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Aliases for SMIM5 Gene

Aliases for SMIM5 Gene

  • Small Integral Membrane Protein 5 2 3 5
  • C17orf109 3 4
  • Chromosome 17 Open Reading Frame 109 2
  • PP12104 3

External Ids for SMIM5 Gene

Previous HGNC Symbols for SMIM5 Gene

  • C17orf109

Previous GeneCards Identifiers for SMIM5 Gene

  • GC17P073632

Summaries for SMIM5 Gene

GeneCards Summary for SMIM5 Gene

SMIM5 (Small Integral Membrane Protein 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM5 Gene

Genomics for SMIM5 Gene

Regulatory Elements for SMIM5 Gene

Enhancers for SMIM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075632 1.6 FANTOM5 Ensembl ENCODE 15.1 +1.9 1868 5.7 HDGF PKNOX1 MLX ARID4B SIN3A ZNF48 ZNF2 GLIS2 ZNF207 ZNF143 MYO15B RECQL5 SMIM5 SAP30BP ENSG00000267801 SMIM6
GH17F075683 1.7 FANTOM5 Ensembl ENCODE 12.1 +59.4 59445 19.7 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A ZNF207 FOS DEK SP5 RECQL5 ITGB4 SAP30BP SMIM5 GALK1 ENSG00000266980 LLGL2 MYO15B MIR6785 TMEM94
GH17F075747 1.2 Ensembl ENCODE 12.2 +114.5 114485 0.6 HDGF ELF3 INSM2 KLF17 ARID4B SIN3A NFXL1 ZNF2 RAD21 ZNF121 RECQL5 SMIM5 ITGB4 UNK GC17P075751 GC17M075722
GH17F075749 1.2 Ensembl ENCODE 12.2 +116.8 116776 1.2 HDGF ARID4B SIN3A ZNF48 ZNF2 GLIS2 ZNF143 ZNF207 SP3 REST RECQL5 SMIM5 ITGB4 UNK TEN1 GC17P075751 GC17M075722
GH17F075334 1.4 FANTOM5 ENCODE 2.4 -291.7 -291655 14.3 HDGF PKNOX1 ATF1 WRNIP1 SIN3A FEZF1 ZNF121 ELK1 GATA2 FOS GRB2 LLGL2 MRPS7 NUP85 MIR6785 TMEM94 CASKIN2 TSEN54 MIF4GD MYO15B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM5 Gene

Chromosome:
17
Start:
75,633,434 bp from pter
End:
75,641,406 bp from pter
Size:
7,973 bases
Orientation:
Plus strand

Genomic View for SMIM5 Gene

Genes around SMIM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM5 Gene

Proteins for SMIM5 Gene

  • Protein details for SMIM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71RC9-SMIM5_HUMAN
    Recommended name:
    Small integral membrane protein 5
    Protein Accession:
    Q71RC9

    Protein attributes for SMIM5 Gene

    Size:
    77 amino acids
    Molecular mass:
    8540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ15244.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW89296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SMIM5 Gene

Post-translational modifications for SMIM5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SMIM5 Gene

Domains & Families for SMIM5 Gene

Protein Domains for SMIM5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM5: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM5 Gene

Function for SMIM5 Gene

Phenotypes for SMIM5 Gene

GenomeRNAi human phenotypes for SMIM5:
genes like me logo Genes that share phenotypes with SMIM5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM5 Gene

Localization for SMIM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM5 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SMIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM5: view

Pathways & Interactions for SMIM5 Gene

SuperPathways for SMIM5 Gene

No Data Available

Interacting Proteins for SMIM5 Gene

Gene Ontology (GO) - Biological Process for SMIM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM5 Gene

Transcripts for SMIM5 Gene

mRNA/cDNA for SMIM5 Gene

(10) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM5 Gene

Small integral membrane protein 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM5 Gene

No ASD Table

Relevant External Links for SMIM5 Gene

GeneLoc Exon Structure for
SMIM5
ECgene alternative splicing isoforms for
SMIM5

Expression for SMIM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMIM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMIM5 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for SMIM5 Gene

This gene is overexpressed in Platelet (27.8), Urine (20.5), and Bone (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMIM5 Gene



Protein tissue co-expression partners for SMIM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMIM5 Gene:

SMIM5

SOURCE GeneReport for Unigene cluster for SMIM5 Gene:

Hs.528605
genes like me logo Genes that share expression patterns with SMIM5: view

No data available for mRNA Expression by UniProt/SwissProt for SMIM5 Gene

Orthologs for SMIM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf109 34
  • 99.13 (n)
SMIM5 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMIM5 34
  • 87.67 (n)
mouse
(Mus musculus)
Mammalia Smim5 34 16 35
  • 80.95 (n)
cow
(Bos Taurus)
Mammalia SMIM5 34 35
  • 78.79 (n)
chicken
(Gallus gallus)
Aves SMIM5 35
  • 55 (a)
OneToOne
Species where no ortholog for SMIM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM5 Gene

ENSEMBL:
Gene Tree for SMIM5 (if available)
TreeFam:
Gene Tree for SMIM5 (if available)

Paralogs for SMIM5 Gene

No data available for Paralogs for SMIM5 Gene

Variants for SMIM5 Gene

Sequence variations from dbSNP and Humsavar for SMIM5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111344412 -- 75,633,564(+) ACAAG(A/G)GCCTC intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs112395083 -- 75,641,634(+) GCACT(A/G)CTCTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs112636100 -- 75,633,483(+) GCCTT(A/G)CCGGG intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs113007891 -- 75,632,571(+) CCTCT(C/T)GTCTT intron-variant, upstream-variant-2KB
rs113422979 -- 75,632,792(+) AGGAA(C/T)GTGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMIM5 Gene

Variant ID Type Subtype PubMed ID
nsv833544 CNV loss 17160897
nsv833543 CNV loss 17160897
nsv576027 CNV gain 21841781
nsv516133 CNV loss 19592680
nsv470603 CNV loss 18288195

Variation tolerance for SMIM5 Gene

Gene Damage Index Score: 1.01; 20.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM5 Gene

Disorders for SMIM5 Gene

Relevant External Links for SMIM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM5

No disorders were found for SMIM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM5 Gene

Publications for SMIM5 Gene

  1. FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data. (PMID: 24318988) Zodro E. … Wesoly J. (Tumour Biol. 2013) 2 3 64
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SMIM5 Gene

Sources for SMIM5 Gene

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