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Aliases for SMIM23 Gene

Aliases for SMIM23 Gene

  • Small Integral Membrane Protein 23 2 3
  • C5orf50 3 4
  • Chromosome 5 Open Reading Frame 50 2
  • CTB-78H18.1 3

External Ids for SMIM23 Gene

Previous HGNC Symbols for SMIM23 Gene

  • C5orf50

Previous GeneCards Identifiers for SMIM23 Gene

  • GC05P171130

Summaries for SMIM23 Gene

GeneCards Summary for SMIM23 Gene

SMIM23 (Small Integral Membrane Protein 23) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM23 Gene

Genomics for SMIM23 Gene

Genomic Location for SMIM23 Gene

Chromosome:
5
Start:
171,772,642 bp from pter
End:
171,794,598 bp from pter
Size:
21,957 bases
Orientation:
Plus strand

Genomic View for SMIM23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SMIM23 Gene

No data available for Regulatory Elements for SMIM23 Gene

Proteins for SMIM23 Gene

  • Protein details for SMIM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLE4-SIM23_HUMAN
    Recommended name:
    Small integral membrane protein 23
    Protein Accession:
    A6NLE4

    Protein attributes for SMIM23 Gene

    Size:
    156 amino acids
    Molecular mass:
    18402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM23 Gene

Proteomics data for SMIM23 Gene at MOPED

Post-translational modifications for SMIM23 Gene

No Post-translational modifications

Other Protein References for SMIM23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM23 Gene

Domains & Families for SMIM23 Gene

Protein Domains for SMIM23 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM23: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM23 Gene

Function for SMIM23 Gene

Phenotypes for SMIM23 Gene

GenomeRNAi human phenotypes for SMIM23:
genes like me logo Genes that share phenotypes with SMIM23: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM23 Gene

Localization for SMIM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM23 Gene

Cell membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM23: view

No data available for Subcellular locations from COMPARTMENTS for SMIM23 Gene

Pathways & Interactions for SMIM23 Gene

SuperPathways for SMIM23 Gene

No Data Available

Interacting Proteins for SMIM23 Gene

Gene Ontology (GO) - Biological Process for SMIM23 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM23 Gene

Drugs & Compounds for SMIM23 Gene

No Compound Related Data Available

Transcripts for SMIM23 Gene

mRNA/cDNA for SMIM23 Gene

(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM23 Gene

No ASD Table

Relevant External Links for SMIM23 Gene

GeneLoc Exon Structure for
SMIM23
ECgene alternative splicing isoforms for
SMIM23

Expression for SMIM23 Gene

mRNA expression in normal human tissues for SMIM23 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM23 Gene

This gene is overexpressed in Testis (x52.8).
genes like me logo Genes that share expression patterns with SMIM23: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SMIM23 Gene

Orthologs for SMIM23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C20H5orf50 35
  • 78.92 (n)
  • 67.65 (a)
SMIM23 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H5orf50 35
  • 80.71 (n)
  • 74.29 (a)
SMIM23 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smim23 35
  • 73.53 (n)
  • 61.03 (a)
1700008A04Rik 16
1700008A04Rik 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMIM23 35
  • 98.09 (n)
  • 96.82 (a)
SMIM23 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306625 35
  • 74.94 (n)
  • 62.77 (a)
Species with no ortholog for SMIM23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM23 Gene

ENSEMBL:
Gene Tree for SMIM23 (if available)
TreeFam:
Gene Tree for SMIM23 (if available)

Paralogs for SMIM23 Gene

No data available for Paralogs for SMIM23 Gene

Variants for SMIM23 Gene

Sequence variations from dbSNP and Humsavar for SMIM23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_057736 -

Variation tolerance for SMIM23 Gene

Gene Damage Index Score: 4.38; 63.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM23 Gene

HapMap Linkage Disequilibrium report
SMIM23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM23 Gene

Disorders for SMIM23 Gene

Relevant External Links for SMIM23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM23
genes like me logo Genes that share disorders with SMIM23: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM23 Gene

Publications for SMIM23 Gene

  1. A genome-wide association study identifies five loci influencing facial morphology in Europeans. (PMID: 23028347) Liu F. … Kayser M. (PLoS Genet. 2012) 2 67
  2. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N. … TrAcgouAt D.A. (BMC Med. Genet. 2013) 67
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 67

Products for SMIM23 Gene

Sources for SMIM23 Gene

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