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Aliases for SMPDL3A Gene

Aliases for SMPDL3A Gene

  • Sphingomyelin Phosphodiesterase, Acid-Like 3A 2 3
  • ASML3a 3 4 6
  • Acid Sphingomyelinase-Like Phosphodiesterase 3a 2 3
  • ASM-Like Phosphodiesterase 3a 3 4
  • 0610010C24Rik 3
  • EC 3.1.4.- 4
  • YR36GH4.1 3
  • EC 3.1.4 63
  • ASM3A 3

External Ids for SMPDL3A Gene

Summaries for SMPDL3A Gene

GeneCards Summary for SMPDL3A Gene

SMPDL3A (Sphingomyelin Phosphodiesterase, Acid-Like 3A) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPDL3B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMPDL3A Gene

Genomics for SMPDL3A Gene

Genomic Location for SMPDL3A Gene

Start:
122,788,456 bp from pter
End:
122,809,720 bp from pter
Size:
21,265 bases
Orientation:
Plus strand

Genomic View for SMPDL3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMPDL3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMPDL3A Gene

Regulatory Elements for SMPDL3A Gene

Proteins for SMPDL3A Gene

  • Protein details for SMPDL3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92484-ASM3A_HUMAN
    Recommended name:
    Acid sphingomyelinase-like phosphodiesterase 3a
    Protein Accession:
    Q92484
    Secondary Accessions:
    • B7Z729
    • Q8WV13

    Protein attributes for SMPDL3A Gene

    Size:
    453 amino acids
    Molecular mass:
    51260 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMPDL3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMPDL3A Gene

Proteomics data for SMPDL3A Gene at MOPED

Selected DME Specific Peptides for SMPDL3A Gene

Post-translational modifications for SMPDL3A Gene

No Post-translational modifications

Other Protein References for SMPDL3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SMPDL3A Gene

Protein Domains for SMPDL3A Gene

Graphical View of Domain Structure for InterPro Entry

Q92484

UniProtKB/Swiss-Prot:

ASM3A_HUMAN
Family:
  • Belongs to the acid sphingomyelinase family.:
    • Q92484
genes like me logo Genes that share domains with SMPDL3A: view

No data available for Gene Families for SMPDL3A Gene

Function for SMPDL3A Gene

Enzyme Numbers (IUBMB) for SMPDL3A Gene

Gene Ontology (GO) - Molecular Function for SMPDL3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004767 sphingomyelin phosphodiesterase activity IEA --
GO:0005515 protein binding IPI 12442002
GO:0016787 hydrolase activity --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with SMPDL3A: view

miRNA for SMPDL3A Gene

miRTarBase miRNAs that target SMPDL3A

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMPDL3A Gene

Localization for SMPDL3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMPDL3A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMPDL3A Gene COMPARTMENTS Subcellular localization image for SMPDL3A gene
Compartment Confidence
extracellular 5
lysosome 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SMPDL3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SMPDL3A: view

Pathways for SMPDL3A Gene

SuperPathways for SMPDL3A Gene

No Data Available

Interacting Proteins for SMPDL3A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357425%0d%0a9606.ENSP00000265922%0d%0a
Selected Interacting proteins: ENSP00000357425 Q92484-ASM3A_HUMAN for SMPDL3A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SMPDL3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006685 sphingomyelin catabolic process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SMPDL3A: view

No data available for Pathways by source for SMPDL3A Gene

Transcripts for SMPDL3A Gene

Unigene Clusters for SMPDL3A Gene

Sphingomyelin phosphodiesterase, acid-like 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMPDL3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for SMPDL3A Gene

GeneLoc Exon Structure for
SMPDL3A
ECgene alternative splicing isoforms for
SMPDL3A

Expression for SMPDL3A Gene

mRNA expression in normal human tissues for SMPDL3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMPDL3A Gene

This gene is overexpressed in Cervix - Ectocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMPDL3A Gene

SOURCE GeneReport for Unigene cluster for SMPDL3A Gene Hs.486357

genes like me logo Genes that share expressions with SMPDL3A: view

No data available for mRNA Expression by UniProt/SwissProt for SMPDL3A Gene

Orthologs for SMPDL3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SMPDL3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMPDL3A 35
  • 99.48 (n)
  • 98.68 (a)
SMPDL3A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMPDL3A 35
  • 86.86 (n)
  • 83.07 (a)
SMPDL3A 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMPDL3A 35
  • 87.54 (n)
  • 83.19 (a)
SMPDL3A 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smpdl3a 35
  • 82.54 (n)
  • 81.04 (a)
Smpdl3a 16
Smpdl3a 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMPDL3A 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMPDL3A 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smpdl3a 35
  • 82.24 (n)
  • 81.26 (a)
chicken
(Gallus gallus)
Aves SMPDL3A 35
  • 71.19 (n)
  • 68.33 (a)
SMPDL3A 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMPDL3A 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smpdl3a 35
  • 67.61 (n)
  • 65.96 (a)
zebrafish
(Danio rerio)
Actinopterygii smpdl3a 35
  • 64.21 (n)
  • 64.59 (a)
smpdl3a 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32052 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK856.5 36
  • 7 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPN1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
ManyToMany
Species with no ortholog for SMPDL3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMPDL3A Gene

ENSEMBL:
Gene Tree for SMPDL3A (if available)
TreeFam:
Gene Tree for SMPDL3A (if available)

Paralogs for SMPDL3A Gene

Paralogs for SMPDL3A Gene

Selected SIMAP similar genes for SMPDL3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMPDL3A: view

Variants for SMPDL3A Gene

Sequence variations from dbSNP and Humsavar for SMPDL3A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7573 -- 122,809,598(+) TTAAA(A/G)TGCTC utr-variant-3-prime
rs869477 -- 122,802,983(-) AGTCA(C/T)AACAC intron-variant
rs869478 -- 122,802,829(-) CCTCA(A/T)GCAAG intron-variant
rs869479 -- 122,802,766(-) TATGA(C/T)TTTTA intron-variant
rs869480 -- 122,803,147(-) TGGTG(A/G)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMPDL3A Gene

Variant ID Type Subtype PubMed ID
nsv830791 CNV Gain 17160897
nsv823834 CNV Gain 20364138
nsv819111 CNV Loss 19587683

Relevant External Links for SMPDL3A Gene

HapMap Linkage Disequilibrium report
SMPDL3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMPDL3A Gene

Disorders for SMPDL3A Gene

Relevant External Links for SMPDL3A

Human Genome Epidemiology (HuGE) Navigator
SMPDL3A
genes like me logo Genes that share disorders with SMPDL3A: view

No data available for UniProtKB/Swiss-Prot for SMPDL3A Gene

Publications for SMPDL3A Gene

  1. Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. (PMID: 12442002) Wright K.O. … Reeder J.E. (J. Urol. 2002) 2 3 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors. (PMID: 22810003) Noto P.B. … Lala D.S. (Mol. Pharmacol. 2012) 3

Products for SMPDL3A Gene

Sources for SMPDL3A Gene

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