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Aliases for SMOX Gene

Aliases for SMOX Gene

  • Spermine Oxidase 2 3
  • Polyamine Oxidase 1 3 4
  • C20orf16 3 4
  • PAOH1 3 4
  • PAO-1 3 4
  • SMO 3 4
  • Putative Cyclin G1 Interacting Protein 3
  • Chromosome 20 Open Reading Frame 16 2
  • Flavin-Containing Spermine Oxidase 3
  • Flavin Containing Amine Oxidase 3
  • EC 1.5.3.16 4
  • PAO1 3
  • PAOH 3
  • PAO 3

External Ids for SMOX Gene

Previous Symbols for SMOX Gene

  • C20orf16

Summaries for SMOX Gene

Entrez Gene Summary for SMOX Gene

  • Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]

GeneCards Summary for SMOX Gene

SMOX (Spermine Oxidase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include polyamine oxidase activity and norspermine:oxygen oxidoreductase activity. An important paralog of this gene is KDM1B.

UniProtKB/Swiss-Prot for SMOX Gene

  • Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal

Gene Wiki entry for SMOX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMOX Gene

Genomics for SMOX Gene

Genomic Location for SMOX Gene

Start:
4,120,980 bp from pter
End:
4,187,747 bp from pter
Size:
66,768 bases
Orientation:
Plus strand

Genomic View for SMOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMOX Gene

Regulatory Elements for SMOX Gene

Proteins for SMOX Gene

  • Protein details for SMOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWM0-SMOX_HUMAN
    Recommended name:
    Spermine oxidase
    Protein Accession:
    Q9NWM0
    Secondary Accessions:
    • A2A2P5
    • A2A2P6
    • A8BE87
    • D3DVZ4
    • Q5TE26
    • Q5TE27
    • Q6UY28
    • Q8IX00
    • Q96LC3
    • Q96LC4
    • Q96QT3
    • Q9BW38
    • Q9H6H1
    • Q9NP51
    • Q9NPY1
    • Q9NPY2

    Protein attributes for SMOX Gene

    Size:
    555 amino acids
    Molecular mass:
    61819 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMOX Gene

neXtProt entry for SMOX Gene

Proteomics data for SMOX Gene at MOPED

Post-translational modifications for SMOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMOX Gene

No data available for DME Specific Peptides for SMOX Gene

Domains for SMOX Gene

Protein Domains for SMOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMOX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWM0

UniProtKB/Swiss-Prot:

SMOX_HUMAN
Family:
  • Belongs to the flavin monoamine oxidase family.:
    • Q9NWM0
genes like me logo Genes that share domains with SMOX: view

No data available for Gene Families for SMOX Gene

Function for SMOX Gene

Molecular function for SMOX Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.6 uM for spermine (isoform 1) {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650}; KM=0.5 uM for spermine (isoform 6) {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650}; KM=3.0 uM for N1-acetylspermine (Isoform 1 and isoform 6) {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650}; Note=Kcat is 27-fold higher with spermine than N1-acetylspermine as substrate for isoform 1 and isoform 6.; pH dependence: Optimum pH is 9.5 with spermine as substrate. {ECO:0000269 PubMed:12141946, ECO:0000269 PubMed:12398765, ECO:0000269 PubMed:18422650};
UniProtKB/Swiss-Prot CatalyticActivity: Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1uM
UniProtKB/Swiss-Prot Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal
UniProtKB/Swiss-Prot Induction: By antitumor polyamine analogs

Enzyme Numbers (IUBMB) for SMOX Gene

Gene Ontology (GO) - Molecular Function for SMOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity --
GO:0046592 polyamine oxidase activity IDA 12477380
GO:0052894 norspermine:oxygen oxidoreductase activity IEA --
GO:0052895 N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity IEA --
GO:0052901 spermine:oxygen oxidoreductase (spermidine-forming) activity IEA --
genes like me logo Genes that share ontologies with SMOX: view

miRNA for SMOX Gene

miRTarBase miRNAs that target SMOX

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMOX Gene

Localization for SMOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMOX Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 4: Cytoplasm. Nucleus.
Isoform 6: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMOX Gene COMPARTMENTS Subcellular localization image for SMOX gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SMOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SMOX: view

Pathways for SMOX Gene

genes like me logo Genes that share pathways with SMOX: view

UniProtKB/Swiss-Prot Q9NWM0-SMOX_HUMAN

  • Pathway: Amine and polyamine degradation; spermine degradation

Interacting Proteins for SMOX Gene

Gene Ontology (GO) - Biological Process for SMOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006595 polyamine metabolic process TAS --
GO:0006596 polyamine biosynthetic process TAS --
GO:0006598 polyamine catabolic process IDA 12477380
GO:0006805 xenobiotic metabolic process TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with SMOX: view

Compounds for SMOX Gene

(6) HMDB Compounds for SMOX Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
N1-Acetylspermine
  • N'-Acetylspermine
25593-72-0
Norspermidine
  • N-(3-aminopropyl)-1,3-Propanediamine
56-18-8
Putrescine
  • 1,4-Butanediamine
110-60-1
Spermidine
  • 1,5,10-Triazadecane
124-20-9

(1) Drugbank Compounds for SMOX Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Spermine
  • 1, 4-Bis(aminopropyl)butanediamine
71-44-3 target ligand

(20) Novoseek inferred chemical compound relationships for SMOX Gene

Compound -log(P) Hits PubMed IDs
apao 95.9 6
spermine 92.4 62
3-aminopropanal 91.3 1
denspm 90.2 8
n1-acetylspermine 90.1 2
genes like me logo Genes that share compounds with SMOX: view

Transcripts for SMOX Gene

Unigene Clusters for SMOX Gene

Spermine oxidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMOX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - -
SP12: - - - -
SP13: - - -

ExUns: 14d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SMOX Gene

GeneLoc Exon Structure for
SMOX
ECgene alternative splicing isoforms for
SMOX

Expression for SMOX Gene

mRNA expression in normal human tissues for SMOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMOX Gene

SOURCE GeneReport for Unigene cluster for SMOX Gene Hs.433337

mRNA Expression by UniProt/SwissProt for SMOX Gene

Q9NWM0-SMOX_HUMAN
Tissue specificity: Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line.
genes like me logo Genes that share expressions with SMOX: view

No data available for mRNA differential expression in normal tissues for SMOX Gene

Orthologs for SMOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMOX 35
  • 99.15 (n)
  • 99.49 (a)
SMOX 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMOX 35
  • 91.53 (n)
  • 96.22 (a)
SMOX 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMOX 35
  • 92.19 (n)
  • 95.04 (a)
SMOX 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smox 35
  • 90.07 (n)
  • 95.49 (a)
Smox 16
Smox 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMOX 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMOX 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smox 35
  • 90.97 (n)
  • 96.21 (a)
chicken
(Gallus gallus)
Aves SMOX 35
  • 75.19 (n)
  • 82.71 (a)
SMOX 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMOX 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1474 35
tropical clawed frog
(Silurana tropicalis)
Amphibia smox 35
  • 73.75 (n)
  • 78.57 (a)
Str.11519 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11707 35
smox 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002616 35
  • 51.33 (n)
  • 38.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10561 36
  • 29 (a)
ManyToMany
CG5653 36
  • 30 (a)
ManyToMany
CG6034 36
  • 29 (a)
ManyToMany
CG7460 36
  • 30 (a)
ManyToMany
CG7737 36
  • 28 (a)
ManyToMany
CG8032 35
  • 48.73 (n)
  • 36.84 (a)
CG8032 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea amx-3 36
  • 28 (a)
ManyToMany
hpo-15 36
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PAO5 35
  • 44.22 (n)
  • 36.64 (a)
rice
(Oryza sativa)
Liliopsida Os01g0710200 35
  • 48.84 (n)
  • 36.58 (a)
Species with no ortholog for SMOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMOX Gene

ENSEMBL:
Gene Tree for SMOX (if available)
TreeFam:
Gene Tree for SMOX (if available)

Paralogs for SMOX Gene

Paralogs for SMOX Gene

Selected SIMAP similar genes for SMOX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SMOX: view

Variants for SMOX Gene

Sequence variations from dbSNP and Humsavar for SMOX Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs880648 -- 4,152,699(-) AGTGA(A/C)TATAC intron-variant
rs910954 -- 4,160,955(-) CTTCA(A/G)CTCCA intron-variant
rs927091 -- 4,164,374(-) GCAGA(C/T)GGCTT intron-variant
rs945771 -- 4,148,504(+) AAACC(C/G)CATTT upstream-variant-2KB
rs945772 -- 4,148,407(+) ACAAG(G/T)CTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMOX Gene

Variant ID Type Subtype PubMed ID
nsv828673 CNV Gain 20364138
nsv833900 CNV Loss 17160897
esv2632874 CNV Deletion 19546169
esv2722126 CNV Deletion 23290073
esv1176085 CNV Deletion 17803354

Relevant External Links for SMOX Gene

HapMap Linkage Disequilibrium report
SMOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMOX Gene

Disorders for SMOX Gene

(4) Novoseek inferred disease relationships for SMOX Gene

Disease -log(P) Hits PubMed IDs
cervical cancer 6.65 2
renal failure chronic 0 2
breast cancer 0 1
tumors 0 8

Relevant External Links for SMOX

Genetic Association Database (GAD)
SMOX
Human Genome Epidemiology (HuGE) Navigator
SMOX
genes like me logo Genes that share disorders with SMOX: view

No data available for UniProtKB/Swiss-Prot for SMOX Gene

Publications for SMOX Gene

  1. Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics. (PMID: 12398765) Murray-Stewart T. … Casero R.A. Jr. (Biochem. J. 2002) 2 3 4 23
  2. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. (PMID: 11454677) Wang Y. … Casero R.A. Jr. (Cancer Res. 2001) 2 3 4 23
  3. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. (PMID: 12141946) Vujcic S. … Porter C.W. (Biochem. J. 2002) 3 4 23 25
  4. Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology. (PMID: 18422650) Murray-Stewart T. … Casero R.A. Jr. (FEBS J. 2008) 3 4 23
  5. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. (PMID: 12727196) Wang Y. … Casero R.A. Jr. (Biochem. Biophys. Res. Commun. 2003) 3 4 25

Products for SMOX Gene

Sources for SMOX Gene

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