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Aliases for SMPDL3B Gene

Aliases for SMPDL3B Gene

  • Sphingomyelin Phosphodiesterase Acid Like 3B 2 3
  • Sphingomyelin Phosphodiesterase Acid-Like 3B 2 3 5
  • Sphingomyelin Phosphodiesterase, Acid-Like 3B 2 3
  • ASM-Like Phosphodiesterase 3b 3 4
  • ASML3B 3 4
  • EC 3.1.4.- 4

External Ids for SMPDL3B Gene

Previous GeneCards Identifiers for SMPDL3B Gene

  • GC01P027867
  • GC01P028134
  • GC01P028261
  • GC01P026518

Summaries for SMPDL3B Gene

GeneCards Summary for SMPDL3B Gene

SMPDL3B (Sphingomyelin Phosphodiesterase Acid Like 3B) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPDL3A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMPDL3B Gene

Genomics for SMPDL3B Gene

Regulatory Elements for SMPDL3B Gene

Enhancers for SMPDL3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMPDL3B on UCSC Golden Path with GeneCards custom track

Promoters for SMPDL3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMPDL3B on UCSC Golden Path with GeneCards custom track

Genomic Location for SMPDL3B Gene

27,934,948 bp from pter
27,959,157 bp from pter
24,210 bases
Plus strand

Genomic View for SMPDL3B Gene

Genes around SMPDL3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMPDL3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMPDL3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMPDL3B Gene

Proteins for SMPDL3B Gene

  • Protein details for SMPDL3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acid sphingomyelinase-like phosphodiesterase 3b
    Protein Accession:
    Secondary Accessions:
    • B7ZB35
    • Q5T0Z0
    • Q96CB7

    Protein attributes for SMPDL3B Gene

    455 amino acids
    Molecular mass:
    50814 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMPDL3B Gene


neXtProt entry for SMPDL3B Gene

Proteomics data for SMPDL3B Gene at MOPED

Post-translational modifications for SMPDL3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMPDL3B Gene

No data available for DME Specific Peptides for SMPDL3B Gene

Domains & Families for SMPDL3B Gene

Protein Domains for SMPDL3B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the acid sphingomyelinase family.
  • Belongs to the acid sphingomyelinase family.
genes like me logo Genes that share domains with SMPDL3B: view

No data available for Gene Families for SMPDL3B Gene

Function for SMPDL3B Gene

Enzyme Numbers (IUBMB) for SMPDL3B Gene

Gene Ontology (GO) - Molecular Function for SMPDL3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004767 sphingomyelin phosphodiesterase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SMPDL3B: view
genes like me logo Genes that share phenotypes with SMPDL3B: view

Animal Models for SMPDL3B Gene

MGI Knock Outs for SMPDL3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for SMPDL3B

CRISPR Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMPDL3B Gene

Localization for SMPDL3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMPDL3B Gene


Subcellular locations from

Jensen Localization Image for SMPDL3B Gene COMPARTMENTS Subcellular localization image for SMPDL3B gene
Compartment Confidence
extracellular 5
lysosome 3
vacuole 3
cytosol 2
golgi apparatus 2
peroxisome 2
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SMPDL3B Gene

Pathways & Interactions for SMPDL3B Gene

SuperPathways for SMPDL3B Gene

No Data Available

Interacting Proteins for SMPDL3B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000363001 for SMPDL3B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SMPDL3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SMPDL3B: view

No data available for Pathways by source and SIGNOR curated interactions for SMPDL3B Gene

Drugs & Compounds for SMPDL3B Gene

No Compound Related Data Available

Transcripts for SMPDL3B Gene

Unigene Clusters for SMPDL3B Gene

Sphingomyelin phosphodiesterase, acid-like 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMPDL3B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -

Relevant External Links for SMPDL3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMPDL3B Gene

mRNA expression in normal human tissues for SMPDL3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMPDL3B Gene

This gene is overexpressed in Pancreas (x10.6), Colon - Transverse (x8.7), and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for SMPDL3B Gene

This gene is overexpressed in Adipocyte (26.2) and Cervix (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMPDL3B Gene

SOURCE GeneReport for Unigene cluster for SMPDL3B Gene Hs.123659

genes like me logo Genes that share expression patterns with SMPDL3B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SMPDL3B Gene

Orthologs for SMPDL3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SMPDL3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMPDL3B 35
  • 84.79 (n)
  • 81.8 (a)
  • 78 (a)
(Canis familiaris)
Mammalia SMPDL3B 35
  • 86.45 (n)
  • 82.68 (a)
  • 79 (a)
(Mus musculus)
Mammalia Smpdl3b 35
  • 80.97 (n)
  • 76.94 (a)
Smpdl3b 16
Smpdl3b 36
  • 75 (a)
(Pan troglodytes)
Mammalia SMPDL3B 35
  • 99.34 (n)
  • 99.34 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Smpdl3b 35
  • 80.67 (n)
  • 75.34 (a)
(Monodelphis domestica)
Mammalia SMPDL3B 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SMPDL3B 36
  • 61 (a)
(Gallus gallus)
Aves SMPDL3B 35
  • 65.58 (n)
  • 62.56 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia SMPDL3B 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smpdl3b 35
  • 61.6 (n)
  • 61.98 (a)
(Danio rerio)
Actinopterygii LOC564392 35
  • 62.33 (n)
  • 56.74 (a)
smpdl3b 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6438 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005806 35
  • 49.22 (n)
  • 36.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32052 35
  • 51.64 (n)
  • 40.64 (a)
CG32052 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ZK856.5 35
  • 47.33 (n)
  • 37.86 (a)
asm-3 36
  • 15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPN1 36
  • 12 (a)
PPN1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
-- 36
  • 40 (a)
Species with no ortholog for SMPDL3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMPDL3B Gene

Gene Tree for SMPDL3B (if available)
Gene Tree for SMPDL3B (if available)

Paralogs for SMPDL3B Gene

Paralogs for SMPDL3B Gene

(1) SIMAP similar genes for SMPDL3B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SMPDL3B: view

Variants for SMPDL3B Gene

Sequence variations from dbSNP and Humsavar for SMPDL3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_048340 -
rs1010081 -- 27,941,205(+) TGGGC(A/G)GCGGG intron-variant, upstream-variant-2KB
rs1010082 -- 27,941,358(+) CAGTG(G/T)ATGAA intron-variant, utr-variant-5-prime
rs1077286 -- 27,935,700(+) atgat(A/G)agtgt intron-variant
rs3813803 -- 27,955,781(-) TCCGG(A/G)CCACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SMPDL3B Gene

Variant ID Type Subtype PubMed ID
nsv871591 CNV Gain 21882294
nsv871458 CNV Gain 21882294

Variation tolerance for SMPDL3B Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.82; 79.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SMPDL3B Gene

Disorders for SMPDL3B Gene

Relevant External Links for SMPDL3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMPDL3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMPDL3B Gene

Publications for SMPDL3B Gene

  1. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. (PMID: 26095358) Heinz L.X. … Superti-Furga G. (Cell Rep 2015) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. Identification of a candidate gene for astigmatism. (PMID: 23322567) Lopes M.C. … Hammond C.J. (Invest. Ophthalmol. Vis. Sci. 2013) 3

Products for SMPDL3B Gene

Sources for SMPDL3B Gene