Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMO Gene

protein-coding   GIFtS: 66
GCID: GC07P128828

smoothened, frizzled family receptor

(Previous names: smoothened (Drosophila) homolog, smoothened homolog (Drosophila),...)
(Previous symbol: SMOH)
 Explore 36 diseases affiliated with
SMO via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SMO    

Aliases
for SMO gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Smoothened, Frizzled Family Receptor1 2     Smoothened Homolog (Drosophila)1
SMOH1 2 3 5     Gx2
FZD111 2     Frizzled Family Member 112
Smoothened, Seven Transmembrane Spanning Receptor1 2     Seven Transmembrane Helix Receptor2
Protein Gx2 3     Smoothened Homolog2
Smoothened (Drosophila) Homolog1     

External Ids:    HGNC: 111191   Entrez Gene: 66082   Ensembl: ENSG000001286027   OMIM: 6015005   UniProtKB: Q998353   

Export aliases for SMO gene to outside databases

Previous GC identifers: GC07P127306 GC07P128368 GC07P128382 GC07P128422 GC07P128615 GC07P123189


Summaries
for SMO gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SMO:
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor
for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog
protein/patched protein complex. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835
Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the
hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal
inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia

summary for SMO:
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family.
Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In
the resting state, Smo receptors are bound to and repressed by, patched (Ptc). Upon Hh-Ptc interaction, Smo
receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the
activity of transcription factors belonging to the Gli family (particularly Cubitus interruptus (Ci)). Smo
receptors are vital for embryogenesis (segmentation and appendage development) and are involved in
maintainence of tissue homeostasis in adults. The human gene encoding the Smo receptor has been localized on
chromosome 7q32.3.

Gene Wiki entry for SMO (Smoothened)


Genomic Views
for SMO gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMO gene promoter:
         HFH-3   NRSF form 1   AP-2gamma   NRSF form 2   Evi-1   Egr-4   FOXI1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMO promoter sequence
   Search SABiosciences Chromatin IP Primers for SMO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.3   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.1

SMO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMO gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P128828:  view genomic region     (about GC identifiers)

Start:
 128,828,713 bp from pter      End:
 128,853,386 bp from pter
Size:
 24,674 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 128,212,668-128,237,345     

Proteins
for SMO gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835 (See protein sequence)
Recommended Name: Smoothened homolog precursor  
Size: 787 amino acids; 86397 Da
Subunit: Interacts with ARRB2 (By similarity). Interacts with KIF7
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SMO: NX_Q99835

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99835

    • SMO Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005622.1  
    ENSEMBL proteins: 
     ENSP00000249373   ENSP00000418720   ENSP00000420749  
    Reactome Protein details: Q99835
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SMO
    OriGene Custom Protein Services for SMO 
    GenScript Custom Purified and Recombinant Proteins Services for SMO
    Novus Biologicals SMO Proteins
    Novus Biologicals SMO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SMO

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005794colocalizes with Golgi apparatus IDA11278759
    GO:0005886plasma membrane IDA19304771
    GO:0005901colocalizes with caveola IDA11278759
    GO:0005929cilium IBA--


    SMO for ontologies           About GeneDecksing



    SMO Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): SMO
    OriGene Custom Antibody Services for SMO 
    GenScript Superior Antibodies for SMO
    Novus Biologicals SMO Antibodies
    Search for Antibodies for SMO at Abcam  
    Uscn Antibodies for SMO
    ThermoFisher Antibodies for SMO

    Assay Products for SMO: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SMO
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SMO

    Protein Domains /
    Families
    for SMO gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SMO for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR026544 SMO
     IPR000539 Frizzled
     IPR015526 Frizzled/SFRP
     IPR020067 Frizzled_dom
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q99835

    ProtoNet protein and cluster: Q99835

    1 Blocks protein family: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Function
    for SMO gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SMO_HUMAN, Q99835
    Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the
    hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal
    inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia

    miRNA
    Products:            		miRTarBase miRNAs that target SMO:
    hsa-mir-326 (MIRT000526), hsa-mir-324-5p (MIRT000527), hsa-mir-125b (MIRT000525)

    OriGene 3'-UTR Clone: SMO
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMO
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SMO (see all 10):
    hsa-miR-300 hsa-miR-381 hsa-miR-188-3p hsa-miR-1270 hsa-miR-370 hsa-miR-620 hsa-miR-127-5p hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmid: SMO 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMO (see all 7)
    OriGene shRNA RFP: SMO
    OriGene siRNA: SMO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMO

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SMO

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMO (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMO
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SMO (NM_005631)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMO 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SMO
    LifeMap BioReagents: cell line associated with SMO: PureStem 7SMOO32, NCr-fac & Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMO

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005113patched binding IPI9811851
    GO:0005119smoothened binding IPI--
    GO:0005515protein binding IPI19592253
    GO:0008144drug binding IDA--


    SMO for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SMO:
     Decreased Wnt reporter activit  Increased G1 DNA content  Synthetic lethal with paclitax 

    Animal Models:
         Mouse knock-outs for SMO: Smotm1Amc Smotm2.1Amc Smotm1.1Pab
         15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Smo):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  normal  respiratory system  skeleton  vision/eye 

    SMO for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SMO gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Hedgehog and PTH signaling pathways in bone and cartilage development
    		Development_Hedgehog and PTH signaling pathways in bone and cartilage development1.00
    		Development Hedgehog and PTH signaling pathways in bone and cartilage development0.97
    2Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    3Hedgehog Signaling Pathway
    		Hedgehog Signaling Pathway1.00
    		Hedgehog Pathway0.32
    4Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Hedgehog signaling pathway0.41
    5Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SMO
        Development Hedgehog and PTH signaling pathways in bone and cartilage development

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMO
        Activation of PKA through GPCR
    PKA Signaling
    Molecular Mechanisms of Cancer
    CRHR Pathway
    Hedgehog Signaling in Mammals

    1 Tocris Bioscience Pathway for SMO
        Hedgehog Pathway

    1 GeneGo (Thomson Reuters) Pathway for SMO
        Development Hedgehog and PTH signaling pathways in bone and cartilage development

    5/6 BioSystems Pathways for SMO (see all 6) 
        Hedgehog Signaling Pathway
    GPCRs, Other
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Signaling events mediated by the Hedgehog family

    4        Reactome Pathways for SMO
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    3         Kegg Pathways  (Kegg details for SMO):
        Hedgehog signaling pathway
    Pathways in cancer
    Basal cell carcinoma


    SMO for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/17 Interacting proteins for SMO (Q998353 ENSP000002493734) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTCH1Q136353, ENSP000003323534I2D: score=3 STRING: ENSP00000332353
    PTCH2Q9Y6C53, ENSP000003612664I2D: score=2 STRING: ENSP00000361266
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    DYNLL2Q96FJ23I2D: score=5 
    RPS21P632203I2D: score=5 
    About this table

    Gene Ontology (GO): 5/81 biological process terms (GO ID links to tree view) (see all 81):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001503ossification ----
    GO:0001570vasculogenesis IBA--
    GO:0001649osteoblast differentiation IBA--
    GO:0001701in utero embryonic development IEA--


    SMO for ontologies           About GeneDecksing



    Drugs & Compounds
    for SMO gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SMO for compounds           About GeneDecksing

    EMD Millipore small molecules for SMO:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for SMO

    Compounds for SMO available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SANT-2Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity[329196-48-7]
    SANT-1Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity[304909-07-7]
    20(S)-HydroxycholesterolAllosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation[516-72-3]

    1 DrugBank Compound for SMO    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FluocinonideFluocinolide (see all 7)356-12-7targetagonist20439738

    1 Novoseek chemical compound relationship for SMO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclopamine 88.3 4 12391318 (3)

    Search CenterWatch for drugs/clinical trials and news about SMO 

    Transcripts
    for SMO gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SMO gene: 
    NM_005631.4  

    Unigene Cluster for SMO:

    Smoothened, frizzled family receptor
    Hs.437846  [show with all ESTs]
    Unigene Representative Sequence: NM_005631
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249373(uc003vor.3 uc003vos.3) ENST00000462420 ENST00000495998
    ENST00000475779

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SMO
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMO
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SMO (see all 10):
    hsa-miR-300 hsa-miR-381 hsa-miR-188-3p hsa-miR-1270 hsa-miR-370 hsa-miR-620 hsa-miR-127-5p hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmid: SMO 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMO (see all 7)
    OriGene shRNA RFP: SMO
    OriGene siRNA: SMO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMO
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMO (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMO
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SMO (NM_005631)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMO 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMO
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMO
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMO
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMO

    Additional cDNA sequence: 

    AF071494.1 AF089720.1 AF120103.1 AF130867.1 BC004332.1 BC009989.2 U84401.1 

    11 DOTS entries:

    DT.313365  DT.121054058  DT.95371710  DT.121054063  DT.91849969  DT.75121134  DT.86853388  DT.91655162 
    DT.91831987  DT.91832489  DT.95169949 

    24/101 AceView cDNA sequences (see all 101):

    AW614083 BC009989 U84401 AI081895 BE785546 AF071494 BM714878 NM_005631 
    BM725012 BE784306 AF120103 BX641825 H98971 AU132302 AW593101 AI751900 
    AU125363 BU509583 BP375963 AA298711 CA440778 CA445076 AI807682 BQ013075 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SMO    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                  -                                       
    SP2:                                                  -     -                                 
    SP3:                                                                                          


    ECgene alternative splicing isoforms for SMO

    Expression
    for SMO gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCCCAAGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SMO expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive Hematopoietic Stem CellsBlood
    AdiposeVascular AdiposeStromal Vascular Preadipocyte Progenitor CellsAdipose
    BoneAutopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneAutopod PeriosteumImmature Endochondral OsteoblastsBone
    BoneCervical VertebraeImmature Endochondral OsteoblastsBone
    BoneLumbar VertebraeImmature Endochondral OsteoblastsBone
    BoneMembranous Facial BonesIntramembranous OsteoblastsBone
    BoneSacral VertebraeImmature Endochondral OsteoblastsBone
    BoneStylopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneStylopod PeriosteumImmature Endochondral OsteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SMO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMO

    SOURCE GeneReport for Unigene cluster: Hs.437846
        SABiosciences Expression via Pathway-Focused PCR Arrays including SMO (see all 8): 
              Angiogenic Growth Factors in human mouse rat
              Leukemia in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMO
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMO
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMO
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMO
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMO

    Orthologs
    for SMO gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SMO gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SMO1 smoothened, frizzled family receptor 81.24(n)
    83.92(a)    		   395949  XM_414970.3  XP_414970.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SMO6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343653.1(22989-52009)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Smo2 smoothened 75.72(n)    AF302766.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii smoh2 smoothened homolog (Drosophila) 77.65(n)   30225  AF395809.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta smo1 smoothened 53.62(n)
    44.52(a)    		   33196  NM_078719.2  NP_523443.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-176
    		 abnormal cell LINeage family member (lin-17)
    		 18(a)
    		 1 ↔ 1
    		 I(2706885-2717551)


    ENSEMBL Gene Tree for SMO (if available)
    TreeFam Gene Tree for SMO (if available) 

    Paralogs
    for SMO gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMO gene
    FZD102  FZD32  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP52  SFRP22  
    1 SIMAP similar gene for SMO using alignment to 4 protein entries:     SMO_HUMAN (see all proteins):
    FZD6

    SMO for paralogs           About GeneDecksing



    Genomic Variants
    for SMO gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/538 NCBI SNPs in SMO are shown (see all 538)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs27181041,2
    		C,H,--128210861(+) attcaA/Gcatga 1 -- us2k14Minor allele frequency- G:0.03NA WA 242
    rs413041851,2
    		C,--128213021(+) GGGGGA/GCCCGG 2 D G mis10--------
    rs559436871,2
    		C,F,--128213649(+) GTGTTG/CAAGAC 1 -- int16Minor allele frequency- C:0.15WA CSA NA 244
    rs732305781,2
    		C,F,--128214128(+) CCAAAT/GGTCCT 1 -- int12Minor allele frequency- G:0.04WA NA 238
    rs765909821,2
    		--128214152(+) GGAGTA/GTACTC 1 -- int11Minor allele frequency- G:0.01WA 118
    rs737215261,2
    		C,F,--128214793(+) AACACC/TAAAGT 1 -- int14Minor allele frequency- T:0.12WA NA 242
    rs734756951,2
    		C,F,--128215010(+) TGTTGC/TCTCTG 1 -- int14Minor allele frequency- T:0.12WA NA 242
    rs734756971,2
    		C,--128215575(+) ATGTAG/AGAACT 1 -- int13Minor allele frequency- A:0.05WA NA 240
    rs77846041,2
    		C,F,A,H,--128215684(+) TGCTGC/AGCATG 1 -- int17Minor allele frequency- A:0.01NS EA NA 626
    rs1137471921,2
    		--128216653(+) AGATCT/GGGAAA 1 -- int12Minor allele frequency- G:0.02CSA WA 120

    HapMap Linkage Disequilibrium report for SMO (128828713 - 128853386 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SMO: --

    1 SABiosciences Cancer Mutation PCR Assay for SMO:
    Cosmic IdAA Change
    13146p.W535L
    3 SABiosciences Cancer Mutation PCR Arrays containing SMO:
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Skin Cancers
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMO
    DNA2.0 Custom Variant and Variant Library Synthesis for SMO

    Disorders / Diseases
    for SMO gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SMO for disorders           About GeneDecksing

    OMIM gene information: 601500    OMIM disorders: --

    20/36 diseases for SMO (see all 36):    About MalaCards
    smith-lemli-opitz syndrome    pallister-hall syndrome    bardet-biedl syndrome    basal cell carcinoma, somatic
    nevoid basal cell carcinoma syndrome    basal cell carcinoma    primitive neuroectodermal tumor    xeroderma pigmentosum
    neuroectodermal tumors    transitional cell carcinoma    chronic lymphocytic leukemia    lymphocytic leukemia
    holoprosencephaly    nevus    medulloblastoma    carcinoma
    pancreatic cancer    endometrial carcinoma    chondrosarcoma    hyperglycemia

    4 diseases from the University of Copenhagen DISEASES database for SMO:
    Basal cell carcinoma     Medulloblastoma     Nevoid basal cell carcinoma syndrome     Pancreatic cancer

    7 Novoseek disease relationships for SMO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma basal cell 71.9 6 11133163 (1), 9581815 (1), 14634745 (1), 17214858 (1) (see all 6)
    medulloblastoma 60.1 4 18288402 (2), 19701203 (1), 18502968 (1)
    somatic mutations 41.5 3 17332280 (1), 15488029 (1), 15656799 (1)
    pancreatic cancer 37.1 6 16804411 (2), 16826192 (2), 20215540 (1)
    tumors 30.6 29 12241103 (3), 16804411 (2), 10504535 (2), 16339184 (2) (see all 10)
    cancer 15.9 2 19304771 (1)
    carcinoma 6.35 1 16330160 (1)

    Human Genome Epidemiology (HuGE) Navigator: SMO (10 documents)

    Export disorders for SMO gene to outside databases

    Publications
    for SMO gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMO gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with SMO)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The mammalian Cos2 homolog Kif7 plays an essential ro le in modulating Hh signal transduction during development. (PubMed id 19592253)1, 2 Endoh-Yamagami S....Peterson A.S. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Chromosomal localization of the human smoothened gene (SMOH) to 7q32. 3 by fluorescence in situ hybridization and radiation hybrid mapping. (PubMed id 9628830)1, 3 Sublett J.E....Reardon D.A. (1998)
    4. Activating Smoothened mutations in sporadic basal-cell carcinoma. (PubMed id 9422511)1, 2 Xie J....de Sauvage F.J. (1998)
    5. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. (PubMed id 8906787)1, 2 Stone D.M.... Rosenthal A. (1996)
    6. PTCH1 and SMO gene alterations in keratocystic odontogenic tumors. (PubMed id 18502968)1, 9 Sun L.S....Li T.J. (2008)
    7. Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. (PubMed id 16804411)1, 9 Shao J....Chen Z. (2006)
    8. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. (PubMed id 9581815)1, 9 Reifenberger J....Reifenberger G. (1998)
    9. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. (PubMed id 19304771)1, 9 Rominger C.M....Rominger D.H. (2009)
    10. Patched and smoothened mRNA expression in human astrocytic tumors inversely correlates with histological malignancy. (PubMed id 12241103)1, 9 Katayam M....Kamiguchi H. (2002)

    External Searches for SMO gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SMO gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6608 HGNC: 11119 AceView: SMO Ensembl:ENSG00000128602 euGenes: HUgn6608
    ECgene: SMO Kegg: 6608 H-InvDB: SMO

    Other Databases showing SMO gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SMO gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMO Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SMO Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SMO gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SMO gene:
    Search GeneIP for patents involving SMO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SMO gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore small molecules (inhibitor) for SMO
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SMO   OriGene shRNA RFP for SMO  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMO   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMO  
     OriGene Protein Over-expression Lysate for SMO   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SMO   OriGene 3'-UTR Clone for SMO  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMO   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMO  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SMO   OriGene Custom Protein Services for SMO  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMO
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMO
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMO
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMO
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMO
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMO
     GenScript Custom Purified and Recombinant Proteins Services for SMO GenScript cDNA clones with any tag delivered in your preferred vector for SMO
     GenScript Custom Assay Services for SMO GenScript Superior Antibodies for SMO
     GenScript Custom overexpressing Cell Line Services for SMO CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SMO promoter
     Search Chromatin IP Primers for SMO
     RT2 qPCR Primer Assay in human, mouse, rat SMO
     GNC Network for SMO
     SABiosciences PCR Arrays including human, mouse, rat SMO
     Tocris compounds for SMO
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for SMO
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SMO antibodies
     SMO proteins
     SMO lysates
     Search for Antibodies for SMO at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SMO
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SMO Proteins, Antibodies, CLIAs, and ELISAs
     Cell Line associated with SMO: PureStem 7SMOO32, NCr-fac & Meso Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMO
     SwitchGear 3'UTR luciferase reporter plasmids for SMO
     SwitchGear Promoter luciferase reporter plasmids for SMO
     ThermoFisher Antibodies for SMO
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMO
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SMO gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4