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Aliases for SMOC2 Gene

Aliases for SMOC2 Gene

  • SPARC Related Modular Calcium Binding 2 2 3 5
  • Secreted Modular Calcium-Binding Protein 2 3 4
  • Smooth Muscle-Associated Protein 2 3 4
  • SMAP-2 3 4
  • SMOC-2 3 4
  • SMAP2 3 4
  • Thyroglobulin Type-1 Repeat Containing Protein 3
  • Smooth Muscle Associated Protein 2 3
  • BA270C4A.1 3
  • DJ421D16.1 3
  • BA37D8.1 3
  • MSTP117 3
  • MSTP140 3
  • MST117 3
  • DTDP1 3

External Ids for SMOC2 Gene

Previous GeneCards Identifiers for SMOC2 Gene

  • GC06P168042
  • GC06P168563
  • GC06P168599
  • GC06P168660
  • GC06P168584
  • GC06P168841
  • GC06P166268

Summaries for SMOC2 Gene

Entrez Gene Summary for SMOC2 Gene

  • This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for SMOC2 Gene

SMOC2 (SPARC Related Modular Calcium Binding 2) is a Protein Coding gene. Diseases associated with SMOC2 include Dentin Dysplasia, Type I, With Microdontia And Misshapen Teeth and Atypical Dentin Dysplasia Due To Smoc2 Deficiency. Among its related pathways are Gastric cancer network 1. GO annotations related to this gene include calcium ion binding and glycosaminoglycan binding. An important paralog of this gene is SMOC1.

UniProtKB/Swiss-Prot for SMOC2 Gene

  • Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.

Gene Wiki entry for SMOC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMOC2 Gene

Genomics for SMOC2 Gene

Regulatory Elements for SMOC2 Gene

Enhancers for SMOC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMOC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMOC2 Gene

168,441,151 bp from pter
168,673,445 bp from pter
232,295 bases
Plus strand

Genomic View for SMOC2 Gene

Genes around SMOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMOC2 Gene

Proteins for SMOC2 Gene

  • Protein details for SMOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPARC-related modular calcium-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KPS7
    • Q4G169
    • Q5TAT7
    • Q5TAT8
    • Q86VV9
    • Q96SF3
    • Q9H1L3
    • Q9H1L4
    • Q9H3U0
    • Q9H4F7
    • Q9HCV2

    Protein attributes for SMOC2 Gene

    446 amino acids
    Molecular mass:
    49674 Da
    Quaternary structure:
    • Binds various proteins from the extracellular matrix.
    • Sequence=AAQ13639.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SMOC2 Gene


neXtProt entry for SMOC2 Gene

Proteomics data for SMOC2 Gene at MOPED

Post-translational modifications for SMOC2 Gene

  • Glycosylation at Asn 206 and Asn 362
  • Modification sites at PhosphoSitePlus

Other Protein References for SMOC2 Gene

Antibody Products

  • Abcam antibodies for SMOC2

No data available for DME Specific Peptides for SMOC2 Gene

Domains & Families for SMOC2 Gene

Gene Families for SMOC2 Gene

Suggested Antigen Peptide Sequences for SMOC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Contains 2 EF-hand domains.
  • Contains 1 Kazal-like domain.
  • Contains 2 thyroglobulin type-1 domains.
genes like me logo Genes that share domains with SMOC2: view

Function for SMOC2 Gene

Molecular function for SMOC2 Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.

Gene Ontology (GO) - Molecular Function for SMOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SMOC2: view
genes like me logo Genes that share phenotypes with SMOC2: view

Human Phenotype Ontology for SMOC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for SMOC2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SMOC2 Gene

Localization for SMOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMOC2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

Jensen Localization Image for SMOC2 Gene COMPARTMENTS Subcellular localization image for SMOC2 gene
Compartment Confidence
extracellular 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SMOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMOC2: view

Pathways & Interactions for SMOC2 Gene

SuperPathways for SMOC2 Gene

Superpath Contained pathways
1 Gastric cancer network 1
genes like me logo Genes that share pathways with SMOC2: view

Pathways by source for SMOC2 Gene

1 BioSystems pathway for SMOC2 Gene

Interacting Proteins for SMOC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000346537 Q9H3U7-SMOC2_HUMAN for SMOC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SMOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with SMOC2: view

No data available for SIGNOR curated interactions for SMOC2 Gene

Drugs & Compounds for SMOC2 Gene

No Compound Related Data Available

Transcripts for SMOC2 Gene

Unigene Clusters for SMOC2 Gene

SPARC related modular calcium binding 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMOC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for SMOC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMOC2 Gene

mRNA expression in normal human tissues for SMOC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMOC2 Gene

This gene is overexpressed in Artery - Aorta (x9.9).

Protein differential expression in normal tissues from HIPED for SMOC2 Gene

This gene is overexpressed in Pancreas (30.6), Testis (24.3), and Gallbladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SMOC2 Gene

SOURCE GeneReport for Unigene cluster for SMOC2 Gene Hs.487200

genes like me logo Genes that share expression patterns with SMOC2: view

Protein tissue co-expression partners for SMOC2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SMOC2 Gene

Orthologs for SMOC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMOC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMOC2 35
  • 87.49 (n)
  • 93.03 (a)
SMOC2 36
  • 89 (a)
(Canis familiaris)
Mammalia SMOC2 35
  • 88.07 (n)
  • 95.18 (a)
SMOC2 36
  • 89 (a)
(Mus musculus)
Mammalia Smoc2 35
  • 84.45 (n)
  • 94.84 (a)
Smoc2 16
Smoc2 36
  • 91 (a)
(Pan troglodytes)
Mammalia SMOC2 35
  • 99.12 (n)
  • 99.52 (a)
SMOC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Smoc2 35
  • 85.13 (n)
  • 95.29 (a)
(Monodelphis domestica)
Mammalia SMOC2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
-- 36
  • 39 (a)
-- 36
  • 76 (a)
(Gallus gallus)
Aves SMOC2 35
  • 79.02 (n)
  • 90.4 (a)
SMOC2 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SMOC2 36
  • 82 (a)
(Danio rerio)
Actinopterygii wufb75d10 35
SMOC2 (1 of 2) 36
  • 69 (a)
SMOC2 (2 of 2) 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta magu 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea T04F3.2 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for SMOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SMOC2 Gene

Gene Tree for SMOC2 (if available)
Gene Tree for SMOC2 (if available)

Paralogs for SMOC2 Gene

Paralogs for SMOC2 Gene

(2) SIMAP similar genes for SMOC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SMOC2: view

Variants for SMOC2 Gene

Sequence variations from dbSNP and Humsavar for SMOC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1077334 -- 168,486,369(+) TTCAC(A/G)GAAGC intron-variant
rs1122274 -- 168,656,135(+) CTTTT(A/G)TTTGT intron-variant
rs1124346 -- 168,657,901(-) AGAGG(C/T)GTTGG intron-variant
rs1232314 -- 168,488,625(+) TCTCA(A/G)TCGAA intron-variant
rs1232315 -- 168,490,573(+) CCTTG(A/G)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMOC2 Gene

Variant ID Type Subtype PubMed ID
nsv886983 CNV Loss 21882294
nsv830868 CNV Gain 17160897
esv1317054 CNV Insertion 17803354
esv2733360 CNV Deletion 23290073
esv2733363 CNV Deletion 23290073
nsv8008 CNV Loss 18304495
esv2670112 CNV Deletion 23128226
nsv442021 CNV CNV 18776908
nsv516247 CNV Loss 19592680
esv2733364 CNV Deletion 23290073
dgv2036e1 CNV Complex 17122850
nsv428156 CNV Gain+Loss 18775914
esv26287 CNV Loss 19812545
esv2733365 CNV Deletion 23290073
nsv350124 CNV Loss 16902084
nsv5595 CNV Loss 18451855
esv2733366 CNV Deletion 23290073
esv2733367 CNV Deletion 23290073
esv2733368 CNV Deletion 23290073
esv3115 CNV Deletion 18987735
esv1003442 CNV Deletion 20482838
esv2674894 CNV Deletion 23128226
esv2364688 CNV Deletion 18987734
esv2659657 CNV Deletion 23128226
nsv886988 CNV Loss 21882294
nsv886989 CNV Loss 21882294
nsv886990 CNV Loss 21882294
nsv524357 CNV Loss 19592680
esv2659436 CNV Deletion 23128226
esv2733369 CNV Deletion 23290073
nsv522533 CNV Loss 19592680
esv2657529 CNV Deletion 23128226
esv2574703 CNV Deletion 19546169
nsv8009 CNV Gain+Loss 18304495
nsv511929 CNV Loss 21212237
nsv821321 CNV Deletion 20802225
esv1954927 CNV Deletion 18987734
esv2125624 CNV Deletion 18987734
esv2733370 CNV Deletion 23290073
esv2418924 CNV Deletion 18987734
esv23308 CNV Gain+Loss 19812545
esv2676251 CNV Deletion 23128226
esv1584909 CNV Deletion 17803354
esv2733371 CNV Deletion 23290073
esv2733372 CNV Deletion 23290073
esv1451948 CNV Deletion 17803354
esv2733374 CNV Deletion 23290073
nsv886991 CNV Gain 21882294
esv2733375 CNV Deletion 23290073
esv24962 CNV Loss 19812545
esv2733376 CNV Deletion 23290073
esv2733377 CNV Deletion 23290073
esv2733378 CNV Deletion 23290073
esv2733379 CNV Deletion 23290073
esv2421506 CNV Deletion 20811451
nsv442022 CNV CNV 18776908
esv2670521 CNV Deletion 23128226
nsv509174 CNV Insertion 20534489
nsv886992 CNV Loss 21882294
esv2733380 CNV Deletion 23290073
esv2667014 CNV Deletion 23128226
esv2733381 CNV Deletion 23290073
esv2733382 CNV Deletion 23290073
esv2733383 CNV Deletion 23290073
nsv821170 CNV Deletion 20802225
dgv1091e201 CNV Deletion 23290073
esv27003 CNV Gain+Loss 19812545
dgv2037e1 CNV Complex 17122850
esv2733386 CNV Deletion 23290073
esv1523390 CNV Deletion 17803354
esv8086 CNV Loss 19470904
esv2733388 CNV Deletion 23290073
nsv349668 CNV Loss 16902084
esv1569263 CNV Insertion 17803354
esv2733390 CNV Deletion 23290073
dgv1092e201 CNV Deletion 23290073
esv2733392 CNV Deletion 23290073
esv2454869 CNV Deletion 19546169
dgv1079n67 CNV Loss 20364138
esv2676022 CNV Deletion 23128226
esv2733393 CNV Deletion 23290073
nsv510953 CNV Complex 20534489
nsv525282 CNV Loss 19592680
esv2733394 CNV Deletion 23290073
esv1170089 CNV Deletion 17803354
esv2733396 CNV Deletion 23290073
esv2733397 CNV Deletion 23290073
nsv830869 CNV Loss 17160897
nsv348653 CNV Loss 16902084
esv25984 CNV Loss 19812545
esv2733398 CNV Deletion 23290073
esv2670774 CNV Deletion 23128226
nsv511930 CNV Loss 21212237
esv2733399 CNV Deletion 23290073
esv1048919 CNV Deletion 17803354
esv2733400 CNV Deletion 23290073
esv2733401 CNV Deletion 23290073
esv1130462 CNV Deletion 17803354
esv2733402 CNV Deletion 23290073
nsv510062 CNV Loss 20534489
esv2733403 CNV Deletion 23290073
esv2659288 CNV Deletion 23128226
nsv509175 CNV Insertion 20534489
esv21613 CNV Gain+Loss 19812545
esv2733404 CNV Deletion 23290073
esv1130498 CNV Deletion 17803354
esv2733405 CNV Deletion 23290073
esv2733407 CNV Deletion 23290073
nsv7390 OTHER Inversion 18451855
esv2534031 CNV Insertion 19546169

Variation tolerance for SMOC2 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMOC2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMOC2 Gene

Disorders for SMOC2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SMOC2 Gene - From: OMIM, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
dentin dysplasia, type i, with microdontia and misshapen teeth
  • dentin dysplasia, type 1
atypical dentin dysplasia due to smoc2 deficiency
  • dentin dysplasia type 1 with microdontia and shape anomalies
dentin dysplasia
  • dentinal dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search SMOC2 in MalaCards View complete list of genes associated with diseases


  • Dentin dysplasia 1 (DTDP1) [MIM:125400]: A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. {ECO:0000269 PubMed:22152679}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SMOC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SMOC2: view

No data available for Genatlas for SMOC2 Gene

Publications for SMOC2 Gene

  1. Identification of a novel smooth muscle associated protein, smap2, upregulated during neointima formation in a rat carotid endarterectomy model. (PMID: 12031507) Nishimoto S. … Komurasaki T. (Biochim. Biophys. Acta 2002) 2 3 4 67
  2. Recessive oligodontia linked to a homozygous loss-of-function mutation in the SMOC2 gene. (PMID: 23317772) Alfawaz S. … Kelsell D.P. (Arch. Oral Biol. 2013) 3
  3. Variants in PTPN22 and SMOC2 genes and the risk of thyroid disease in the Jordanian Arab population. (PMID: 23463390) Alkhateeb A. … Tashtoush R. (Endocrine 2013) 3
  4. Lack of association between SMOC2 polymorphism and age-related macular degeneration in Jordanian Arabs. (PMID: 22964816) Alkhateeb A.M. … Al-Khatib S.Q. (Saudi Med J 2012) 3
  5. Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects. (PMID: 22152679) Bloch-Zupan A. … Dollfus H. (Am. J. Hum. Genet. 2011) 3

Products for SMOC2 Gene

Sources for SMOC2 Gene