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Aliases for SMO Gene

Aliases for SMO Gene

  • Smoothened, Frizzled Class Receptor 2 3
  • Smoothened, Seven Transmembrane Spanning Receptor 2 3
  • Smoothened, Frizzled Family Receptor 2 3
  • Frizzled Family Member 11 2 3
  • Protein Gx 3 4
  • SMOH 3 4
  • Seven Transmembrane Helix Receptor 3
  • Smoothened (Drosophila) Homolog 2
  • Smoothened Homolog (Drosophila) 2
  • Smoothened Homolog 3
  • FZD11 3
  • SMOH, 6
  • Gx 3

External Ids for SMO Gene

Previous Symbols for SMO Gene

  • SMOH

Summaries for SMO Gene

Entrez Gene Summary for SMO Gene

  • The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

GeneCards Summary for SMO Gene

SMO (Smoothened, Frizzled Class Receptor) is a Protein Coding gene. Diseases associated with SMO include pancreatic cancer and basal cell carcinoma, somatic. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for SMO Gene

  • G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehogs proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

Tocris Summary for SMO Gene

  • Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to and repressed by, patched (Ptc). Upon Hh-Ptc interaction, Smo receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the activity of transcription factors belonging to the Gli family (particularly Cubitus interruptus (Ci)). Smo receptors are vital for embryogenesis (segmentation and appendage development) and are involved in maintainence of tissue homeostasis in adults. The human gene encoding the Smo receptor has been localized on chromosome 7q32.3.

Gene Wiki entry for SMO Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMO Gene

Genomics for SMO Gene

Genomic Location for SMO Gene

129,188,872 bp from pter
129,213,545 bp from pter
24,674 bases
Plus strand

Genomic View for SMO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMO Gene

Proteins for SMO Gene

  • Protein details for SMO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Smoothened homolog
    Protein Accession:
    Secondary Accessions:
    • A4D1K5

    Protein attributes for SMO Gene

    787 amino acids
    Molecular mass:
    86397 Da
    Quaternary structure:
    • Homodimer. Interacts with ARRB2. Interacts with KIF7. Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO.

    Three dimensional structures from OCA and Proteopedia for SMO Gene

neXtProt entry for SMO Gene

Proteomics data for SMO Gene at MOPED

Post-translational modifications for SMO Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn35, Asn188, and Asn309

Other Protein References for SMO Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SMO Gene

Domains for SMO Gene

Gene Families for SMO Gene

  • FZD :GPCR / Class F : Frizzled receptors

Protein Domains for SMO Gene


  • Contains 1 FZ (frizzled) domain.:
    • Q99835
  • Belongs to the G-protein coupled receptor Fz/Smo family.:
    • Q99835
genes like me logo Genes that share domains with SMO: view

Function for SMO Gene

Molecular function for SMO Gene

UniProtKB/Swiss-Prot Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehogs proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

Gene Ontology (GO) - Molecular Function for SMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005113 patched binding IPI 9811851
GO:0005515 protein binding IPI 19592253
GO:0008144 drug binding IDA 19304771
genes like me logo Genes that share ontologies with SMO: view
genes like me logo Genes that share phenotypes with SMO: view

Animal Models for SMO Gene

MGI Knock Outs for SMO:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SMO Gene

Localization for SMO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMO Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium.

Subcellular locations from

Jensen Localization Image for SMO Gene COMPARTMENTS Subcellular localization image for SMO gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005794 colocalizes_with Golgi apparatus IDA 11278759
GO:0005886 plasma membrane IDA 19304771
GO:0005901 colocalizes_with caveola IDA 11278759
GO:0005929 cilium --
genes like me logo Genes that share ontologies with SMO: view

Pathways for SMO Gene

genes like me logo Genes that share pathways with SMO: view

Gene Ontology (GO) - Biological Process for SMO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001503 ossification --
GO:0001570 vasculogenesis IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with SMO: view

Compounds for SMO Gene

(4) ApexBio Compounds for SMO Gene

Compound Action Cas Number
BMS-833923 orally bioavailable small-molecule SMO (Smoothened) inhibitor [1059734-66-5]
HhAntag A small molecule inhibitor of GLI1-mediated transcription [496794-70-8]
LDE225 Diphosphate orally bioavailable small-molecule Smoothened (Smo) antagonist [1218778-77-8]
Purmorphamine Cell-permeable Smoothened inhibitor, activates Hedgehog pathway [483367-10-8]

(4) Tocris Compounds for SMO Gene

Compound Action Cas Number
GSA 10 Smo receptor agonist [300833-95-8]
Jervine Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo [469-59-0]
MRT 10 Smoothened (Smo) antagonist [330829-30-6]
SMANT hydrochloride Inhibits Smoothened (Smo) accumulation [1177600-74-6]

(2) Drugbank Compounds for SMO Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Fluocinolide
356-12-7 target agonist
  • GDC-0449
879085-55-9 target antagonist

(1) Novoseek inferred chemical compound relationships for SMO Gene

Compound -log(P) Hits PubMed IDs
cyclopamine 88.3 3
genes like me logo Genes that share compounds with SMO: view

Transcripts for SMO Gene

Unigene Clusters for SMO Gene

Smoothened, frizzled family receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMO Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2: - -

Relevant External Links for SMO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMO Gene

mRNA expression in normal human tissues for SMO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SMO Gene

SOURCE GeneReport for Unigene cluster for SMO Gene Hs.437846

genes like me logo Genes that share expressions with SMO: view

Orthologs for SMO Gene

This gene was present in the common ancestor of animals.

Orthologs for SMO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMO 36
  • 98.94 (n)
  • 98.73 (a)
SMO 37
  • 99 (a)
(Bos Taurus)
Mammalia SMO 36
  • 92.1 (n)
  • 96.13 (a)
SMO 37
  • 96 (a)
(Canis familiaris)
Mammalia SMO 36
  • 92.22 (n)
  • 96.75 (a)
SMO 37
  • 97 (a)
(Mus musculus)
Mammalia Smo 36
  • 90.13 (n)
  • 94.08 (a)
Smo 16
Smo 37
  • 93 (a)
(Monodelphis domestica)
Mammalia SMO 37
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia SMO 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Smo 36
  • 89.52 (n)
  • 93.95 (a)
(Gallus gallus)
Aves SMO 36
  • 81.2 (n)
  • 83.69 (a)
SMO 37
  • 79 (a)
(Anolis carolinensis)
Reptilia SMO 37
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Smo 36
tropical clawed frog
(Silurana tropicalis)
Amphibia smo 36
  • 70.3 (n)
  • 76.28 (a)
(Danio rerio)
Actinopterygii smo 36
  • 68.82 (n)
  • 74.71 (a)
smo 37
  • 66 (a)
smoh 36
African malaria mosquito
(Anopheles gambiae)
Insecta GPRSMO 36
  • 55.44 (n)
  • 45.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta smo 36
  • 53.58 (n)
  • 44.44 (a)
smo 37
  • 28 (a)
(Caenorhabditis elegans)
Secernentea lin-17 37
  • 19 (a)
Species with no ortholog for SMO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMO Gene

Gene Tree for SMO (if available)
Gene Tree for SMO (if available)

Paralogs for SMO Gene

Selected SIMAP similar genes for SMO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SMO: view

Variants for SMO Gene

Sequence variations from dbSNP and Humsavar for SMO Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3824 -- 129,213,012(+) CATGT(C/G)CTCTC utr-variant-3-prime
rs9607 -- 129,213,216(+) GGTTC(A/G)GCTCT utr-variant-3-prime
rs1061275 -- 129,213,179(+) CCCCT(C/T)GCTGC utr-variant-3-prime
rs1061280 -- 129,213,282(+) GCATC(A/G)TCTCT utr-variant-3-prime
rs1061282 -- 129,213,351(+) GCTGC(C/T)GTAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SMO Gene

Variant ID Type Subtype PubMed ID
nsv831127 CNV Gain 17160897
esv2735147 CNV Deletion 23290073

Relevant External Links for SMO Gene

HapMap Linkage Disequilibrium report

Disorders for SMO Gene

(7) Novoseek inferred disease relationships for SMO Gene

Disease -log(P) Hits PubMed IDs
carcinoma basal cell 71.9 6
medulloblastoma 60.1 4
somatic mutations 41.5 3
pancreatic cancer 37.1 5
tumors 30.6 18

Relevant External Links for SMO

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SMO: view

No data available for UniProtKB/Swiss-Prot for SMO Gene

Publications for SMO Gene

  1. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. (PMID: 9581815) Reifenberger J. … Reifenberger G. (Cancer Res. 1998) 3 23
  2. PTCH gene mutations in invasive transitional cell carcinoma of the bladder. (PMID: 9764827) McGarvey T.W. … Malkowicz S.B. (Oncogene 1998) 3 23
  3. Patched and smoothened mRNA expression in human astrocytic tumors inversely correlates with histological malignancy. (PMID: 12241103) Katayam M. … Kamiguchi H. (J. Neurooncol. 2002) 3 23
  4. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. (PMID: 16339184) Sicklick J.K. … Diehl A.M. (Carcinogenesis 2006) 3 23
  5. Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells. (PMID: 16867986) De Rivoyre M. … Mus-Veteau I. (J. Biol. Chem. 2006) 3 23

Products for SMO Gene

  • Addgene plasmids for SMO

Sources for SMO Gene

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