Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SMIM22 Gene

Aliases for SMIM22 Gene

  • Small Integral Membrane Protein 22 2 3 5

External Ids for SMIM22 Gene

Previous GeneCards Identifiers for SMIM22 Gene

  • GC16P004839

Summaries for SMIM22 Gene

GeneCards Summary for SMIM22 Gene

SMIM22 (Small Integral Membrane Protein 22) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM22 Gene

Genomics for SMIM22 Gene

Regulatory Elements for SMIM22 Gene

Enhancers for SMIM22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SMIM22 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM22 Gene

4,788,391 bp from pter
4,796,491 bp from pter
8,101 bases
Plus strand

Genomic View for SMIM22 Gene

Genes around SMIM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM22 Gene

Proteins for SMIM22 Gene

  • Protein details for SMIM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 22
    Protein Accession:
    Secondary Accessions:
    • K7EIG5
    • K7EIH2

    Protein attributes for SMIM22 Gene

    135 amino acids
    Molecular mass:
    14570 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SMIM22 Gene


neXtProt entry for SMIM22 Gene

Post-translational modifications for SMIM22 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SMIM22 Gene

Domains & Families for SMIM22 Gene

Protein Domains for SMIM22 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM22: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM22 Gene

Function for SMIM22 Gene

Phenotypes for SMIM22 Gene

GenomeRNAi human phenotypes for SMIM22:
genes like me logo Genes that share phenotypes with SMIM22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM22 Gene

Localization for SMIM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM22 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM22: view

No data available for Subcellular locations from COMPARTMENTS for SMIM22 Gene

Pathways & Interactions for SMIM22 Gene

SuperPathways for SMIM22 Gene

No Data Available

Interacting Proteins for SMIM22 Gene

Gene Ontology (GO) - Biological Process for SMIM22 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMIM22 Gene

Drugs & Compounds for SMIM22 Gene

No Compound Related Data Available

Transcripts for SMIM22 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM22 Gene

No ASD Table

Relevant External Links for SMIM22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM22 Gene

mRNA expression in normal human tissues for SMIM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMIM22 Gene

This gene is overexpressed in Colon - Transverse (x13.0), Stomach (x7.4), Pancreas (x5.7), Small Intestine - Terminal Ileum (x4.7), and Minor Salivary Gland (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SMIM22 Gene:

genes like me logo Genes that share expression patterns with SMIM22: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SMIM22 Gene

Orthologs for SMIM22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM22 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Smim22 34
  • 76.67 (n)
  • 72.5 (a)
Smim22 16
Smim22 35
  • 67 (a)
(Rattus norvegicus)
Mammalia Smim22 34
  • 77.5 (n)
  • 72.5 (a)
(Danio rerio)
Actinopterygii SMIM22 35
  • 25 (a)
Species where no ortholog for SMIM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM22 Gene

Gene Tree for SMIM22 (if available)
Gene Tree for SMIM22 (if available)

Paralogs for SMIM22 Gene

No data available for Paralogs for SMIM22 Gene

Variants for SMIM22 Gene

Sequence variations from dbSNP and Humsavar for SMIM22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3085033 -- 4,793,109(-) ttttt(-/TT)gagac intron-variant
rs9674422 -- 4,792,734(+) gaagc(A/G)gaggt intron-variant
rs4360941 -- 4,794,548(+) cccta(C/G)tagct intron-variant, upstream-variant-2KB
rs7185700 -- 4,793,389(+) tggga(A/C)atgga intron-variant, upstream-variant-2KB
rs34855027 -- 4,790,717(+) GAGGA(-/A)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM22 Gene

Variant ID Type Subtype PubMed ID
esv2422516 CNV deletion 17116639
esv26756 CNV gain+loss 19812545
nsv1046986 CNV gain 25217958

Variation tolerance for SMIM22 Gene

Gene Damage Index Score: 3.95; 59.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM22 Gene

Disorders for SMIM22 Gene

Relevant External Links for SMIM22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMIM22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM22 Gene

Publications for SMIM22 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for SMIM22 Gene

Sources for SMIM22 Gene

Loading form....