Aliases for SMOX Gene
External Ids for SMOX Gene
Previous HGNC Symbols for SMOX Gene
Previous GeneCards Identifiers for SMOX Gene
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]
GeneCards Summary for SMOX Gene
SMOX (Spermine Oxidase) is a Protein Coding gene. Diseases associated with SMOX include Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly and Autosomal Genetic Disease. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and spermine:oxygen oxidoreductase (spermidine-forming) activity. An important paralog of this gene is PAOX.
UniProtKB/Swiss-Prot for SMOX Gene
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.