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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMOC2 Gene

protein-coding   GIFtS: 52
GCID: GC06P168841

SPARC related modular calcium binding 2
 Explore 4 diseases affiliated with
SMOC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SMOC2    

Aliases
for SMOC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SPARC Related Modular Calcium Binding 21 2     MSTP1172
SMAP21 2 3 5     MSTP1402
Secreted Modular Calcium-Binding Protein 22 3     BA270C4A.11
Smooth Muscle-Associated Protein 22 3     BA37D8.11
SMAP-22 3     DJ421D16.11
SMOC-22 3     Smooth Muscle Associated Protein 22
DTDP12     SPARC-Related Modular Calcium-Binding Protein 22
MST1172     Thyroglobulin Type-1 Repeat Containing Protein2

External Ids:    HGNC: 203231   Entrez Gene: 640942   Ensembl: ENSG000001125627   OMIM: 6072235   UniProtKB: Q9H3U73   

Export aliases for SMOC2 gene to outside databases

Previous GC identifers: GC06P168042 GC06P168563 GC06P168599 GC06P168660 GC06P168584 GC06P166268


Summaries
for SMOC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SMOC2:
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which
are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which
promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic
activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin
type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling
angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: SMOC2_HUMAN, Q9H3U7
Function: Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation,
migration, as well as angiogenesis

Gene Wiki entry for SMOC2


Genomic Views
for SMOC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMOC2 gene promoter:
         C/EBPbeta   AML1a   NRSF form 1   FOXO3   MyoD   IRF-1   NRSF form 2   Sox9   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMOC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SMOC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMOC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

SMOC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMOC2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P168841:  view genomic region     (about GC identifiers)

Start:
 168,841,831 bp from pter      End:
 169,073,984 bp from pter
Size:
 232,154 bases      Orientation:
 plus strand

Proteins
for SMOC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SMOC2_HUMAN, Q9H3U7 (See protein sequence)
Recommended Name: SPARC-related modular calcium-binding protein 2 precursor  
Size: 446 amino acids; 49674 Da
Subunit: Binds various proteins from the extracellular matrix (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity)
Sequence caution: Sequence=AAQ13639.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KPS7 Q4G169 Q5TAT7 Q5TAT8 Q86VV9 Q96SF3 Q9H1L3 Q9H1L4 Q9H3U0 Q9H4F7 Q9HCV2
Alternative splicing: 2 isoforms:  Q9H3U7-1   Q9H3U7-2   

Explore the universe of human proteins at neXtProt for SMOC2: NX_Q9H3U7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3U7

    • SMOC2 Protein expression data from MOPED and PaxDb:    About this image 
    SMOC2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001159884.1  NP_071421.1  

    ENSEMBL proteins: 
     ENSP00000348630   ENSP00000346537   ENSP00000375949   ENSP00000398696  

    Human Recombinant Protein Products for SMOC2: 
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    Novus Biologicals SMOC2 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SMOC2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IEA--
    GO:0005614interstitial matrix IEA--
    GO:0031012extracellular matrix ----

    SMOC2 for ontologies           About GeneDecksing



    SMOC2 Antibody Products: 
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    Uscn ELISAs and CLIAs for SMOC2

    Protein Domains /
    Families
    for SMOC2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SMOC2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR018247 EF_Hand_1_Ca_BS
     IPR002350 Prot_inh_Kazal
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR019577 SPARC/Testican_Ca-bd-dom

    Graphical View of Domain Structure for InterPro Entry Q9H3U7

    ProtoNet protein and cluster: Q9H3U7

    1 Blocks protein family: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: SMOC2_HUMAN, Q9H3U7
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 2 thyroglobulin type-1 domains


    Function
    for SMOC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMOC2_HUMAN, Q9H3U7
    Function: Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation,
    migration, as well as angiogenesis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005539glycosaminoglycan binding ----
    GO:0008201heparin binding IEA--
         
    SMOC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SMOC2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMOC2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate SMOC2 (see all 50):
    hsa-miR-140-5p hsa-miR-548j hsa-miR-513a-5p hsa-miR-548k hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: SMOC2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMOC2 (see all 7)
    OriGene shRNA RFP: SMOC2
    OriGene siRNA: SMOC2
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SMOC2 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SMOC2 
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMOC2


    Pathways & Interactions
    for SMOC2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMOC2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SMOC2 (Q9H3U73 ENSP000003465374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BANF1O755313, ENSP000003102754I2D: score=1 STRING: ENSP00000310275
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization IEA--

    SMOC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SMOC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMOC2
    Search CenterWatch for drugs/clinical trials and news about SMOC2 

    Transcripts
    for SMOC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SMOC2 gene (2 alternative transcripts): 
    NM_001166412.1  NM_022138.2  

    Unigene Cluster for SMOC2:

    SPARC related modular calcium binding 2
    Hs.487200  [show with all ESTs]
    Unigene Representative Sequence: NM_022138
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356284(uc003qws.2 uc011egu.2) ENST00000354536(uc003qwr.2)
    ENST00000392100 ENST00000417208 ENST00000477998

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SMOC2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMOC2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate SMOC2 (see all 50):
    hsa-miR-140-5p hsa-miR-548j hsa-miR-513a-5p hsa-miR-548k hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: SMOC2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMOC2 (see all 7)
    OriGene shRNA RFP: SMOC2
    OriGene siRNA: SMOC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMOC2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SMOC2 
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SMOC2 (NM_022138)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMOC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMOC2

    Additional cDNA sequence: 

    AB014730.1 AB014737.1 AF173892.1 AF176778.1 AJ249902.1 AJ420521.1 AK056700.1 AK297839.1 
    AK314613.1 AK315920.1 AL832303.1 BC028420.1 BC047583.1 

    8 DOTS entries:

    DT.116957  DT.100025804  DT.100780778  DT.40118653  DT.97797330  DT.121404528  DT.121404511  DT.91642353 

    24/236 AceView cDNA sequences (see all 236):

    CB051485 BE857998 BU733086 CD679310 BQ004721 AA732827 CD676889 W69579 
    BQ446435 BM670733 AI095665 AA601518 BU730968 AI926591 BP345455 CD672368 
    BF062703 AW192904 BP346044 BU789194 AI130013 BM677616 AW664335 AI918635 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SMOC2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                          -                 -                 -                                 
    SP2:                          -                                   -                                 
    SP3:                                            -                                                   


    ECgene alternative splicing isoforms for SMOC2

    Expression
    for SMOC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMOC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAATGTTGT
    SMOC2 Expression
    About this image

    SMOC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    OvaryAntral FollicleCumulus CellsOvary
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    BoneMandibular ProcessBone
    BoneMaxillary ProcessBone
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    Posterior foregut-like cells (A scalable, suspensi...)

    See SMOC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMOC2

    SOURCE GeneReport for Unigene cluster: Hs.487200
        SABiosciences Expression via Pathway-Focused PCR Array including SMOC2: 
              Polycomb & Trithorax Target Genes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for SMOC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SMOC2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SMOC21 SPARC related modular calcium binding 2 78.51(n)
    90.21(a)    		   421559  XM_419600.3  XP_419600.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SMOC26
    --
    		 --
    		 85(a)
    37(a)
    		 1 ↔ 1
    possible ortholog
    		 1(224243155-224372888)
    GL343958.1(79919-99429)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb75d102 wufb75d10 74.28(n)   322867  CK127336.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta magu1 CG2264-PA 45.66(n)
    35.15(a)    		   36048  NM_165732.1  NP_724873.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea T04F3.21 Protein T04F3.2 40.7(n)
    29.28(a)    		   179609  NM_073563.1  NP_505964.1 


    ENSEMBL Gene Tree for SMOC2 (if available)
    TreeFam Gene Tree for SMOC2 (if available) 

    Paralogs
    for SMOC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMOC2 gene
    SMOC12  
    2 SIMAP similar genes for SMOC2 using alignment to 3 protein entries:     SMOC2_HUMAN (see all proteins):
    SMOC1    SPARC

    SMOC2 for paralogs           About GeneDecksing



    Genomic Variants
    for SMOC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5694 NCBI SNPs in SMOC2 are shown (see all 5694)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1913188131,2
    		--168839869(+) CCAAAC/GCTGCC 2 -- us2k10--------
    rs594418181,2
    		C--168839895(+) TTGGAC/GAAATG 2 -- us2k12Minor allele frequency- G:0.21WA 120
    rs1166311671,2
    		--168839958(+) AAGACG/ATGTTG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1407202931,2
    		--168840002(+) ATTTTC/TTTCTG 2 -- us2k10--------
    rs753042371,2
    		C,F--168840164(+) AAGTCT/CGCTTC 2 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1451993951,2
    		--168840190(+) GCAGCA/GGACGA 2 -- us2k10--------
    rs1838499511,2
    		--168840283(+) CTTTAA/GTAGCA 2 -- us2k10--------
    rs38971881,2
    		C,H--168840465(-) TGGGTC/GCAGAA 2 -- us2k17Minor allele frequency- G:0.00NS EA NA 546
    rs1870145771,2
    		--168840554(+) GATTCA/CCTGGG 2 -- us2k10--------
    rs793984611,2
    		F--168840733(+) ACAGCC/TCCCTC 2 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for SMOC2 (168841831 - 169073984 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 35 variations for SMOC2
         15/16 CNVs (see all 16): 69683 3655 69680 69679 44241 23791 69685 38633 94231 38634 99809 69681 69684 32852 62600
         15/18 Indels (see all 18): 47056 28185 51853 99810 81750 47057 99811 33827 94230 12883 47055 33429 81749 28187 42803
         1 Inversion: 37271
    Human Gene Mutation Database (HGMD): SMOC2

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    Disorders / Diseases
    for SMOC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SMOC2 for disorders           About GeneDecksing

    OMIM gene information: 607223    OMIM disorders: --

    UniProtKB/Swiss-Prot: SMOC2_HUMAN, Q9H3U7
  • Defects in SMOC2 are the cause of dentin dysplasia typ1 (DTDP1) [MIM:125400]. A dental defect in which both
    • primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal
    shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very
    mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may
    be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root
    canals are usually absent

    4 diseases for SMOC2:    About MalaCards
    pulmonary function    dentin dysplasia    ischemia    vitiligo

    1 disease from the University of Copenhagen DISEASES database for SMOC2:
    Dentin dysplasia
    Human Genome Epidemiology (HuGE) Navigator: SMOC2 (3 documents)

    Export disorders for SMOC2 gene to outside databases

    Publications
    for SMOC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMOC2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SMOC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel smooth muscle associated protein, smap2, upregulated during neointima formation in a rat carotid endarterectomy model. (PubMed id 12031507)1, 2, 3 Nishimoto S....Komurasaki T. (2002)
    2. Homozygosity mapping and candidate prioritization ide ntify mutations, missed by whole-exome sequencing, in SMOC2, causing major dent al developmental defects. (PubMed id 22152679)1, 2 Bloch-Zupan A....Dollfus H. (2011)
    3. The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. (PubMed id 16774925)1, 2 Rocnik E.F.... Vaziri C. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Characterization of SMOC-2, a modular extracellular calcium-binding protein. (PubMed id 12741954)1, 2 Vannahme C.... Hartmann U. (2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. SMOC2 gene variant and the risk of vitiligo in Jordan ian Arabs. (PubMed id 20965805)1 Alkhateeb A....Qarqaz F. (2010)
    10. Genome-Wide Association Study of Generalized Vitiligo in an Isolated European Founder Population Identifies SMOC2, in Close Proximit y to IDDM8. (PubMed id 19890347)1 Birlea S.A....Spritz R.A. (2010)

    External Searches for SMOC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing SMOC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64094 HGNC: 20323 AceView: SMOC2 Ensembl:ENSG00000112562 euGenes: HUgn64094
    ECgene: SMOC2 H-InvDB: SMOC2

    Other Databases showing SMOC2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SMOC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMOC2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SMOC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SMOC2 gene:
    Search GeneIP for patents involving SMOC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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