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SMO Gene

protein-coding GIFtS: 65

GC07P128615

smoothened homolog (Drosophila)
(Previous name: smoothened (Drosophila) homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SMOH)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Gx ^²
SMOH ^², ³, ⁵
smoothened ^²

Descriptions
Gx protein ^³
seven transmembrane helix receptor ^²
smoothened (Drosophila) homolog ^¹
smoothened homolog (Drosophila) ^²

External Ids
HGNC: 11119¹
Entrez Gene: 6608²
UniProtKB: Q99835³
Ensembl: ENSG00000128602⁷

Search outside databases for aliases for SMO gene

Previous GC identifers: GC07P127306 GC07P128368 GC07P128382 GC07P128422

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835

Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to

transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched

is thought to prevent normal inhibition by patched of smoothened (SMO)

Gene Wiki entry for SMO (Smoothened)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SMO gene

Entrez Gene cytogenetic band: 7q32.3 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q32.1

SMO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P128615: (about GC identifiers)

Start:	128,615,949 bp from pter
End:	128,640,622 bp from pter
Size:	24,674 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 128,212,668-128,237,345

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835 (See protein sequence)

Recommended Name: Smoothened homolog precursor

Size: 787 amino acids; 86397 Da

Subcellular location: Membrane; Multi-pass membrane protein

REFSEQ proteins: NP_005622.1

ENSEMBL proteins:

ENSP00000249373

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Smoothened)
	Human Recombinant Proteins from Abnova (SMO)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005929	cilium	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	TAS	9422511

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Antibodies for SMO:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SMO
	Sigma-Aldrich Antibodies for SMO
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Smoothened), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SMO)
	Novus Biologicals Antibodies for SMO

Assays for SMO:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99835

ProtoNet protein and cluster: Q99835

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835

Similarity: Belongs to the G-protein coupled receptor Fz/Smo family

Similarity: Contains 1 FZ (frizzled) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SMO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SMO)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005631

Applied Biosystems Silencer® siRNAs for SMO

Sigma-Aldrich siRNA and siRNA Panels for SMO

Sigma-Aldrich shRNA Panels and shRNA for SMO

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SMO
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005631
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005631
untagged cDNA clone in CMV expression vector: NM_005631

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005631

UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835

Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to

transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched

is thought to prevent normal inhibition by patched of smoothened (SMO)

15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Smo):

	craniofacial	digestive/alimentary	embryogenesis	growth/size
hearing/vestibular/ear	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	limbs/digits/tail
nervous system	no phenotypic analysis	normal	respiratory system	skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004926	non-G-protein coupled 7TM receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	TAS	8906787

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for SMO (Your Favorite Gene powered by Ingenuity) (see all 9 )

Molecular Mechanisms of Cancer
Wnt/&beta
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
Factors Promoting Cardiogenesis in Vertebrates
Axonal Guidance Signaling

GeneDecks SMO for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SMO

5/32 Interacting proteins for SMO (ENSP00000249373³) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTCH1	ENSP00000332353³	STRING (score=.999)
GLI1	ENSP00000228682³	STRING (score=.996)
SHH	ENSP00000297261³	STRING (score=.996)
ADRBK1	ENSP00000312262³	STRING (score=.992)
GLI2	ENSP00000354586³	STRING (score=.992)

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5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001570	vasculogenesis	IEA	--
GO:0001649	osteoblast differentiation	IEA	--
GO:0001755	neural crest cell migration	IEA	--
GO:0002052	positive regulation of neuroblast proliferation	IEA	--
GO:0003007	heart morphogenesis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for SMO

Browse Small Molecules at Sigma-Aldrich

Compounds for SMO available from Tocris Bioscience

Compound	Action	CAS number
SANT-1	Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity	[304909-07-7]

About this table

1 Novoseek chemical compound relationship for SMO gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclopamine	89.82	4	12391318 (3)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SMO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SMO)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005631

Sigma-Aldrich siRNA and siRNA Panels for SMO

Sigma-Aldrich shRNA Panels and shRNA for SMO

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005631

REFSEQ mRNAs for SMO gene:

NM_005631.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005631

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005631
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005631
                                 untagged cDNA clone in CMV expression vector: NM_005631

Additional cDNA sequence:

AF071494.1 AF089720.1 AF120103.1 AF130867.1 BC004332.1 BC009989.2 U84401.1

6 DOTS entries:

DT.313365 DT.121054058 DT.95371710 DT.121054063 DT.75121134 DT.86853388

24/101 AceView cDNA sequences (see all 101 ):

AW614083 AI081895 NM_005631 BC009989 BM725012 U84401 AF071494 BE785546

AU132302 BX641825 BE784306 AW593101 H98971 AF120103 BM714878 R71695

BU726335 AI820024 BM680230 BV182837 AI885759 AI422943 CA445076 AI140041

highest scoring ESTs for SMO:

U84401 AA070437 AA377764 AA448522 AA524933 AA738463 AF065155 AF071494 AF120103 AF130867

Unigene Cluster for SMO:

Smoothened homolog (Drosophila)

Hs.437846 [show with all ESTs]

Unigene Representative Sequence: NM_005631

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SMO

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12
SP1:																	-
SP2:																	-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for SMO

1 Ensembl transcript including schematic representation:

ENST00000249373

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SMO expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SMO

¹ / ² / ³

4 probe-sets matching SMO gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49344_at²^{, 3}	U95-B	1	1.00	1.00	0.89	1.33	AF065155	0.80	1.00	0.91	1
32960_at²^{, 3}	U95-A	1	1.00	1.00	0.11	0.69	U84401	1.00	1.00	1.00	1
218629_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005631	0.60	1.00	0.82	1
218629_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SMO for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCCCAAGGC

SOURCE GeneReport for Unigene cluster: Hs.437846
Expression variation in blood from EXPOLDB for SMO

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SMO gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SMO¹	--	smoothened homolog (Drosophila)	92.32(n) 96.9(a)	482262 XM_539381.2 XP_539381.2
chimpanzee (Pan troglodytes)	SMO¹	--	smoothened homolog (Drosophila)	99.41(n) 99.11(a)	463718 XM_519371.2 XP_519371.2
cow (Bos taurus)	SMO¹	--	smoothened homolog (Drosophila)	92.31(n) 96.26(a)	539308 XM_586374.3 XP_586374.1
rat (Rattus norvegicus)	Smo¹	--	smoothened homolog (Drosophila)	89.5(n) 93.65(a)	25273 NM_012807.1 NP_036939.1
mouse (Mus musculus)	Smo^{1, 5}	6 (7.20 cM)⁵	smoothened homolog (Drosophila)^{1, 5}	89.92(n)¹ 93.39(a)¹	319757¹ NM_176996.3¹ NP_795970.2¹ AA002990⁵ AF089721⁵ (see all 22)

About this table Species with no ortholog for SMO

ENSEMBL Gene Tree for SMO

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SMO gene

SFRP1² SFRP5² SFRP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/191 NCBI SNPs in SMO are shown (see all 191 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9607^1,2	A,C,F,H	128640293(+)	`GGTTCG/AGCTCT`	1	--	ut3¹		13	MN NA EU EA WA	1342
	rs1061280^1,2	A,C,F,H	128640359(+)	`GCATCA/GTCTCT`	1	--	ut3¹		8	MN NA EU EA WA	736
	rs6962740^1,2	A,C,F,H	128614047(+)	`agcacG/Caggag`	1	--	ng5¹		4	EU EA WA	418
	rs1061285^1,2	A,C,F	128640544(+)	`TCAGAC/AAGCAG`	1	--	ut3¹ ese³		1	MN	184
	rs3824^1,2	C,F,H	128640089(+)	`CATGTC/GCTCTC`	1	--	ut3¹ ese³		14	MN EA NA EU WA	2736
	rs2703098^1,2	C,F,H	128640149(+)	`CTTCTC/TCTGTT`	1	--	ut3¹ ese³ trp³		4	EU EA WA	420
	rs2075780^1,2	C,F	128639617(+)	`GATCCC/TGTCTT`	1	--	ut3¹ ese³		5	EA NA	2498
	rs1061282^1,2	F	128640428(+)	`GCTGCC/TGTAGC`	1	--	ut3¹ ese³		1	MN	184
	rs1061283^1,2	F	128640539(+)	`AAGAAT/GCAGAC`	1	--	ut3¹		1	MN	184
	rs17710891^1,2	H	128636425(+)	`TCTACG/CACTTC`	1	H/D	mis¹ ese³		7	NA EU EA WA	544

About this table

HapMap Linkage Disequilibrium images for SMO (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601500

UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835

Defects in SMO are involved in basal cell carcinoma (BCC)

7 Novoseek disease relationships for SMO gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma basal cell	73.53	6	11133163 (1), 9581815 (1), 14634745 (1), 17214858 (1) (see all 6)
medulloblastoma	56.90	3	18288402 (2), 18502968 (1)
somatic mutations	43.71	3	17332280 (1), 15488029 (1), 15656799 (1)
pancreatic cancer	31.70	4	16804411 (2), 16826192 (2)
tumors	26.51	26	12241103 (3), 16804411 (2), 10504535 (2), 16339184 (2) (see all 9)
cancer	3.17	2	19304771 (1)
carcinoma	0.00	1	16330160 (1)

About this table

Human Genome Epidemiology Navigator: SMO (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

New Drug Combination May Enhance Effectiveness of Colorectal Cancer Treatments

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/60 PubMed articles for SMO gene (see all 60 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Activating Smoothened mutations in sporadic basal-cell carcinoma. (PubMed id 9422511)^{3, 4} Xie J....de Sauvage F.J. (1998)
Chromosomal localization of the human smoothened gene (SMOH) to 7q32. 3 by fluorescence in situ hybridization and radiation hybrid mapping. (PubMed id 9628830)^{2, 3} Sublett J.E....Reardon D.A. (1998)
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. (PubMed id 8906787)^{3, 4} Stone D.M.... Rosenthal A. (1996)
PTCH1 and SMO gene alterations in keratocystic odontogenic tumors. (PubMed id 18502968)^{1, 3} Sun L.S....Li T.J. (2008)
Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. (PubMed id 16804411)^{1, 3} Shao J....Chen Z. (2006)
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. (PubMed id 9581815)^{1, 3} Reifenberger J....Reifenberger G. (1998)
Patched and smoothened mRNA expression in human astrocytic tumors inversely correlates with histological malignancy. (PubMed id 12241103)^{1, 3} Katayam M....Kamiguchi H. (2002)
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. (PubMed id 16339184)^{1, 3} Sicklick J.K....Diehl A.M. (2006)
PTCH gene mutations in invasive transitional cell carcinoma of the bladder. (PubMed id 9764827)^{1, 3} McGarvey T.W....Malkowicz S.B. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6608	HGNC: 11119	AceView: SMO	Ensembl:ENSG00000128602	euGenes: HUgn6608
ECgene: SMO	H-InvDB: SMO

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SMO	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SMO
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SMO:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SMO-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SMO		Antibodies for SMO
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SMO		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SMO)
	Antibodies (SMO)
	Chimera RNAi (SMO)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Smoothened)
	Antibodies (Smoothened)

Search OriGene for SMO

Tocris compounds for SMO

	Drugs for SMO
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SMO

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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SMO Gene at Home site.
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SMO Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for SMO

Summaries
for SMO

Genomic Location
for SMO

Proteins
for SMO

Protein Domains/
Families
for SMO

Gene Function
for SMO

Pathways & Interactions
for SMO

Drugs & Compounds
for SMO

Transcripts
for SMO

Expression
for SMO

Orthologs
for SMO

Paralogs
for SMO

SNPs/Variants
for SMO

Disorders & Mutations
for SMO

Medical News
for SMO

Publications
for SMO

Search for SMO

Genome Databases showing SMO

Other Databases showing SMO

Specialized Databases showing SMO

Licensable Technologies
for SMO

Services
for SMO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SMO Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor SMO

Summariesfor SMO

Genomic Locationfor SMO

Proteinsfor SMO

Protein Domains/Familiesfor SMO

Gene Functionfor SMO

Pathways & Interactionsfor SMO

Drugs & Compoundsfor SMO

Transcriptsfor SMO

Expression for SMO

Orthologsfor SMO

Paralogsfor SMO

SNPs/Variantsfor SMO

Disorders & Mutationsfor SMO

Medical Newsfor SMO

Publicationsfor SMO

Search for SMO

Genome Databases showing SMO

Other Databases showing SMO

Specialized Databases showing SMO

Licensable Technologiesfor SMO

Servicesfor SMO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SMO

Summaries
for SMO

Genomic Location
for SMO

Proteins
for SMO

Protein Domains/
Families
for SMO

Gene Function
for SMO

Pathways & Interactions
for SMO

Drugs & Compounds
for SMO

Transcripts
for SMO

Expression
for SMO

Orthologs
for SMO

Paralogs
for SMO

SNPs/Variants
for SMO

Disorders & Mutations
for SMO

Medical News
for SMO

Publications
for SMO

Licensable Technologies
for SMO

Services
for SMO