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SMPDL3A Gene

protein-coding   GIFtS: 52
GCID: GC06P123112

Sphingomyelin Phosphodiesterase, Acid-Like 3A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingomyelin Phosphodiesterase, Acid-Like 3A1 2     ASM3A2
Acid Sphingomyelinase-Like Phosphodiesterase 3a1 2     ASML3a2
ASM-Like Phosphodiesterase 3a2 3     yR36GH4.12
ASML3A3 5     EC 3.1.4.-3
0610010C24Rik2     EC 3.1.48

External Ids:    HGNC: 173891   Entrez Gene: 109242   Ensembl: ENSG000001725947   OMIM: 6107285   UniProtKB: Q924843   

Export aliases for SMPDL3A gene to outside databases

Previous GC identifers: GC06P123090 GC06P123091 GC06P123152 GC06P120686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SMPDL3A Gene:
SMPDL3A (sphingomyelin phosphodiesterase, acid-like 3A) is a protein-coding gene. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMPDL3A gene promoter:
         TBP   USF1   NF-1   AML1a   Nkx2-5   C/EBPalpha   Evi-1   Egr-4   USF-1   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMPDL3A promoter sequence
   Search Chromatin IP Primers for SMPDL3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMPDL3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.32

SMPDL3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMPDL3A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P123112:  view genomic region     (about GC identifiers)

Start:
123,109,971 bp from pter      End:
123,130,865 bp from pter
Size:
20,895 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASM3A_HUMAN, Q92484 (See protein sequence)
Recommended Name: Acid sphingomyelinase-like phosphodiesterase 3a precursor  
Size: 453 amino acids; 51260 Da
Secondary accessions: Q8WV13

Explore the universe of human proteins at neXtProt for SMPDL3A: NX_Q92484

Explore proteomics data for SMPDL3A at MOPED

4 DME Specific Peptides for SMPDL3A (Q92484)
 LNTNLYY  DFIKNSGQ  HLDPTYHIT  SFMIWTGDSPPHVPV 


See SMPDL3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001273067.1  NP_006705.1  

ENSEMBL proteins: 
 ENSP00000357425   ENSP00000442152  

SMPDL3A Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for SMPDL3A
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR017064 ASM-like_Pdiesterase_prd
 IPR004843 PEstase_dom

Graphical View of Domain Structure for InterPro Entry Q92484

ProtoNet protein and cluster: Q92484

UniProtKB/Swiss-Prot: ASM3A_HUMAN, Q92484
Similarity: Belongs to the acid sphingomyelinase family


Find genes that share domains with SMPDL3A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Enzyme Numbers (IUBMB): EC 3.1.4.-1 EC 3.1.42

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004767sphingomyelin phosphodiesterase activity IEA--
GO:0005515protein binding IPI12442002
GO:0016787hydrolase activity ----
GO:0016798hydrolase activity, acting on glycosyl bonds IEA--
     
Find genes that share ontologies with SMPDL3A           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMPDL3A
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miRNA
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miRTarBase miRNAs that target SMPDL3A:
hsa-mir-335-5p (MIRT018214), hsa-mir-26b-5p (MIRT029820), hsa-mir-124-3p (MIRT022831)

Block miRNA regulation of human, mouse, rat SMPDL3A using miScript Target Protectors
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SwitchGear 3'UTR luciferase reporter plasmidSMPDL3A 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ASM3A_HUMAN, Q92484: Secreted (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
lysosome3
mitochondrion1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

Find genes that share ontologies with SMPDL3A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMPDL3A
Interactions:

    Search GeneGlobe Interaction Network for SMPDL3A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for SMPDL3A (Q924843 ENSP000003574254) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
BRINP1O604773, ENSP000002659224I2D: score=1 STRING: ENSP00000265922
APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
HNF1AP208233I2D: score=1 
GTF2E1ENSP000002838754STRING: ENSP00000283875
NCLENSP000003181954STRING: ENSP00000318195
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006685sphingomyelin catabolic process IEA--
GO:0008150biological_process ND--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SMPDL3A (ASM3A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SMPDL3A gene (2 alternative transcripts): 
NM_001286138.1  NM_006714.4  

Unigene Cluster for SMPDL3A:

Sphingomyelin phosphodiesterase, acid-like 3A
Hs.486357  [show with all ESTs]
Unigene Representative Sequence: AK096144
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368440(uc003pzg.3 uc003pzh.3) ENST00000487215 ENST00000539041

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat SMPDL3A
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OriGene qPCR primer pairs and template standards for SMPDL3A
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  QuantiFast Probe-based Assays in human, mouse, rat SMPDL3A

Additional mRNA sequence: 

AK000184.1 AK096144.1 AK301365.1 BC018999.2 Y08136.1 

9 DOTS entries:

DT.411812  DT.40112298  DT.100788124  DT.91649755  DT.100723717  DT.75156210  DT.100788126  DT.40206248 
DT.100788120 

Selected AceView cDNA sequences (see all 95):

CB156170 BC018999 N31113 BI757489 BM985118 BC066591 AI285540 BM846911 
NM_006714 BX360162 BX102025 BX337330 CR620022 BE222616 BX360150 AK000184 
AV729052 BM795153 Y08136 BI962992 AA873600 CK903607 CA488054 BU633775 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMPDL3A (see all 7)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1:                                                        -                                                         
SP2:                                -     -     -           -                                                         
SP3:                                -     -     -           -     -     -                                             
SP4:                                -     -     -           -     -                                                   
SP5:                                                                                            -     -               


ECgene alternative splicing isoforms for SMPDL3A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SMPDL3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAAGGCCTTT
SMPDL3A Expression
About this image


SMPDL3A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
 
 Neural Crest (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
 
 Peripheral Nervous System (Nervous System)
         Schwann Precursor Cells Peripheral Nerve Domain
 
 Inner Cell Mass (Early Embryonic Tissues)
         Inner Cell Mass Cells Inner Cell Mass
SMPDL3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SMPDL3A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.486357
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMPDL3A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SMPDL3A gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Smpdl3a1 , 5 sphingomyelin phosphodiesterase, acid-like 3A1, 5 82.54(n)1
81.04(a)1
  10 (29.25 cM)5
573191  NM_020561.21  NP_065586.31 
 577943355 
chicken
(Gallus gallus)
Aves SMPDL3A1 sphingomyelin phosphodiesterase, acid-like 3A 71.19(n)
68.33(a)
  776223  XM_004940259.1  XP_004940316.1 
lizard
(Anolis carolinensis)
Reptilia SMPDL3A6
sphingomyelin phosphodiesterase, acid-like 3A
62(a)
1 ↔ 1
1(182220320-182259327)
tropical clawed frog
(Xenopus tropicalis)
Amphibia AL854787.22   -- 78.79(n)    AL854787.2 
zebrafish
(Danio rerio)
Actinopterygii smpdl3a1 sphingomyelin phosphodiesterase, acid-like 3A 64.21(n)
64.59(a)
  541525  NM_001014338.1  NP_001014360.1 
fruit fly
(Drosophila melanogaster)
Insecta CG320526
--
28(a)
1 → many
3L(9792162-9801813)
worm
(Caenorhabditis elegans)
Secernentea ZK856.56
Protein ZK856.5 (ZK856.5) mRNA, complete cds
7(a)
1 → many
V(10186007-10190131) WBGene00014106
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPN16
Vacuolar endopolyphosphatase with a role in phosph...
12(a)
1 → many
IV(1362878-1364902) YDR452W


ENSEMBL Gene Tree for SMPDL3A (if available)
TreeFam Gene Tree for SMPDL3A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SMPDL3A gene
SMPD12  SMPDL3B2  
2 SIMAP similar genes for SMPDL3A using alignment to 2 protein entries:     ASM3A_HUMAN (see all proteins):
SMPDL3B    ASM

Find genes that share paralogs with SMPDL3A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SMPDL3A (see all 512)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2010594311,2
C--123107999(-) TCACTC/TCTTTT 1 -- us2k10--------
rs1421134821,2
--123108029(+) TTATCC/GTTTTC 1 -- us2k10--------
rs1154738151,2
F--123108073(+) GTTGTT/CTTGTT 1 -- us2k11Minor allele frequency- C:0.01WA 118
rs1896331541,2
C--123108114(+) CACCAG/TTTTTT 1 -- us2k10--------
rs1926071121,2
--123108165(+) GAGAAA/GCTCCA 1 -- us2k10--------
rs94822871,2
C,F,A,H--123108171(+) CTCCAG/AGGACC 1 -- us2k16Minor allele frequency- A:0.05NS EA WA NA 616
rs1475215121,2
C--123108186(+) TGTCCA/TCCACT 1 -- us2k10--------
rs1169270601,2
C,F--123108433(+) GATACA/GGCAAT 1 -- us2k11Minor allele frequency- G:0.02NA 120
rs1843583881,2
--123108476(+) CTAGAC/TGGGCA 1 -- us2k10--------
rs760749891,2
C--123108501(+) TGGGCA/GGGGGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SMPDL3A (123109971 - 123130865 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SMPDL3A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv819111CNV Loss19587683
nsv830791CNV Gain17160897
nsv823834CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SMPDL3A
DNA2.0 Custom Variant and Variant Library Synthesis for SMPDL3A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610728    OMIM disorders: --


Find genes that share disorders with SMPDL3A           About GenesLikeMe

Human Genome Epidemiology (HuGE) Navigator: SMPDL3A (1 document)

Export disorders for SMPDL3A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SMPDL3A gene integrated from 10 sources:
(articles sorted by number of sources associating them with SMPDL3A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. (PubMed id 12442002)1, 3, 9 Wright K.O....Reeder J.E. (J. Urol. 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  4. Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors. (PubMed id 22810003)1 Noto P.B....Lala D.S. (Mol. Pharmacol. 2012)
  5. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  7. An investigation into the human serum &quot;interactome&quot;. (PubMed id 15174051)1 Zhou M....Conrads T.P. (Electrophoresis 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. (PubMed id 19159951)9 Daigeler A....Marcus L. (Langenbecks Arch Surg 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10924 HGNC: 17389 AceView: SMPDL3A Ensembl:ENSG00000172594 euGenes: HUgn10924
ECgene: SMPDL3A H-InvDB: SMPDL3A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SMPDL3A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SMPDL3A gene:
Search GeneIP for patents involving SMPDL3A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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