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Aliases for SMIM21 Gene

Aliases for SMIM21 Gene

  • Small Integral Membrane Protein 21 2 3 5
  • C18orf62 3 4
  • Chromosome 18 Open Reading Frame 62 2

External Ids for SMIM21 Gene

Previous HGNC Symbols for SMIM21 Gene

  • C18orf62

Previous GeneCards Identifiers for SMIM21 Gene

  • GC18M073122

Summaries for SMIM21 Gene

GeneCards Summary for SMIM21 Gene

SMIM21 (Small Integral Membrane Protein 21) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM21 Gene

Genomics for SMIM21 Gene

Genomic Location for SMIM21 Gene

Chromosome:
18
Start:
75,409,476 bp from pter
End:
75,455,653 bp from pter
Size:
46,178 bases
Orientation:
Minus strand

Genomic View for SMIM21 Gene

Genes around SMIM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM21 Gene

No data available for Regulatory Elements for SMIM21 Gene

Proteins for SMIM21 Gene

  • Protein details for SMIM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B7S5-SMI21_HUMAN
    Recommended name:
    Small integral membrane protein 21
    Protein Accession:
    Q3B7S5

    Protein attributes for SMIM21 Gene

    Size:
    101 amino acids
    Molecular mass:
    11722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM21 Gene

Proteomics data for SMIM21 Gene at MOPED

Post-translational modifications for SMIM21 Gene

No Post-translational modifications

Other Protein References for SMIM21 Gene

No data available for DME Specific Peptides for SMIM21 Gene

Domains & Families for SMIM21 Gene

Protein Domains for SMIM21 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM21: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM21 Gene

Function for SMIM21 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM21 Gene

Localization for SMIM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM21 Gene

Membrane; Single-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SMIM21 Gene

Pathways & Interactions for SMIM21 Gene

SuperPathways for SMIM21 Gene

No Data Available

Interacting Proteins for SMIM21 Gene

Gene Ontology (GO) - Biological Process for SMIM21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM21 Gene

Drugs & Compounds for SMIM21 Gene

No Compound Related Data Available

Transcripts for SMIM21 Gene

mRNA/cDNA for SMIM21 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM21 Gene

Small integral membrane protein 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM21 Gene

No ASD Table

Relevant External Links for SMIM21 Gene

GeneLoc Exon Structure for
SMIM21
ECgene alternative splicing isoforms for
SMIM21

Expression for SMIM21 Gene

mRNA expression in normal human tissues for SMIM21 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM21 Gene

This gene is overexpressed in Testis (x47.8).

Protein differential expression in normal tissues from HIPED for SMIM21 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMIM21 Gene



SOURCE GeneReport for Unigene cluster for SMIM21 Gene Hs.666744

genes like me logo Genes that share expression patterns with SMIM21: view

Protein tissue co-expression partners for SMIM21 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SMIM21 Gene

Orthologs for SMIM21 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SMIM21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM21 35
  • 98.02 (n)
  • 96.04 (a)
SMIM21 36
  • 96 (a)
OneToOne
Species with no ortholog for SMIM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM21 Gene

ENSEMBL:
Gene Tree for SMIM21 (if available)
TreeFam:
Gene Tree for SMIM21 (if available)

Paralogs for SMIM21 Gene

No data available for Paralogs for SMIM21 Gene

Variants for SMIM21 Gene

Sequence variations from dbSNP and Humsavar for SMIM21 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs719179 -- 75,434,441(-) GATTT(C/T)GTTGC intron-variant
rs1319789 -- 75,449,202(+) atcta(A/C)atata intron-variant
rs1347527 -- 75,449,203(+) tctac(A/G)tatat intron-variant
rs1080754 -- 75,448,918(+) taaag(C/G)taaag intron-variant
rs1561080 -- 75,433,892(-) CTGAG(C/T)GAAGC intron-variant

Variation tolerance for SMIM21 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM21 Gene

HapMap Linkage Disequilibrium report
SMIM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM21 Gene

Disorders for SMIM21 Gene

Relevant External Links for SMIM21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM21

No disorders were found for SMIM21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM21 Gene

Publications for SMIM21 Gene

  1. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L. … Koeleman B.P. (Ann. Rheum. Dis. 2015) 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SMIM21 Gene

Sources for SMIM21 Gene

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