Aliases for SMPD2 Gene
External Ids for SMPD2 Gene
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
GeneCards Summary for SMPD2 Gene
SMPD2 (Sphingomyelin Phosphodiesterase 2, Neutral Membrane (Neutral Sphingomyelinase)) is a Protein Coding gene. Diseases associated with SMPD2 include lipid storage disease. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include sphingomyelin phosphodiesterase activity.
UniProtKB/Swiss-Prot for SMPD2 Gene
Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF