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Aliases for SMIM8 Gene

Aliases for SMIM8 Gene

  • Small Integral Membrane Protein 8 2 3 5
  • C6orf162 3 4
  • Chromosome 6 Open Reading Frame 162 2
  • UPF0708 Protein C6orf162 3
  • DJ102H19.2 3

External Ids for SMIM8 Gene

Previous HGNC Symbols for SMIM8 Gene

  • C6orf162

Previous GeneCards Identifiers for SMIM8 Gene

  • GC06P088033

Summaries for SMIM8 Gene

GeneCards Summary for SMIM8 Gene

SMIM8 (Small Integral Membrane Protein 8) is a Protein Coding gene.

Additional gene information for SMIM8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM8 Gene

Genomics for SMIM8 Gene

Regulatory Elements for SMIM8 Gene

Enhancers for SMIM8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H087151 1.4 ENCODE dbSUPER 14.5 -168.2 -168183 6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 ZNF292 RARS2 SLC35A1 LINC01590 RCN1P1 TAF13P1 ST13P16 SMIM8 ORC3 CGA
GH06H087321 1.1 ENCODE 18.3 +0.1 54 1 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 SP3 ZNF292 SLC35A1 SMIM8 LINC01590 GJB7
GH06H087213 1.1 Ensembl ENCODE 14.5 -108.5 -108541 1 HDAC1 FOXA2 ZFP64 SIN3A TCF12 FOS ATF7 NCOA1 ELF1 ZEB2 SMIM8 LINC01590 CGA SLC35A1 ORC3 GC06P087226 LOC100418923
GH06H087697 1.8 FANTOM5 ENCODE dbSUPER 5.6 +377.8 377775 6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC35A1 ZNF292 LINC01590 RARS2 ENSG00000272008 ORC3 AKIRIN2 SMIM8 GC06M087700 GC06P087659
GH06H087722 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.1 +401.7 401711 4 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 FOS JUNB ZNF292 AKIRIN2 C6orf163 SLC35A1 SMIM8 RARS2 LINC01590 ENSG00000238628 GC06P087742
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM8 on UCSC Golden Path with GeneCards custom track

Promoters for SMIM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199742 118 1399 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 SP3

Genomic Location for SMIM8 Gene

Chromosome:
6
Start:
87,322,583 bp from pter
End:
87,399,749 bp from pter
Size:
77,167 bases
Orientation:
Plus strand

Genomic View for SMIM8 Gene

Genes around SMIM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM8 Gene

Proteins for SMIM8 Gene

  • Protein details for SMIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KF7-SMIM8_HUMAN
    Recommended name:
    Small integral membrane protein 8
    Protein Accession:
    Q96KF7
    Secondary Accessions:
    • B2R4V6
    • E1P505
    • Q5TEZ3
    • Q6NSD2
    • Q8IZ10

    Protein attributes for SMIM8 Gene

    Size:
    97 amino acids
    Molecular mass:
    11059 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK38513.1; Type=Frameshift; Positions=87; Evidence={ECO:0000305};

neXtProt entry for SMIM8 Gene

Post-translational modifications for SMIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SMIM8 Gene

Domains & Families for SMIM8 Gene

Gene Families for SMIM8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMIM8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMIM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KF7

UniProtKB/Swiss-Prot:

SMIM8_HUMAN :
  • Belongs to the SMIM8 family.
Family:
  • Belongs to the SMIM8 family.
genes like me logo Genes that share domains with SMIM8: view

Function for SMIM8 Gene

Phenotypes From GWAS Catalog for SMIM8 Gene

genes like me logo Genes that share phenotypes with SMIM8: view

Animal Models for SMIM8 Gene

MGI Knock Outs for SMIM8:

Animal Model Products

CRISPR Products

miRNA for SMIM8 Gene

miRTarBase miRNAs that target SMIM8

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SMIM8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMIM8 Gene

Localization for SMIM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM8 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM8 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SMIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM8: view

Pathways & Interactions for SMIM8 Gene

SuperPathways for SMIM8 Gene

No Data Available

Interacting Proteins for SMIM8 Gene

Gene Ontology (GO) - Biological Process for SMIM8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM8 Gene

Drugs & Compounds for SMIM8 Gene

No Compound Related Data Available

Transcripts for SMIM8 Gene

Unigene Clusters for SMIM8 Gene

Small integral membrane protein 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SMIM8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM8 Gene

No ASD Table

Relevant External Links for SMIM8 Gene

GeneLoc Exon Structure for
SMIM8
ECgene alternative splicing isoforms for
SMIM8

Expression for SMIM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM8 Gene

Protein differential expression in normal tissues from HIPED for SMIM8 Gene

This gene is overexpressed in CD8 Tcells (39.8), Testis (16.7), and Placenta (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMIM8 Gene



Protein tissue co-expression partners for SMIM8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SMIM8 Gene:

SMIM8

SOURCE GeneReport for Unigene cluster for SMIM8 Gene:

Hs.70769

Evidence on tissue expression from TISSUES for SMIM8 Gene

  • Blood(4.4)
  • Nervous system(4.2)
  • Lymph node(4.1)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with SMIM8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM8 Gene

Orthologs for SMIM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM8 33
  • 99.31 (n)
-- 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SMIM8 33
  • 91.07 (n)
-- 34
  • 74 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SMIM8 33 34
  • 89 (n)
mouse
(Mus musculus)
Mammalia Smim8 33 16 34
  • 85.57 (n)
rat
(Rattus norvegicus)
Mammalia Smim8 33
  • 84.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves C6ORF162 34 33
  • 73.91 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia smim8 33
  • 70.83 (n)
Str.536 33
zebrafish
(Danio rerio)
Actinopterygii smim8 33 34
  • 63.26 (n)
Species where no ortholog for SMIM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM8 Gene

ENSEMBL:
Gene Tree for SMIM8 (if available)
TreeFam:
Gene Tree for SMIM8 (if available)

Paralogs for SMIM8 Gene

No data available for Paralogs for SMIM8 Gene

Variants for SMIM8 Gene

Sequence variations from dbSNP and Humsavar for SMIM8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000015505 -- 87,333,862(+) GCGTC(A/G)TTATA intron-variant
rs1000060726 -- 87,340,389(+) GAGAG(A/G)AGATA intron-variant, utr-variant-3-prime
rs1000130638 -- 87,339,017(+) ACTGA(A/G)ACTCT intron-variant
rs1000227413 -- 87,323,408(+) TCCCA(A/G)TGCTA intron-variant
rs1000744043 -- 87,329,296(+) TTTAG(A/G)CAGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMIM8 Gene

Variant ID Type Subtype PubMed ID
esv2667119 CNV deletion 23128226
nsv349083 CNV deletion 16902084
nsv5386 CNV deletion 18451855
nsv823771 CNV loss 20364138

Variation tolerance for SMIM8 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM8 Gene

Disorders for SMIM8 Gene

Relevant External Links for SMIM8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM8

No disorders were found for SMIM8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM8 Gene

Publications for SMIM8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 60
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 60

Products for SMIM8 Gene

Sources for SMIM8 Gene

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