Aliases for SMO Gene
External Ids for SMO Gene
Previous HGNC Symbols for SMO Gene
Previous GeneCards Identifiers for SMO Gene
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
GeneCards Summary for SMO Gene
SMO (Smoothened, Frizzled Class Receptor) is a Protein Coding gene. Diseases associated with SMO include basal cell carcinoma, somatic and basal cell carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is FZD10.
UniProtKB/Swiss-Prot for SMO Gene
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehogs proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to and repressed by, patched (Ptc). Upon Hh-Ptc interaction, Smo receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the activity of transcription factors belonging to the Gli family (particularly Cubitus interruptus (Ci)). Smo receptors are vital for embryogenesis (segmentation and appendage development) and are involved in maintainence of tissue homeostasis in adults. The human gene encoding the Smo receptor has been localized on chromosome 7q32.3.