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Aliases for SMIM21 Gene

Aliases for SMIM21 Gene

  • Small Integral Membrane Protein 21 2 3
  • C18orf62 3 4
  • Chromosome 18 Open Reading Frame 62 2

External Ids for SMIM21 Gene

Previous HGNC Symbols for SMIM21 Gene

  • C18orf62

Previous GeneCards Identifiers for SMIM21 Gene

  • GC18M073122

Summaries for SMIM21 Gene

GeneCards Summary for SMIM21 Gene

SMIM21 (Small Integral Membrane Protein 21) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM21 Gene

Genomics for SMIM21 Gene

Genomic Location for SMIM21 Gene

75,409,476 bp from pter
75,455,653 bp from pter
46,178 bases
Minus strand

Genomic View for SMIM21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMIM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM21 Gene

No data available for Regulatory Elements for SMIM21 Gene

Proteins for SMIM21 Gene

  • Protein details for SMIM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 21
    Protein Accession:

    Protein attributes for SMIM21 Gene

    101 amino acids
    Molecular mass:
    11722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM21 Gene

Proteomics data for SMIM21 Gene at MOPED

Post-translational modifications for SMIM21 Gene

No Post-translational modifications

Other Protein References for SMIM21 Gene

No data available for DME Specific Peptides for SMIM21 Gene

Domains & Families for SMIM21 Gene

Protein Domains for SMIM21 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM21: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM21 Gene

Function for SMIM21 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM21

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM21 Gene

Localization for SMIM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM21 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM21: view

No data available for Subcellular locations from COMPARTMENTS for SMIM21 Gene

Pathways & Interactions for SMIM21 Gene

SuperPathways for SMIM21 Gene

No Data Available

Interacting Proteins for SMIM21 Gene

Gene Ontology (GO) - Biological Process for SMIM21 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMIM21 Gene

Drugs & Compounds for SMIM21 Gene

No Compound Related Data Available

Transcripts for SMIM21 Gene

mRNA/cDNA for SMIM21 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM21 Gene

Small integral membrane protein 21:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM21 Gene

No ASD Table

Relevant External Links for SMIM21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM21 Gene

mRNA expression in normal human tissues for SMIM21 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM21 Gene

This gene is overexpressed in Testis (x47.8).

Protein differential expression in normal tissues from HIPED for SMIM21 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMIM21 Gene

SOURCE GeneReport for Unigene cluster for SMIM21 Gene Hs.666744

genes like me logo Genes that share expression patterns with SMIM21: view

Protein tissue co-expression partners for SMIM21 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SMIM21 Gene

Orthologs for SMIM21 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SMIM21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMIM21 35
  • 98.02 (n)
  • 96.04 (a)
SMIM21 36
  • 96 (a)
Species with no ortholog for SMIM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM21 Gene

Gene Tree for SMIM21 (if available)
Gene Tree for SMIM21 (if available)

Paralogs for SMIM21 Gene

No data available for Paralogs for SMIM21 Gene

Variants for SMIM21 Gene

Sequence variations from dbSNP and Humsavar for SMIM21 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs184941615 -- 75,448,037(+) AAATC(A/G)AAAGA intron-variant
rs184949304 -- 75,429,226(+) AAAAG(A/T)TGTGA upstream-variant-2KB, utr-variant-5-prime
rs185116787 -- 75,438,872(+) CCCCG(A/G)GCAGG intron-variant
rs185319889 -- 75,432,546(+) TCTAG(C/T)AGCTA utr-variant-5-prime
rs185464910 -- 75,442,539(+) CTGTC(C/T)CTTTC intron-variant

Variation tolerance for SMIM21 Gene

Residual Variation Intolerance Score: 62.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM21 Gene

Disorders for SMIM21 Gene

Relevant External Links for SMIM21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SMIM21: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM21 Gene

Publications for SMIM21 Gene

  1. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L. … Koeleman B.P. (Ann. Rheum. Dis. 2015) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for SMIM21 Gene

Sources for SMIM21 Gene

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