Aliases for SMPD3 Gene
External Ids for SMPD3 Gene
Previous GeneCards Identifiers for SMPD3 Gene
GeneCards Summary for SMPD3 Gene
SMPD3 (Sphingomyelin Phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include sphingomyelin phosphodiesterase activity.
UniProtKB/Swiss-Prot for SMPD3 Gene
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.