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SMIM24 Gene

protein-coding   GIFtS: 31
GCID: GC19M003474

Small Integral Membrane Protein 24

(Previous name: chromosome 19 open reading frame 77)
(Previous symbol: C19orf77)
  Search for SMIM24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Integral Membrane Protein 241 2
C19orf771 2
Chromosome 19 Open Reading Frame 771
Transmembrane Protein C19orf772
Transmembrane Protein HSPC3232

External Ids:    HGNC: 372441   Entrez Gene: 2844222   Ensembl: ENSG000000959327   UniProtKB: O752643   

Export aliases for SMIM24 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SMIM24 Gene:
SMIM24 (small integral membrane protein 24) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SMIM24
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SMIM24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMIM24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

SMIM24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMIM24 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003474:  view genomic region     (about GC identifiers)

Start:
3,474,405 bp from pter      End:
3,480,540 bp from pter
Size:
6,136 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CS077_HUMAN, O75264 (See protein sequence)
Recommended Name: Transmembrane protein C19orf77 precursor  
Size: 130 amino acids; 14964 Da
Sequence caution: Sequence=AAC33194.1; Type=Erroneous gene model prediction; Note=Wrong choice of frame and
superfluous exons were predicted; Sequence=AAF29001.1; Type=Frameshift; Positions=111; Sequence=EAW69320.1;
Type=Erroneous gene model prediction; Note=Wrong choice of frame and superfluous exons were predicted;
Secondary accessions: B9EJF4 Q9P059

Explore the universe of human proteins at neXtProt for SMIM24: NX_O75264

Explore proteomics data for SMIM24 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SMIM24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001129975.1  
    ENSEMBL proteins: 
     ENSP00000467484   ENSP00000215531   ENSP00000465692  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026628 PDZK-int_prot1_fam

    Graphical View of Domain Structure for InterPro Entry O75264

    ProtoNet protein and cluster: O75264


    Find genes that share domains with SMIM24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with SMIM24           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SMIM24:
     Decreased number of cells in m 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CS077_HUMAN, O75264: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SMIM24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMIM24
    Interactions:

        Search GeneGlobe Interaction Network for SMIM24

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with SMIM24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMIM24 (CS077)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMIM24 gene: 
    NM_001136503.1  

    Unigene Cluster for SMIM24:

    Chromosome 19 open reading frame 77
    Hs.130714  [show with all ESTs]
    Unigene Representative Sequence: BM923201
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591708 ENST00000215531(uc010xhk.1) ENST00000587847 ENST00000586804

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    Additional mRNA sequence: 

    AF161441.1 BC146979.1 BC146984.1 

    4 DOTS entries:

    DT.408095  DT.95194283  DT.121450449  DT.100755314 

    Selected AceView cDNA sequences (see all 52):

    AA306783 BM829862 BX280344 BM819640 AA336054 BM769701 AA946948 BQ028034 
    CB178719 BM769757 BM769185 BM821088 BM790972 BQ084083 BM663689 BQ083024 
    BU949434 BG036576 AW024675 BI765147 AA335971 BM821300 BM855658 BU733823 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SMIM24    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b
    SP1:        -     -                                 
    SP2:                                                
    SP3:        -                                       


    ECgene alternative splicing isoforms for SMIM24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMIM24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SMIM24 Expression
    About this image

    SMIM24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMIM24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130714
        Custom PCR Arrays for SMIM24
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMIM24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SMIM24 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2210404O07Rik1 , 5 RIKEN cDNA 2210404O07 gene1, 5 70(n)1
    60(a)1
      10 (39.72 cM)5
    722731  NM_001099917.11  NP_001093387.11 
     813930515 


    ENSEMBL Gene Tree for SMIM24 (if available)
    TreeFam Gene Tree for SMIM24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMIM24 (see all 139)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120064681,2
    C,F--3473947(+) CAGCAT/CTGCAT 1 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1156265521,2
    C,F--3474156(+) GTCACA/G/TTGCCC 1 -- ds50011WA 118
    rs349952611,2
    C--3474211(+) ACGGCA/GCTCAG 1 -- ds50010--------
    rs112675751,2
    C--3474213(+) GCGCTCAGGGCTC
    AAAGTC
    /-
    CAGGG
    1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs61464461,2
    C--3474222(+) GCTCA-/AAGTCC
    AGGGCTCA
    GGACA
    1 -- ds50010--------
    rs104089911,2
    C,F,H--3474259(+) ATTGCC/TGGGGG 1 -- ds50015Minor allele frequency- T:0.02NS EA WA 420
    rs1476954821,2
    --3474286(+) AGGGCC/GTCTGG 1 -- ds50010--------
    rs1423163701,2
    --3474390(+) AGAGAA/TGACAG 1 -- ds50010--------
    rs104158281,2
    C,F--3474468(+) GTGGGT/AGCATG 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs10553921,2
    C,F,H--3474471(-) TCCCAT/CGCACC 1 -- ut3113Minor allele frequency- C:0.12EA MN NS NA CSA WA 2250

    HapMap Linkage Disequilibrium report for SMIM24 (3474405 - 3480540 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SMIM24: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMIM24
    DNA2.0 Custom Variant and Variant Library Synthesis for SMIM24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMIM24 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SMIM24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284422 HGNC: 37244 AceView: LOC284422 Ensembl:ENSG00000095932 euGenes: HUgn284422
    ECgene: SMIM24 H-InvDB: SMIM24

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMIM24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMIM24 gene:
    Search GeneIP for patents involving SMIM24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for SMIM24
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for SMIM24
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMIM24
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMIM24
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     Search Addgene for plasmids for SMIM24
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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