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SMPDL3B Gene

protein-coding   GIFtS: 50
GCID: GC01P028261

Sphingomyelin Phosphodiesterase, Acid-Like 3B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingomyelin Phosphodiesterase, Acid-Like 3B1 2
ASML3B2 3
ASM-Like Phosphodiesterase 3b2 3
Acid Sphingomyelinase-Like Phosphodiesterase 3b2
EC 3.1.4.-3

External Ids:    HGNC: 214161   Entrez Gene: 272932   Ensembl: ENSG000001307687   UniProtKB: Q924853   

Export aliases for SMPDL3B gene to outside databases

Previous GC identifers: GC01P027867 GC01P027945 GC01P028134 GC01P026518


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SMPDL3B Gene:
SMPDL3B (sphingomyelin phosphodiesterase, acid-like 3B) is a protein-coding gene. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPDL3A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMPDL3B gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   IRF-1   C/EBPalpha   CREB   PPAR-alpha   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMPDL3B promoter sequence
   Search Chromatin IP Primers for SMPDL3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMPDL3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

SMPDL3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMPDL3B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028261:  view genomic region     (about GC identifiers)

Start:
28,261,504 bp from pter      End:
28,285,668 bp from pter
Size:
24,165 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ASM3B_HUMAN, Q92485 (See protein sequence)
Recommended Name: Acid sphingomyelinase-like phosphodiesterase 3b precursor  
Size: 455 amino acids; 50814 Da
Secondary accessions: B7ZB35 Q5T0Z0 Q96CB7
Alternative splicing: 2 isoforms:  Q92485-1   Q92485-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMPDL3B: NX_Q92485

Explore proteomics data for SMPDL3B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn72, Asn164, Asn343
  • Modification sites at PhosphoSitePlus

  • See SMPDL3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001009568.1  NP_055289.2  

    ENSEMBL proteins: 
     ENSP00000363001   ENSP00000449057   ENSP00000388092   ENSP00000362995   ENSP00000449450  

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    antibodies-online antibodies for SMPDL3B (17 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017064 ASM-like_Pdiesterase_prd
     IPR004843 PEstase_dom

    Graphical View of Domain Structure for InterPro Entry Q92485

    ProtoNet protein and cluster: Q92485

    UniProtKB/Swiss-Prot: ASM3B_HUMAN, Q92485
    Similarity: Belongs to the acid sphingomyelinase family


    Find genes that share domains with SMPDL3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 3.1.4.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004767sphingomyelin phosphodiesterase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0016798hydrolase activity, acting on glycosyl bonds IEA--
         
    Find genes that share ontologies with SMPDL3B           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Smpdl3b):
     behavior/neurological  other 

    Find genes that share phenotypes with SMPDL3B           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SMPDL3B

    miRNA
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    miRTarBase miRNAs that target SMPDL3B:
    hsa-let-7a-5p (MIRT052379)

    Block miRNA regulation of human, mouse, rat SMPDL3B using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SMPDL3B:
    hsa-miR-1207-5p hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSMPDL3B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASM3B_HUMAN, Q92485: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome3
    extracellular2
    peroxisome2
    cytosol1
    golgi apparatus1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SMPDL3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMPDL3B
    Interactions:

        Search GeneGlobe Interaction Network for SMPDL3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for SMPDL3B (ENSP000003630014) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2E1ENSP000002838754STRING: ENSP00000283875
    NCLENSP000003181954STRING: ENSP00000318195
    NOLC1ENSP000003590244STRING: ENSP00000359024
    RNF20ENSP000003737724STRING: ENSP00000373772
    RNF40ENSP000003256774STRING: ENSP00000325677
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006685sphingomyelin catabolic process IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with SMPDL3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMPDL3B (ASM3B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMPDL3B gene (2 alternative transcripts): 
    NM_001009568.1  NM_014474.2  

    Unigene Cluster for SMPDL3B:

    Sphingomyelin phosphodiesterase, acid-like 3B
    Hs.123659  [show with all ESTs]
    Unigene Representative Sequence: AK293566
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373894(uc001bpg.3 uc010ofr.2) ENST00000548116(uc010ofq.2)
    ENST00000411604 ENST00000373888(uc001bpf.3) ENST00000466793 ENST00000549094

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SMPDL3B:
    hsa-miR-1207-5p hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSMPDL3B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SMPDL3B
      QuantiFast Probe-based Assays in human, mouse, rat SMPDL3B

    Additional mRNA sequence: 

    AK293489.1 AK293566.1 AK301349.1 AK316500.1 BC014444.1 Y08134.1 

    4 DOTS entries:

    DT.209935  DT.100775446  DT.102823217  DT.121445257 

    Selected AceView cDNA sequences (see all 69):

    CB160850 BM795371 AU099361 AU105486 CR613549 AU076428 CA489839 BE271909 
    BM924641 BQ710341 AA928880 AA635056 AU105491 BC014444 BF032464 AW015709 
    NM_014474 CA438608 BM048081 CA425405 BE999992 AI492184 BI760069 AL569955 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMPDL3B (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                -     -     -     -                 -                                                               
    SP2:                                                                                                                          -         
    SP3:                                -     -     -                       -                                                               
    SP4:                                -                                                                                                   
    SP5:                                -     -     -     -           -     -     -                                                         


    ECgene alternative splicing isoforms for SMPDL3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMPDL3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTTTGAAAA
    SMPDL3B Expression
    About this image


    SMPDL3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    SMPDL3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMPDL3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123659
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SMPDL3B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smpdl3b1 , 5 sphingomyelin phosphodiesterase, acid-like 3B1, 5 80.97(n)1
    76.94(a)1
      4 (65.82 cM)5
    1003401  NM_133888.21  NP_598649.11 
     1327329665 
    chicken
    (Gallus gallus)
    Aves SMPDL3B1 sphingomyelin phosphodiesterase, acid-like 3B 65.58(n)
    62.56(a)
      769013  NM_001252280.1  NP_001239209.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMPDL3B6
    sphingomyelin phosphodiesterase, acid-like 3B
    59(a)
    1 ↔ 1
    GL343743.1(63482-70782)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia smpdl3b1 sphingomyelin phosphodiesterase, acid-like 3B 61.6(n)
    61.98(a)
      100489638  XM_002939352.2  XP_002939398.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5643921 acid sphingomyelinase-like phosphodiesterase 3b-like 62.33(n)
    56.74(a)
      564392  XM_687730.6  XP_692822.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG320521 CG32052 51.64(n)
    40.64(a)
      326184  NM_168375.4  NP_729555.4 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK856.51 ZK856.5 47.33(n)
    37.86(a)
      191439  NM_073219.5  NP_505620.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPN1(YDR452W)4 Vacuolar endopolyphosphatase with a role in phosphate more   --   4(1362878-1364902) 852063  NP_010740.1 


    ENSEMBL Gene Tree for SMPDL3B (if available)
    TreeFam Gene Tree for SMPDL3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMPDL3B gene
    SMPDL3A2  SMPD12  
    1 SIMAP similar gene for SMPDL3B using alignment to 4 protein entries:     ASM3B_HUMAN (see all proteins):
    SMPDL3A

    Find genes that share paralogs with SMPDL3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMPDL3B (see all 524)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558411661,2
    C,F--26514945(+) TCTTTT/CTTTTT 2 -- us2k13Minor allele frequency- C:0.33WA NA 6
    rs2013719171,2
    --26514945(+) TCTTT-/CTTTTT 2 -- us2k10--------
    rs1864151091,2
    --26514970(+) GTCTCA/GCTCTG 2 -- us2k10--------
    rs359748061,2
    C,F--26514993(+) GAGTGC/TAGTGG 2 -- us2k13Minor allele frequency- T:0.50NA CSA 6
    rs1916017891,2
    --26515003(+) GCACTA/TTCTCG 2 -- us2k10--------
    rs1834969231,2
    --26515010(+) CTCGGC/TTCACT 2 -- us2k10--------
    rs1889375151,2
    --26515051(+) CTCCTG/TCCTCA 2 -- us2k10--------
    rs115860191,2
    C,A,H--26515208(+) ccaagG/Ttgggc 2 -- us2k13Minor allele frequency- T:0.17NA 6
    rs1924866331,2
    --26515306(+) GGTGGC/TGCATG 2 -- us2k10--------
    rs115873201,2
    C,F,H--26515345(+) agacaG/Agataa 2 -- us2k110Minor allele frequency- A:0.32NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for SMPDL3B (28261504 - 28285668 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SMPDL3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871458CNV Gain21882294
    nsv871591CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMPDL3B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SMPDL3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification of a candidate gene for astigmatism. (PubMed id 23322567)1 Lopes M.C....Hammond C.J. (amp 2013)
    4. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    6. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 
    10. Generation of biologically active linear and cyclic peptides has revealed a unique fine specificity of rituximab and its possible cross-reactivity with acid sphingomyelinase-like phosphodiesterase 3b precursor. (PubMed id 16223774)9 Perosa F....Dammacco F. (Blood 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27293 HGNC: 21416 AceView: SMPDL3B Ensembl:ENSG00000130768 euGenes: HUgn27293
    ECgene: SMPDL3B H-InvDB: SMPDL3B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMPDL3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMPDL3B gene:
    Search GeneIP for patents involving SMPDL3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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