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Aliases for SMLR1 Gene

Aliases for SMLR1 Gene

  • Small Leucine Rich Protein 1 2 3 5

External Ids for SMLR1 Gene

Previous GeneCards Identifiers for SMLR1 Gene

  • GC06P131150

Summaries for SMLR1 Gene

GeneCards Summary for SMLR1 Gene

SMLR1 (Small Leucine Rich Protein 1) is a Protein Coding gene.

Additional gene information for SMLR1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMLR1 Gene

Genomics for SMLR1 Gene

Regulatory Elements for SMLR1 Gene

Enhancers for SMLR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H130932 1.3 Ensembl ENCODE 17 +108.4 108372 7 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ATF7 SMLR1 AKAP7 EPB41L2
GH06H130826 1 ENCODE 21.6 +0.1 136 3 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 PAF1 REST MIER2 SMLR1 AKAP7 EPB41L2
GH06H130966 1.2 ENCODE dbSUPER 16.2 +141.5 141519 4 ELF3 PKNOX1 FOXA2 FEZF1 DNMT3B ZSCAN9 RAD21 SLC30A9 ZSCAN5C SCRT2 SMLR1 AKAP7 EPB41L2
GH06H130980 1.1 Ensembl ENCODE dbSUPER 16.1 +154.3 154344 3 ZNF202 RFX1 HLF MAFG ZNF316 ZSCAN5C PRDM10 MAFK EMSY MED23 SMLR1 AKAP7 EPB41L2
GH06H130814 1 ENCODE 16.2 -11.8 -11757 2 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ATF7 SP5 SMLR1 EPB41L2 PIR48495
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMLR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMLR1 Gene

Chromosome:
6
Start:
130,827,405 bp from pter
End:
130,837,135 bp from pter
Size:
9,731 bases
Orientation:
Plus strand

Genomic View for SMLR1 Gene

Genes around SMLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMLR1 Gene

Proteins for SMLR1 Gene

  • Protein details for SMLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H3BR10-SMLR1_HUMAN
    Recommended name:
    Small leucine-rich protein 1
    Protein Accession:
    H3BR10

    Protein attributes for SMLR1 Gene

    Size:
    107 amino acids
    Molecular mass:
    12312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMLR1 Gene

Post-translational modifications for SMLR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMLR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMLR1 Gene

Domains & Families for SMLR1 Gene

Gene Families for SMLR1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SMLR1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMLR1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMLR1 Gene

Function for SMLR1 Gene

Phenotypes From GWAS Catalog for SMLR1 Gene

Gene Ontology (GO) - Molecular Function for SMLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SMLR1: view

Phenotypes for SMLR1 Gene

genes like me logo Genes that share phenotypes with SMLR1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMLR1 Gene

Localization for SMLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMLR1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMLR1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SMLR1 Gene

Pathways & Interactions for SMLR1 Gene

SuperPathways for SMLR1 Gene

No Data Available

Interacting Proteins for SMLR1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000456026%0d%0a9606.ENSP00000354032%0d%0a
Selected Interacting proteins: H3BR10-SMLR1_HUMAN ENSP00000456026 for SMLR1 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for SMLR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMLR1 Gene

Drugs & Compounds for SMLR1 Gene

No Compound Related Data Available

Transcripts for SMLR1 Gene

mRNA/cDNA for SMLR1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMLR1 Gene

Small leucine-rich protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMLR1 Gene

No ASD Table

Relevant External Links for SMLR1 Gene

GeneLoc Exon Structure for
SMLR1
ECgene alternative splicing isoforms for
SMLR1

Expression for SMLR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMLR1 Gene

This gene is overexpressed in Liver (x44.9).

Protein differential expression in normal tissues from HIPED for SMLR1 Gene

This gene is overexpressed in Gallbladder (30.4), Fetal Liver (26.3), and Liver (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SMLR1 Gene



Protein tissue co-expression partners for SMLR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMLR1 Gene:

SMLR1

SOURCE GeneReport for Unigene cluster for SMLR1 Gene:

Hs.388715
genes like me logo Genes that share expression patterns with SMLR1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMLR1 Gene

Orthologs for SMLR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746017 33
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia SMLR1 33
  • 81.31 (n)
mouse
(Mus musculus)
Mammalia Smlr1 34
  • 65 (a)
OneToOne
Species where no ortholog for SMLR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMLR1 Gene

ENSEMBL:
Gene Tree for SMLR1 (if available)
TreeFam:
Gene Tree for SMLR1 (if available)

Paralogs for SMLR1 Gene

No data available for Paralogs for SMLR1 Gene

Variants for SMLR1 Gene

Sequence variations from dbSNP and Humsavar for SMLR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000003991 -- 130,836,697(+) AGAAA(C/T)ATGTT intron-variant, utr-variant-3-prime
rs1000267077 -- 130,836,418(+) GGCAG(C/G)TGCCA intron-variant, utr-variant-3-prime
rs1001019098 -- 130,833,824(+) CTCCC(C/T)AACAT intron-variant
rs1001251294 -- 130,829,699(+) TCCCA(A/T)TAACC intron-variant
rs1001440586 -- 130,832,374(+) GCAAC(A/G)CACAT intron-variant

Variation tolerance for SMLR1 Gene

Gene Damage Index Score: 12.22; 94.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMLR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMLR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMLR1 Gene

Disorders for SMLR1 Gene

Relevant External Links for SMLR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMLR1

No disorders were found for SMLR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMLR1 Gene

Publications for SMLR1 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for SMLR1 Gene

Sources for SMLR1 Gene

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