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Aliases for SMIM8 Gene

Aliases for SMIM8 Gene

  • Small Integral Membrane Protein 8 2 3
  • C6orf162 3 4
  • Chromosome 6 Open Reading Frame 162 2
  • UPF0708 Protein C6orf162 3
  • DJ102H19.2 3

External Ids for SMIM8 Gene

Previous HGNC Symbols for SMIM8 Gene

  • C6orf162

Previous GeneCards Identifiers for SMIM8 Gene

  • GC06P088033

Summaries for SMIM8 Gene

GeneCards Summary for SMIM8 Gene

SMIM8 (Small Integral Membrane Protein 8) is a Protein Coding gene. An important paralog of this gene is ENSG00000226524.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM8 Gene

Genomics for SMIM8 Gene

Genomic Location for SMIM8 Gene

87,322,583 bp from pter
87,342,328 bp from pter
19,746 bases
Plus strand

Genomic View for SMIM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM8 Gene

No data available for Regulatory Elements for SMIM8 Gene

Proteins for SMIM8 Gene

  • Protein details for SMIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 8
    Protein Accession:
    Secondary Accessions:
    • B2R4V6
    • E1P505
    • Q5TEZ3
    • Q6NSD2
    • Q8IZ10

    Protein attributes for SMIM8 Gene

    97 amino acids
    Molecular mass:
    11059 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK38513.1; Type=Frameshift; Positions=87; Evidence={ECO:0000305};

neXtProt entry for SMIM8 Gene

Proteomics data for SMIM8 Gene at MOPED

Post-translational modifications for SMIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM8 Gene

No data available for DME Specific Peptides for SMIM8 Gene

Domains for SMIM8 Gene

Protein Domains for SMIM8 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMIM8 family.
  • Belongs to the SMIM8 family.
genes like me logo Genes that share domains with SMIM8: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SMIM8 Gene

Function for SMIM8 Gene

Phenotypes for SMIM8 Gene

GenomeRNAi human phenotypes for SMIM8:
genes like me logo Genes that share phenotypes with SMIM8: view

Animal Model Products

miRNA for SMIM8 Gene

miRTarBase miRNAs that target SMIM8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM8 Gene

Localization for SMIM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM8 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM8: view

No data available for Subcellular locations from COMPARTMENTS for SMIM8 Gene

Pathways for SMIM8 Gene

SuperPathways for SMIM8 Gene

No Data Available

Interacting Proteins for SMIM8 Gene

Gene Ontology (GO) - Biological Process for SMIM8 Gene


No data available for Pathways by source for SMIM8 Gene

Transcripts for SMIM8 Gene

Unigene Clusters for SMIM8 Gene

Small integral membrane protein 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM8 Gene

No ASD Table

Relevant External Links for SMIM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM8 Gene

mRNA expression in normal human tissues for SMIM8 Gene

Protein differential expression in normal tissues for SMIM8 Gene

This gene is overexpressed in CD8 Tcells (39.8), Testis (16.7), and Placenta (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SMIM8 Gene

SOURCE GeneReport for Unigene cluster for SMIM8 Gene Hs.70769

genes like me logo Genes that share expressions with SMIM8: view

Expression partners for SMIM8 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMIM8 Gene

Orthologs for SMIM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMIM8 35
  • 89 (n)
  • 90.72 (a)
SMIM8 36
  • 91 (a)
(Canis familiaris)
Mammalia SMIM8 35
  • 91.07 (n)
  • 92.78 (a)
-- 36
  • 74 (a)
(Mus musculus)
Mammalia Smim8 35
  • 85.57 (n)
  • 88.66 (a)
Smim8 16
Smim8 36
  • 89 (a)
(Pan troglodytes)
Mammalia SMIM8 35
  • 99.31 (n)
  • 97.94 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Smim8 35
  • 84.88 (n)
  • 86.6 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Gallus gallus)
Aves C6ORF162 35
  • 73.91 (n)
  • 77.17 (a)
C6ORF162 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smim8 35
  • 70.83 (n)
  • 71.87 (a)
Str.536 35
(Danio rerio)
Actinopterygii smim8 35
  • 63.26 (n)
  • 69.32 (a)
smim8 36
  • 61 (a)
Species with no ortholog for SMIM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM8 Gene

Gene Tree for SMIM8 (if available)
Gene Tree for SMIM8 (if available)

Paralogs for SMIM8 Gene

Paralogs for SMIM8 Gene

genes like me logo Genes that share paralogs with SMIM8: view

Variants for SMIM8 Gene

Sequence variations from dbSNP and Humsavar for SMIM8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs15836 -- 87,340,800(-) GACAC(A/T)ATAAA utr-variant-3-prime, intron-variant
rs173333 -- 87,338,036(+) TTTAG(G/T)AACAT intron-variant
rs142237739 -- 87,335,792(+) GCTTT(A/G)TTGCC intron-variant
rs142127961 -- 87,333,567(+) CATTA(C/G)AAGAA intron-variant
rs140620743 -- 87,336,902(+) TTGGT(A/G)TGTAT intron-variant

Relevant External Links for SMIM8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM8 Gene

Disorders for SMIM8 Gene

No disorders were found for SMIM8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SMIM8 Gene

Publications for SMIM8 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3

Products for SMIM8 Gene

Sources for SMIM8 Gene

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