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Aliases for SMIM24 Gene

Aliases for SMIM24 Gene

  • Small Integral Membrane Protein 24 2 3 5
  • C19orf77 3 4
  • Chromosome 19 Open Reading Frame 77 2
  • Transmembrane Protein C19orf77 3
  • Transmembrane Protein HSPC323 3
  • MAP17-Related Dimer 3
  • HSPC323 3
  • MARDI 3

External Ids for SMIM24 Gene

Previous HGNC Symbols for SMIM24 Gene

  • C19orf77

Summaries for SMIM24 Gene

GeneCards Summary for SMIM24 Gene

SMIM24 (Small Integral Membrane Protein 24) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM24 Gene

Genomics for SMIM24 Gene

Regulatory Elements for SMIM24 Gene

Enhancers for SMIM24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G003477 1.5 Ensembl ENCODE dbSUPER 10 +0.2 220 4.9 HDGF PKNOX1 ARID4B DMAP1 ZNF48 SLC30A9 SP3 SP5 NFYC MXD4 CACTIN MFSD12 CACTIN-AS1 ZNF77 APBA3 ENSG00000269807 SMIM24 ENSG00000267304 ENSG00000279599
GH19G003472 1.1 ENCODE dbSUPER 13.2 +6.8 6820 3.1 RB1 KLF17 ZNF2 RAD21 ZNF121 EGR1 ZNF416 ZNF143 PCBP1 EGR2 SMIM24 CACTIN ZNF77 ENSG00000279599
GH19G003450 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +28.2 28217 3.9 ATF1 MLX SIN3A BRCA1 ZNF121 FOS JUNB TSHZ1 ZNF662 ZNF623 NFIC SMIM24 GNA15 ENSG00000279599
GH19G003468 0.8 dbSUPER 12.2 +10.5 10480 2.8 CTCF ZNF792 AGO1 ZNF384 EBF1 RAD21 ZNF121 GLIS2 ZNF366 POLR2A SMIM24 NFIC MFSD12 ENSG00000279599
GH19G003386 1.5 Ensembl ENCODE dbSUPER 6.5 +92.0 91961 4.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 TCF12 JUNB NCOA1 NFIC SMIM24 DOHH ENSG00000279599
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM24 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM24 Gene

Chromosome:
19
Start:
3,473,986 bp from pter
End:
3,480,542 bp from pter
Size:
6,557 bases
Orientation:
Minus strand

Genomic View for SMIM24 Gene

Genes around SMIM24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM24 Gene

Proteins for SMIM24 Gene

  • Protein details for SMIM24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75264-SIM24_HUMAN
    Recommended name:
    Small integral membrane protein 24
    Protein Accession:
    O75264
    Secondary Accessions:
    • B9EJF4
    • Q9P059

    Protein attributes for SMIM24 Gene

    Size:
    130 amino acids
    Molecular mass:
    14964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC33194.1; Type=Erroneous gene model prediction; Note=Wrong choice of frame and superfluous exons were predicted.; Evidence={ECO:0000305}; Sequence=AAF29001.1; Type=Frameshift; Positions=111; Evidence={ECO:0000305}; Sequence=EAW69320.1; Type=Erroneous gene model prediction; Note=Wrong choice of frame and superfluous exons were predicted.; Evidence={ECO:0000305};

neXtProt entry for SMIM24 Gene

Post-translational modifications for SMIM24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM24 Gene

Domains & Families for SMIM24 Gene

Protein Domains for SMIM24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMIM24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM24: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SMIM24 Gene

Function for SMIM24 Gene

Gene Ontology (GO) - Molecular Function for SMIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SMIM24: view
genes like me logo Genes that share phenotypes with SMIM24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM24 Gene

Localization for SMIM24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM24 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM24 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SMIM24: view

Pathways & Interactions for SMIM24 Gene

SuperPathways for SMIM24 Gene

No Data Available

Interacting Proteins for SMIM24 Gene

Gene Ontology (GO) - Biological Process for SMIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SMIM24: view

No data available for Pathways by source and SIGNOR curated interactions for SMIM24 Gene

Drugs & Compounds for SMIM24 Gene

No Compound Related Data Available

Transcripts for SMIM24 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM24 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b
SP1: - -
SP2:
SP3: -

Relevant External Links for SMIM24 Gene

GeneLoc Exon Structure for
SMIM24
ECgene alternative splicing isoforms for
SMIM24

Expression for SMIM24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMIM24 Gene

This gene is overexpressed in Kidney - Cortex (x19.9), Small Intestine - Terminal Ileum (x16.1), and Stomach (x6.1).

Protein differential expression in normal tissues from HIPED for SMIM24 Gene

This gene is overexpressed in Urine (28.8), Fetal gut (19.1), Kidney (9.9), and Adrenal (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMIM24 Gene



Protein tissue co-expression partners for SMIM24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SMIM24 Gene:

SMIM24

Evidence on tissue expression from TISSUES for SMIM24 Gene

  • Blood(4)
  • Kidney(2.9)
genes like me logo Genes that share expression patterns with SMIM24: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM24 Gene

Orthologs for SMIM24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM24 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C20H19orf77 34
  • 76.78 (n)
C19orf77 35
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2210404O07Rik 34 35
  • 70 (n)
Smim24 16
rat
(Rattus norvegicus)
Mammalia LOC100366121 34
  • 69.49 (n)
cow
(Bos Taurus)
Mammalia C19orf77 35
  • 58 (a)
OneToOne
Species where no ortholog for SMIM24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM24 Gene

ENSEMBL:
Gene Tree for SMIM24 (if available)
TreeFam:
Gene Tree for SMIM24 (if available)

Paralogs for SMIM24 Gene

No data available for Paralogs for SMIM24 Gene

Variants for SMIM24 Gene

Sequence variations from dbSNP and Humsavar for SMIM24 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000173961 -- 3,479,862(+) GGAGG(G/T)GCTTA intron-variant
rs1000237971 -- 3,482,324(+) GACCC(G/T)CCTTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000283480 -- 3,476,907(+) GGATG(G/T)ATGAT intron-variant
rs1000287354 -- 3,482,229(+) AGGAC(C/T)ACCCC nc-transcript-variant, upstream-variant-2KB
rs1000440180 -- 3,476,436(+) CACGG(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM24 Gene

Variant ID Type Subtype PubMed ID
esv24346 CNV gain 19812545
nsv1118805 CNV deletion 24896259
nsv470114 CNV loss 18288195
nsv526602 CNV loss 19592680
nsv953948 CNV deletion 24416366

Variation tolerance for SMIM24 Gene

Gene Damage Index Score: 2.14; 38.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM24 Gene

Disorders for SMIM24 Gene

Relevant External Links for SMIM24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM24

No disorders were found for SMIM24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM24 Gene

Publications for SMIM24 Gene

  1. MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2. (PMID: 27288013) Coady M.J. … Lapointe J.Y. (J. Am. Soc. Nephrol. 2016) 3 64
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for SMIM24 Gene

Sources for SMIM24 Gene

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