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Aliases for SMIM21 Gene

Aliases for SMIM21 Gene

  • Small Integral Membrane Protein 21 2 3 5
  • C18orf62 3 4
  • Chromosome 18 Open Reading Frame 62 2

External Ids for SMIM21 Gene

Previous HGNC Symbols for SMIM21 Gene

  • C18orf62

Previous GeneCards Identifiers for SMIM21 Gene

  • GC18M073122

Summaries for SMIM21 Gene

GeneCards Summary for SMIM21 Gene

SMIM21 (Small Integral Membrane Protein 21) is a Protein Coding gene.

Additional gene information for SMIM21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM21 Gene

Genomics for SMIM21 Gene

GeneHancer (GH) Regulatory Elements for SMIM21 Gene

Promoters and enhancers for SMIM21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I075454 Enhancer 0.6 Ensembl ENCODE 550.8 0.0 -40 2.4 SUZ12 ZFX EZH2 GC18P075455 SMIM21 ENSG00000266774 TSHZ1
GH18I075427 Promoter 0.5 EPDnew 550.3 +28.0 28039 0.1 GC18P075428 PIR41034 SMIM21 ENSG00000266774
GH18I075430 Enhancer 0.9 FANTOM5 27 +25.5 25463 0.2 PKNOX1 INSM2 KLF17 FEZF1 ZEB1 ZNF335 GLIS2 ZNF366 ZSCAN5C SCRT2 SMIM21 GC18P075428 PIR41034 ENSG00000266774
GH18I075363 Enhancer 0.4 UCNEbase 11 +92.4 92373 0.5 SMIM21 ENSG00000276993 GC18M075233
GH18I075364 Enhancer 0.2 ENCODE 11 +91.6 91580 0.1 SMIM21 ENSG00000276993 GC18M075233
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMIM21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMIM21 Gene

Genomic Locations for SMIM21 Gene
chr18:75,409,476-75,455,653
(GRCh38/hg38)
Size:
46,178 bases
Orientation:
Minus strand
chr18:73,121,431-73,139,658
(GRCh37/hg19)

Genomic View for SMIM21 Gene

Genes around SMIM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM21 Gene

Proteins for SMIM21 Gene

  • Protein details for SMIM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B7S5-SMI21_HUMAN
    Recommended name:
    Small integral membrane protein 21
    Protein Accession:
    Q3B7S5

    Protein attributes for SMIM21 Gene

    Size:
    101 amino acids
    Molecular mass:
    11722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM21 Gene

Post-translational modifications for SMIM21 Gene

No Post-translational modifications

Other Protein References for SMIM21 Gene

No data available for DME Specific Peptides for SMIM21 Gene

Domains & Families for SMIM21 Gene

Gene Families for SMIM21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMIM21 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM21: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM21 Gene

Function for SMIM21 Gene

Phenotypes From GWAS Catalog for SMIM21 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM21 Gene

Localization for SMIM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM21 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM21 gene
Compartment Confidence
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SMIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SMIM21 Gene

Pathways & Interactions for SMIM21 Gene

SuperPathways for SMIM21 Gene

No Data Available

Interacting Proteins for SMIM21 Gene

Gene Ontology (GO) - Biological Process for SMIM21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM21 Gene

Drugs & Compounds for SMIM21 Gene

No Compound Related Data Available

Transcripts for SMIM21 Gene

mRNA/cDNA for SMIM21 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM21 Gene

Small integral membrane protein 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM21 Gene

No ASD Table

Relevant External Links for SMIM21 Gene

GeneLoc Exon Structure for
SMIM21
ECgene alternative splicing isoforms for
SMIM21

Expression for SMIM21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM21 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM21 Gene

This gene is overexpressed in Testis (x47.8).

Protein differential expression in normal tissues from HIPED for SMIM21 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMIM21 Gene



Protein tissue co-expression partners for SMIM21 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMIM21 Gene:

SMIM21

SOURCE GeneReport for Unigene cluster for SMIM21 Gene:

Hs.666744
genes like me logo Genes that share expression patterns with SMIM21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM21 Gene

Orthologs for SMIM21 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SMIM21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM21 33 34
  • 98.02 (n)
Species where no ortholog for SMIM21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM21 Gene

ENSEMBL:
Gene Tree for SMIM21 (if available)
TreeFam:
Gene Tree for SMIM21 (if available)

Paralogs for SMIM21 Gene

No data available for Paralogs for SMIM21 Gene

Variants for SMIM21 Gene

Sequence variations from dbSNP and Humsavar for SMIM21 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000039958 -- 75,414,077(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000057000 -- 75,413,986(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000069177 -- 75,440,639(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000123507 -- 75,448,036(-) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000187475 -- 75,424,641(-) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM21 Gene

Variant ID Type Subtype PubMed ID
esv3583154 CNV loss 25503493
esv3643133 CNV loss 21293372

Variation tolerance for SMIM21 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM21 Gene

Disorders for SMIM21 Gene

Additional Disease Information for SMIM21

No disorders were found for SMIM21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM21 Gene

Publications for SMIM21 Gene

  1. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L … Koeleman BP (Annals of the rheumatic diseases 2015) 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SMIM21 Gene

Sources for SMIM21 Gene

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