich ataxia hearing loss ataxia choroiditis

immunodeficiency neuronitis hiv type 1

1 Novoseek disease relationship for SMPX gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	0	3	10559313 (1), 11860675 (1), 11000245 (1)

Export disorders for SMPX gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SMPX gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with SMPX)

Utopia: connect your pdf to the dynamic
world of online information

Identification, mapping, and genomic structure of a novel X- chromosomal human gene (SMPX) encoding a small muscular protein. (PubMed id 10598820)^{1, 2, 9} Patzak D.... Wehnert M. (1999)
Identification of a novel stretch-responsive skeletal muscle gene (Smpx). (PubMed id 11401441)^{1, 2, 9} Kemp T.J.... Coulton G.R. (2001)
Nonsense mutations in SMPX, encoding a protein responsive to physical force, result in X-chromosomal hearing loss. (PubMed id 21549336)^{1, 2} Huebner A.K.... Kurth I. (2011)
Next-generation sequencing identifies mutations of SMPX, which encodes the small muscle protein, X-linked, as a cause of progressive hearing impairment. (PubMed id 21549342)^{1, 2} Schraders M.... Kremer H. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel deletion in SMPX causes a rare form of X-linked progressive hearing loss in two families due to a founder effect. (PubMed id 22911656)² Abdelfatah N.... Young T.L. (2013)
Variable degrees of hearing impairment in a Dutch DFN X4 (DFN6) family. (PubMed id 21893181)¹ Weegerink N.J....Kunst H.P. (2011)
The DNA sequence of the human X chromosome. (PubMed id 15772651)² Ross M.T.... Bentley D.R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23676	HGNC: 11122	AceView: SMPX	Ensembl:ENSG00000091482	euGenes: HUgn23676
ECgene: SMPX	H-InvDB: SMPX

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SMPX	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SMPX gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SMPX gene:
Search GeneIP for patents involving SMPX

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	EMD Millipore Custom Antibody & Bulk Services
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	Browse OriGene Antibodies		OriGene shRNA RFP for SMPX
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMPX		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPX
	OriGene Protein Over-expression Lysate for SMPX		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SMPX		OriGene 3'-UTR Clone for SMPX
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPX		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPX
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SMPX		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SMPX		OriGene Custom Protein Services for SMPX
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMPX
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMPX
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMPX
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMPX
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPX
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPX

	GenScript Custom Purified and Recombinant Proteins Services for SMPX		GenScript cDNA clones with any tag delivered in your preferred vector for SMPX
	GenScript Custom Assay Services for SMPX		GenScript Custom Superior Antibodies Services for SMPX
	GenScript Custom overexpressing Cell Line Services for SMPX		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in SMPX promoter
	Search Chromatin IP Primers for SMPX
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Search Tocris compounds for SMPX

	Browse Sino Biological Proteins and Antibodies
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SMPX antibodies
	SMPX lysates

	Antibodies for SMPX
	See all of Abcam's Antibodies, Kits and Proteins for SMPX
	Custom Antibody / Protein Production Service
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Browse ProSpec Recombinant Proteins

SMPX Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SMPX

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SMPX

	SwitchGear 3'UTR luciferase reporter plasmids for SMPX
	SwitchGear Promoter luciferase reporter plasmids for SMPX

ThermoFisher Antibodies for SMPX

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPX

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SMPX

Sirion Biotech Customized:

	stable knockdown cell line services for SMPX
	inducible knockdown cell line services for SMPX
	design and validation of potent shRNA sequences against SMPX
	adenovirus for potent knockdown of SMPX
	adenovirus for overexpression of SMPX
	stable overexpressing cell line services for SMPX
	inducible overexpressing cell line services for SMPX

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SMPX gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

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SMPX Gene

small muscle protein, X-linked

Aliases
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for SMPX gene

Protein Domains /
Families
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Function
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Pathways & Interactions
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Expression
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Orthologs
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External Searches for SMPX gene

Genome Databases showing SMPX gene

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Intellectual Property
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Export list of displayed genes

SMPX Gene

small muscle protein, X-linked

Aliasesfor SMPX gene

Summariesfor SMPX gene

Genomic Viewsfor SMPX gene

Proteinsfor SMPX gene

Protein Domains /Familiesfor SMPX gene

Functionfor SMPX gene

Pathways & Interactionsfor SMPX gene

Drugs & Compoundsfor SMPX gene

Transcriptsfor SMPX gene

Expression for SMPX gene

Orthologsfor SMPX gene

Paralogsfor SMPX gene

Genomic Variantsfor SMPX gene

Disorders / Diseasesfor SMPX gene

Publicationsfor SMPX gene

External Searches for SMPX gene

Genome Databases showing SMPX gene

Other Databases showing SMPX gene

Specialized Databases showing SMPX gene

Intellectual Propertyfor SMPX gene

Productsfor SMPX gene

View Random Gene

Aliases
for SMPX gene

Summaries
for SMPX gene

Genomic Views
for SMPX gene

Proteins
for SMPX gene

Protein Domains /
Families
for SMPX gene

Function
for SMPX gene

Pathways & Interactions
for SMPX gene

Drugs & Compounds
for SMPX gene

Transcripts
for SMPX gene

Expression
for SMPX gene

Orthologs
for SMPX gene

Paralogs
for SMPX gene

Genomic Variants
for SMPX gene

Disorders / Diseases
for SMPX gene

Publications
for SMPX gene

Intellectual Property
for SMPX gene

Products
for SMPX gene