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Aliases for SMIM3 Gene

Aliases for SMIM3 Gene

  • Small Integral Membrane Protein 3 2 3 5
  • NGF-Induced Differentiation Clone 67 Protein 3 4
  • Small Membrane Protein NID67 3 4
  • C5orf62 3 4
  • NID67 3 4
  • Chromosome 5 Open Reading Frame 62 2
  • MST150 3

External Ids for SMIM3 Gene

Previous HGNC Symbols for SMIM3 Gene

  • C5orf62

Previous GeneCards Identifiers for SMIM3 Gene

  • GC05P150159

Summaries for SMIM3 Gene

GeneCards Summary for SMIM3 Gene

SMIM3 (Small Integral Membrane Protein 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM3 Gene

Genomics for SMIM3 Gene

Regulatory Elements for SMIM3 Gene

Enhancers for SMIM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G149956 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -818.3 -818297 6.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZBTB7B HMGXB3 ZNF300 ZNF300P1 RPL7P1 TIGD6 SLC26A2 RPS20P4 RPS14 PDGFRB SMIM3
GH05G150777 1.8 FANTOM5 ENCODE dbSUPER 10.9 +3.2 3171 8.1 HDGF FOXA2 PKNOX1 MLX ZFP64 SIN3A ARID4B FEZF1 ZNF2 SLC30A9 RPL7P1 RBM22 HMGXB3 SMIM3 ZNF300 TNIP1 RPS14 CCDC69 ANXA6 DCTN4
GH05G150458 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -318.7 -318746 1.2 ARID4B SIN3A YY1 GLIS2 ZNF143 KLF7 FOS ZNF263 SP3 SP5 NDST1 NDST1-AS1 RPS14 SMIM3 SYNPO ZNF300 SLC6A7 GC05P150482
GH05G150460 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -316.5 -316471 1.3 HDAC1 HDGF TBP PKNOX1 RB1 ZNF366 IKZF2 ZNF263 ZEB2 ZNF398 NDST1 SYNPO RPS14 NDST1-AS1 SMIM3 RBM22 ENSG00000253852 ZNF300 GC05P150482
GH05G150800 1.4 Ensembl ENCODE dbSUPER 11.9 +23.5 23455 1.3 HDAC1 ATF1 ARNT ZFP64 ZBTB40 RAD21 ZNF335 ZNF366 ZNF143 CREM SMIM3 DCTN4 IRGM
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM3 on UCSC Golden Path with GeneCards custom track

Promoters for SMIM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189041 1254 1601 HDGF ATF1 PKNOX1 ZFP64 ARID4B SIN3A ZNF48 SLC30A9 GLIS2 ZNF143

Genomic Location for SMIM3 Gene

Chromosome:
5
Start:
150,777,946 bp from pter
End:
150,796,736 bp from pter
Size:
18,791 bases
Orientation:
Plus strand

Genomic View for SMIM3 Gene

Genes around SMIM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM3 Gene

Proteins for SMIM3 Gene

  • Protein details for SMIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL3-SMIM3_HUMAN
    Recommended name:
    Small integral membrane protein 3
    Protein Accession:
    Q9BZL3
    Secondary Accessions:
    • Q3MIG3
    • Q6ZUV4

    Protein attributes for SMIM3 Gene

    Size:
    60 amino acids
    Molecular mass:
    6593 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01839.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI01841.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI06041.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAC86114.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW61705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SMIM3 Gene

Post-translational modifications for SMIM3 Gene

No Post-translational modifications

Other Protein References for SMIM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM3 Gene

Domains & Families for SMIM3 Gene

Protein Domains for SMIM3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SMIM3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SMIM3 Gene

Function for SMIM3 Gene

Molecular function for SMIM3 Gene

UniProtKB/Swiss-Prot Induction:
By NGF.

Gene Ontology (GO) - Molecular Function for SMIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SMIM3: view

Phenotypes for SMIM3 Gene

genes like me logo Genes that share phenotypes with SMIM3: view

Animal Models for SMIM3 Gene

MGI Knock Outs for SMIM3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM3 Gene

Localization for SMIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM3 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM3: view

No data available for Subcellular locations from COMPARTMENTS for SMIM3 Gene

Pathways & Interactions for SMIM3 Gene

SuperPathways for SMIM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMIM3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM3 Gene

Drugs & Compounds for SMIM3 Gene

No Compound Related Data Available

Transcripts for SMIM3 Gene

mRNA/cDNA for SMIM3 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(186) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM3 Gene

Small integral membrane protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM3 Gene

No ASD Table

Relevant External Links for SMIM3 Gene

GeneLoc Exon Structure for
SMIM3
ECgene alternative splicing isoforms for
SMIM3

Expression for SMIM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SMIM3 Gene:

SMIM3

SOURCE GeneReport for Unigene cluster for SMIM3 Gene:

Hs.29444

Evidence on tissue expression from TISSUES for SMIM3 Gene

  • Intestine(4)
  • Pancreas(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SMIM3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM3 Gene

Orthologs for SMIM3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM3 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia SMIM3 34 35
  • 90 (n)
cow
(Bos Taurus)
Mammalia MGC128424 34 35
  • 87.22 (n)
mouse
(Mus musculus)
Mammalia Smim3 34 16 35
  • 84.75 (n)
rat
(Rattus norvegicus)
Mammalia Smim3 34
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia SMIM3 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMIM3 35
  • 68 (a)
OneToOne
Species where no ortholog for SMIM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM3 Gene

ENSEMBL:
Gene Tree for SMIM3 (if available)
TreeFam:
Gene Tree for SMIM3 (if available)

Paralogs for SMIM3 Gene

No data available for Paralogs for SMIM3 Gene

Variants for SMIM3 Gene

Sequence variations from dbSNP and Humsavar for SMIM3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000260503 -- 150,796,403(+) CTCCT(C/G)CTGTA utr-variant-3-prime
rs1000282995 -- 150,778,323(+) AACAG(C/G)ACTGG utr-variant-5-prime
rs1000406452 -- 150,782,461(+) CCCTC(C/T)TCCCC intron-variant
rs1000448542 -- 150,788,173(+) CTTGC(C/G)AAATG intron-variant
rs1000467326 -- 150,784,372(+) GACTC(C/T)ATATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM3 Gene

Variant ID Type Subtype PubMed ID
dgv10114n54 CNV loss 21841781
dgv5817n100 CNV loss 25217958
dgv5818n100 CNV loss 25217958
esv2759386 CNV loss 17122850
nsv428129 CNV loss 18775914
nsv435820 CNV deletion 17901297
nsv5067 CNV deletion 18451855
nsv950426 CNV duplication 24416366

Variation tolerance for SMIM3 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM3 Gene

Disorders for SMIM3 Gene

Relevant External Links for SMIM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM3

No disorders were found for SMIM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM3 Gene

Publications for SMIM3 Gene

  1. NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells. (PMID: 11288140) Vician L. … Herschman H.R. (J. Neurosci. Res. 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 64

Products for SMIM3 Gene

Sources for SMIM3 Gene

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