Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SMIM2 Gene

Aliases for SMIM2 Gene

  • Small Integral Membrane Protein 2 2 3 5
  • C13orf44 3 4
  • Chromosome 13 Open Reading Frame 44 2

External Ids for SMIM2 Gene

Previous HGNC Symbols for SMIM2 Gene

  • C13orf44

Previous GeneCards Identifiers for SMIM2 Gene

  • GC13M044723

Summaries for SMIM2 Gene

GeneCards Summary for SMIM2 Gene

SMIM2 (Small Integral Membrane Protein 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM2 Gene

Genomics for SMIM2 Gene

Regulatory Elements for SMIM2 Gene

Enhancers for SMIM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SMIM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM2 Gene

Chromosome:
13
Start:
44,143,151 bp from pter
End:
44,161,257 bp from pter
Size:
18,107 bases
Orientation:
Minus strand

Genomic View for SMIM2 Gene

Genes around SMIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM2 Gene

Proteins for SMIM2 Gene

  • Protein details for SMIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVW6-SMIM2_HUMAN
    Recommended name:
    Small integral membrane protein 2
    Protein Accession:
    Q9BVW6
    Secondary Accessions:
    • Q5SZS7

    Protein attributes for SMIM2 Gene

    Size:
    85 amino acids
    Molecular mass:
    9520 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM2 Gene

Post-translational modifications for SMIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM2 Gene

Domains & Families for SMIM2 Gene

Protein Domains for SMIM2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM2 Gene

Function for SMIM2 Gene

Gene Ontology (GO) - Molecular Function for SMIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SMIM2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM2 Gene

Localization for SMIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMIM2 Gene COMPARTMENTS Subcellular localization image for SMIM2 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM2: view

Pathways & Interactions for SMIM2 Gene

SuperPathways for SMIM2 Gene

No Data Available

Interacting Proteins for SMIM2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383270%0d%0a9606.ENSP00000365576%0d%0a
Selected Interacting proteins: ENSP00000383270 Q9BVW6-SMIM2_HUMAN for SMIM2 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for SMIM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM2 Gene

Drugs & Compounds for SMIM2 Gene

No Compound Related Data Available

Transcripts for SMIM2 Gene

mRNA/cDNA for SMIM2 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM2 Gene

No ASD Table

Relevant External Links for SMIM2 Gene

GeneLoc Exon Structure for
SMIM2
ECgene alternative splicing isoforms for
SMIM2

Expression for SMIM2 Gene

mRNA expression in normal human tissues for SMIM2 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM2 Gene

This gene is overexpressed in Testis (x21.0).

NURSA nuclear receptor signaling pathways regulating expression of SMIM2 Gene:

SMIM2

SOURCE GeneReport for Unigene cluster for SMIM2 Gene:

Hs.534877
genes like me logo Genes that share expression patterns with SMIM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SMIM2 Gene

Orthologs for SMIM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SMIM2 34
  • 80 (n)
  • 61.33 (a)
chimpanzee
(Pan troglodytes)
Mammalia LOC741476 34
  • 99.22 (n)
  • 100 (a)
SMIM2 35
  • 100 (a)
OneToOne
Species where no ortholog for SMIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM2 Gene

ENSEMBL:
Gene Tree for SMIM2 (if available)
TreeFam:
Gene Tree for SMIM2 (if available)

Paralogs for SMIM2 Gene

No data available for Paralogs for SMIM2 Gene

Variants for SMIM2 Gene

Sequence variations from dbSNP and Humsavar for SMIM2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs4146984 -- 44,163,056(+) TCTTA(C/T)TCATA upstream-variant-2KB
rs3809349 -- 44,161,322(+) CTACT(C/G)TGTTG upstream-variant-2KB
rs3809350 -- 44,162,043(+) GTGAG(C/T)TTCTA upstream-variant-2KB
rs3809351 -- 44,162,050(+) TCTAC(A/G)TATTC upstream-variant-2KB
rs3809352 -- 44,162,517(+) TCCAG(A/C)AGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMIM2 Gene

Variant ID Type Subtype PubMed ID
nsv1048346 CNV gain 25217958

Variation tolerance for SMIM2 Gene

Gene Damage Index Score: 0.45; 9.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM2 Gene

Disorders for SMIM2 Gene

Relevant External Links for SMIM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM2

No disorders were found for SMIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM2 Gene

Publications for SMIM2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for SMIM2 Gene

Sources for SMIM2 Gene

Content