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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMOX Gene

protein-coding   GIFtS: 57
GCID: GC20P004101

spermine oxidase

(Previous name: chromosome 20 open reading frame 16 )
(Previous symbol: C20orf16)
 Explore 26 diseases affiliated with
SMOX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SMOX    

Aliases
for SMOX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Spermine Oxidase1 2     MGC10101
C20orf161 2 3     Chromosome 20 Open Reading Frame 161
SMO1 2 3     DJ779E11.11
PAO1 2     PAOH12
PAOh11 3     Flavin Containing Amine Oxidase2
Polyamine Oxidase 12 3     Flavin-Containing Spermine Oxidase2
PAO-12 3     Putative Cyclin G1 Interacting Protein2
FLJ207461     EC 1.5.3.163

External Ids:    HGNC: 158621   Entrez Gene: 544982   Ensembl: ENSG000000888267   UniProtKB: Q9NWM03   

Export aliases for SMOX gene to outside databases

Previous GC identifers: GC20P004124 GC20P004077


Summaries
for SMOX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SMOX:
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These
molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive
oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission
through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and
their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of
spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different
isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity
on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and
substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
(provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and
spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental
conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential
to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine
production via aldehyde dehydrogenase conversion of 3-amino-propanal

summary for SMOX:
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family.
Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In
the resting state, Smo receptors are bound to and repressed by, patched (Ptc). Upon Hh-Ptc interaction, Smo
receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the
activity of transcription factors belonging to the Gli family (particularly Cubitus interruptus (Ci)). Smo
receptors are vital for embryogenesis (segmentation and appendage development) and are involved in
maintainence of tissue homeostasis in adults. The human gene encoding the Smo receptor has been localized on
chromosome 7q32.3.

Gene Wiki entry for SMOX


Genomic Views
for SMOX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMOX gene promoter:
         c-Fos   NF-1   NF-1/L   AP-1   Pax-5   PPAR-gamma1   FOXC1   PPAR-gamma2   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMOX promoter sequence
   Search SABiosciences Chromatin IP Primers for SMOX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SMOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMOX gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P004101:  view genomic region     (about GC identifiers)

Start:
 4,101,627 bp from pter      End:
 4,168,394 bp from pter
Size:
 66,768 bases      Orientation:
 plus strand

Proteins
for SMOX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0 (See protein sequence)
Recommended Name: Spermine oxidase  
Size: 555 amino acids; 61819 Da
Cofactor: Binds 1 FAD per subunit (By similarity)
Subcellular location: Isoform 1: Cytoplasm. Nucleus
Subcellular location: Isoform 4: Cytoplasm. Nucleus
Subcellular location: Isoform 6: Cytoplasm. Nucleus
Secondary accessions: A2A2P5 A2A2P6 A8BE87 D3DVZ4 Q5TE26 Q5TE27 Q6UY28 Q8IX00 Q96LC3 Q96LC4 Q96QT3
Q9BW38 Q9H6H1 Q9NP51 Q9NPY1 Q9NPY2
Alternative splicing: 6 isoforms:  Q9NWM0-1   Q9NWM0-2   Q9NWM0-3   Q9NWM0-4   Q9NWM0-5   Q9NWM0-6   (Substrate specificities and affinities comparable to those of isoform 1)

Explore the universe of human proteins at neXtProt for SMOX: NX_Q9NWM0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NWM0

    • SMOX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257620.1  NP_787033.1  NP_787034.1  NP_787035.1  NP_787036.1  

    ENSEMBL proteins: 
     ENSP00000344595   ENSP00000307252   ENSP00000278795   ENSP00000341775   ENSP00000368773  
     ENSP00000407269  
    Reactome Protein details: Q9NWM0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SMOX
    OriGene Protein Over-expression Lysate (see all 5): SMOX
    OriGene Custom Protein Services for SMOX 
    GenScript Custom Purified and Recombinant Proteins Services for SMOX
    Novus Biologicals SMOX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SMOX

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    SMOX for ontologies           About GeneDecksing



    SMOX Antibody Products: 
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    Novus Biologicals SMOX Antibody
    Search for Antibodies for SMOX at Abcam  
    Uscn Antibodies for SMOX
    Search ThermoFisher Antibodies for SMOX

    Assay Products for SMOX: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for SMOX
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SMOX

    Protein Domains /
    Families
    for SMOX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SMOX for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry Q9NWM0

    ProtoNet protein and cluster: Q9NWM0

    UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
    Similarity: Belongs to the flavin monoamine oxidase family


    Function
    for SMOX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
    Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and
    spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental
    conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential
    to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine
    production via aldehyde dehydrogenase conversion of 3-amino-propanal
    Catalytic activity: Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2)
    Enzyme regulation: Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1uM
    Biophysicochemical properties: Kinetic parameters: KM=0.6 uM for spermine (isoform 1); KM=0.5 uM for spermine (isoform
    6); KM=3.0 uM for N1-acetylspermine (Isoform 1 and isoform 6); Note=Kcat is 27-fold higher with spermine than
    N1-acetylspermine as substrate for isoform 1 and isoform 6; pH dependence: Optimum pH is 9.5 with spermine as
    substrate;
    Induction: By antitumor polyamine analogs

    Enzyme Number (IUBMB): EC 1.5.3.161

    miRNA
    Products:            		miRTarBase miRNAs that target SMOX:
    hsa-mir-326 (MIRT000526), hsa-mir-324-5p (MIRT000527), hsa-mir-125b (MIRT000525)

    OriGene 3'-UTR Clone (see all 4): SMOX
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMOX
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SMOX:
    hsa-miR-124 hsa-miR-506 hsa-miR-548v hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SMOX 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMOX (see all 7)
    OriGene shRNA RFP: SMOX
    OriGene siRNA: SMOX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMOX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SMOX

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMOX (see all 14)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMOX (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): SMOX (NM_175839)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMOX 

    Cell Line
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    Search LifeMap BioReagents cell lines for SMOX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMOX

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity ----
    GO:0046592polyamine oxidase activity IDA12477380
    GO:0052894norspermine:oxygen oxidoreductase activity IEA--
    GO:0052895N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity IEA--
    GO:0052901spermine:oxygen oxidoreductase (spermidine-forming) activity IEA--


    SMOX for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Smoxtm1Lex for SMOX
         1 MGI phenotypic allele for Smox (no phenotypes)

    SMOX for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SMOX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
    		Amine Oxidase reactions0.50
    		Interconversion of polyamines0.00
    		Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs0.00
    2Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    3Metabolism
    		Metabolism1.00
    4Biological oxidations
    		Biological oxidations1.00
    5Cytochrome P450 - arranged by substrate type
    		Phase 1 - Functionalization of compounds0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Tocris Bioscience Pathway for SMOX
        Hedgehog Pathway

    5/8        Reactome Pathways for SMOX (see all 8)
        Metabolism of polyamines
    Interconversion of polyamines
    Metabolism
    Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs
    Phase 1 - Functionalization of compounds


    UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
    Pathway: Amine and polyamine degradation; spermine degradation


    SMOX for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMOX

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SMOX (ENSP000003072524) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006595polyamine metabolic process TAS--
    GO:0006596polyamine biosynthetic process TAS--
    GO:0006598polyamine catabolic process IDA12477380
    GO:0006805xenobiotic metabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--


    SMOX for ontologies           About GeneDecksing



    Drugs & Compounds
    for SMOX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SMOX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SMOX available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SANT-2Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity[329196-48-7]
    SANT-1Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity[304909-07-7]
    20(S)-HydroxycholesterolAllosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation[516-72-3]

    6 HMDB Compounds for SMOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    1 DrugBank Compound for SMOX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Spermine1, 4-Bis(aminopropyl)butanediamine (see all 5)71-44-3targetligand12141946 12727196 11258887 15133083 12477380

    10/20 Novoseek chemical compound relationships for SMOX gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apao 95.9 10 20012116 (4), 19589128 (1), 17611701 (1)
    spermine 92.4 129 19811743 (3), 20012116 (3), 16354669 (3), 20000632 (3) (see all 43)
    3-aminopropanal 91.3 1 20000632 (1)
    denspm 90.2 23 17987291 (3), 19097065 (2), 20514439 (2), 17611701 (1)
    n1-acetylspermine 90.1 3 12477380 (1), 1366693 (1)
    cpenspm 90.1 2 9326648 (2)
    spermidine 89.4 34 15133083 (2), 16354669 (2), 15247269 (2), 11258887 (1) (see all 20)
    n1,n12-diacetylspermine 84.9 1 2327969 (1)
    n1-acetylspermidine 83.2 1 16354669 (1)
    putrescine 65.1 1 16554974 (1)

    Search CenterWatch for drugs/clinical trials and news about SMOX 

    Transcripts
    for SMOX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SMOX gene (5 alternative transcripts): 
    NM_001270691.1  NM_175839.2  NM_175840.2  NM_175841.2  NM_175842.2  

    Unigene Cluster for SMOX:

    Spermine oxidase
    Hs.433337  [show with all ESTs]
    Unigene Representative Sequence: NM_001270691
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493223 ENST00000339123(uc002wkl.1 uc002wkn.1 uc010zqo.1)
    ENST00000305958(uc002wkm.1 uc002wkp.2) ENST00000278795(uc002wkk.1)
    ENST00000484515 ENST00000346595 ENST00000379460(uc002wko.1) ENST00000457205
    ENST00000494098 ENST00000486998 ENST00000466004

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): SMOX
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMOX
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SMOX:
    hsa-miR-124 hsa-miR-506 hsa-miR-548v hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SMOX 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMOX (see all 7)
    OriGene shRNA RFP: SMOX
    OriGene siRNA: SMOX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMOX
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): SMOX (NM_175839)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMOX 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMOX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMOX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMOX

    Additional cDNA sequence: 

    AF519179.1 AK000753.1 AK025938.1 AK123237.1 AK293485.1 AL162058.1 AY033889.1 AY033890.1 
    AY033891.1 AY358104.1 BC000669.2 EF032141.1 U61836.1 

    14 DOTS entries:

    DT.40230447  DT.100810118  DT.100810121  DT.95110672  DT.92372507  DT.100036804  DT.100810116  DT.101976683 
    DT.120836564  DT.86846018  DT.92439439  DT.97843460  DT.101986406  DT.121191208 

    24/202 AceView cDNA sequences (see all 202):

    CA441081 AW136764 BM759021 NM_019025 AK127286 BI914178 NM_175841 CB153916 
    BU552591 BI819413 NM_175839 BF769711 CR622005 AW438617 BQ957294 AL553893 
    CR598868 AA341953 AK000753 BX401001 BU191985 NM_175842 BF941771 BF771919 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SMOX (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
    SP1:                    -     -     -     -     -     -           -                                   -                                                         
    SP2:                    -     -     -     -     -     -           -                                   -                                   -                     
    SP3:                                                              -                                   -                                   -                     
    SP4:                    -     -     -     -     -     -           -                                   -                                   -                     
    SP5:                                                                                                                                                            

    ExUns: 14d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SMOX

    Expression
    for SMOX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGTGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SMOX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SMOX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMOX

    SOURCE GeneReport for Unigene cluster: Hs.433337

    UniProtKB/Swiss-Prot: SMOX_HUMAN, Q9NWM0
    Tissue specificity: Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal
    kidney cell line

        SABiosciences Custom PCR Arrays for SMOX
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    In Situ
    Assay Products:     
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    Orthologs
    for SMOX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMOX gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SMOX1 spermine oxidase 75.38(n)
    82.89(a)    		   422934  XM_420872.3  XP_420872.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SMOX6
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL343407.1(107398-138517)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.14742 Xenopus laevis transcribed sequence with moderate similarity more 76.92(n)    BU914753.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.117072 Danio rerio mRNA similar to chromosome 20 open reading more 78.35(n)    BC044478.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG80321 CG8032 49.06(n)
    36.84(a)    		   41026  NM_141554.2  NP_649811.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PAO51 putative polyamine oxidase 5 45.04(n)
    37.93(a)    		   829093  NM_119117.1  NP_194701.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g07102001 hypothetical protein 49.26(n)
    36.09(a)    		   4327828  NM_001050573.1  NP_001044038.1 


    ENSEMBL Gene Tree for SMOX (if available)
    TreeFam Gene Tree for SMOX (if available) 

    Paralogs
    for SMOX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMOX gene
    KDM1B2  PAOX2  KDM1A2  
    1 SIMAP similar gene for SMOX using alignment to 2 protein entries:     SMOX_HUMAN (see all proteins):
    PAOX

    SMOX for paralogs           About GeneDecksing



    Genomic Variants
    for SMOX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/824 NCBI SNPs in SMOX are shown (see all 824)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs60524001,2
    		--4127432(+) agatcC/Gcatca 5 -- us2k10--------
    rs1448001631,2
    		--4127455(+) CTGGGA/CAACAG 5 -- us2k10--------
    rs1883003611,2
    		--4127503(+) TTAAAC/TCACTA 5 -- us2k10--------
    rs1387472001,2
    		--4127549(+) TGAGAC/TGTGCA 5 -- us2k10--------
    rs61393271,2
    		C,F,H,--4127639(+) CCTCCC/TGGTGG 5 -- us2k1 trp36Minor allele frequency- T:0.09NS NA CSA WA EA 482
    rs48136731,2
    		C,F,A,--4127694(+) TTTTTA/CTTTTT 5 -- us2k1 tfbs37Minor allele frequency- C:0.15NA WA CSA EA 366
    rs607474981,2
    		C,--4127880(+) CATGGA/TAAGGT 5 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1418909661,2
    		--4127883(+) GGAAAG/TGTCCC 5 -- us2k10--------
    rs1178871971,2
    		--4127894(+) CTAACA/GTAGAA 5 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1432343371,2
    		--4127944(+) AGGTCG/TTCAAC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for SMOX (4101627 - 4168394 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SMOX
         1 CNV: 102905
         1 Indel: 26826

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    Disorders / Diseases
    for SMOX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SMOX for disorders           About GeneDecksing

    20/26 diseases for SMOX (see all 26):    About MalaCards
    cor pulmonale    congenital diaphragmatic hernia    cervical intraepithelial neoplasia    pulmonary embolism
    interstitial lung disease    panic disorder    respiratory failure    pneumothorax
    mood disorder    ulcerative colitis    hepatopulmonary syndrome    cervicitis
    hernia    breast cancer    noma    cervical carcinoma
    colon cancer    gastric cancer    lung carcinoma    colorectal cancer

    8 diseases from the University of Copenhagen DISEASES database for SMOX:
    Respiratory failure     Hepatopulmonary syndrome     Chronic obstructive pulmonary disease     Pneumonia
    Pulmonary hypertension     Meconium aspiration syndrome     Cor pulmonale     Pneumothorax

    4 Novoseek disease relationships for SMOX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical cancer 6.65 2 11855874 (1), 7577467 (1)
    renal failure chronic 0 3 16269634 (1), 16554974 (1)
    breast cancer 0 1 19727732 (1)
    tumors 0 10 10999758 (4), 17987291 (2), 16207710 (1), 19685053 (1)

    Human Genome Epidemiology (HuGE) Navigator: SMOX (2 documents)

    Export disorders for SMOX gene to outside databases

    Publications
    for SMOX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMOX gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with SMOX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. (PubMed id 11454677)1, 2, 3, 9 Wang Y....Casero R.A. Jr. (2001)
    2. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. (PubMed id 12141946)1, 2, 7, 9 Vujcic S.... Porter C.W. (2002)
    3. Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics. (PubMed id 12398765)1, 2, 3, 9 Murray-Stewart T.... Casero R.A. Jr. (2002)
    4. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. (PubMed id 12727196)1, 2, 7 Wang Y.... Casero R.A. Jr. (2003)
    5. Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology. (PubMed id 18422650)1, 2, 9 Murray-Stewart T....Casero R.A.Jr. (2008)
    6. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. (PubMed id 12477380)1, 7, 9 Vujcic S.... Porter C.W. (2003)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Catabolism of polyamines. (PubMed id 15221502)1, 2 Seiler N. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    External Searches for SMOX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SMOX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54498 HGNC: 15862 AceView: SMOX Ensembl:ENSG00000088826 euGenes: HUgn54498
    ECgene: SMOX H-InvDB: SMOX

    Other Databases showing SMOX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SMOX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMOX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SMOX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SMOX gene:
    Search GeneIP for patents involving SMOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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