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SMOX Gene

protein-coding   GIFtS: 60
GCID: GC20P004101

Spermine Oxidase

(Previous name: chromosome 20 open reading frame 16)
(Previous symbol: C20orf16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Spermine Oxidase1 2     PAOH12
C20orf161 2 3     Flavin Containing Amine Oxidase2
Polyamine Oxidase 12 3     Flavin-Containing Spermine Oxidase2
PAO-12 3     Putative Cyclin G1 Interacting Protein2
SMO2 3     EC 1.5.3.163
Chromosome 20 Open Reading Frame 161     PAOh13
PAO2     

External Ids:    HGNC: 158621   Entrez Gene: 544982   Ensembl: ENSG000000888267   UniProtKB: Q9NWM03   
ORGUL members:         

Export aliases for SMOX gene to outside databases

Previous GC identifers: GC20P004124 GC20P004077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMOX Gene:
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine.
These molecules participate in a broad range of cellular functions which include cell cycle modulation,
scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles
in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular
signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme
that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple
transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed
to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have
distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional
levels of complexity in polyamine catabolism. (provided by RefSeq, Jul 2012)

GeneCards Summary for SMOX Gene:
SMOX (spermine oxidase) is a protein-coding gene. Diseases associated with SMOX include meconium aspiration syndrome, and cor pulmonale. GO annotations related to this gene include polyamine oxidase activity and norspermine:oxygen oxidoreductase activity. An important paralog of this gene is KDM1B.

UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine
and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental
conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the
potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to
beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal

summary for SMOX Gene:
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family.
Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In
the resting state, Smo receptors are bound to and repressed by, patched (Ptc). Upon Hh-Ptc interaction, Smo
receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the
activity of transcription factors belonging to the Gli family (particularly Cubitus interruptus (Ci)). Smo
receptors are vital for embryogenesis (segmentation and appendage development) and are involved in
maintainence of tissue homeostasis in adults. The human gene encoding the Smo receptor has been localized on
chromosome 7q32.3.

Gene Wiki entry for SMOX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMOX gene promoter:
         c-Fos   NF-1   NF-1/L   AP-1   Pax-5   PPAR-gamma1   FOXC1   PPAR-gamma2   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMOX promoter sequence
   Search Chromatin IP Primers for SMOX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SMOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMOX gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P004101:  view genomic region     (about GC identifiers)

Start:
4,101,627 bp from pter      End:
4,168,394 bp from pter
Size:
66,768 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0 (See protein sequence)
Recommended Name: Spermine oxidase  
Size: 555 amino acids; 61819 Da
Cofactor: Binds 1 FAD per subunit (By similarity)
Secondary accessions: A2A2P5 A2A2P6 A8BE87 D3DVZ4 Q5TE26 Q5TE27 Q6UY28 Q8IX00 Q96LC3 Q96LC4
Q96QT3 Q9BW38 Q9H6H1 Q9NP51 Q9NPY1 Q9NPY2
Alternative splicing: 6 isoforms:  Q9NWM0-1   Q9NWM0-2   Q9NWM0-3   Q9NWM0-4   Q9NWM0-5   Q9NWM0-6   (Substrate specificities and affinities comparable to those of isoform 1)

Explore the universe of human proteins at neXtProt for SMOX: NX_Q9NWM0

Explore proteomics data for SMOX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SMOX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257620.1  NP_787033.1  NP_787034.1  NP_787035.1  NP_787036.1  

    ENSEMBL proteins: 
     ENSP00000344595   ENSP00000307252   ENSP00000278795   ENSP00000341775   ENSP00000368773  
     ENSP00000407269  
    Reactome Protein details: Q9NWM0

    SMOX Human Recombinant Protein Products:

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    Novus Biologicals SMOX Lysate
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    Cloud-Clone Corp. Proteins for SMOX

    SMOX Antibody Products:

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    Cloud-Clone Corp. ELISAs for SMOX
    Cloud-Clone Corp. CLIAs for SMOX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry Q9NWM0

    ProtoNet protein and cluster: Q9NWM0

    UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
    Similarity: Belongs to the flavin monoamine oxidase family


    SMOX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMOX_HUMAN, Q9NWM0
    Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine
    and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental
    conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the
    potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to
    beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal
    Catalytic activity: Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2)
    Enzyme regulation: Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1uM
    Biophysicochemical properties: Kinetic parameters: KM=0.6 uM for spermine (isoform 1); KM=0.5 uM for spermine
    (isoform 6); KM=3.0 uM for N1-acetylspermine (Isoform 1 and isoform 6); Note=Kcat is 27-fold higher with spermine
    than N1-acetylspermine as substrate for isoform 1 and isoform 6; pH dependence: Optimum pH is 9.5 with spermine
    as substrate;
    Induction: By antitumor polyamine analogs

         Enzyme Number (IUBMB): EC 1.5.3.161

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity ----
    GO:0046592polyamine oxidase activity IDA12477380
    GO:0052894norspermine:oxygen oxidoreductase activity IEA--
    GO:0052895N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity IEA--
    GO:0052901spermine:oxygen oxidoreductase (spermidine-forming) activity IEA--
         
    SMOX for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Smox (no phenotypes)

    SMOX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Smoxtm1Lex for SMOX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMOX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMOX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMOX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMOX

    miRNA
    Products:
        
    miRTarBase miRNAs that target SMOX:
    hsa-mir-615-3p (MIRT040277)

    Block miRNA regulation of human, mouse, rat SMOX using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SMOX:
    hsa-miR-124 hsa-miR-506 hsa-miR-548v hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSMOX 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SMOX

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): SMOX (NM_175839)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMOX

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMOX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMOX_HUMAN, Q9NWM0: Isoform 1: Cytoplasm. Nucleus
    SMOX_HUMAN, Q9NWM0: Isoform 4: Cytoplasm. Nucleus
    SMOX_HUMAN, Q9NWM0: Isoform 6: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane3
    extracellular2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    SMOX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SMOX About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Interconversion of polyamines0.00
    Metabolism of polyamines0.00
    Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs0.00
    2Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Amine Oxidase reactions0.00
    3Biological oxidations
    Biological oxidations0.56
    4Metabolism
    Metabolism0.38
    5beta-Alanine metabolism
    beta-Alanine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SMOX
        Activation of PKA through GPCR
    PKA Signaling
    Molecular Mechanisms of Cancer
    CRHR Pathway
    Hedgehog Signaling in Mammals

    1 Tocris Bioscience Pathway for SMOX
        Hedgehog Pathway

    2 Reactome Pathways for SMOX
        Interconversion of polyamines
    Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs


    2 Kegg Pathways  (Kegg details for SMOX):
        Arginine and proline metabolism
    beta-Alanine metabolism

    UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
    Pathway: Amine and polyamine degradation; spermine degradation


    SMOX for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMOX
    Interactions:

        Search GeneGlobe Interaction Network for SMOX

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SMOX (ENSP000003072524) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    METTL11BENSP000004080584STRING: ENSP00000408058
    NTMT1ENSP000003615584STRING: ENSP00000361558
    SRMENSP000003661564STRING: ENSP00000366156
    UMPSENSP000002326074STRING: ENSP00000232607
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006595polyamine metabolic process TAS--
    GO:0006596polyamine biosynthetic process TAS--
    GO:0006598polyamine catabolic process IDA12477380
    GO:0006805xenobiotic metabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    SMOX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SMOX available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SMANT hydrochlorideInhibits Smoothened (Smo) accumulation[1177600-74-6]
    JervineInhibitor of Hedgehog (Hh) signaling; binds directly to Smo[469-59-0]
    GSA 10Smo receptor agonist[300833-95-8]
    MRT 10Smoothened (Smo) antagonist[330829-30-6]

    6 HMDB Compounds for SMOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    1 DrugBank Compound for SMOX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Spermine1, 4-Bis(aminopropyl)butanediamine (see all 5)71-44-3targetligand12141946 12727196 11258887 15133083 12477380

    Selected Novoseek inferred chemical compound relationships for SMOX gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apao 95.9 10 20012116 (4), 19589128 (1), 17611701 (1)
    spermine 92.4 129 19811743 (3), 20012116 (3), 16354669 (3), 20000632 (3) (see all 43)
    3-aminopropanal 91.3 1 20000632 (1)
    denspm 90.2 23 17987291 (3), 19097065 (2), 20514439 (2), 17611701 (1)
    n1-acetylspermine 90.1 3 12477380 (1), 1366693 (1)
    cpenspm 90.1 2 9326648 (2)
    spermidine 89.4 34 15133083 (2), 16354669 (2), 15247269 (2), 11258887 (1) (see all 20)
    n1,n12-diacetylspermine 84.9 1 2327969 (1)
    n1-acetylspermidine 83.2 1 16354669 (1)
    putrescine 65.1 1 16554974 (1)



    SMOX for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SMOX gene (5 alternative transcripts): 
    NM_001270691.1  NM_175839.2  NM_175840.2  NM_175841.2  NM_175842.2  

    Unigene Cluster for SMOX:

    Spermine oxidase
    Hs.433337  [show with all ESTs]
    Unigene Representative Sequence: NM_001270691
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493223 ENST00000339123(uc002wkl.1 uc002wkn.1 uc010zqo.1)
    ENST00000305958(uc002wkm.1 uc002wkp.2) ENST00000278795(uc002wkk.1)
    ENST00000484515 ENST00000346595 ENST00000602910 ENST00000379460(uc002wko.1)
    ENST00000457205 ENST00000494098 ENST00000486998 ENST00000466004
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate SMOX:
    hsa-miR-124 hsa-miR-506 hsa-miR-548v hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSMOX 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): SMOX (NM_175839)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMOX
    Primer
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    OriGene qPCR primer pairs and template standards for SMOX
    OriGene qSTAR qPCR primer pairs in human, mouse for SMOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMOX
      QuantiTect SYBR Green Assays in human, mouse, rat SMOX
      QuantiFast Probe-based Assays in human, mouse, rat SMOX

    Additional mRNA sequence: 

    AF519179.1 AK000753.1 AK025938.1 AK123237.1 AK293485.1 AL162058.1 AY033889.1 AY033890.1 
    AY033891.1 AY358104.1 BC000669.2 EF032141.1 U61836.1 

    14 DOTS entries:

    DT.40230447  DT.100810118  DT.100810121  DT.95110672  DT.92372507  DT.100036804  DT.100810116  DT.101976683 
    DT.120836564  DT.86846018  DT.92439439  DT.97843460  DT.101986406  DT.121191208 

    Selected AceView cDNA sequences (see all 202):

    BM759021 BM827550 NM_175840 CR598868 AA341953 CA441081 AK127286 BQ957294 
    NM_175842 BF941771 NM_175839 BF771919 AL553893 BF769711 BU191985 BX401001 
    AK000753 CB153916 BU552591 BI819413 AW438617 NM_019025 CR622005 NM_175841 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMOX (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
    SP1:                    -     -     -     -     -     -           -                                   -                                                         
    SP2:                    -     -     -     -     -     -           -                                   -                                   -                     
    SP3:                                                              -                                   -                                   -                     
    SP4:                    -     -     -     -     -     -           -                                   -                                   -                     
    SP5:                                                                                                                                                            

    ExUns: 14d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SMOX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SMOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTGCTGT
    SMOX Expression
    About this image


    SMOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
    SMOX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMOX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433337

    UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
    Tissue specificity: Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal
    kidney cell line

        Custom PCR Arrays for SMOX
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMOX gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smox1 , 5 spermine oxidase1, 5 90.07(n)1
    95.49(a)1
      2 (63.45 cM)5
    2286081  NM_145533.21  NP_663508.11 
     1314914965 
    chicken
    (Gallus gallus)
    Aves SMOX1 spermine oxidase 75.19(n)
    82.71(a)
      422934  XM_420872.4  XP_420872.3 
    lizard
    (Anolis carolinensis)
    Reptilia SMOX6
    spermine oxidase
    80(a)
    1 ↔ 1
    GL343407.1(107371-138995)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.14742 Xenopus laevis transcribed sequence with moderate similarity more 76.92(n)    BU914753.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.117072 Danio rerio mRNA similar to chromosome 20 open reading more 78.35(n)    BC044478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80321 CG8032 48.73(n)
    36.84(a)
      41026  NM_001275451.1  NP_001262380.1 
    worm
    (Caenorhabditis elegans)
    Secernentea amx-36
    hpo-156
    Protein HPO-15 (hpo-15) mRNA, complete cds
    28(a)
    23(a)
    many ↔ many
    many ↔ many
    V(20898937-20903441) WBGene00000139
    V(5509933-5513830) WBGene00016061
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PAO51 PAO5 44.22(n)
    36.64(a)
      829093  NM_119117.1  NP_194701.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07102001 Os01g0710200 48.84(n)
    36.58(a)
      4327828  NM_001050573.1  NP_001044038.1 


    ENSEMBL Gene Tree for SMOX (if available)
    TreeFam Gene Tree for SMOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMOX gene
    KDM1B2  PAOX2  KDM1A2  
    1 SIMAP similar gene for SMOX using alignment to 2 protein entries:     SMOX_HUMAN (see all proteins):
    PAOX

    SMOX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SMOX (see all 1004)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365464
    A breast cancer sample4--see VAR_0365462 Q K mis40--------
    rs60524001,2
    F--4127432(+) agatcC/Gcatca 5 -- us2k10--------
    rs1448001631,2
    --4127455(+) CTGGGA/CAACAG 5 -- us2k10--------
    rs1883003611,2
    --4127503(+) TTAAAC/TCACTA 5 -- us2k10--------
    rs1387472001,2
    --4127549(+) TGAGAC/TGTGCA 5 -- us2k10--------
    rs61393271,2
    C,F,H--4127639(+) CCTCCC/TGGTGG 5 -- us2k1 trp36Minor allele frequency- T:0.09NS NA CSA WA EA 482
    rs48136731,2
    C,F,A--4127694(+) TTTTTA/CTTTTT 5 -- us2k1 tfbs37Minor allele frequency- C:0.15NA WA CSA EA 366
    rs607474981,2
    C,F--4127880(+) CATGGA/TAAGGT 5 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1418909661,2
    --4127883(+) GGAAAG/TGTCCC 5 -- us2k10--------
    rs1178871971,2
    C,F--4127894(+) CTAACA/GTAGAA 5 -- us2k11Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for SMOX (4101627 - 4168394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SMOX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1176085CNV Deletion17803354
    esv2632874CNV Deletion19546169
    esv2722126CNV Deletion23290073
    nsv833900CNV Loss17160897
    nsv828673CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMOX
    DNA2.0 Custom Variant and Variant Library Synthesis for SMOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    Selected diseases for SMOX (see all 23):    
    About MalaCards
    meconium aspiration syndrome    cor pulmonale    pneumothorax    hepatopulmonary syndrome
    congenital diaphragmatic hernia    noma    pulmonary embolism    cervical intraepithelial neoplasia
    respiratory failure    panic disorder    interstitial lung disease    mood disorder
    cervicitis    ulcerative colitis    breast and colorectal cancer    cervical cancer
    hypertension    breast cancer    cerebritis    colorectal cancer


    SMOX for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SMOX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical cancer 6.65 2 11855874 (1), 7577467 (1)
    renal failure chronic 0 3 16269634 (1), 16554974 (1)
    breast cancer 0 1 19727732 (1)
    tumors 0 10 10999758 (4), 17987291 (2), 16207710 (1), 19685053 (1)

    Genetic Association Database (GAD): SMOX
    Human Genome Epidemiology (HuGE) Navigator: SMOX (2 documents)

    Export disorders for SMOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMOX gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with SMOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. (PubMed id 11454677)1, 2, 3, 9 Wang Y....Casero R.A. Jr. (Cancer Res. 2001)
    2. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. (PubMed id 12141946)1, 2, 7, 9 Vujcic S.... Porter C.W. (Biochem. J. 2002)
    3. Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics. (PubMed id 12398765)1, 2, 3, 9 Murray-Stewart T.... Casero R.A. Jr. (Biochem. J. 2002)
    4. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. (PubMed id 12727196)1, 2, 7 Wang Y.... Casero R.A. Jr. (Biochem. Biophys. Res. Commun. 2003)
    5. Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology. (PubMed id 18422650)1, 2, 9 Murray-Stewart T....Casero R.A. Jr. (FEBS J. 2008)
    6. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. (PubMed id 12477380)1, 7, 9 Vujcic S.... Porter C.W. (Biochem. J. 2003)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Catabolism of polyamines. (PubMed id 15221502)1, 2 Seiler N. (Amino Acids 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54498 HGNC: 15862 AceView: SMOX Ensembl:ENSG00000088826 euGenes: HUgn54498
    ECgene: SMOX Kegg: 54498 H-InvDB: SMOX

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SMOX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SMOX gene:
    Search GeneIP for patents involving SMOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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