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Aliases for SMPDL3B Gene

Aliases for SMPDL3B Gene

  • Sphingomyelin Phosphodiesterase, Acid-Like 3B 2 3
  • ASM-Like Phosphodiesterase 3b 3 4
  • ASML3B 3 4
  • Acid Sphingomyelinase-Like Phosphodiesterase 3b 3
  • EC 3.1.4.- 4

External Ids for SMPDL3B Gene

Previous GeneCards Identifiers for SMPDL3B Gene

  • GC01P027867
  • GC01P028134
  • GC01P028261
  • GC01P026518

Summaries for SMPDL3B Gene

GeneCards Summary for SMPDL3B Gene

SMPDL3B (Sphingomyelin Phosphodiesterase, Acid-Like 3B) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPDL3A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMPDL3B Gene

Genomics for SMPDL3B Gene

Regulatory Elements for SMPDL3B Gene

Genomic Location for SMPDL3B Gene

27,934,993 bp from pter
27,959,157 bp from pter
24,165 bases
Plus strand

Genomic View for SMPDL3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMPDL3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMPDL3B Gene

Proteins for SMPDL3B Gene

  • Protein details for SMPDL3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acid sphingomyelinase-like phosphodiesterase 3b
    Protein Accession:
    Secondary Accessions:
    • B7ZB35
    • Q5T0Z0
    • Q96CB7

    Protein attributes for SMPDL3B Gene

    455 amino acids
    Molecular mass:
    50814 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMPDL3B Gene


neXtProt entry for SMPDL3B Gene

Proteomics data for SMPDL3B Gene at MOPED

Post-translational modifications for SMPDL3B Gene

  • Glycosylation at Asn72, Asn164, and Asn343
  • Modification sites at PhosphoSitePlus

Other Protein References for SMPDL3B Gene

No data available for DME Specific Peptides for SMPDL3B Gene

Domains for SMPDL3B Gene

Protein Domains for SMPDL3B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q92485
  • Belongs to the acid sphingomyelinase family.
genes like me logo Genes that share domains with SMPDL3B: view

No data available for Gene Families for SMPDL3B Gene

Function for SMPDL3B Gene

Enzyme Numbers (IUBMB) for SMPDL3B Gene

Gene Ontology (GO) - Molecular Function for SMPDL3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004767 sphingomyelin phosphodiesterase activity IEA --
GO:0016787 hydrolase activity --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with SMPDL3B: view

Phenotypes for SMPDL3B Gene

genes like me logo Genes that share phenotypes with SMPDL3B: view

Animal Model Products

CRISPR Products

miRNA for SMPDL3B Gene

miRTarBase miRNAs that target SMPDL3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMPDL3B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMPDL3B Gene

Localization for SMPDL3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMPDL3B Gene


Subcellular locations from

Jensen Localization Image for SMPDL3B Gene COMPARTMENTS Subcellular localization image for SMPDL3B gene
Compartment Confidence
lysosome 3
extracellular 2
peroxisome 2
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMPDL3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SMPDL3B: view

Pathways for SMPDL3B Gene

SuperPathways for SMPDL3B Gene

No Data Available

Interacting Proteins for SMPDL3B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000363001 for SMPDL3B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SMPDL3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006685 sphingomyelin catabolic process IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with SMPDL3B: view

No data available for Pathways by source for SMPDL3B Gene

Transcripts for SMPDL3B Gene

Unigene Clusters for SMPDL3B Gene

Sphingomyelin phosphodiesterase, acid-like 3B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMPDL3B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMPDL3B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -

Relevant External Links for SMPDL3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMPDL3B Gene

mRNA expression in normal human tissues for SMPDL3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMPDL3B Gene

This gene is overexpressed in Pancreas (10.6), Colon - Transverse (8.7), and Stomach (4.5).

Protein differential expression in normal tissues for SMPDL3B Gene

This gene is overexpressed in Adipocyte (26.2) and Cervix (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMPDL3B Gene

SOURCE GeneReport for Unigene cluster for SMPDL3B Gene Hs.123659

genes like me logo Genes that share expressions with SMPDL3B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for SMPDL3B Gene

Orthologs for SMPDL3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SMPDL3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMPDL3B 35
  • 84.79 (n)
  • 81.8 (a)
  • 78 (a)
(Canis familiaris)
Mammalia SMPDL3B 35
  • 86.45 (n)
  • 82.68 (a)
  • 79 (a)
(Mus musculus)
Mammalia Smpdl3b 35
  • 80.97 (n)
  • 76.94 (a)
Smpdl3b 16
Smpdl3b 36
  • 75 (a)
(Pan troglodytes)
Mammalia SMPDL3B 35
  • 99.34 (n)
  • 99.34 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Smpdl3b 35
  • 80.67 (n)
  • 75.34 (a)
(Monodelphis domestica)
Mammalia SMPDL3B 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SMPDL3B 36
  • 61 (a)
(Gallus gallus)
Aves SMPDL3B 35
  • 65.58 (n)
  • 62.56 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia SMPDL3B 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smpdl3b 35
  • 61.6 (n)
  • 61.98 (a)
(Danio rerio)
Actinopterygii LOC564392 35
  • 62.33 (n)
  • 56.74 (a)
smpdl3b 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6438 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005806 35
  • 49.22 (n)
  • 36.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32052 35
  • 51.64 (n)
  • 40.64 (a)
CG32052 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ZK856.5 35
  • 47.33 (n)
  • 37.86 (a)
asm-3 36
  • 15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPN1 36
  • 12 (a)
PPN1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
-- 36
  • 40 (a)
Species with no ortholog for SMPDL3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMPDL3B Gene

Gene Tree for SMPDL3B (if available)
Gene Tree for SMPDL3B (if available)

Paralogs for SMPDL3B Gene

Paralogs for SMPDL3B Gene

Selected SIMAP similar genes for SMPDL3B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SMPDL3B: view

Variants for SMPDL3B Gene

Sequence variations from dbSNP and Humsavar for SMPDL3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1010081 -- 27,941,205(+) TGGGC(A/G)GCGGG intron-variant
rs1010082 -- 27,941,358(+) CAGTG(G/T)ATGAA intron-variant
rs1077286 -- 27,935,700(+) atgat(A/G)agtgt intron-variant
rs3737807 -- 27,935,391(-) CTAAG(G/T)CCCAC intron-variant
rs3737808 -- 27,935,089(-) GTGCC(G/T)GAGCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SMPDL3B Gene

Variant ID Type Subtype PubMed ID
nsv871591 CNV Gain 21882294
nsv871458 CNV Gain 21882294

Relevant External Links for SMPDL3B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMPDL3B Gene

Disorders for SMPDL3B Gene

No disorders were found for SMPDL3B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SMPDL3B Gene

Publications for SMPDL3B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Identification of a candidate gene for astigmatism. (PMID: 23322567) Lopes M.C. … Hammond C.J. (Invest. Ophthalmol. Vis. Sci. 2013) 3

Products for SMPDL3B Gene

Sources for SMPDL3B Gene

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