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Aliases for SMIM6 Gene

Aliases for SMIM6 Gene

  • Small Integral Membrane Protein 6 2 3 5
  • C17orf110 3 4
  • Chromosome 17 Open Reading Frame 110 2

External Ids for SMIM6 Gene

Previous HGNC Symbols for SMIM6 Gene

  • C17orf110

Previous GeneCards Identifiers for SMIM6 Gene

  • GC17P073645

Summaries for SMIM6 Gene

GeneCards Summary for SMIM6 Gene

SMIM6 (Small Integral Membrane Protein 6) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM6 Gene

Genomics for SMIM6 Gene

Regulatory Elements for SMIM6 Gene

Enhancers for SMIM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G075638 2 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -1.1 -1110 9.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 RECQL5 SAP30BP MYO15B SMIM6 MRPS7 LLGL2 EVPL CASKIN2 FOXJ1 SMIM5
GH17G075683 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +48.1 48057 19.7 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A ZBTB7B ZNF207 FOS DEK RECQL5 ITGB4 SAP30BP SMIM5 GALK1 TMEM94 LLGL2 MYO15B TEN1 MRPS7
GH17G075085 2 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -553.3 -553327 11.9 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000267342 NAT9 MGC16275 SLC16A5 CDR2L RN7SL573P MIF4GD SUMO2 MRPS7 MRPL58
GH17G075575 1.5 Ensembl ENCODE dbSUPER 5.2 -67.3 -67278 4.1 PKNOX1 MLX ARID4B FEZF1 ZNF2 SLC30A9 ZNF263 SP3 SP5 ZNF488 MYO15B NUP85 LLGL2 MRPS7 NT5C SMIM6 HID1 GC17M075573 GC17P075565
GH17G075665 1.3 ENCODE dbSUPER 5.3 +22.5 22496 3.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 FOS RECQL5 MIF4GD ENSG00000267078 SPHK1 ST6GALNAC2 SMIM6 ENSG00000264829
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM6 Gene

Chromosome:
17
Start:
75,644,822 bp from pter
End:
75,647,977 bp from pter
Size:
3,156 bases
Orientation:
Plus strand

Genomic View for SMIM6 Gene

Genes around SMIM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM6 Gene

Proteins for SMIM6 Gene

  • Protein details for SMIM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DI80-SMIM6_HUMAN
    Recommended name:
    Small integral membrane protein 6
    Protein Accession:
    P0DI80

    Protein attributes for SMIM6 Gene

    Size:
    62 amino acids
    Molecular mass:
    7017 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM6 Gene

Post-translational modifications for SMIM6 Gene

No Post-translational modifications

Other Protein References for SMIM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM6 Gene

Domains & Families for SMIM6 Gene

Protein Domains for SMIM6 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM6: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM6 Gene

Function for SMIM6 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM6 Gene

Localization for SMIM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM6 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM6: view

No data available for Subcellular locations from COMPARTMENTS for SMIM6 Gene

Pathways & Interactions for SMIM6 Gene

SuperPathways for SMIM6 Gene

No Data Available

Interacting Proteins for SMIM6 Gene

Gene Ontology (GO) - Biological Process for SMIM6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM6 Gene

Drugs & Compounds for SMIM6 Gene

No Compound Related Data Available

Transcripts for SMIM6 Gene

mRNA/cDNA for SMIM6 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM6 Gene

Small integral membrane protein 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM6 Gene

No ASD Table

Relevant External Links for SMIM6 Gene

GeneLoc Exon Structure for
SMIM6
ECgene alternative splicing isoforms for
SMIM6

Expression for SMIM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM6 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM6 Gene

This gene is overexpressed in Testis (x11.6), Stomach (x7.4), and Kidney - Cortex (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of SMIM6 Gene:

SMIM6

SOURCE GeneReport for Unigene cluster for SMIM6 Gene:

Hs.662541
genes like me logo Genes that share expression patterns with SMIM6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM6 Gene

Orthologs for SMIM6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf110 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia SMIM6 35
  • 56 (a)
OneToOne
Species where no ortholog for SMIM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM6 Gene

ENSEMBL:
Gene Tree for SMIM6 (if available)
TreeFam:
Gene Tree for SMIM6 (if available)

Paralogs for SMIM6 Gene

No data available for Paralogs for SMIM6 Gene

Variants for SMIM6 Gene

Sequence variations from dbSNP and Humsavar for SMIM6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000140249 -- 75,646,101(+) TTGTG(A/C)CAGTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000740986 -- 75,644,486(+) CCTGT(C/G)GTCCC intron-variant, upstream-variant-2KB
rs1001122212 -- 75,645,700(+) AACCC(A/G)GGTCA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001236558 -- 75,645,758(+) CTGTC(A/G)TCCAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002248632 -- 75,643,774(+) CACCA(C/T)CTCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMIM6 Gene

Variant ID Type Subtype PubMed ID
nsv470603 CNV loss 18288195
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv833543 CNV loss 17160897
nsv833544 CNV loss 17160897

Variation tolerance for SMIM6 Gene

Gene Damage Index Score: 0.36; 7.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM6 Gene

Disorders for SMIM6 Gene

Relevant External Links for SMIM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM6

No disorders were found for SMIM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM6 Gene

Publications for SMIM6 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for SMIM6 Gene

Sources for SMIM6 Gene

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