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Aliases for SMIM4 Gene

Aliases for SMIM4 Gene

  • Small Integral Membrane Protein 4 2 3
  • C3orf78 3 4
  • Chromosome 3 Open Reading Frame 78 2
  • UPF0640 Protein C3orf78 3

External Ids for SMIM4 Gene

Previous Symbols for SMIM4 Gene

  • C3orf78

Summaries for SMIM4 Gene

GeneCards Summary for SMIM4 Gene

SMIM4 (Small Integral Membrane Protein 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM4 Gene

Genomics for SMIM4 Gene

Genomic Location for SMIM4 Gene

Start:
52,534,013 bp from pter
End:
52,579,237 bp from pter
Size:
45,225 bases
Orientation:
Plus strand

Genomic View for SMIM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM4 Gene

No data available for Regulatory Elements for SMIM4 Gene

Proteins for SMIM4 Gene

  • Protein details for SMIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVI0-SMIM4_HUMAN
    Recommended name:
    Small integral membrane protein 4
    Protein Accession:
    Q8WVI0
    Secondary Accessions:

    Protein attributes for SMIM4 Gene

    Size:
    70 amino acids
    Molecular mass:
    8696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17996.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SMIM4 Gene

Proteomics data for SMIM4 Gene at MOPED

Post-translational modifications for SMIM4 Gene

No Post-translational modifications

Other Protein References for SMIM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM4 Gene

Domains for SMIM4 Gene

Protein Domains for SMIM4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WVI0

UniProtKB/Swiss-Prot:

SMIM4_HUMAN
Family:
  • Belongs to the SMIM4 family.:
    • Q8WVI0
genes like me logo Genes that share domains with SMIM4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SMIM4 Gene

Function for SMIM4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMIM4 Gene

Localization for SMIM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM4 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM4: view

No data available for Subcellular locations from COMPARTMENTS for SMIM4 Gene

Pathways for SMIM4 Gene

SuperPathways for SMIM4 Gene

No Data Available

Interacting Proteins for SMIM4 Gene

Gene Ontology (GO) - Biological Process for SMIM4 Gene

None

No data available for Pathways by source for SMIM4 Gene

Transcripts for SMIM4 Gene

Unigene Clusters for SMIM4 Gene

Small integral membrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM4 Gene

ExUns: 1a · 1b ^ 2
SP1: -
SP2:

Relevant External Links for SMIM4 Gene

GeneLoc Exon Structure for
SMIM4
ECgene alternative splicing isoforms for
SMIM4

Expression for SMIM4 Gene

mRNA expression in normal human tissues for SMIM4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SMIM4 Gene

SOURCE GeneReport for Unigene cluster for SMIM4 Gene Hs.660577

genes like me logo Genes that share expressions with SMIM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMIM4 Gene

Orthologs for SMIM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMIM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC745959 35
  • 100 (n)
  • 100 (a)
SMIM4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMIM4 35
  • 93.24 (n)
  • 92.75 (a)
SMIM4 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMIM4 35
  • 92.75 (n)
  • 91.3 (a)
SMIM4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smim4 16
Smim4 36
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMIM4 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smim4 35
  • 93.94 (n)
  • 96.97 (a)
lizard
(Anolis carolinensis)
Reptilia SMIM4 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SMIM4 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32736 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for SMIM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM4 Gene

ENSEMBL:
Gene Tree for SMIM4 (if available)
TreeFam:
Gene Tree for SMIM4 (if available)

Paralogs for SMIM4 Gene

No data available for Paralogs for SMIM4 Gene

Variants for SMIM4 Gene

Sequence variations from dbSNP and Humsavar for SMIM4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6445528 -- 52,538,431(+) AAATT(A/G)TGATG intron-variant
rs7430233 -- 52,540,131(+) CAGAA(G/T)AGAAA intron-variant
rs7616526 -- 52,539,393(+) GGTAA(C/T)GGGGG intron-variant
rs7625180 -- 52,538,857(+) AATAC(A/G)TCTGG intron-variant
rs7630073 -- 52,539,222(+) TAATC(G/T)GTGGT intron-variant

Relevant External Links for SMIM4 Gene

HapMap Linkage Disequilibrium report
SMIM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM4 Gene

Disorders for SMIM4 Gene

No disorders were found for SMIM4 Gene.

No data available for UniProtKB/Swiss-Prot for SMIM4 Gene

Publications for SMIM4 Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for SMIM4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SMIM4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM4
    • Block miRNA regulation of SMIM4 using miScript Target Protectors

    Sources for SMIM4 Gene

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