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Aliases for SMIM9 Gene

Aliases for SMIM9 Gene

  • Small Integral Membrane Protein 9 2 3 5
  • CXorf68 3 4
  • Chromosome X Open Reading Frame 68 2

External Ids for SMIM9 Gene

Previous HGNC Symbols for SMIM9 Gene

  • CXorf68

Previous GeneCards Identifiers for SMIM9 Gene

  • GC0XM154055

Summaries for SMIM9 Gene

GeneCards Summary for SMIM9 Gene

SMIM9 (Small Integral Membrane Protein 9) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM9 Gene

Genomics for SMIM9 Gene

Regulatory Elements for SMIM9 Gene

Enhancers for SMIM9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF154826 1.5 FANTOM5 Ensembl ENCODE 0.4 +6.7 6722 2.0 ELF3 MLX ARID4B DMAP1 RAD21 THRB ZSCAN9 ZNF48 YY1 RARA F8A1 F8A2 SNORA36A DKC1 MIR664B IKBKG GAB3 EMD MPP1 DNASE1L1
GH0XF154823 0.4 Ensembl 0.4 +11.2 11162 0.2 ZNF263 MPP1 SMIM9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM9 Gene

Chromosome:
X
Start:
154,823,348 bp from pter
End:
154,834,662 bp from pter
Size:
11,315 bases
Orientation:
Minus strand

Genomic View for SMIM9 Gene

Genes around SMIM9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM9 Gene

Proteins for SMIM9 Gene

  • Protein details for SMIM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGZ8-SMIM9_HUMAN
    Recommended name:
    Small integral membrane protein 9
    Protein Accession:
    A6NGZ8

    Protein attributes for SMIM9 Gene

    Size:
    99 amino acids
    Molecular mass:
    10777 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM9 Gene

Post-translational modifications for SMIM9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM9 Gene

Domains & Families for SMIM9 Gene

Protein Domains for SMIM9 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM9: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM9 Gene

Function for SMIM9 Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM9 Gene

Localization for SMIM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM9 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM9 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for SMIM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM9: view

Pathways & Interactions for SMIM9 Gene

SuperPathways for SMIM9 Gene

No Data Available

Interacting Proteins for SMIM9 Gene

Gene Ontology (GO) - Biological Process for SMIM9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM9 Gene

Transcripts for SMIM9 Gene

mRNA/cDNA for SMIM9 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM9 Gene

Small integral membrane protein 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM9 Gene

No ASD Table

Relevant External Links for SMIM9 Gene

GeneLoc Exon Structure for
SMIM9
ECgene alternative splicing isoforms for
SMIM9

Expression for SMIM9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMIM9 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM9 Gene

This gene is overexpressed in Testis (x20.5) and Heart - Left Ventricle (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of SMIM9 Gene:

SMIM9

SOURCE GeneReport for Unigene cluster for SMIM9 Gene:

Hs.220762
genes like me logo Genes that share expression patterns with SMIM9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SMIM9 Gene

Orthologs for SMIM9 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SMIM9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM9 34 35
  • 98.99 (n)
Species where no ortholog for SMIM9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM9 Gene

ENSEMBL:
Gene Tree for SMIM9 (if available)
TreeFam:
Gene Tree for SMIM9 (if available)

Paralogs for SMIM9 Gene

No data available for Paralogs for SMIM9 Gene

Variants for SMIM9 Gene

Sequence variations from dbSNP and Humsavar for SMIM9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10126699 -- 154,826,165(+) TTCTG(C/T)GCCTC intron-variant
rs10127070 -- 154,828,109(+) CAAAT(G/T)CCGGT intron-variant
rs1050705 -- 154,835,925(-) AACTT(A/G)ATAAT upstream-variant-2KB, utr-variant-3-prime
rs111290608 -- 154,824,214(+) TAGCC(G/T)GGCGT intron-variant
rs111382768 -- 154,825,586(+) AATGA(C/G/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM9 Gene

Variant ID Type Subtype PubMed ID
nsv516158 CNV gain 19592680
esv3577568 CNV gain 25503493
esv33784 CNV gain+loss 17666407
esv29972 CNV gain 17803354

Variation tolerance for SMIM9 Gene

Gene Damage Index Score: 1.53; 29.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM9 Gene

Disorders for SMIM9 Gene

Relevant External Links for SMIM9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM9

No disorders were found for SMIM9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM9 Gene

Publications for SMIM9 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3 64

Products for SMIM9 Gene

Sources for SMIM9 Gene

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