Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SMPDL3A Gene

protein-coding GIFtS: 51
GCID: GC06P123152

sphingomyelin phosphodiesterase, acid-like 3A

Explore 4 diseases affiliated with
SMPDL3A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sphingomyelin Phosphodiesterase, Acid-Like 3A¹ ²		FLJ20177¹
ASM3A¹ ²		0610010C24Rik²
ASML3a¹ ²		Acid Sphingomyelinase-Like Phosphodiesterase 3a²
YR36GH4.1¹		EC 3.1.4.-³
ASM-Like Phosphodiesterase 3a² ³		EC 3.1.4⁸
ASML3A³ ⁵

External Ids:	HGNC: 17389¹	Entrez Gene: 10924²	Ensembl: ENSG00000172594⁷	OMIM: 610728⁵	UniProtKB: Q92484³

Export aliases for SMPDL3A gene to outside databases

Previous GC identifers: GC06P123090 GC06P123091 GC06P120686

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SMPDL3A gene promoter:
TBP USF1 NF-1 AML1a Nkx2-5 C/EBPalpha Evi-1 Egr-4 USF-1 Cart-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMPDL3A promoter sequence

Search SABiosciences Chromatin IP Primers for SMPDL3A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMPDL3A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31 Ensembl cytogenetic band: 6q22.31 HGNC cytogenetic band: 6q22.32

SMPDL3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMPDL3A gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P123152: view genomic region (about GC identifiers)

Start:	123,109,971 bp from pter	End:	123,130,865 bp from pter
Size:	20,895 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ASM3A_HUMAN, Q92484 (See protein sequence)

Recommended Name: Acid sphingomyelinase-like phosphodiesterase 3a precursor

Size: 453 amino acids; 51260 Da

Subcellular location: Secreted (By similarity)

Secondary accessions: Q8WV13

Explore the universe of human proteins at neXtProt for SMPDL3A: NX_Q92484

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92484

4 DME Specific Peptides for SMPDL3A (Q92484)

LNTNLYY

DFIKNSGQ

HLDPTYHIT

SFMIWTGDSPPHVPV

SMPDL3A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006705.1

ENSEMBL proteins:

ENSP00000357425 ENSP00000442152

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SMPDL3A OriGene Custom Protein Services for SMPDL3A
	GenScript Custom Purified and Recombinant Proteins Services for SMPDL3A
	Novus Biologicals SMPDL3A Protein Novus Biologicals SMPDL3A Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SMPDL3A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005615	extracellular space	IEA	--

SMPDL3A for ontologies About GeneDecksing

SMPDL3A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SMPDL3A
	GenScript Custom Superior Antibodies Services for SMPDL3A
	Novus Biologicals SMPDL3A Antibodies
	Search for Antibodies for SMPDL3A at Abcam
	Uscn Antibodies for SMPDL3A
	ThermoFisher Antibody for SMPDL3A

Assay Products for SMPDL3A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SMPDL3A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SMPDL3A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SMPDL3A for domains About GeneDecksing

2 InterPro domains/families:

IPR004843 Metallo_PEstase_dom

IPR017064 ASM-like_Pdiesterase_prd

Graphical View of Domain Structure for InterPro Entry Q92484

ProtoNet protein and cluster: Q92484

UniProtKB/Swiss-Prot: ASM3A_HUMAN, Q92484

Similarity: Belongs to the acid sphingomyelinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Enzyme Numbers (IUBMB): EC 3.1.4.-¹ EC 3.1.4²

miRNA Products:		OriGene 3'-UTR Clone: SMPDL3A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMPDL3A
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SMPDL3A
		SwitchGear 3'UTR luciferase reporter plasmid: SMPDL3A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMPDL3A (see all 7) OriGene shRNA RFP: SMPDL3A OriGene siRNA: SMPDL3A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMPDL3A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SMPDL3A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPDL3A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPDL3A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SMPDL3A (NM_006714)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMPDL3A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPDL3A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SMPDL3A
		Search LifeMap BioReagents cell lines for SMPDL3A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMPDL3A

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004767	sphingomyelin phosphodiesterase activity	IEA	--
GO:0005515	protein binding	IPI	12442002
GO:0016787	hydrolase activity	--	--
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	--

SMPDL3A for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SMPDL3A

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for SMPDL3A (Q92484³ ENSP00000357425⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DBC1	O60477³, ENSP00000265922⁴	I2D: score=1 STRING: ENSP00000265922
APOA1	P02647³, ENSP00000236850⁴	I2D: score=1 STRING: ENSP00000236850
HNF1A	P20823³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006685	sphingomyelin catabolic process	IEA	--
GO:0008150	biological_process	ND	--

SMPDL3A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SMPDL3A
Search CenterWatch for drugs/clinical trials and news about SMPDL3A / ASM3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SMPDL3A gene:

NM_006714.3

Unigene Cluster for SMPDL3A:

Sphingomyelin phosphodiesterase, acid-like 3A

Hs.486357 [show with all ESTs]

Unigene Representative Sequence: AK096144

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368440(uc003pzg.3 uc003pzh.3) ENST00000487215 ENST00000539041

miRNA Products:		OriGene 3'-UTR Clone: SMPDL3A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMPDL3A
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SMPDL3A
		SwitchGear 3'UTR luciferase reporter plasmid: SMPDL3A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMPDL3A (see all 7) OriGene shRNA RFP: SMPDL3A OriGene siRNA: SMPDL3A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMPDL3A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPDL3A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPDL3A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SMPDL3A (NM_006714)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMPDL3A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPDL3A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPDL3A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SMPDL3A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPDL3A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPDL3A

Additional cDNA sequence:

AK000184.1 AK096144.1 AK301365.1 BC018999.2 Y08136.1

9 DOTS entries:

DT.411812 DT.40112298 DT.100788124 DT.91649755 DT.100723717 DT.75156210 DT.100788126 DT.40206248

DT.100788120

24/95 AceView cDNA sequences (see all 95):

BM795153 BC018999 AV729052 BM985118 CR620022 BX360150 AI285540 BX360162

NM_006714 CB156170 BM846911 BI757489 BE222616 N31113 BX102025 BC066591

AK000184 BX337330 BM805174 AA406438 BI494241 CF994334 AI005229 CD109701

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SMPDL3A (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b
SP1:																			-
SP2:											-		-		-				-
SP3:											-		-		-				-		-		-
SP4:											-		-		-				-		-
SP5:																															-		-

ECgene alternative splicing isoforms for SMPDL3A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SMPDL3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGGCCTTT

About this image

SMPDL3A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SMPDL3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMPDL3A

SOURCE GeneReport for Unigene cluster: Hs.486357

SABiosciences Custom PCR Arrays for SMPDL3A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPDL3A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SMPDL3A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPDL3A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPDL3A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMPDL3A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SMPDL3A gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Smpdl3a^{1 , 5}	sphingomyelin phosphodiesterase, acid-like 3A^{1, 5}	82.54(n)¹ 81.04(a)¹		10 (29.25 cM)⁵ 57319¹ NM_020561.2¹ NP_065586.3¹ 57794335⁵
chicken (Gallus gallus)	Aves	SMPDL3A¹	sphingomyelin phosphodiesterase, acid-like 3A	71.62(n) 68.19(a)		776223 XM_001235756.2 XP_001235757.2
lizard (Anolis carolinensis)	Reptilia	SMPDL3A⁶	--	65(a)	1 ↔ 1	1(182221410-182246860)
tropical clawed frog (Xenopus tropicalis)	Amphibia	AL854787.2²	--	78.79(n)		AL854787.2
zebrafish (Danio rerio)	Actinopterygii	smpdl3a¹	sphingomyelin phosphodiesterase, acid-like 3A	64.39(n) 64.77(a)		541525 NM_001014338.1 NP_001014360.1
fruit fly (Drosophila melanogaster)	Insecta	CG32052⁶	--	28(a)	1 → many	3L(9792162-9801813)
worm (Caenorhabditis elegans)	Secernentea	ZK856.5⁶	Protein ZK856.5	27(a)	1 → many	V(10185981-10190113)

ENSEMBL Gene Tree for SMPDL3A (if available)
TreeFam Gene Tree for SMPDL3A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SMPDL3A gene

SMPD1² SMPDL3B²

2 SIMAP similar genes for SMPDL3A using alignment to 2 protein entries: ASM3A_HUMAN (see all proteins):

SMPDL3B ASM

SMPDL3A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201059431^1,2	C	--	123107999(-)	`TCACTC/TCTTTT`	1	--	us2k¹		0	--	--	--	--
rs142113482^1,2		--	123108029(+)	`TTATCC/GTTTTC`	1	--	us2k¹		0	--	--	--	--
rs115473815^1,2		--	123108073(+)	`GTTGTT/CTTGTT`	1	--	us2k¹		1		WA	118
rs189633154^1,2		--	123108114(+)	`CACCAG/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs192607112^1,2		--	123108165(+)	`GAGAAA/GCTCCA`	1	--	us2k¹		0	--	--	--	--
rs9482287^1,2	C,F,A,H,	--	123108171(+)	`CTCCAG/AGGACC`	1	--	us2k¹		6		NS EA WA NA	616
rs147521512^1,2		--	123108186(+)	`TGTCCA/TCCACT`	1	--	us2k¹		0	--	--	--	--
rs116927060^1,2	F,	--	123108433(+)	`GATACA/GGCAAT`	1	--	us2k¹		1		NA	120
rs184358388^1,2		--	123108476(+)	`CTAGAC/TGGGCA`	1	--	us2k¹		0	--	--	--	--
rs76074989^1,2	C	--	123108501(+)	`TGGGCA/GGGGGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SMPDL3A (123109971 - 123130865 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SMPDL3A
1 Indel: 59288

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMPDL3A

DNA2.0 Custom Variant and Variant Library Synthesis for SMPDL3A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SMPDL3A for disorders           About GeneDecksing

OMIM gene information: 610728    OMIM disorders: --

4 diseases for SMPDL3A:    About MalaCards

fibrous histiocytoma malignant fibrous histiocytoma histiocytoma sarcoma

Human Genome Epidemiology (HuGE) Navigator: SMPDL3A (1 document)

Export disorders for SMPDL3A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SMPDL3A gene integrated from 9 sources:
(articles sorted by number of sources associating them with SMPDL3A)

Utopia: connect your pdf to the dynamic
world of online information

Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. (PubMed id 12442002)^{1, 3, 9} Wright K.O....Reeder J.E. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Regulation of sphingomyelin phosphodiesterase acid-lik e 3A gene (SMPDL3A) by liver X receptors. (PubMed id 22810003)¹ Noto P.B....Lala D.S. (2012)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. (PubMed id 19159951)⁹ Daigeler A....Marcus L. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10924	HGNC: 17389	AceView: SMPDL3A	Ensembl:ENSG00000172594	euGenes: HUgn10924
ECgene: SMPDL3A	H-InvDB: SMPDL3A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SMPDL3A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SMPDL3A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SMPDL3A gene:
Search GeneIP for patents involving SMPDL3A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SMPDL3A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMPDL3A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPDL3A
	OriGene Protein Over-expression Lysate for SMPDL3A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SMPDL3A		OriGene 3'-UTR Clone for SMPDL3A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPDL3A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPDL3A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SMPDL3A		OriGene Custom Protein Services for SMPDL3A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMPDL3A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMPDL3A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMPDL3A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMPDL3A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPDL3A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPDL3A

	GenScript Custom Purified and Recombinant Proteins Services for SMPDL3A		GenScript cDNA clones with any tag delivered in your preferred vector for SMPDL3A
	GenScript Custom Assay Services for SMPDL3A		GenScript Custom Superior Antibodies Services for SMPDL3A
	GenScript Custom overexpressing Cell Line Services for SMPDL3A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SMPDL3A promoter
	Search Chromatin IP Primers for SMPDL3A
	RT² qPCR Primer Assay in human, mouse, rat SMPDL3A
	Search GNC Networks for SMPDL3A
	SABiosciences Custom PCR Arrays for SMPDL3A

Search Tocris compounds for SMPDL3A

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SMPDL3A antibodies
	SMPDL3A proteins
	SMPDL3A lysates

	Search for Antibodies for SMPDL3A at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SMPDL3A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SMPDL3A Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SMPDL3A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMPDL3A

	SwitchGear 3'UTR luciferase reporter plasmids for SMPDL3A
	SwitchGear Promoter luciferase reporter plasmids for SMPDL3A

ThermoFisher Antibody for SMPDL3A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPDL3A

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SMPDL3A gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SMPDL3A Gene

sphingomyelin phosphodiesterase, acid-like 3A

Aliases
for SMPDL3A gene

Summaries
for SMPDL3A gene

Genomic Views
for SMPDL3A gene

Proteins
for SMPDL3A gene

Protein Domains /
Families
for SMPDL3A gene

Function
for SMPDL3A gene

Pathways & Interactions
for SMPDL3A gene

Drugs & Compounds
for SMPDL3A gene

Transcripts
for SMPDL3A gene

Expression
for SMPDL3A gene

Orthologs
for SMPDL3A gene

Paralogs
for SMPDL3A gene

Genomic Variants
for SMPDL3A gene

Disorders / Diseases
for SMPDL3A gene

Publications
for SMPDL3A gene

External Searches for SMPDL3A gene

Genome Databases showing SMPDL3A gene

Other Databases showing SMPDL3A gene

Specialized Databases showing SMPDL3A gene

Intellectual Property
for SMPDL3A gene

Products
for SMPDL3A gene

View Random Gene

Advanced Search

Export list of displayed genes

SMPDL3A Gene

sphingomyelin phosphodiesterase, acid-like 3A

Aliasesfor SMPDL3A gene

Summariesfor SMPDL3A gene

Genomic Viewsfor SMPDL3A gene

Proteinsfor SMPDL3A gene

Protein Domains /Familiesfor SMPDL3A gene

Functionfor SMPDL3A gene

Pathways & Interactionsfor SMPDL3A gene

Drugs & Compoundsfor SMPDL3A gene

Transcriptsfor SMPDL3A gene

Expression for SMPDL3A gene

Orthologsfor SMPDL3A gene

Paralogsfor SMPDL3A gene

Genomic Variantsfor SMPDL3A gene

Disorders / Diseasesfor SMPDL3A gene

Publicationsfor SMPDL3A gene

External Searches for SMPDL3A gene

Genome Databases showing SMPDL3A gene

Other Databases showing SMPDL3A gene

Specialized Databases showing SMPDL3A gene

Intellectual Propertyfor SMPDL3A gene

Productsfor SMPDL3A gene

View Random Gene

Aliases
for SMPDL3A gene

Summaries
for SMPDL3A gene

Genomic Views
for SMPDL3A gene

Proteins
for SMPDL3A gene

Protein Domains /
Families
for SMPDL3A gene

Function
for SMPDL3A gene

Pathways & Interactions
for SMPDL3A gene

Drugs & Compounds
for SMPDL3A gene

Transcripts
for SMPDL3A gene

Expression
for SMPDL3A gene

Orthologs
for SMPDL3A gene

Paralogs
for SMPDL3A gene

Genomic Variants
for SMPDL3A gene

Disorders / Diseases
for SMPDL3A gene

Publications
for SMPDL3A gene

Intellectual Property
for SMPDL3A gene

Products
for SMPDL3A gene