SMPD2 Gene
protein-coding GIFtS: 60
GCID: GC06P109761
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sphingomyelin phosphodiesterase 2, neutral membrane (neutral...
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Aliases
for SMPD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sphingomyelin Phosphodiesterase 2, Neutral Membrane (NeutralSphingomyelinase)1 2 | | NSMASE2 | | ISC11 2 | | NSMASE12 | | NSMase1 | | Lyso-PAF-PLC3 | | Lyso-Platelet-Activating Factor-Phospholipase C2 3 | | Sphingomyelin Phosphodiesterase 22 | | Neutral Sphingomyelinase2 3 | | EC 3.1.4.123 | | N-SMase2 3 | | Lyso-PAF-PLC3 |
Export aliases for SMPD2 gene to outside databasesPrevious GC identifers: GC06P109597 GC06P109784 GC06P109807 GC06P109868 GC06P107328 |
Summaries
for SMPD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SMPD2:
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity betweenbacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likelyto be as a sphingomyelinase and instead as a lysophospholipase. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: NSMA_HUMAN, O60906Function: Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems tobe Lyso-PAF
Gene Wiki entry for SMPD2
|
Genomic Views
for SMPD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMPD2 gene promoter:
AP-1 ATF-2 MyoD c-Jun NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMPD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMPD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21SMPD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P109761: view genomic region
(about GC identifiers)
Start:
|
109,761,931 bp from pter |
End:
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109,765,122 bp from pter |
Size:
|
3,192 bases |
Orientation:
|
plus strand |
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Proteins
for SMPD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NSMA_HUMAN, O60906 (See
protein sequence)Recommended Name: Sphingomyelin phosphodiesterase 2 Size: 423 amino acids; 47646 Da
Cofactor: Magnesium
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5TED1 Q9BWR3Explore the universe of human proteins at neXtProt for SMPD2: NX_O60906
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60906
SMPD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003071.2
ENSEMBL proteins: ENSP00000258052 ENSP00000399731 Reactome Protein details: O60906
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SMPD2 for ontologies About GeneDecksing
SMPD2 Antibody Products:
Assay Products for SMPD2: |
Protein
Domains /
Families
for SMPD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMPD2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60906ProtoNet protein and cluster: O60906 UniProtKB/Swiss-Prot: NSMA_HUMAN, O60906Similarity: Belongs to the neutral sphingomyelinase family |
Function
for SMPD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NSMA_HUMAN, O60906Function: Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems tobe Lyso-PAFCatalytic activity: Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholineBiophysicochemical properties: pH dependence: Optimum pH is 6.5-7.5;Enzyme Number (IUBMB): EC 3.1.4.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SMPD2 (NM_003080) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMPD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMPD2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004767 | sphingomyelin phosphodiesterase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
SMPD2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SMPD2:
Animal Models:
Mouse knock-out Smpd2tm1Wst for SMPD2
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Smpd2):
SMPD2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SMPD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sphingolipid metabolism | | | 2 | Metabolism | | | 3 | Ca, cAMP and Lipid Signaling | | | 4 | Apoptosis and Autophagy | | | 5 | Ceramide signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMPD2 (see all 7)
2 
Cell Signaling Technology (CST) Pathways for SMPD2
3  BioSystems Pathways for SMPD2
5/8 
Reactome Pathways for SMPD2 (see all 8)
2 
Kegg Pathways (Kegg details for SMPD2):
UniProtKB/Swiss-Prot: NSMA_HUMAN, O60906Pathway: Lipid metabolism; sphingolipid metabolism
SMPD2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMPD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/88 Interacting proteins for SMPD2 (O609063 ENSP000002580524) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006665 | sphingolipid metabolic process |
TAS | -- | | GO:0006684 | sphingomyelin metabolic process |
TAS | 9520418 | | GO:0006687 | glycosphingolipid metabolic process |
TAS | -- | | GO:0007243 | intracellular protein kinase cascade |
IEA | -- |
SMPD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMPD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SMPD2 for compounds About GeneDecksing
 Browse Tocris compounds for SMPD2
10/154 HMDB Compounds for SMPD2 (see all 154) About this table
10/20 Novoseek chemical compound relationships for SMPD2 gene (see all 20) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ceramide |
92 |
68 |
14871831 (3), 15642349 (3), 15741222 (3), 11901191 (2) (see all 39) |
| c2ceramide |
75.3 |
3 |
16777978 (3) |
| manumycin |
73.7 |
3 |
14563682 (1), 12270134 (1), 11597471 (1) |
| phosphorylcholine |
62.3 |
2 |
16517606 (1), 9763522 (1) |
| lactosylceramide |
54.4 |
1 |
16691498 (1) |
| sphingosine |
38.6 |
1 |
8379453 (1) |
| sterol |
36.5 |
1 |
9763522 (1) |
| n acetylcysteine |
32 |
4 |
12387875 (1), 17707397 (1) |
| lipid |
29.7 |
5 |
11001565 (1), 19572936 (1), 8379453 (1), 9520418 (1) |
| dithiothreitol |
29.7 |
3 |
9195931 (1), 10832103 (1) |
Search CenterWatch for drugs/clinical trials and news about SMPD2 / NSMA
|
Transcripts
for SMPD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMPD2 gene: NM_003080.2 Unigene Cluster for SMPD2: Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Hs.55235 [show with all ESTs]Unigene Representative Sequence: NM_0030803 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000258052(uc010kdq.3 uc003pti.3) ENST00000439615 ENST00000458487
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SMPD2 (NM_003080) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMPD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPD2 |
Additional cDNA sequence: AJ222801.1 AK310148.1 AK313515.1 BC000038.2 3 DOTS entries: DT.311601 DT.40132320 DT.95264543 24/88 AceView cDNA sequences (see all 88): AI083508 BM840848 BM966928 AI274249 BM769617 AI380803 BM769177 BM769176 BQ083596 BM785558 AI420934 CR591613 BM769106 BU726050 CA314251 BM544667 BI869842 BM790786 BU726647 BM795556 AI913972 BP371432 BU500306 BX375234
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SMPD2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMPD2
|
Expression
for SMPD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMPD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTAGGAAG
About this image
See SMPD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMPD2
SOURCE GeneReport for Unigene cluster: Hs.55235
SABiosciences Custom PCR Arrays for SMPD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMPD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMPD2 |
Orthologs
for SMPD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SMPD2 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for SMPD2 (if available)
TreeFam Gene Tree for SMPD2 (if available) |
Paralogs
for SMPD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SMPD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMPD2 (109761931 - 109765122 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMPD2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMPD2 |
|
Disorders
/ Diseases
for SMPD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMPD2 for disorders About GeneDecksing
OMIM gene information: 603498
OMIM disorders: --
19  diseases for SMPD2: About MalaCardsniemann-pick disease lipid storage disease pick's disease atopic dermatitis
myocardial infarction multiple sclerosis dermatitis insulinoma
atherosclerosis alzheimer's disease neurodegeneration prostate cancer
breast cancer leukemia cholesterol retinitis
prostatitis immunodeficiency neuronitis
1 disease from the University of Copenhagen DISEASES database for SMPD2:Niemann-Pick disease 7 Novoseek disease relationships for SMPD2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SMPD2 (4 documents)
Export disorders for SMPD2 gene to outside databases
|
Publications
for SMPD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMPD2 gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with SMPD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? (PubMed id 9520418)1, 2, 3, 9 Tomiuk S.... Stoffel W. (1998)
- Function of the cloned putative neutral sphingomyelinase as lyso- platelet activating factor-phospholipase C. (PubMed id 10608884)1, 2, 9 Sawai H.... Hannun Y.A. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. (PubMed id 15509740)1, 9 Jana A. and Pahan K. (2004)
- Regulation of sphingomyelinases in cells of the oligodendrocyte lineage. (PubMed id 14689449)1, 9 Testai F.D....Dawson G. (2004)
- Transcriptional regulation of neutral sphingomyelinas e 2 gene expression of a human breast cancer cell line, MCF-7, induced by the a nti-cancer drug, daunorubicin. (PubMed id 19698806)1, 9 Ito H....Murate T. (2009)
- Aggregated low density lipoprotein induces tissue fac tor by inhibiting sphingomyelinase activity in human vascular smooth muscle cel ls. (PubMed id 19817993)1, 9 Camino-LA^pez S....Llorente-CortAcs V. (2009)
- Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. (PubMed id 15175033)1, 9 Jensen J.M....Proksch E. (2004)
- Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. (PubMed id 17272284)1, 9 Tani M. and Hannun Y.A. (2007)
- Regulation of CC ligand 5/RANTES by acid sphingomyeli nase and acid ceramidase. (PubMed id 21335555)1 Jenkins R.W....Hannun Y.A. (2011)
|
External Searches for SMPD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SMPD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMPD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMPD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SMPD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SMPD2 gene:
Search GeneIP for patents involving SMPD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMPD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SMPD2 | | OriGene shRNA RFP for SMPD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMPD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMPD2 | | | OriGene Protein Over-expression Lysate for SMPD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMPD2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMPD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMPD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SMPD2 | | OriGene Custom Protein Services for SMPD2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMPD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMPD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMPD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMPD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMPD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMPD2 |
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| | Antibodies & Assays for SMPD2 |
| | | | Search Tocris compounds for SMPD2 |
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 | | | SMPD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMPD2 |
|  |  |  | | | | ThermoFisher Antibodies for SMPD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMPD2 |
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