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SMNDC1 Gene

protein-coding   GIFtS: 58
GCID: GC10M112042

Survival Motor Neuron Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Survival Motor Neuron Domain Containing 11 2     SMN-Related Protein2 3
SMNR2 3 5     Splicing Factor 301
SPF302 3 5     Survival Of Motor Neuron-Related1
Tudor Domain Containing 16C1 2     TDRD16C2
Survival Motor Neuron Domain-Containing Protein 12 3     Splicing Factor 30, Survival Of Motor Neuron-Related2
30 KDa Splicing Factor SMNrp2 3     Survival Of Motor Neuron-Related-Splicing Factor 302

External Ids:    HGNC: 169001   Entrez Gene: 102852   Ensembl: ENSG000001199537   OMIM: 6035195   UniProtKB: O759403   

Export aliases for SMNDC1 gene to outside databases

Previous GC identifers: GC10M111717 GC10M105683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMNDC1 Gene:
This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause
of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein
that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with
abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SMNDC1 Gene:
SMNDC1 (survival motor neuron domain containing 1) is a protein-coding gene. Diseases associated with SMNDC1 include proximal spinal muscular atrophy, and neuronitis. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: SPF30_HUMAN, O75940
Function: Necessary for spliceosome assembly. Overexpression causes apoptosis

Gene Wiki entry for SMNDC1 (Survival motor neuron domain containing 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMNDC1 gene promoter:
         HOXA9B   HOXA9   ER-alpha   MEF-2   Tal-1beta   Evi-1   MEF-2A   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMNDC1 promoter sequence
   Search Chromatin IP Primers for SMNDC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMNDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q23

SMNDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMNDC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M112042:  view genomic region     (about GC identifiers)

Start:
112,050,488 bp from pter      End:
112,064,709 bp from pter
Size:
14,222 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPF30_HUMAN, O75940 (See protein sequence)
Recommended Name: Survival of motor neuron-related-splicing factor 30  
Size: 238 amino acids; 26711 Da
Subunit: Associates with spliceosomes. Associates with U4/U5/U6 tri-snRNP and with U2 snRNP
2 PDB 3D structures from and Proteopedia for SMNDC1:
4A4F (3D)        4A4H (3D)    
Secondary accessions: B2RA27 D3DRB1 Q5T3K6

Explore the universe of human proteins at neXtProt for SMNDC1: NX_O75940

Explore proteomics data for SMNDC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys165
  • Modification sites at PhosphoSitePlus

  • See SMNDC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005862.1  
    ENSEMBL proteins: 
     ENSP00000358616   ENSP00000358605  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    2 InterPro protein domains:
     IPR010304 Survival_motor_neuron
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry O75940

    ProtoNet protein and cluster: O75940

    2 Blocks protein domains:
    IPB002999 Tudor domain
    IPB010304 Survival motor neuron


    UniProtKB/Swiss-Prot: SPF30_HUMAN, O75940
    Domain: The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins
    Similarity: Belongs to the SMN family
    Similarity: Contains 1 Tudor domain


    SMNDC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPF30_HUMAN, O75940
    Function: Necessary for spliceosome assembly. Overexpression causes apoptosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI15494309
    GO:0044822poly(A) RNA binding IDA--
         
    SMNDC1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMNDC1
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    Block miRNA regulation of human, mouse, rat SMNDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMNDC1 (see all 14):
    hsa-miR-3678-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-548e hsa-miR-548o hsa-miR-1284 hsa-miR-548m hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSMNDC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPF30_HUMAN, O75940: Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and
    in Cajal (coiled) bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0015030Cajal body IEA--
    GO:0016607nuclear speck IEA--

    SMNDC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SMNDC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SMNDC1):
        Spliceosome


    SMNDC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SMNDC1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SMNDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMNDC1 (O759401, 2, 3 ENSP000003586054) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNB1Q149741, 3, ENSP000002901584EBI-1052641,EBI-286758 I2D: score=2 STRING: ENSP00000290158
    SF3A2Q154282, 3, ENSP000002214944MINT-5205548 I2D: score=2 STRING: ENSP00000221494
    PRPF3O433951, 2, ENSP000003153794EBI-1052641,EBI-744322 MINT-8334120 MINT-8332482 STRING: ENSP00000315379
    FDFT1P372683, ENSP000002205844I2D: score=2 STRING: ENSP00000220584
    PPANQ9NQ553, ENSP000002531074I2D: score=2 STRING: ENSP00000253107
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions TAS9731529
    GO:0006397mRNA processing IEA--
    GO:0006915apoptotic process IEA--
    GO:0008380RNA splicing TAS9731529

    SMNDC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMNDC1 (SPF30)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SMNDC1 gene: 
    NM_005871.3  

    Unigene Cluster for SMNDC1:

    Survival motor neuron domain containing 1
    Hs.632093  [show with all ESTs]
    Unigene Representative Sequence: BC039110
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369603(uc001kzc.4) ENST00000369592 ENST00000460483 ENST00000471297
    ENST00000477763

    miRNA
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    Block miRNA regulation of human, mouse, rat SMNDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMNDC1 (see all 14):
    hsa-miR-3678-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-548e hsa-miR-548o hsa-miR-1284 hsa-miR-548m hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSMNDC1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SMNDC1
      QuantiFast Probe-based Assays in human, mouse, rat SMNDC1

    Additional mRNA sequence: 

    AF083385.1 AF107463.1 AK314013.1 BC011234.1 BC039110.1 

    9 DOTS entries:

    DT.116225  DT.91643720  DT.100778255  DT.91789763  DT.92430432  DT.95074367  DT.121297735  DT.95349781 
    DT.97856885 

    Selected AceView cDNA sequences (see all 190):

    AI702787 AI612769 CB987938 CR603913 NM_005871 BQ961928 BM793460 AW628794 
    BQ003737 CF242880 BE676629 AI290803 CR591263 BC039110 CR612539 AI306730 
    BE348655 BF446299 AI401397 AL522559 AA902865 AI748825 AA360488 AI679475 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SMNDC1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:                          -           -     -           -                     
    SP2:                          -                 -           -                     
    SP3:                          -           -     -                                 
    SP4:                                      -     -           -                     
    SP5:                          -                                                   


    ECgene alternative splicing isoforms for SMNDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMNDC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SMNDC1 Expression
    About this image

    SMNDC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMNDC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632093

    UniProtKB/Swiss-Prot: SPF30_HUMAN, O75940
    Tissue specificity: Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including SMNDC1: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SMNDC1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smndc11 , 5 survival motor neuron domain containing 11, 5 90.06(n)1
    99.58(a)1
      19 (47.67 cM)5
    764791  NM_172429.21  NP_766017.11 
     533792145 
    chicken
    (Gallus gallus)
    Aves SMNDC11 survival motor neuron domain containing 1 85.29(n)
    95.8(a)
      423889  XM_421753.4  XP_421753.2 
    lizard
    (Anolis carolinensis)
    Reptilia SMNDC16
    survival motor neuron domain containing 1
    95(a)
    1 ↔ 1
    3(45172755-45180702)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979002 X.laevis histone H1-like maternal (B4) protein mRNA, more 79.87(n)    M36655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045967.12   -- 75.31(n)    BC045967.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG174541 CG17454 51.08(n)
    49.54(a)
      7354399  NM_001144529.2  NP_001138001.1 
    worm
    (Caenorhabditis elegans)
    Secernentea smr-16
    Protein SMR-1, isoform a
    31(a)
    1 ↔ 1
    III(1143062-1145220) WBGene00004891


    ENSEMBL Gene Tree for SMNDC1 (if available)
    TreeFam Gene Tree for SMNDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMNDC1 gene

    SMNDC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SMNDC1
    PGOHUM00000247520


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMNDC1 (see all 241)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57878461,2
    C--105695741(+) TTTTC-/TTTTTT 1 -- us2k1 trp32Minor allele frequency- T:0.25NA 4
    rs344952711,2
    C--112055396(+) TTTTTT/-GGCGA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1818918481,2
    --112412795(+) CCAAAA/CATCTA 1 -- ds50010--------
    rs107872271,2
    C,F,A,H--112412904(+) GAAACC/GTCTCA 1 -- ds500123Minor allele frequency- G:0.34NA NS EA WA 2486
    rs1868726771,2
    --112412954(+) ACTTGC/GAGGTT 1 -- ds50010--------
    rs569699891,2
    C,F--112412999(+) CCCTTG/TTGTTA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1913136161,2
    --112413085(+) AAAATC/TACCTT 1 -- ut310--------
    rs1459201201,2
    --112413251(+) ATTATC/TGTCAG 1 -- ut310--------
    rs1831649481,2
    --112413252(+) TTATCA/GTCAGA 1 -- ut310--------
    rs115592691,2
    C,F,H--112413357(+) ACACTG/TTATAC 1 -- ut31 ese34Minor allele frequency- T:0.01NS NA 344

    HapMap Linkage Disequilibrium report for SMNDC1 (112050488 - 112064709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SMNDC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896001CNV Loss21882294
    nsv7211OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603519    OMIM disorders: --

    7 diseases for SMNDC1:    About MalaCards
    proximal spinal muscular atrophy    neuronitis    spinal muscular atrophy    muscular atrophy
    rosacea    malaria    alzheimer's disease


    SMNDC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SMNDC1
    Human Genome Epidemiology (HuGE) Navigator: SMNDC1 (1 document)

    Export disorders for SMNDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMNDC1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with SMNDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. (PubMed id 9731529)1, 2, 3 Neubauer G.... Mann M. (Nat. Genet. 1998)
    2. Characterization of a gene encoding survival motor neuron (SMN)- related protein, a constituent of the spliceosome complex. (PubMed id 9817934)1, 2, 3 Talbot K.... Davies K.E. (Hum. Mol. Genet. 1998)
    3. Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins. (PubMed id 22101937)1, 2 Tripsianes K.... Sattler M. (Nat. Struct. Mol. Biol. 2011)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome. (PubMed id 11331595)1, 2 Meister G.... Fischer U. (EMBO J. 2001)
    8. SPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. (PubMed id 11331295)1, 2 Rappsilber J.... Mann M. (J. Biol. Chem. 2001)
    9. Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3. (PubMed id 18211889)1, 9 Little J.T. and Jurica M.S. (J. Biol. Chem. 2008)
    10. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. (PubMed id 23850713)1 Yang S.K....Song K. (Gut 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10285 HGNC: 16900 AceView: SMNDC1 Ensembl:ENSG00000119953 euGenes: HUgn10285
    ECgene: SMNDC1 Kegg: 10285 H-InvDB: SMNDC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMNDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMNDC1 gene:
    Search GeneIP for patents involving SMNDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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