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Aliases for SMOX Gene

Aliases for SMOX Gene

  • Spermine Oxidase 2 3
  • Polyamine Oxidase 1 3 4
  • C20orf16 3 4
  • PAOH1 3 4
  • PAO-1 3 4
  • SMO 3 4
  • Putative Cyclin G1 Interacting Protein 3
  • Chromosome 20 Open Reading Frame 16 2
  • Flavin-Containing Spermine Oxidase 3
  • Flavin Containing Amine Oxidase 3
  • EC 1.5.3.16 4
  • PAO1 3
  • PAOH 3
  • PAO 3

External Ids for SMOX Gene

Previous HGNC Symbols for SMOX Gene

  • C20orf16

Previous GeneCards Identifiers for SMOX Gene

  • GC20P004124
  • GC20P004077

Summaries for SMOX Gene

Entrez Gene Summary for SMOX Gene

  • Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]

GeneCards Summary for SMOX Gene

SMOX (Spermine Oxidase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include oxidoreductase activity and spermine:oxygen oxidoreductase (spermidine-forming) activity. An important paralog of this gene is KDM1B.

UniProtKB/Swiss-Prot for SMOX Gene

  • Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal

Gene Wiki entry for SMOX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMOX Gene

Genomics for SMOX Gene

Regulatory Elements for SMOX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMOX Gene

Chromosome:
20
Start:
4,120,980 bp from pter
End:
4,187,747 bp from pter
Size:
66,768 bases
Orientation:
Plus strand

Genomic View for SMOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMOX Gene

Proteins for SMOX Gene

  • Protein details for SMOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWM0-SMOX_HUMAN
    Recommended name:
    Spermine oxidase
    Protein Accession:
    Q9NWM0
    Secondary Accessions:
    • A2A2P5
    • A2A2P6
    • A8BE87
    • D3DVZ4
    • Q5TE26
    • Q5TE27
    • Q6UY28
    • Q8IX00
    • Q96LC3
    • Q96LC4
    • Q96QT3
    • Q9BW38
    • Q9H6H1
    • Q9NP51
    • Q9NPY1
    • Q9NPY2

    Protein attributes for SMOX Gene

    Size:
    555 amino acids
    Molecular mass:
    61819 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMOX Gene

neXtProt entry for SMOX Gene

Proteomics data for SMOX Gene at MOPED

Post-translational modifications for SMOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SMOX Gene

Domains & Families for SMOX Gene

Protein Domains for SMOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMOX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWM0

UniProtKB/Swiss-Prot:

SMOX_HUMAN :
  • Belongs to the flavin monoamine oxidase family.
Family:
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with SMOX: view

No data available for Gene Families for SMOX Gene

Function for SMOX Gene

Molecular function for SMOX Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.6 uM for spermine (isoform 1) {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650}; KM=0.5 uM for spermine (isoform 6) {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650}; KM=3.0 uM for N1-acetylspermine (Isoform 1 and isoform 6) {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650}; Note=Kcat is 27-fold higher with spermine than N1-acetylspermine as substrate for isoform 1 and isoform 6.; pH dependence: Optimum pH is 9.5 with spermine as substrate. {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650};
UniProtKB/Swiss-Prot CatalyticActivity:
Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1uM
UniProtKB/Swiss-Prot Function:
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal
UniProtKB/Swiss-Prot Induction:
By antitumor polyamine analogs

Enzyme Numbers (IUBMB) for SMOX Gene

Gene Ontology (GO) - Molecular Function for SMOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity --
GO:0046592 polyamine oxidase activity IDA 12477380
GO:0052894 norspermine:oxygen oxidoreductase activity IEA --
GO:0052895 N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity IEA --
GO:0052901 spermine:oxygen oxidoreductase (spermidine-forming) activity IEA --
genes like me logo Genes that share ontologies with SMOX: view
genes like me logo Genes that share phenotypes with SMOX: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMOX

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SMOX Gene

Localization for SMOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMOX Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 4: Cytoplasm. Nucleus.
Isoform 6: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMOX Gene COMPARTMENTS Subcellular localization image for SMOX gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 18422650
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SMOX: view

Pathways & Interactions for SMOX Gene

genes like me logo Genes that share pathways with SMOX: view

UniProtKB/Swiss-Prot Q9NWM0-SMOX_HUMAN

  • Pathway: Amine and polyamine degradation; spermine degradation

Interacting Proteins for SMOX Gene

Gene Ontology (GO) - Biological Process for SMOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006595 polyamine metabolic process TAS --
GO:0006596 polyamine biosynthetic process TAS --
GO:0006598 polyamine catabolic process IDA 12477380
GO:0006805 xenobiotic metabolic process TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with SMOX: view

No data available for SIGNOR curated interactions for SMOX Gene

Drugs & Compounds for SMOX Gene

(7) Drugs for SMOX Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Channel blocker, Target, ligand 0
FAD Approved Pharma 0
Ornithine Approved Nutra Full agonist, Agonist 31
putrescine Experimental Pharma Antagonist, Pore Blocker 0
spermidine Experimental Pharma Antagonist, Pore Blocker 0

(18) Additional Compounds for SMOX Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
3-Aminopropionaldehyde
  • 3-Aminopropanal
  • 3-Aminopropionaldehyde
  • beta-Aminopropion aldehyde
352-92-1
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
56-18-8
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with SMOX: view

Transcripts for SMOX Gene

Unigene Clusters for SMOX Gene

Spermine oxidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMOX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMOX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - -
SP12: - - - -
SP13: - - -

ExUns: 14d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SMOX Gene

GeneLoc Exon Structure for
SMOX
ECgene alternative splicing isoforms for
SMOX

Expression for SMOX Gene

mRNA expression in normal human tissues for SMOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SMOX Gene

This gene is overexpressed in Pancreatic juice (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMOX Gene



SOURCE GeneReport for Unigene cluster for SMOX Gene Hs.433337

mRNA Expression by UniProt/SwissProt for SMOX Gene

Q9NWM0-SMOX_HUMAN
Tissue specificity: Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line.
genes like me logo Genes that share expression patterns with SMOX: view

Protein tissue co-expression partners for SMOX Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SMOX Gene

Orthologs for SMOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMOX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMOX 35
  • 91.53 (n)
  • 96.22 (a)
SMOX 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMOX 35
  • 92.19 (n)
  • 95.04 (a)
SMOX 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smox 35
  • 90.07 (n)
  • 95.49 (a)
Smox 16
Smox 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMOX 35
  • 99.15 (n)
  • 99.49 (a)
SMOX 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smox 35
  • 90.97 (n)
  • 96.21 (a)
oppossum
(Monodelphis domestica)
Mammalia SMOX 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMOX 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMOX 35
  • 75.19 (n)
  • 82.71 (a)
SMOX 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMOX 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smox 35
  • 73.75 (n)
  • 78.57 (a)
Str.11519 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1474 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11707 35
smox 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002616 35
  • 51.33 (n)
  • 38.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8032 35
  • 48.73 (n)
  • 36.84 (a)
CG10561 36
  • 29 (a)
ManyToMany
CG5653 36
  • 30 (a)
ManyToMany
CG6034 36
  • 29 (a)
ManyToMany
CG7460 36
  • 30 (a)
ManyToMany
CG7737 36
  • 28 (a)
ManyToMany
CG8032 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea amx-3 36
  • 28 (a)
ManyToMany
hpo-15 36
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PAO5 35
  • 44.22 (n)
  • 36.64 (a)
rice
(Oryza sativa)
Liliopsida Os01g0710200 35
  • 48.84 (n)
  • 36.58 (a)
Species with no ortholog for SMOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMOX Gene

ENSEMBL:
Gene Tree for SMOX (if available)
TreeFam:
Gene Tree for SMOX (if available)

Paralogs for SMOX Gene

Paralogs for SMOX Gene

(1) SIMAP similar genes for SMOX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMOX: view

Variants for SMOX Gene

Sequence variations from dbSNP and Humsavar for SMOX Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs880648 -- 4,152,699(-) AGTGA(A/C)TATAC intron-variant
rs910954 -- 4,160,955(-) CTTCA(A/G)CTCCA intron-variant
rs927091 -- 4,164,374(-) GCAGA(C/T)GGCTT intron-variant
rs945771 -- 4,148,504(+) AAACC(C/G)CATTT upstream-variant-2KB
rs945772 -- 4,148,407(+) ACAAG(G/T)CTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMOX Gene

Variant ID Type Subtype PubMed ID
nsv828673 CNV Gain 20364138
nsv833900 CNV Loss 17160897
esv2632874 CNV Deletion 19546169
esv2722126 CNV Deletion 23290073
esv1176085 CNV Deletion 17803354

Variation tolerance for SMOX Gene

Residual Variation Intolerance Score: 9.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMOX Gene

HapMap Linkage Disequilibrium report
SMOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMOX Gene

Disorders for SMOX Gene

Relevant External Links for SMOX

Genetic Association Database (GAD)
SMOX
Human Genome Epidemiology (HuGE) Navigator
SMOX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMOX
genes like me logo Genes that share disorders with SMOX: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMOX Gene

Publications for SMOX Gene

  1. Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. (PMID: 15133083) Bacchi C.J. … Wittner M. (Microbiology (Reading, Engl.) 2004) 23 25 26 67
  2. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. (PMID: 12477380) Vujcic S. … Porter C.W. (Biochem. J. 2003) 23 25 26 67
  3. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. (PMID: 12141946) Vujcic S. … Porter C.W. (Biochem. J. 2002) 23 25 26 67
  4. Structural bases for inhibitor binding and catalysis in polyamine oxidase. (PMID: 11258887) Binda C. … Mattevi A. (Biochemistry 2001) 23 25 26 67
  5. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. (PMID: 12727196) Wang Y. … Casero R.A. Jr. (Biochem. Biophys. Res. Commun. 2003) 25 26 67

Products for SMOX Gene

Sources for SMOX Gene

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