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Aliases for SMPD5 Gene

Aliases for SMPD5 Gene

  • Sphingomyelin Phosphodiesterase 5 2 3 5
  • Mitochondria-Associated NSMase 2 3
  • Sphingomyelin Phosphodiesterase 3 3
  • MA-NSMase 3

External Ids for SMPD5 Gene

Previous GeneCards Identifiers for SMPD5 Gene

  • GC08P145105

Summaries for SMPD5 Gene

GeneCards Summary for SMPD5 Gene

SMPD5 (Sphingomyelin Phosphodiesterase 5) is a Protein Coding gene.

Additional gene information for SMPD5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMPD5 Gene

Genomics for SMPD5 Gene

Regulatory Elements for SMPD5 Gene

Enhancers for SMPD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H144046 1.3 Ensembl ENCODE dbSUPER 0.7 +2.9 2868 6.7 RING1 ARID4B ZNF76 ZIC2 CCNT2 HIC1 ZFHX2 POLR2A EZH2 PAF1 ZNF251 LRRC14 ZNF517 ZNF250 LOC105375803 TMED10P1 ENSG00000255224 ENSG00000255164 GPAA1 CYC1
GH08H144014 1.5 FANTOM5 Ensembl ENCODE 0.3 -32.2 -32243 0.9 ZSCAN4 INSM2 KLF17 SIN3A ZEB1 ZNF155 GLIS2 ZNF366 SCRT2 FOS ZNF7 ZNF250 ZNF623 ZNF251 VPS28 GPAA1 AK3P2 ZNF16 SPATC1 CPSF1
GH08H144035 0.2 Ensembl 0.4 -10.8 -10839 0.7 SMPD5 PARP10
GH08H144019 0.2 Ensembl 0.3 -27.1 -27075 0.7 PARP10 SMPD5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMPD5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMPD5 Gene

Genomic Locations for SMPD5 Gene
4,409 bases
Plus strand

Genomic View for SMPD5 Gene

Genes around SMPD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMPD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMPD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMPD5 Gene

Proteins for SMPD5 Gene

Post-translational modifications for SMPD5 Gene

No Post-translational modifications

Other Protein References for SMPD5 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for SMPD5 Gene

Domains & Families for SMPD5 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMPD5 Gene

Function for SMPD5 Gene

Phenotypes for SMPD5 Gene

GenomeRNAi human phenotypes for SMPD5:
genes like me logo Genes that share phenotypes with SMPD5: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMPD5 Gene

Localization for SMPD5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SMPD5 Gene

Pathways & Interactions for SMPD5 Gene

SuperPathways for SMPD5 Gene

No Data Available

Interacting Proteins for SMPD5 Gene

Gene Ontology (GO) - Biological Process for SMPD5 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMPD5 Gene

Drugs & Compounds for SMPD5 Gene

No Compound Related Data Available

Transcripts for SMPD5 Gene

mRNA/cDNA for SMPD5 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMPD5 Gene

Sphingomyelin phosphodiesterase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMPD5 Gene

No ASD Table

Relevant External Links for SMPD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMPD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMPD5 Gene

mRNA differential expression in normal tissues according to GTEx for SMPD5 Gene

This gene is overexpressed in Whole Blood (x8.3).

NURSA nuclear receptor signaling pathways regulating expression of SMPD5 Gene:


SOURCE GeneReport for Unigene cluster for SMPD5 Gene:

genes like me logo Genes that share expression patterns with SMPD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMPD5 Gene

Orthologs for SMPD5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMPD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMPD5 33
  • 78.11 (n)
(Canis familiaris)
Mammalia LOC102156747 33
  • 74.34 (n)
(Mus musculus)
Mammalia Smpd5 33 16
  • 72.46 (n)
(Rattus norvegicus)
Mammalia Smpd5 33
  • 71.84 (n)
Species where no ortholog for SMPD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMPD5 Gene

Gene Tree for SMPD5 (if available)
Gene Tree for SMPD5 (if available)

Paralogs for SMPD5 Gene

No data available for Paralogs for SMPD5 Gene

Variants for SMPD5 Gene

Sequence variations from dbSNP and Humsavar for SMPD5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000711175 -- 144,047,138(+) GTCAA(C/T)GCCCA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002328750 -- 144,048,545(+) CGGGA(A/G)TCCAT upstream-variant-2KB
rs1002525489 -- 144,050,469(+) GCAGG(A/G)GAGGA intron-variant
rs1002641564 -- 144,050,709(+) CTTAG(C/G)GGGAG intron-variant
rs1003594694 -- 144,049,615(+) CGCGC(A/G)GGACG reference, missense

Relevant External Links for SMPD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SMPD5 Gene

Disorders for SMPD5 Gene

No disorders were found for SMPD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SMPD5 Gene

Publications for SMPD5 Gene

  1. Sphingolipid metabolism and neutral sphingomyelinases. (PMID: 23579449) Airola MV … Hannun YA (Handbook of experimental pharmacology 2013) 2 3 60

Products for SMPD5 Gene

Sources for SMPD5 Gene

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